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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-cystine
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Accession:CHEBI:16283 term browser browse the term
Definition:The L-enantiomer of the sulfur-containing amino acid cystine.
Synonyms:exact_synonym: (2R,2'R)-3,3'-disulfanediylbis(2-aminopropanoic acid)
 related_synonym: (R,R)-3,3'-dithiobis(2-aminopropanoic acid);   (R-(R*,R*))-3,3'-Dithiobis(2-aminopropanoic acid);   3,3'-Dithiobis-L-alanine;   E921;   Formula=C6H12N2O4S2;   InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1;   InChIKey=LEVWYRKDKASIDU-IMJSIDKUSA-N;   L-Dicysteine;   L-alpha-Diamino-beta-dithiolactic acid;   SMILES=N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O;   beta,beta'-diamino-beta,beta'-dicarboxydiethyl disulfide;   beta,beta'-dithiodialanine;   bis(beta-amino-beta-carboxyethyl) disulfide;   oxidized L-cysteine
 alt_id: CHEBI:13097;   CHEBI:21278;   CHEBI:6209
 xref: Beilstein:1728094;   CAS:56-89-3;   DrugBank:DB00138;   Drug_Central:4130;   Gmelin:397179;   HMDB:HMDB0000192;   KEGG:C00491;   KEGG:D03636;   KNApSAcK:C00001352
 xref_mesh: MESH:D003553
 xref: PMID:14726201;   PMID:24264736;   PMID:24327171;   Reaxys:1728094
 cyclic_relationship: is_conjugate_acid_of CHEBI:63163;   is_enantiomer_of CHEBI:35494;   is_tautomer_of CHEBI:35491


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L-cystine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kyat1 kynurenine aminotransferase 1 increases amination ISO KYAT1 protein results in increased amination of Cystine CTD PMID:22093698 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] CTD PMID:19850060 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] CTD PMID:19850060 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases uptake
multiple interactions
ISO SLC3A1 protein results in increased uptake of Cystine
[SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine
CTD PMID:14978168, PMID:18845132 NCBI chr 6:8,284,937...8,318,649
Ensembl chr 6:8,284,878...8,318,674
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine
CTD PMID:19576933, PMID:22216172 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine
CTD PMID:19576933, PMID:22216172 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slc7a9 solute carrier family 7 member 9 multiple interactions ISO [SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine CTD PMID:14978168 NCBI chr 1:91,709,034...91,738,492
Ensembl chr 1:91,716,383...91,738,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        food additive 14685
          flour treatment agent 5551
            L-cystine 7
              L-cystine di-2-naphthylamide 0
              L-cystine mono-2-naphthylamide 0
              L-cystine residue 0
              L-cystinyl group 0
              L-cystyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        amino acid 14072
                                          alpha-amino acid 11539
                                            L-alpha-amino acid 11374
                                              serine family amino acid 1851
                                                L-cysteine 1133
                                                  L-cysteine derivative 1122
                                                    L-cystine 7
                                                      L-cystine di-2-naphthylamide 0
                                                      L-cystine mono-2-naphthylamide 0
                                                      L-cystine residue 0
                                                      L-cystinyl group 0
                                                      L-cystyl group 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.