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Accession:CHEBI:15956 term browser browse the term
Definition:An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins.
Synonyms:exact_synonym: 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid
 related_synonym: (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid;   5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid;   Coenzyme R;   D-Biotin;   Formula=C10H16N2O3S;   InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1;   InChIKey=YBJHBAHKTGYVGT-ZKWXMUAHSA-N;   SMILES=[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2;   Vitamin H;   biotina;   biotine;   biotinum;   cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid;   cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid;   cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid;   vitamin B7
 alt_id: CHEBI:13905;   CHEBI:22882;   CHEBI:22884;   CHEBI:3108;   CHEBI:41236
 xref: Beilstein:86838 "Beilstein";   CAS:58-85-5 "ChemIDplus";   CAS:58-85-5 "KEGG COMPOUND";   CAS:58-85-5 "NIST Chemistry WebBook";   COMe:MOL000144;   DrugBank:DB00121;   Drug_Central:373 "DrugCentral";   Gmelin:1918703 "Gmelin";   HMDB:HMDB0000030;   KEGG:C00120;   KEGG:D00029;   KNApSAcK:C00000756;   LINCS:LSM-3994
 xref_mesh: MESH:D001710
 xref: MetaCyc:BIOTIN;   PDBeChem:BTN;   PMID:11435506 "Europe PMC";   PMID:11800048 "Europe PMC";   PMID:12055344 "Europe PMC";   PMID:12803839 "Europe PMC";   PMID:15012185 "Europe PMC";   PMID:15202718 "Europe PMC";   PMID:15272000 "Europe PMC";   PMID:15899401 "Europe PMC";   PMID:16419467 "Europe PMC";   PMID:16676358 "Europe PMC";   PMID:16677798 "Europe PMC";   PMID:16769720 "Europe PMC";   PMID:17297119 "Europe PMC";   PMID:18452485 "Europe PMC";   PMID:18509457 "Europe PMC";   PMID:19319844 "Europe PMC";   PMID:19727438 "Europe PMC";   PMID:19928962 "Europe PMC";   PMID:20967359 "Europe PMC";   PMID:20974274 "Europe PMC";   PMID:21248194 "Europe PMC";   PMID:21356565 "Europe PMC";   PMID:21373679 "Europe PMC";   PMID:21596550 "Europe PMC";   PMID:21871906 "Europe PMC";   PMID:25515858 "Europe PMC";   Reaxys:86838 "Reaxys";   Wikipedia:Biotin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57586

show annotations for term's descendants       view all columns           Sort by:
biotin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cxcl11 C-X-C motif chemokine ligand 11 JBrowse link 14 17,195,395 17,198,170 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Hba-a2 hemoglobin alpha, adult chain 2 JBrowse link 10 15,589,364 15,590,207 RGD:6480464
G Herc4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 JBrowse link 20 26,755,948 26,831,267 RGD:6480464
G Hira histone cell cycle regulator JBrowse link 11 86,168,196 86,276,430 RGD:6480464
G Ighg1 immunoglobulin heavy constant gamma 1 JBrowse link 6 139,140,572 139,784,388 RGD:6480464
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Sele selectin E JBrowse link 13 82,355,234 82,365,323 RGD:6480464
G Sell selectin L JBrowse link 13 82,369,820 82,387,774 RGD:6480464
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6480464
G Slc5a6 solute carrier family 5 member 6 JBrowse link 6 26,685,823 26,697,110 RGD:6480464
G Tmprss15 transmembrane serine protease 15 JBrowse link 11 17,561,591 17,684,903 RGD:6480464
G Tpr translocated promoter region, nuclear basket protein JBrowse link 13 67,611,685 67,672,833 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          cofactor 15860
            biotin 15
              GCB 0
              biocytin + 0
              biotin amide 0
              biotinyl group + 0
              biotinyl-5'-AMP 0
              biotinyl-CoA 0
              vitamin B complex 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        carboacyl group 16944
                                          univalent carboacyl group 16944
                                            carbamoyl group 16623
                                              carboxamide 16623
                                                monocarboxylic acid amide 13187
                                                  urea 4951
                                                    ureas 4948
                                                      biotins 15
                                                        biotin 15
                                                          GCB 0
                                                          biocytin + 0
                                                          biotin amide 0
                                                          biotinyl group + 0
                                                          biotinyl-5'-AMP 0
                                                          biotinyl-CoA 0
                                                          vitamin B complex 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.