Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydroxyacetone
go back to main search page
Accession:CHEBI:16016 term browser browse the term
Definition:A ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones.
Synonyms:related_synonym: 1,3-Dihydroxy-2-propanone;   1,3-Dihydroxyacetone;   1,3-Dihydroxydimethyl ketone;   1,3-Dihydroxypropan-2-one;   1,3-Dihydroxypropanone;   1,3-propanediol-2-one;   Bis(hydroxymethyl) ketone;   DHA;   Formula=C3H6O3;   Glycerone;   InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2;   InChIKey=RXKJFZQQPQGTFL-UHFFFAOYSA-N;   SMILES=C(CO)(CO)=O;   alpha,alpha'-dihydroxyacetone
 alt_id: CHEBI:14340;   CHEBI:24354;   CHEBI:39809;   CHEBI:5453
 xref: Beilstein:1740268;   CAS:96-26-4;   DrugBank:DB01775;   HMDB:HMDB0001882;   KEGG:C00184;   KEGG:D07841
 xref_mesh: MESH:D004098
 xref: MetaCyc:DIHYDROXYACETONE;   PDBeChem:2HA;   PMID:20936361;   PMID:21549029;   PMID:21598406;   PMID:23543734;   PMID:23554234;   PMID:23748086;   PMID:24209782;   Reaxys:1740268;   Wikipedia:Dihydroxyacetone


show annotations for term's descendants           Sort by:
 
dihydroxyacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO Dihydroxyacetone results in increased cleavage of CASP3 protein CTD PMID:29193605 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP10 protein CTD PMID:30959092 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP13 protein CTD PMID:30959092 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming decreases secretion ISO Dihydroxyacetone results in decreased secretion of MUC5AC protein CTD PMID:30959092 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Dihydroxyacetone inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Dihydroxyacetone results in increased cleavage of PARP1 protein CTD PMID:29193605 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
dihydroxyacetone phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate]
CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Tpi1 triosephosphate isomerase 1 affects metabolic processing EXP TPI1 protein affects the metabolism of Dihydroxyacetone Phosphate CTD PMID:14762718 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            dihydroxyacetone 8
              1-hydroxy-3-methoxyacetone 0
              1-palmitoylglycerone 3-phosphate 0
              1-stearoylglycerone 3-phosphate 0
              dihydroxyacetone phosphate 2
              glycerone derivative + 2
              glycerone phosphate(2-) 0
              glycerone sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        oxyketone 8631
                                          alpha-oxyketone 8631
                                            alpha-hydroxy ketone 8631
                                              primary alpha-hydroxy ketone 7516
                                                dihydroxyacetone 8
                                                  1-hydroxy-3-methoxyacetone 0
                                                  1-palmitoylglycerone 3-phosphate 0
                                                  1-stearoylglycerone 3-phosphate 0
                                                  dihydroxyacetone phosphate 2
                                                  glycerone derivative + 2
                                                  glycerone phosphate(2-) 0
                                                  glycerone sulfate 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.