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ONTOLOGY REPORT - ANNOTATIONS


Term:ecdysone
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Accession:CHEBI:16688 term browser browse the term
Definition:A 6-oxo steroid that is 5beta-cholest-7-en-6-one substituted by hydroxy groups at positions 2, 3, 14, 22 and 25 respectively (the 2beta, 3beta, 22R stereoisomer). It is a steroid prohormone of the major insect moulting hormone 20-hydroxyecdysone.
Synonyms:exact_synonym: (2beta,3beta,5beta,22R)-2,3,14,22,25-pentahydroxycholest-7-en-6-one
 related_synonym: (22R)-2beta,3beta,14,22,25-pentahydroxy-5beta-cholest-7-en-6-one;   (22R)-2beta,3beta,14alpha,22,25-pentahydroxy-5beta-cholest-7-en-6-one;   Formula=C27H44O6;   InChI=1S/C27H44O6/c1-15(20(28)8-9-24(2,3)32)16-7-11-27(33)18-12-21(29)19-13-22(30)23(31)14-25(19,4)17(18)6-10-26(16,27)5/h12,15-17,19-20,22-23,28,30-33H,6-11,13-14H2,1-5H3/t15-,16+,17-,19-,20+,22+,23-,25+,26+,27+/m0/s1;   InChIKey=UPEZCKBFRMILAV-JMZLNJERSA-N;   SMILES=[H][C@@]1(CC[C@@]2(O)C3=CC(=O)[C@]4([H])C[C@@H](O)[C@@H](O)C[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)[C@H](O)CCC(C)(C)O
 alt_id: CHEBI:14205;   CHEBI:23889;   CHEBI:4741
 xref: CAS:3604-87-3 "KEGG COMPOUND";   KEGG:C00477;   KNApSAcK:C00003651;   LIPID_MAPS_instance:LMST01010210 "LIPID MAPS";   PMID:19342482 "Europe PMC";   PMID:22310011 "Europe PMC";   PMID:22828514 "Europe PMC";   PMID:23017214 "Europe PMC";   PMID:23072462 "Europe PMC";   Reaxys:2422986 "Reaxys";   Wikipedia:Ecdysone


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20-hydroxyecdysone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    role 19695
      biological role 19693
        prohormone 6
          ecdysone 6
            (24R)-11alpha,20,24-trihydroxyecdysone 0
            (25R)-11alpha,20,26-trihydroxyecdysone 0
            (25S)-11alpha,20,26-trihydroxyecdysone 0
            2,22,25-trideoxyecdysone 0
            2-dehydroecdysone 0
            2-deoxyecdysone 0
            20,26-dihydroxyecdysone 0
            20-hydroxyecdysone 6
            22-deoxy-20,21-dihydroxyecdysone 0
            25-deoxyecdysone 0
            3-dehydroecdysone 0
            ecdysone 25-O-D-glucopyranoside 0
            ecdysteroid ester + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    p-block element atom 19628
                      carbon group element atom 19522
                        carbon atom 19516
                          organic molecular entity 19516
                            organic molecule 19434
                              organic cyclic compound 19201
                                organic polycyclic compound 16037
                                  steroid 12790
                                    hydroxy steroid 12376
                                      3-hydroxy steroid 10004
                                        sterol 411
                                          3beta-sterol 405
                                            ecdysone 6
                                              (24R)-11alpha,20,24-trihydroxyecdysone 0
                                              (25R)-11alpha,20,26-trihydroxyecdysone 0
                                              (25S)-11alpha,20,26-trihydroxyecdysone 0
                                              2,22,25-trideoxyecdysone 0
                                              2-dehydroecdysone 0
                                              2-deoxyecdysone 0
                                              20,26-dihydroxyecdysone 0
                                              20-hydroxyecdysone 6
                                              22-deoxy-20,21-dihydroxyecdysone 0
                                              25-deoxyecdysone 0
                                              3-dehydroecdysone 0
                                              ecdysone 25-O-D-glucopyranoside 0
                                              ecdysteroid ester + 0
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