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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:biotin
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Accession:CHEBI:15956 term browser browse the term
Definition:An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins.
Synonyms:exact_synonym: 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid
 related_synonym: (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid;   5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid;   Coenzyme R;   D-Biotin;   Formula=C10H16N2O3S;   InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1;   InChIKey=YBJHBAHKTGYVGT-ZKWXMUAHSA-N;   SMILES=[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2;   Vitamin H;   biotina;   biotine;   biotinum;   cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid;   cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid;   cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid;   vitamin B7
 alt_id: CHEBI:13905;   CHEBI:22882;   CHEBI:22884;   CHEBI:3108;   CHEBI:41236
 xref: Beilstein:86838;   CAS:58-85-5;   COMe:MOL000144;   DrugBank:DB00121;   Drug_Central:373;   Gmelin:1918703;   HMDB:HMDB0000030;   KEGG:C00120;   KEGG:D00029;   KNApSAcK:C00000756;   LINCS:LSM-3994
 xref_mesh: MESH:D001710
 xref: MetaCyc:BIOTIN;   PDBeChem:BTN;   PMID:11435506;   PMID:11800048;   PMID:12055344;   PMID:12803839;   PMID:15012185;   PMID:15202718;   PMID:15272000;   PMID:15899401;   PMID:16419467;   PMID:16676358;   PMID:16677798;   PMID:16769720;   PMID:17297119;   PMID:18452485;   PMID:18509457;   PMID:19319844;   PMID:19727438;   PMID:19928962;   PMID:20967359;   PMID:20974274;   PMID:21248194;   PMID:21356565;   PMID:21373679;   PMID:21596550;   PMID:21871906;   PMID:25515858;   Reaxys:86838;   Wikipedia:Biotin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57586


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biotin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; Biotin inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein] CTD PMID:32383521 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein] CTD PMID:32383521 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 decreases expression ISO Biotin results in decreased expression of CXCL11 mRNA CTD PMID:15219929 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO Biotin results in increased expression of and results in increased activity of CYP1B1 protein
Biotin results in increased expression of CYP1B1 mRNA
CTD PMID:15219929, PMID:15333708 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Biotin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions ISO [Chromium co-treated with Biotin] results in decreased expression of HBA1 protein modified form; [chromium tripicolinate co-treated with Biotin] results in decreased expression of HBA1 protein modified form CTD PMID:17684468 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
JBrowse link
G Herc4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 increases expression ISO Biotin results in increased expression of HERC4 mRNA CTD PMID:15219929 NCBI chr20:26,755,948...26,831,267
Ensembl chr20:26,755,911...26,830,931
JBrowse link
G Hira histone cell cycle regulator decreases expression ISO Biotin results in decreased expression of HIRA mRNA CTD PMID:15219929 NCBI chr11:86,168,196...86,276,430
Ensembl chr11:86,168,196...86,276,430
JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 increases expression ISO Biotin results in increased expression of IGHG1 mRNA CTD PMID:15219929 NCBI chr 6:139,140,572...139,784,388
Ensembl chr 6:139,140,679...139,142,218
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein] CTD PMID:32383521 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein] CTD PMID:32383521 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; Biotin inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 decreases expression ISO Biotin results in decreased expression of LAMP1 mRNA CTD PMID:15219929 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Biotin results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Sele selectin E affects binding ISO [Acetylglucosamine analog binds to Biotin] which binds to SELE protein CTD PMID:12191509 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sell selectin L affects binding EXP [Acetylglucosamine analog binds to Biotin] which binds to SELL protein CTD PMID:12191509 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Selp selectin P affects binding ISO [Acetylglucosamine analog binds to Biotin] which binds to SELP protein CTD PMID:12191509 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Slc5a6 solute carrier family 5 member 6 affects expression
increases transport
multiple interactions
increases uptake
ISO
EXP
Biotin affects the expression of SLC5A6 mRNA; Biotin affects the expression of SLC5A6 protein
SLC5A6 results in increased transport of Biotin
Sodium affects the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]
2,4-Dinitrophenol inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; 4-Chloromercuribenzenesulfonate inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Azides inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; calmidazolium inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; chelerythrine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Gramicidin inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Iodoacetates inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Probenecid inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Sodium affects the reaction [SLC5A6 results in increased transport of Biotin]; Sodium promotes the reaction [SLC5A6 protein results in increased transport of Biotin]; Staurosporine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]; Tetradecanoylphorbol Acetate promotes the reaction [SLC5A6 protein results in increased transport of Biotin]; Trifluoperazine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]
SLC5A6 results in increased uptake of Biotin
SLC5A6 protein results in increased transport of Biotin; SLC5A6 results in increased transport of Biotin
CTD PMID:9516450, PMID:10329687, PMID:10516089, PMID:12646417, PMID:15561972 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
JBrowse link
G Tmprss15 transmembrane serine protease 15 increases expression ISO Biotin results in increased expression of TMPRSS15 mRNA CTD PMID:15219929 NCBI chr11:17,561,591...17,684,903
Ensembl chr11:17,561,596...17,684,903
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; Biotin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein] CTD PMID:32383521 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO Biotin results in increased expression of TPR mRNA CTD PMID:15219929 NCBI chr13:67,611,685...67,672,833
Ensembl chr13:67,611,708...67,672,827
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          cofactor 15529
            biotin 21
              GCB 0
              biocytin + 0
              biotin amide 0
              biotinyl group + 0
              biotinyl-5'-AMP 0
              biotinyl-CoA 0
              vitamin B complex 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                monocarboxylic acid amide 14551
                                                  urea 4984
                                                    ureas 4982
                                                      biotins 21
                                                        biotin 21
                                                          GCB 0
                                                          biocytin + 0
                                                          biotin amide 0
                                                          biotinyl group + 0
                                                          biotinyl-5'-AMP 0
                                                          biotinyl-CoA 0
                                                          vitamin B complex 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.