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ONTOLOGY REPORT - ANNOTATIONS


Term:S-adenosyl-L-homocysteine
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Accession:CHEBI:16680 term browser browse the term
Definition:An organic sulfide that is the S-adenosyl derivative of L-homocysteine.
Synonyms:related_synonym: (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic acid;   2-S-adenosyl-L-homocysteine;   Adenosyl-L-homocysteine;   AdoHcy;   Formula=C14H20N6O5S;   InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1;   InChIKey=ZJUKTBDSGOFHSH-WFMPWKQPSA-N;   S-(5'-Deoxyadenosin-5'-yl)-L-homocysteine;   S-(5'-adenosyl)-L-homocysteine;   S-Adenosylhomocysteine;   S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl]-L-homocysteine;   SAH;   SMILES=N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O;   adenosylhomocysteine
 alt_id: CHEBI:12741;   CHEBI:12759;   CHEBI:12761;   CHEBI:22034;   CHEBI:45495;   CHEBI:8945
 xref: Beilstein:99188 "Beilstein";   CAS:979-92-0 "ChemIDplus";   CAS:979-92-0 "KEGG COMPOUND";   DrugBank:DB01752;   Gmelin:692100 "Gmelin";   HMDB:HMDB0000939;   KEGG:C00021;   KNApSAcK:C00007230
 xref_mesh: MESH:D012435
 xref: MetaCyc:ADENOSYL-HOMO-CYS;   PDBeChem:SAH;   PMID:11700066 "Europe PMC";   PMID:11746687 "Europe PMC";   PMID:11961214 "Europe PMC";   PMID:11997462 "Europe PMC";   PMID:12767735 "Europe PMC";   PMID:15026045 "Europe PMC";   PMID:15057524 "Europe PMC";   PMID:15542683 "Europe PMC";   PMID:15645450 "Europe PMC";   PMID:16109423 "Europe PMC";   PMID:16197293 "Europe PMC";   PMID:16197315 "Europe PMC";   PMID:16253211 "Europe PMC";   PMID:16423634 "Europe PMC";   PMID:16519522 "Europe PMC";   PMID:17044778 "Europe PMC";   PMID:17172447 "Europe PMC";   PMID:17300772 "Europe PMC";   PMID:17439666 "Europe PMC";   PMID:17726531 "Europe PMC";   PMID:18976670 "Europe PMC";   PMID:19249293 "Europe PMC";   PMID:19357721 "Europe PMC";   PMID:21837278 "Europe PMC";   PMID:22225784 "Europe PMC";   PMID:22455498 "Europe PMC";   PMID:24145794 "Europe PMC";   Reaxys:99188 "Reaxys";   Wikipedia:S-Adenosyl-L-homocysteine
 cyclic_relationship: is_conjugate_acid_of CHEBI:67009;   is_tautomer_of CHEBI:57856


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S-adenosyl-L-homocysteine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahcy adenosylhomocysteinase JBrowse link 3 150,587,833 150,603,057 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Atp7b ATPase copper transporting beta JBrowse link 16 74,865,516 74,944,935 RGD:6480464
G Bace1 beta-secretase 1 JBrowse link 8 50,140,092 50,162,388 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Col1a2 collagen type I alpha 2 chain JBrowse link 4 31,534,225 31,569,152 RGD:6480464
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:6480464
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:6480464
G Fgf19 fibroblast growth factor 19 JBrowse link 1 218,058,405 218,061,693 RGD:6480464
G Hbb hemoglobin subunit beta JBrowse link 1 168,971,269 168,972,680 RGD:6480464
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 5 151,776,004 151,779,319 RGD:6480464
G Ogg1 8-oxoguanine DNA glycosylase JBrowse link 4 145,282,828 145,289,367 RGD:6480464
G Pemt phosphatidylethanolamine N-methyltransferase JBrowse link 10 46,339,821 46,404,640 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:6480464
G Slc19a1 solute carrier family 19 member 1 JBrowse link 20 12,334,675 12,354,517 RGD:6480464
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6480464
G Timp2 TIMP metallopeptidase inhibitor 2 JBrowse link 10 107,338,465 107,386,072 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        epitope 6710
          S-adenosyl-L-homocysteine 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        amino acid 12315
                                          alpha-amino acid 7422
                                            non-proteinogenic alpha-amino acid 1503
                                              homocysteines 389
                                                homocysteine 117
                                                  homocysteine derivative 19
                                                    S-adenosyl-L-homocysteine 19
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.