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ONTOLOGY REPORT - ANNOTATIONS


Term:spermine
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Accession:CHEBI:15746 term browser browse the term
Definition:A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.
Synonyms:related_synonym: 4,9-diaza-1,12-dodecanediamine;   4,9-diazadodecane-1,12-diamine;   Formula=C10H26N4;   InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2;   InChIKey=PFNFFQXMRSDOHW-UHFFFAOYSA-N;   N,N'-Bis(3-aminopropyl)-1,4-butanediamine;   N,N'-bis(3-aminopropyl)butane-1,4-diamine;   SMILES=NCCCNCCCCNCCCN
 alt_id: CHEBI:15098;   CHEBI:26734;   CHEBI:45583;   CHEBI:9219
 xref: Beilstein:1750791 "Beilstein";   CAS:71-44-3 "ChemIDplus";   CAS:71-44-3 "KEGG COMPOUND";   CAS:71-44-3 "NIST Chemistry WebBook";   DrugBank:DB00127;   Gmelin:454653 "Gmelin";   HMDB:HMDB0001256;   KEGG:C00750;   KNApSAcK:C00001432
 xref_mesh: MESH:D013096
 xref: MetaCyc:SPERMINE;   PDBeChem:SPM;   PMID:10873205 "Europe PMC";   PMID:10930630 "Europe PMC";   PMID:11341774 "Europe PMC";   PMID:11543598 "Europe PMC";   PMID:11805860 "Europe PMC";   PMID:15145762 "Europe PMC";   PMID:15308338 "Europe PMC";   PMID:15500473 "Europe PMC";   PMID:15972654 "Europe PMC";   PMID:16146631 "Europe PMC";   PMID:16253230 "Europe PMC";   PMID:16664713 "Europe PMC";   PMID:19275753 "Europe PMC";   PMID:19593412 "Europe PMC";   PMID:19962967 "Europe PMC";   PMID:22735334 "Europe PMC";   PMID:23289636 "Europe PMC";   PMID:23418509 "Europe PMC";   PMID:23506248 "Europe PMC";   PMID:23820617 "Europe PMC";   PMID:23887925 "Europe PMC";   PMID:7521253 "Europe PMC";   PMID:7721849 "Europe PMC";   PMID:8524182 "Europe PMC";   PMID:8832899 "Europe PMC";   PMID:9151701 "Europe PMC";   Reaxys:1750791 "Reaxys";   Wikipedia:Spermine
 cyclic_relationship: is_conjugate_base_of CHEBI:45725


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spermine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actn2 actinin alpha 2 JBrowse link 17 66,304,530 66,397,647 RGD:6480464
G Actn3 actinin alpha 3 JBrowse link 1 220,120,532 220,136,460 RGD:6480464
G Adrb1 adrenoceptor beta 1 JBrowse link 1 277,537,585 277,538,985 RGD:6480464
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:6480464
G Ankrd2 ankyrin repeat domain 2 JBrowse link 1 261,281,859 261,291,307 RGD:6480464
G Asic1 acid sensing ion channel subunit 1 JBrowse link 7 141,324,714 141,354,937 RGD:6480464
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 JBrowse link 1 197,855,912 197,875,038 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bves blood vessel epicardial substance JBrowse link 20 50,439,885 50,474,678 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Casr calcium-sensing receptor JBrowse link 11 67,188,204 67,262,261 RGD:6480464
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit JBrowse link 3 60,445,657 60,460,724 RGD:6480464
G Ckm creatine kinase, M-type JBrowse link 1 80,321,507 80,331,841 RGD:6480464
G Cobl cordon-bleu WH2 repeat protein JBrowse link 14 92,341,949 92,497,169 RGD:6480464
G Col19a1 collagen type XIX alpha 1 chain JBrowse link 9 30,508,003 30,864,836 RGD:6480464
G Diablo diablo, IAP-binding mitochondrial protein JBrowse link 12 38,490,230 38,503,344 RGD:6480464
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:6480464
G Dmp1 dentin matrix acidic phosphoprotein 1 JBrowse link 14 6,889,851 6,923,961 RGD:6480464
G Fabp1 fatty acid binding protein 1 JBrowse link 4 99,063,181 99,066,957 RGD:6480464
G Fis1 fission, mitochondrial 1 JBrowse link 12 22,750,485 22,765,324 RGD:6480464
G Gja5 gap junction protein, alpha 5 JBrowse link 2 199,162,745 199,184,942 RGD:6480464
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:6480464
G Ibsp integrin-binding sialoprotein JBrowse link 14 6,801,200 6,813,987 RGD:6480464
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 JBrowse link 1 141,874,354 141,893,674 RGD:6480464
G Ky kyphoscoliosis peptidase JBrowse link 8 110,982,777 111,022,666 RGD:6480464
G Lmod2 leiomodin 2 JBrowse link 4 51,553,439 51,561,135 RGD:6480464
G Map4 microtubule-associated protein 4 JBrowse link 8 118,013,584 118,159,934 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:6480464
G Mybph myosin binding protein H JBrowse link 13 51,034,228 51,041,903 RGD:6480464
G Myf5 myogenic factor 5 JBrowse link 7 49,729,533 49,732,974 RGD:6480464
G Myf6 myogenic factor 6 JBrowse link 7 49,739,643 49,741,490 RGD:6480464
G Myh1 myosin heavy chain 1 JBrowse link 10 53,740,841 53,764,610 RGD:6480464
G Myh3 myosin heavy chain 3 JBrowse link 10 53,621,375 53,645,194 RGD:6480464
G Myh4 myosin heavy chain 4 JBrowse link 10 53,778,456 53,801,605 RGD:6480464
G Myh8 myosin heavy chain 8 JBrowse link 10 53,818,818 53,848,490 RGD:6480464
G Myl1 myosin, light chain 1 JBrowse link 9 73,937,820 73,958,480 RGD:6480464
G Mylpf myosin light chain, phosphorylatable, fast skeletal muscle JBrowse link 1 198,655,835 198,658,590 RGD:6480464
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:6480464
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:6480464
G Myom2 myomesin 2 JBrowse link 16 79,587,136 79,672,871 RGD:6480464
G Neb nebulin JBrowse link 3 37,658,081 37,855,843 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Odc1 ornithine decarboxylase 1 JBrowse link 6 42,852,529 42,859,142 RGD:6480464
G Ryr1 ryanodine receptor 1 JBrowse link 1 87,959,596 88,066,252 RGD:6480464
G Scn8a sodium voltage-gated channel alpha subunit 8 JBrowse link 7 142,575,629 142,683,659 RGD:6480464
G Smox spermine oxidase JBrowse link 3 124,068,796 124,103,726 RGD:6480464
G Smyd1 SET and MYND domain containing 1 JBrowse link 4 99,071,122 99,125,143 RGD:6480464
G Tnnc2 troponin C2, fast skeletal type JBrowse link 3 161,243,607 161,246,335 RGD:6480464
G Tnni1 troponin I1, slow skeletal type JBrowse link 13 52,624,856 52,637,297 RGD:6480464
G Tnni2 troponin I2, fast skeletal type JBrowse link 1 215,609,110 215,611,652 RGD:6480464
G Tnnt1 troponin T1, slow skeletal type JBrowse link 1 72,889,270 72,899,629 RGD:6480464
G Tnnt3 troponin T3, fast skeletal type JBrowse link 1 215,666,628 215,683,628 RGD:6480464
G Tpm2 tropomyosin 2 JBrowse link 5 59,016,616 59,025,971 RGD:6480464
G Trdn triadin JBrowse link 1 25,403,390 25,787,664 RGD:6480464
G Ttn titin JBrowse link 3 63,565,160 63,837,815 RGD:6480464
G Unc5c unc-5 netrin receptor C JBrowse link 2 247,045,813 247,397,483 RGD:6480464
G Vgll2 vestigial-like family member 2 JBrowse link 20 33,077,106 33,082,962 RGD:6480464
G Xirp1 xin actin-binding repeat containing 1 JBrowse link 8 128,694,809 128,712,092 RGD:6480464
N(1),N(12)-diethylspermine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sat1 spermidine/spermine N1-acetyl transferase 1 JBrowse link X 43,626,480 43,629,767 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    role 19695
      chemical role 19211
        antioxidant 14137
          spermine 66
            N(4)-aminopropylspermine 0
            substituted spermine + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    main group molecular entity 19628
                      s-block molecular entity 19393
                        hydrogen molecular entity 19382
                          hydrides 18296
                            inorganic hydride 17211
                              pnictogen hydride 17174
                                nitrogen hydride 17010
                                  azane 16703
                                    ammonia 16700
                                      organic amino compound 16699
                                        polyamine 8082
                                          tetramine 184
                                            spermine 66
                                              N(4)-aminopropylspermine 0
                                              substituted spermine + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.