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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-nitropropane
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Accession:CHEBI:16037 term browser browse the term
Definition:A secondary nitroalkane that is propane in which a hydrogen at position 2 has been replaced by a nitro group. Mainly used as a solvent (b.p. 120degreeC).
Synonyms:related_synonym: Formula=C3H7NO2;   InChI=1S/C3H7NO2/c1-3(2)4(5)6/h3H,1-2H3;   InChIKey=FGLBSLMDCBOPQK-UHFFFAOYSA-N;   SMILES=CC(C)[N+]([O-])=O;   dimethylnitromethane;   i-C3H7NO2;   isonitropropane;   sec-nitropropane
 alt_id: CHEBI:11632;   CHEBI:1226;   CHEBI:19727;   CHEBI:44443
 xref: CAS:79-46-9;   KEGG:C02116
 xref_mesh: MESH:C016617
 xref: MetaCyc:CPD-244;   PDBeChem:NIS;   PMID:1934149;   PMID:21860502;   PMID:22319232;   PMID:25892624;   Reaxys:1740684;   UM-BBD_compID:c0555;   Wikipedia:2-Nitropropane


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2-nitropropane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP 2-nitropropane results in increased expression of ABCB1B mRNA CTD PMID:17070881 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases expression EXP 2-nitropropane results in decreased expression of ACMSD mRNA CTD PMID:17070881 NCBI chr13:44,424,689...44,468,734
Ensembl chr13:44,424,689...44,468,734
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression EXP 2-nitropropane results in increased expression of ACSL3 mRNA CTD PMID:17070881 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
JBrowse link
G Aen apoptosis enhancing nuclease increases expression EXP 2-nitropropane results in increased expression of AEN mRNA CTD PMID:17070881 NCBI chr 1:140,584,328...140,593,749
Ensembl chr 1:140,584,380...140,593,745
JBrowse link
G Afp alpha-fetoprotein multiple interactions
increases expression
EXP diphenyldiselenide inhibits the reaction [2-nitropropane results in increased expression of AFP protein] CTD PMID:15804453 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP 2-nitropropane results in increased expression of AKR7A3 mRNA CTD PMID:17070881 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP 2-nitropropane results in increased expression of ALDH1A1 mRNA CTD PMID:17070881 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 increases expression EXP 2-nitropropane results in increased expression of ALDH1A4 mRNA CTD PMID:17070881 NCBI chr 1:240,584,233...240,601,843
Ensembl chr 1:240,562,423...240,601,744
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 affects response to substance
increases expression
multiple interactions
ISO APEX1 protein affects the susceptibility to 2-nitropropane
2-nitropropane results in increased expression of APEX1 mRNA; 2-nitropropane results in increased expression of APEX1 protein
APEX1 protein inhibits the reaction [2-nitropropane results in increased activity of CASP3 protein]; APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of GADD45G mRNA]; APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein]
CTD PMID:19268524 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apoa2 apolipoprotein A2 decreases expression EXP 2-nitropropane results in decreased expression of APOA2 mRNA CTD PMID:17070881 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP 2-nitropropane results in decreased expression of APOA4 mRNA CTD PMID:17070881 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP 2-nitropropane results in decreased expression of APOC3 mRNA CTD PMID:17070881 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP 2-nitropropane results in increased expression of ATP6V1D mRNA CTD PMID:17070881 NCBI chr 6:102,032,271...102,047,754
Ensembl chr 6:102,032,276...102,047,758
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP 2-nitropropane results in increased expression of BAX mRNA CTD PMID:17070881 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP 2-nitropropane results in increased expression of BTG2 mRNA CTD PMID:17070881 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G C7 complement C7 increases expression EXP 2-nitropropane results in increased expression of C7 mRNA CTD PMID:17070881 NCBI chr 2:54,707,621...54,781,624
Ensembl chr 2:54,709,138...54,777,729
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO 2-nitropropane results in increased activity of CASP3 protein
APEX1 protein inhibits the reaction [2-nitropropane results in increased activity of CASP3 protein]
CTD PMID:19268524 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP 2-nitropropane results in decreased activity of CAT protein
diphenyldiselenide inhibits the reaction [2-nitropropane results in decreased activity of CAT protein]; m-trifluoromethyl-diphenyl diselenide inhibits the reaction [2-nitropropane results in decreased activity of CAT protein]
CTD PMID:16445897, PMID:18818063 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cblc Cbl proto-oncogene C increases expression EXP 2-nitropropane results in increased expression of CBLC mRNA CTD PMID:17070881 NCBI chr 1:80,699,321...80,716,146
Ensembl chr 1:80,699,323...80,716,146
JBrowse link
G Ccng1 cyclin G1 increases expression EXP 2-nitropropane results in increased expression of CCNG1 mRNA CTD PMID:17070881 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cd276 Cd276 molecule increases expression EXP 2-nitropropane results in increased expression of CD276 mRNA CTD PMID:17070881 NCBI chr 8:63,312,060...63,350,411
Ensembl chr 8:63,318,019...63,350,269
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP 2-nitropropane results in increased expression of CDKN1A mRNA CTD PMID:17070881 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cpq carboxypeptidase Q decreases expression EXP 2-nitropropane results in decreased expression of CPQ mRNA CTD PMID:17070881 NCBI chr 7:71,709,174...72,167,413
Ensembl chr 7:71,709,157...72,167,417
JBrowse link
G Cryab crystallin, alpha B increases expression EXP 2-nitropropane results in increased expression of CRYAB mRNA CTD PMID:17070881 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 increases expression EXP 2-nitropropane results in increased expression of CYP2C13 mRNA CTD PMID:17070881 NCBI chr 1:258,796,624...258,877,023
Ensembl chr 1:258,796,622...258,877,045
JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 increases expression EXP 2-nitropropane results in increased expression of CYP4F5 mRNA CTD PMID:17070881 NCBI chr 7:14,559,806...14,574,345
Ensembl chr 7:14,529,482...14,574,361
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression EXP 2-nitropropane results in increased expression of DDAH1 mRNA CTD PMID:17070881 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014
JBrowse link
G Epcam epithelial cell adhesion molecule increases expression EXP 2-nitropropane results in increased expression of EPCAM mRNA CTD PMID:17070881 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP 2-nitropropane results in increased expression of EPHX1 mRNA CTD PMID:17070881 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP 2-nitropropane results in increased expression of FAS mRNA CTD PMID:17070881 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression EXP 2-nitropropane results in decreased expression of FHIT mRNA CTD PMID:17070881 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression
multiple interactions
ISO 2-nitropropane results in increased expression of GADD45G mRNA
APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of GADD45G mRNA]
CTD PMID:19268524 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP 2-nitropropane results in increased expression of GRIA3 mRNA CTD PMID:17070881 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP 2-nitropropane results in increased expression of GSTM1 mRNA CTD PMID:17070881 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression EXP 2-nitropropane results in decreased expression of HSD17B6 mRNA CTD PMID:17070881 NCBI chr 7:2,412,370...2,431,249
Ensembl chr 7:2,412,363...2,431,197
Ensembl chr13:2,412,363...2,431,197
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression EXP 2-nitropropane results in increased expression of IL2RA mRNA CTD PMID:17070881 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 2-nitropropane results in increased expression of MGMT mRNA CTD PMID:17070881 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression EXP 2-nitropropane results in decreased expression of NUPR1 mRNA CTD PMID:17070881 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Olr37 olfactory receptor 37 decreases expression EXP 2-nitropropane results in decreased expression of OLR37 mRNA CTD PMID:17070881 NCBI chr 1:164,755,094...164,756,059 JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression EXP 2-nitropropane results in increased expression of PHLDA3 mRNA CTD PMID:17070881 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Polb DNA polymerase beta multiple interactions ISO 2-nitropropane results in increased expression of and results in increased activity of POLB protein; POLB protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein] CTD PMID:12189182 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271
JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 increases expression EXP 2-nitropropane results in increased expression of RHOBTB2 mRNA CTD PMID:17070881 NCBI chr15:51,465,148...51,485,562
Ensembl chr15:51,465,148...51,485,692
JBrowse link
G Serpina7 serpin family A member 7 increases expression EXP 2-nitropropane results in increased expression of SERPINA7 mRNA CTD PMID:17070881 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Slc16a10 solute carrier family 16 member 10 decreases expression EXP 2-nitropropane results in decreased expression of SLC16A10 mRNA CTD PMID:17070881 NCBI chr20:45,138,433...45,260,155
Ensembl chr20:45,143,453...45,260,119
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 decreases expression EXP 2-nitropropane results in decreased expression of SPINK1 mRNA CTD PMID:17070881 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase decreases expression EXP 2-nitropropane results in decreased expression of SUGCT mRNA CTD PMID:17070881 NCBI chr17:49,991,314...51,030,950 JBrowse link
G Sulf2 sulfatase 2 increases expression EXP 2-nitropropane results in increased expression of SULF2 mRNA CTD PMID:17070881 NCBI chr 3:162,791,349...162,872,984
Ensembl chr 3:162,791,355...162,872,831
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP 2-nitropropane results in decreased expression of SULT2A1 mRNA CTD PMID:17070881 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein]; POLB protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein] CTD PMID:12189182, PMID:16720738, PMID:19268524 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression EXP 2-nitropropane results in increased expression of ZMAT3 mRNA CTD PMID:17070881 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        xenobiotic 18413
          2-nitropropane 50
Path 2
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  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      pnictogen 18674
                        nitrogen atom 18565
                          nitrogen molecular entity 18565
                            nitro compound 7279
                              C-nitro compound 6880
                                nitrohydrocarbon 1558
                                  nitroalkane 50
                                    secondary nitroalkane 50
                                      2-nitropropane 50
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.