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ONTOLOGY REPORT - ANNOTATIONS


Term:aztreonam
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Accession:CHEBI:161680 term browser browse the term
Definition:A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.
Synonyms:exact_synonym: (2S,3S)-3-{(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(2-carboxypropan-2-yloxy)imino]acetamido}-2-methyl-4-oxoazetidine-1-sulfonate
 related_synonym: (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid;   AZT;   Azactam;   Formula=C13H17N5O8S2;   InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1;   InChIKey=WZPBZJONDBGPKJ-VEHQQRBSSA-N;   Primbactam;   SMILES=C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\\c2csc([NH3+])n2)C(=O)N1S([O-])(=O)=O;   aztreonamum
 alt_id: CHEBI:2960;   CHEBI:41008
 xref: Beilstein:3577211;   CAS:78110-38-0;   DrugBank:DB00355;   Drug_Central:279;   KEGG:C06840;   KEGG:D00240
 xref_mesh: MESH:D001398
 xref: PDBeChem:AZR;   PMID:1384868;   PMID:15123864;   PMID:24119095;   PMID:24176390;   PMID:24369293;   PMID:25049240;   PMID:25091537;   PMID:25295210;   PMID:28543395;   PMID:29017833;   Patent:NL8100571;   Reaxys:3577211;   Wikipedia:Aztreonam


show annotations for term's descendants       view all columns           Sort by:
 
aztreonam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcg5 ATP binding cassette subfamily G member 5 JBrowse link 6 7,935,771 7,961,207 RGD:6480464
G Abcg8 ATP binding cassette subfamily G member 8 JBrowse link 6 7,961,413 7,980,708 RGD:6480464
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 JBrowse link 14 86,345,946 86,560,694 RGD:6480464
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 JBrowse link 13 53,750,470 53,870,288 RGD:6480464
G RT1-Ha RT1 class II, locus Ha JBrowse link 20 3,875,478 3,885,140 RGD:6480464
G Slc10a1 solute carrier family 10 member 1 JBrowse link 6 104,617,730 104,631,355 RGD:6480464
G Slc10a2 solute carrier family 10 member 2 JBrowse link 16 90,324,420 90,350,254 RGD:6480464
G Slc51b solute carrier family 51 subunit beta JBrowse link 8 70,930,196 70,938,559 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      biological role 19716
        antimicrobial agent 17275
          antibacterial agent 12992
            antibacterial drug 3123
              aztreonam 9
                aztreonyl group + 0
                aztreonyl-L-lysine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic group 18465
                              organic divalent group 18458
                                organodiyl group 18458
                                  carbonyl group 18354
                                    carbonyl compound 18354
                                      carboxylic acid 18033
                                        carboacyl group 17190
                                          univalent carboacyl group 17190
                                            carbamoyl group 16927
                                              carboxamide 16927
                                                lactam 7825
                                                  beta-lactam 791
                                                    beta-lactam antibiotic 779
                                                      monobactam 9
                                                        aztreonam 9
                                                          aztreonyl group + 0
                                                          aztreonyl-L-lysine + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.