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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingosine
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Accession:CHEBI:16393 term browser browse the term
Definition:A sphing-4-enine in which the double bond is trans.
Synonyms:exact_synonym: (2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol
 related_synonym: (2S,3R)-(E)-2-amino-1,3-dihydroxy-4-octadecene;   (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-ene-1-ol;   (2S,3R,4E)-2-amino-4-octadecene-1,3-diol;   (2S,3R,E)-2-aminooctadec-4-ene-1,3-diol;   (4E)-sphing-4-enine;   (4E)-sphingenine;   (E)-2-amino-4-octadecan-1,3-diol;   (E)-D-erythro-4-octadecene-1,3-diol;   2-amino-4-octadecene-1,3-diol;   C18 sphingosine;   D-(+)-erythro-1,3-dihydroxy-2-amino-4-trans-octadecene;   D-erythro-sphingosine;   Formula=C18H37NO2;   InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1;   InChIKey=WWUZIQQURGPMPG-KRWOKUGFSA-N;   SMILES=CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@@H](N)CO;   Sph;   Sphing-4-enine;   Sphingenine;   Sphingoid;   Sphingosine d18:1;   sphingosin;   trans-4-sphingenine;   trans-D-erythro-2-amino-4-octadecene-1,3-diol
 alt_id: CHEBI:15102;   CHEBI:207585;   CHEBI:26741;   CHEBI:9224
 xref: Beilstein:1727294 "Beilstein";   Beilstein:4676153 "Beilstein";   CAS:123-78-4 "ChemIDplus";   CAS:123-78-4 "KEGG COMPOUND";   DrugBank:DB03203;   HMDB:HMDB0000252;   KEGG:C00319;   LIPID_MAPS_instance:LMSP01010001 "LIPID MAPS"
 xref_mesh: MESH:D013110
 xref: PDBeChem:SQS;   PMID:10453988 "Europe PMC";   PMID:16341241 "Europe PMC";   PMID:24731183 "Europe PMC";   PMID:8482346 "Europe PMC";   Reaxys:1727294 "Reaxys"
 cyclic_relationship: is_conjugate_base_of CHEBI:57756;   is_enantiomer_of CHEBI:46967


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sphingosine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:6480464
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:6480464
G Tat tyrosine aminotransferase JBrowse link 19 41,675,639 41,686,195 RGD:6480464
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:6480464
N,N-dimethylsphingosine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:6480464
G Asah2 N-acylsphingosine amidohydrolase 2 JBrowse link 1 250,557,042 250,665,083 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:6480464
N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
N-acetylsphingosine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Clk1 CDC-like kinase 1 JBrowse link 9 65,296,777 65,308,017 RGD:6480464
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:6480464
G Dapk1 death associated protein kinase 1 JBrowse link 17 4,297,038 4,454,941 RGD:6480464
G Dffb DNA fragmentation factor subunit beta JBrowse link 5 171,250,559 171,261,875 RGD:6480464
G Dnm1l dynamin 1-like JBrowse link 11 88,830,968 88,882,271 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Fis1 fission, mitochondrial 1 JBrowse link 12 22,750,485 22,765,324 RGD:6480464
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:6480464
G Gsta5 glutathione S-transferase alpha 5 JBrowse link 8 85,553,659 85,564,914 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hnf1a HNF1 homeobox A JBrowse link 12 47,407,811 47,433,342 RGD:6480464
G Id2 inhibitor of DNA binding 2 JBrowse link 6 44,360,077 44,361,908 RGD:6480464
G Il16 interleukin 16 JBrowse link 1 145,781,923 145,881,538 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6480464
G Klf6 Kruppel-like factor 6 JBrowse link 17 67,887,939 67,945,052 RGD:6480464
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:6480464
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:6480464
G Mir15b microRNA 15b JBrowse link 2 165,605,923 165,606,020 RGD:6480464
G Mir20a microRNA 20a JBrowse link 15 100,180,334 100,180,418 RGD:6480464
G Mir25 microRNA 25 JBrowse link 12 19,307,340 19,307,423 RGD:6480464
G Mir93 microRNA 93 JBrowse link 12 19,307,543 19,307,629 RGD:6480464
G Mirlet7b microRNA let-7b JBrowse link 7 126,590,627 126,590,711 RGD:6480464
G Mirlet7d microRNA let-7d JBrowse link 17 16,419,980 16,420,077 RGD:6480464
G Mirlet7i microRNA let-7i JBrowse link 7 66,802,731 66,802,815 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:6480464
G Nrp2 neuropilin 2 JBrowse link 9 69,496,875 69,609,802 RGD:6480464
G Odc1 ornithine decarboxylase 1 JBrowse link 6 42,852,529 42,859,142 RGD:6480464
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:6480464
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:6480464
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6480464
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rhob ras homolog family member B JBrowse link 6 33,689,127 33,691,301 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6480464
G Tfe3 transcription factor binding to IGHM enhancer 3 JBrowse link X 15,574,579 15,587,826 RGD:6480464
G Tgif1 TGFB-induced factor homeobox 1 JBrowse link 9 119,181,079 119,190,698 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6480464
G Txnip thioredoxin interacting protein JBrowse link 2 198,683,168 198,686,971 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
N-hexadecanoylsphingosine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asah2 N-acylsphingosine amidohydrolase 2 JBrowse link 1 250,557,042 250,665,083 RGD:6480464
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6480464
G Atf6 activating transcription factor 6 JBrowse link 13 89,053,457 89,242,531 RGD:6480464
G Cs citrate synthase JBrowse link 7 2,752,680 2,778,963 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:6480464
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 JBrowse link 4 180,423,452 180,800,088 RGD:6480464
G Lipc lipase C, hepatic type JBrowse link 8 77,272,582 77,398,485 RGD:6480464
G Lipg lipase G, endothelial type JBrowse link 18 70,903,528 70,924,434 RGD:6480464
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:6480464
G Pacs2 phosphofurin acidic cluster sorting protein 2 JBrowse link 6 137,824,136 137,889,144 RGD:6480464
G Pc pyruvate carboxylase JBrowse link 1 219,759,157 219,859,854 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Vdac1 voltage-dependent anion channel 1 JBrowse link 10 37,724,915 37,752,827 RGD:6480464
sphingosine 1-phosphate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Cxcr1 C-X-C motif chemokine receptor 1 JBrowse link 9 81,466,430 81,469,299 RGD:6480464
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6480464
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6480464
G Lama3 laminin subunit alpha 3 JBrowse link 18 3,704,866 3,941,215 RGD:6480464
G Lamb3 laminin subunit beta 3 JBrowse link 13 112,031,614 112,073,187 RGD:6480464
G Lamc2 laminin subunit gamma 2 JBrowse link 13 70,566,643 70,632,126 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:6480464
G Nrp2 neuropilin 2 JBrowse link 9 69,496,875 69,609,802 RGD:6480464
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:6480464
G Plcb4 phospholipase C, beta 4 JBrowse link 3 128,601,163 128,971,720 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:6480464
G S1pr2 sphingosine-1-phosphate receptor 2 JBrowse link 8 21,984,914 21,995,806 RGD:6480464
G S1pr3 sphingosine-1-phosphate receptor 3 JBrowse link 17 13,799,383 13,812,877 RGD:6480464
G Smpd2 sphingomyelin phosphodiesterase 2 JBrowse link 20 46,212,070 46,215,183 RGD:6480464
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:6480464
G Spns2 sphingolipid transporter 2 JBrowse link 10 59,010,428 59,049,482 RGD:6480464
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          metabolite 19101
            eukaryotic metabolite 18744
              animal metabolite 18484
                mammalian metabolite 18465
                  mouse metabolite 17887
                    sphingosine 113
                      1-O-acyl-N-acylsphingosine + 0
                      2-(2-hydroxyacyl)sphingosine + 0
                      3-dehydrosphingosine 0
                      6-hydroxysphing-4E-enine 0
                      D-glucosylsphingosine + 0
                      N,N-dimethylsphingosine 10
                      N-acyl-beta-D-galactosylsphingosine + 0
                      N-acylsphingosine + 77
                      N-decanoylsphingosine 1-phosphate 0
                      N-docosanoylsphingosine-1-phosphate 0
                      N-dodecanoylsphingosine 1-phosphate 0
                      N-hexacosanoylsphingosine 1-phosphate 0
                      N-hexadecanoylsphingosine 1-phosphate 0
                      N-icosanoylsphingosine 1-phosphate 0
                      N-octadecanoylsphingosine 1-phosphate 0
                      N-tetracosanoylsphingosine 1-phosphate 0
                      N-tetradecanoylsphingosine 1-phosphate 0
                      alpha-psychosine 0
                      beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Sph 0
                      hexosyl-(1<->1')-N-acylsphingosine 0
                      psychosine + 0
                      sphinga-4E,14Z-dienine + 0
                      sphinga-4E,8E-dienine + 0
                      sphingosine 1-phosphate 38
                      sphingosine-1-phosphocholine + 0
                      sphingosine-based sphingolipid + 77
                      sphingosylphosphocholine acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    main group molecular entity 19539
                      s-block molecular entity 19322
                        hydrogen molecular entity 19312
                          hydrides 18241
                            inorganic hydride 17110
                              pnictogen hydride 17068
                                nitrogen hydride 16889
                                  azane 16565
                                    ammonia 16562
                                      organic amino compound 16561
                                        amino alcohol 864
                                          aminodiol 153
                                            2-aminooctadecene-1,3-diol 113
                                              2-aminooctadec-4-ene-1,3-diol 113
                                                sphing-4-enine 113
                                                  sphingosine 113
                                                    1-O-acyl-N-acylsphingosine + 0
                                                    2-(2-hydroxyacyl)sphingosine + 0
                                                    3-dehydrosphingosine 0
                                                    6-hydroxysphing-4E-enine 0
                                                    D-glucosylsphingosine + 0
                                                    N,N-dimethylsphingosine 10
                                                    N-acyl-beta-D-galactosylsphingosine + 0
                                                    N-acylsphingosine + 77
                                                    N-decanoylsphingosine 1-phosphate 0
                                                    N-docosanoylsphingosine-1-phosphate 0
                                                    N-dodecanoylsphingosine 1-phosphate 0
                                                    N-hexacosanoylsphingosine 1-phosphate 0
                                                    N-hexadecanoylsphingosine 1-phosphate 0
                                                    N-icosanoylsphingosine 1-phosphate 0
                                                    N-octadecanoylsphingosine 1-phosphate 0
                                                    N-tetracosanoylsphingosine 1-phosphate 0
                                                    N-tetradecanoylsphingosine 1-phosphate 0
                                                    alpha-psychosine 0
                                                    beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Sph 0
                                                    hexosyl-(1<->1')-N-acylsphingosine 0
                                                    psychosine + 0
                                                    sphinga-4E,14Z-dienine + 0
                                                    sphinga-4E,8E-dienine + 0
                                                    sphingosine 1-phosphate 38
                                                    sphingosine-1-phosphocholine + 0
                                                    sphingosine-based sphingolipid + 77
                                                    sphingosylphosphocholine acid 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.