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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:corticosterone
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Accession:CHEBI:16827 term browser browse the term
Definition:A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Synonyms:exact_synonym: 11beta,21-dihydroxypregn-4-ene-3,20-dione
 related_synonym: (11beta)-11,21-dihydroxypregn-4-ene-3,20-dione;   11beta,21-Dihydroxy-4-pregnene-3,20-dione;   11beta,21-dihydroxyprogesterone;   17-deoxycortisol;   Formula=C21H30O4;   InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1;   InChIKey=OMFXVFTZEKFJBZ-HJTSIMOOSA-N;   Kendall's compound B;   Reichstein's substance H;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)C(=O)CO
 alt_id: CHEBI:14022;   CHEBI:19131;   CHEBI:3891;   CHEBI:41361;   CHEBI:57911
 xref: Beilstein:2339601;   CAS:50-22-6;   HMDB:HMDB0001547;   KEGG:C02140;   LINCS:LSM-5814;   LIPID_MAPS_instance:LMST02030186
 xref_mesh: MESH:D003345
 xref: MetaCyc:CORTICOSTERONE;   PDBeChem:C0R;   PMID:10438974;   PMID:11448093;   PMID:16817814;   PMID:24446162;   Wikipedia:Corticosterone


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corticosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Corticosterone results in increased expression of A2M mRNA CTD PMID:15755911 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO Corticosterone results in decreased activity of ABCG2 protein CTD PMID:15365089 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions EXP [Corticosterone co-treated with oleoyl-estrone] affects the expression of ACACA mRNA CTD PMID:19545626 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acan aggrecan decreases expression
multiple interactions
EXP Corticosterone results in decreased expression of ACAN mRNA
Mifepristone inhibits the reaction [Corticosterone results in decreased expression of ACAN mRNA]
CTD PMID:29660438, PMID:29966748, PMID:32663519 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Ace angiotensin I converting enzyme increases expression
multiple interactions
decreases methylation
EXP Corticosterone results in increased expression of ACE mRNA
Mifepristone inhibits the reaction [Corticosterone results in increased expression of ACE mRNA]
Corticosterone results in decreased methylation of ACE promoter
CTD PMID:15755911, PMID:30423288 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO ACHE protein inhibits the reaction [Paraoxon results in increased abundance of Corticosterone] CTD PMID:17005312 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acly ATP citrate lyase multiple interactions EXP [Corticosterone co-treated with oleoyl-estrone] affects the expression of ACLY mRNA CTD PMID:19545626 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle increases expression EXP Corticosterone results in increased expression of ACTA1 mRNA CTD PMID:15755911 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Actg2 actin gamma 2, smooth muscle increases expression EXP Corticosterone results in increased expression of ACTG2 mRNA CTD PMID:15755911 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Corticosterone results in increased expression of ADAMTS1 mRNA CTD PMID:15755911 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Corticosterone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adm adrenomedullin increases expression EXP Corticosterone results in increased expression of ADM mRNA CTD PMID:15755911 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
decreases expression
ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of ADORA1 mRNA] CTD PMID:31344373 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression EXP Corticosterone results in increased expression of ADRB2 mRNA CTD PMID:15755911 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Agt angiotensinogen increases secretion ISO AGT protein results in increased secretion of Corticosterone CTD PMID:28235592 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases expression
EXP Mifepristone inhibits the reaction [Corticosterone results in increased expression of AGTR1A mRNA]
Corticosterone results in decreased expression of AGTR1A mRNA
CTD PMID:30423288 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
decreases expression
EXP Mifepristone inhibits the reaction [Corticosterone results in increased expression of AGTR2 mRNA]
Corticosterone results in decreased expression of AGTR2 mRNA
CTD PMID:30423288 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions ISO [AKR1D1 protein co-treated with NADP] results in increased reduction of Corticosterone CTD PMID:25500266 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression EXP Corticosterone results in decreased expression of AKT1 mRNA CTD PMID:29966748 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 decreases expression EXP Corticosterone results in decreased expression of ALDH18A1 mRNA CTD PMID:15755911 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
decreases expression
EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of ALPL mRNA] CTD PMID:30423288 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Angptl2 angiopoietin-like 2 decreases expression EXP Corticosterone results in decreased expression of ANGPTL2 mRNA CTD PMID:15755911 NCBI chr 3:12,262,822...12,292,665
Ensembl chr 3:12,262,822...12,292,663
JBrowse link
G Aqp1 aquaporin 1 increases expression EXP Corticosterone results in increased expression of AQP1 mRNA CTD PMID:15755911 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Ar androgen receptor multiple interactions
increases activity
affects binding
ISO
EXP
[Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [AR protein binds to TRAF6 protein]; Corticosterone binds to and results in increased activity of AR protein mutant form; Corticosterone inhibits the reaction [Metribolone results in increased activity of AR protein]; Corticosterone inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
Corticosterone results in increased activity of AR protein
Corticosterone binds to AR protein
CTD PMID:11956172, PMID:14565775, PMID:18324785, PMID:21543282, PMID:29162470, PMID:29625166 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arrb1 arrestin, beta 1 decreases expression
multiple interactions
ISO Corticosterone results in decreased expression of ARRB1 mRNA
Fluoxetine inhibits the reaction [Corticosterone results in decreased expression of ARRB1 mRNA]
CTD PMID:19477151 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 decreases expression
multiple interactions
ISO Corticosterone results in decreased expression of ARRB2 mRNA
Fluoxetine inhibits the reaction [Corticosterone results in decreased expression of ARRB2 mRNA]
CTD PMID:19477151 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression EXP Corticosterone results in decreased expression of ASNS mRNA CTD PMID:15755911 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP Corticosterone results in decreased expression of ATP1A3 mRNA CTD PMID:15755911 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549
JBrowse link
G Atp6v1g1 ATPase H+ transporting V1 subunit G1 decreases expression EXP Corticosterone results in decreased expression of ATP6V1G1 mRNA CTD PMID:15755911 NCBI chr 5:79,367,663...79,373,843
Ensembl chr 5:79,367,663...79,373,843
JBrowse link
G Aurkb aurora kinase B decreases expression EXP Corticosterone results in decreased expression of AURKB mRNA CTD PMID:15755911 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Avp arginine vasopressin decreases expression EXP Corticosterone results in decreased expression of AVP mRNA CTD PMID:32437893 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
affects expression
multiple interactions
EXP Corticosterone results in increased expression of BAX protein
Corticosterone affects the expression of BAX mRNA
Estradiol inhibits the reaction [Corticosterone results in increased expression of BAX protein]; Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in increased expression of BAX protein]]; so-ochim-tang-gamibang affects the reaction [Corticosterone affects the expression of BAX mRNA]; Testosterone inhibits the reaction [Corticosterone results in increased expression of BAX protein]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased expression of BAX protein]]
CTD PMID:27988398, PMID:29625166 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
decreases expression
EXP Estradiol inhibits the reaction [Corticosterone results in decreased expression of BCL2 protein]; Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in decreased expression of BCL2 protein]]; so-ochim-tang-gamibang affects the reaction [Corticosterone affects the expression of BCL2 mRNA]; Testosterone inhibits the reaction [Corticosterone results in decreased expression of BCL2 protein]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in decreased expression of BCL2 protein]] CTD PMID:27988398, PMID:29625166 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
EXP [Corticosterone results in increased expression of BCL2L1 protein] which results in decreased susceptibility to Doxorubicin; BCL2L1 protein affects the reaction [Corticosterone results in decreased susceptibility to Doxorubicin]; JUN protein affects the reaction [Corticosterone results in increased expression of BCL2L1 mRNA]; Mifepristone inhibits the reaction [Corticosterone results in increased expression of BCL2L1 protein]
Corticosterone results in increased expression of BCL2L1 mRNA; Corticosterone results in increased expression of BCL2L1 protein
CTD PMID:15755911, PMID:24480152, PMID:26915917 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
ISO
EXP
Corticosterone results in decreased expression of BDNF protein
so-ochim-tang-gamibang inhibits the reaction [Corticosterone results in decreased expression of BDNF mRNA]
2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of BDNF protein]; KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of BDNF protein]]
CTD PMID:22244747, PMID:22850435, PMID:27988398 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bex1 brain expressed, X-linked 1 decreases expression EXP Corticosterone results in decreased expression of BEX1 mRNA CTD PMID:15755911 NCBI chr  X:106,761,388...106,771,656 JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression
multiple interactions
EXP Corticosterone results in decreased expression of BGLAP mRNA
Enalapril inhibits the reaction [Corticosterone results in decreased expression of BGLAP mRNA]
CTD PMID:30423288 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression EXP Corticosterone results in increased expression of BMP2 mRNA CTD PMID:15755911 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression EXP Corticosterone results in increased expression of BMP6 mRNA CTD PMID:15755911 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP Corticosterone results in increased expression of BTG2 mRNA CTD PMID:15755911 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G C3 complement C3 affects expression EXP Corticosterone affects the expression of C3 mRNA CTD PMID:18363858 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Calca calcitonin-related polypeptide alpha increases abundance EXP CALCA protein results in increased abundance of Corticosterone CTD PMID:12639925 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Capn6 calpain 6 decreases expression EXP Corticosterone results in decreased expression of CAPN6 mRNA CTD PMID:15755911 NCBI chr  X:115,049,113...115,073,824
Ensembl chr  X:115,049,154...115,073,890
JBrowse link
G Cars cysteinyl-tRNA synthetase decreases expression EXP Corticosterone results in decreased expression of CARS mRNA CTD PMID:15755911 NCBI chr 1:216,759,367...216,801,652
Ensembl chr 1:216,759,366...216,801,656
JBrowse link
G Cartpt CART prepropeptide increases abundance
multiple interactions
EXP CARTPT protein results in increased abundance of Corticosterone
astressin B inhibits the reaction [CARTPT protein results in increased abundance of Corticosterone]
CTD PMID:15271883 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269
JBrowse link
G Casp12 caspase 12 decreases expression EXP Corticosterone results in decreased expression of CASP12 mRNA CTD PMID:15755911 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
EXP Corticosterone inhibits the reaction [Deoxyglucose results in increased activity of CASP3 protein]; Corticosterone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Corticosterone inhibits the reaction [Palmitates results in increased activity of CASP3 protein]; Estradiol inhibits the reaction [Corticosterone results in increased cleavage of CASP3 protein]; Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in increased cleavage of CASP3 protein]]; Mifepristone inhibits the reaction [Corticosterone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; so-ochim-tang-gamibang inhibits the reaction [Corticosterone results in increased expression of CASP3 mRNA]; Testosterone inhibits the reaction [Corticosterone results in increased cleavage of CASP3 protein]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased cleavage of CASP3 protein]] CTD PMID:15755911, PMID:26915917, PMID:27988398, PMID:29625166 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 decreases expression EXP Corticosterone results in decreased expression of CASP4 mRNA CTD PMID:15755911 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
EXP Estradiol inhibits the reaction [Corticosterone results in increased cleavage of CASP8 protein]; Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in increased cleavage of CASP8 protein]]; Testosterone inhibits the reaction [Corticosterone results in increased cleavage of CASP8 protein]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased cleavage of CASP8 protein]] CTD PMID:29625166 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase increases activity
multiple interactions
ISO Corticosterone results in increased activity of CAT protein
Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]]; Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Sulpiride promotes the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]]
CTD PMID:14730115 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
EXP
ISO
Corticosterone results in decreased expression of CCL2 mRNA
Corticosterone promotes the reaction [Isoflurophate results in increased expression of CCL2 mRNA]
[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of CCL2 mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of CCL2 mRNA]
CTD PMID:15755911, PMID:28782715, PMID:29751049 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccn3 cellular communication network factor 3 increases expression EXP Corticosterone results in increased expression of CCN3 mRNA CTD PMID:15755911 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Ccnb1 cyclin B1 decreases expression EXP Corticosterone results in decreased expression of CCNB1 mRNA; Corticosterone results in decreased expression of CCNB1 protein CTD PMID:15755911 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Corticosterone results in decreased expression of CCND1 protein CTD PMID:12807724 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases expression EXP Corticosterone results in decreased expression of CCND2 mRNA; Corticosterone results in decreased expression of CCND2 protein CTD PMID:15755911 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccne1 cyclin E1 decreases expression EXP Corticosterone results in decreased expression of CCNE1 protein CTD PMID:12807724 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cd200 Cd200 molecule decreases expression EXP Corticosterone results in decreased expression of CD200 mRNA CTD PMID:15755911 NCBI chr11:60,371,617...60,398,450
Ensembl chr11:60,371,684...60,403,196
JBrowse link
G Cd36 CD36 molecule increases expression EXP Corticosterone results in increased expression of CD36 mRNA CTD PMID:15755911 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd59 CD59 molecule increases expression EXP Corticosterone results in increased expression of CD59 mRNA CTD PMID:15755911 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of CD68 mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of CD68 mRNA] CTD PMID:29751049 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cdc20 cell division cycle 20 decreases expression EXP Corticosterone results in decreased expression of CDC20 mRNA CTD PMID:15755911 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO [Corticosterone results in increased phosphorylation of NDRG1 protein] which results in increased expression of and results in increased localization of CDH2 protein CTD PMID:21655274 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP Corticosterone results in decreased expression of CDK1 mRNA CTD PMID:15755911 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases activity
decreases expression
EXP Corticosterone promotes the reaction [CDKN1A protein binds to CDK2 protein]
Corticosterone results in decreased activity of CDK2 protein
Corticosterone results in decreased expression of CDK2 protein
CTD PMID:12807724 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
decreases activity
EXP Corticosterone inhibits the reaction [CDKN1A protein binds to CDK4 protein]; Corticosterone promotes the reaction [CDKN1B protein binds to CDK4 protein]
Corticosterone results in decreased expression of CDK4 protein
Corticosterone results in decreased activity of CDK4 protein
CTD PMID:12807724 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression
multiple interactions
EXP Corticosterone affects the expression of CDKN1A protein
Corticosterone inhibits the reaction [CDKN1A protein binds to CDK4 protein]; Corticosterone promotes the reaction [CDKN1A protein binds to CDK2 protein]
CTD PMID:12807724 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
EXP Corticosterone promotes the reaction [CDKN1B protein binds to CDK4 protein]
Corticosterone results in increased expression of CDKN1B protein
CTD PMID:12807724 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression EXP Corticosterone results in decreased expression of CDKN2A mRNA CTD PMID:15755911 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdo1 cysteine dioxygenase type 1 increases expression EXP Corticosterone results in increased expression of CDO1 mRNA CTD PMID:15755911 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686
JBrowse link
G Ceacam4 CEA cell adhesion molecule 4 increases expression EXP Corticosterone results in increased expression of CEACAM10 mRNA CTD PMID:15755911 NCBI chr 1:81,643,809...81,650,085
Ensembl chr 1:81,643,816...81,650,094
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression EXP Corticosterone results in increased expression of CEBPA mRNA CTD PMID:30423288 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions
EXP Corticosterone results in increased expression of CEBPB mRNA
CEBPB protein affects the reaction [Corticosterone results in increased expression of PTGS2 mRNA]; CEBPB protein affects the reaction [Corticosterone results in increased expression of PTGS2 protein]; Corticosterone promotes the reaction [CEBPB protein binds to PTGS2 promoter]
CTD PMID:15755911, PMID:18650268 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Corticosterone results in increased expression of CEBPD mRNA CTD PMID:15755911 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cfd complement factor D decreases expression ISO Corticosterone results in decreased expression of CFD mRNA; Corticosterone results in decreased expression of CFD protein CTD PMID:2912985 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression EXP Corticosterone results in decreased expression of CKS2 mRNA CTD PMID:15755911 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Cldn2 claudin 2 multiple interactions ISO [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of CLDN2 protein CTD PMID:29751049 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769
JBrowse link
G Cnr1 cannabinoid receptor 1 increases abundance ISO CNR1 gene mutant form results in increased abundance of Corticosterone CTD PMID:15081793 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression
multiple interactions
EXP Corticosterone results in decreased expression of COL2A1 mRNA; Corticosterone results in decreased expression of COL2A1 protein
Mifepristone inhibits the reaction [Corticosterone results in decreased expression of COL2A1 mRNA]
CTD PMID:29660438, PMID:29966748, PMID:32663519 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions
decreases expression
ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of COMT mRNA] CTD PMID:31344373 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cp ceruloplasmin increases expression EXP Corticosterone results in increased expression of CP mRNA CTD PMID:15755911 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Corticosterone results in increased expression of CPT1A mRNA CTD PMID:15755911 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation ISO Corticosterone results in decreased phosphorylation of CREB1 protein CTD PMID:22850435 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crebbp CREB binding protein multiple interactions
decreases expression
ISO 2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]; KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]] CTD PMID:22850435 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
decreases expression
increases expression
affects expression
increases abundance
EXP
ISO
Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]; Corticosterone affects the reaction [Nitroprusside results in increased secretion of CRH protein]; Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]; E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]
Corticosterone results in decreased expression of CRH mRNA
Corticosterone results in increased expression of CRH mRNA
Corticosterone affects the expression of CRH mRNA
CRH protein results in increased abundance of Corticosterone
CTD PMID:3015567, PMID:7816204, PMID:18835572, PMID:21359208, PMID:26821211, PMID:32437893 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 decreases expression EXP Corticosterone results in decreased expression of CRHR1 mRNA CTD PMID:18363858 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 increases expression EXP Corticosterone results in increased expression of CRISPLD2 mRNA CTD PMID:15755911 NCBI chr19:52,647,038...52,705,118
Ensembl chr19:52,647,070...52,705,131
JBrowse link
G Cs citrate synthase decreases activity EXP Corticosterone results in decreased activity of CS protein CTD PMID:22244747 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression EXP Corticosterone results in increased expression of CSRP2 mRNA CTD PMID:15755911 NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases expression EXP Corticosterone results in increased expression of CSRP3 mRNA CTD PMID:15755911 NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367
JBrowse link
G Ctnna1 catenin alpha 1 multiple interactions ISO [Corticosterone results in increased phosphorylation of NDRG1 protein] which results in increased expression of and results in increased localization of CTNNA1 protein CTD PMID:21655274 NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Corticosterone results in increased phosphorylation of NDRG1 protein] promotes the reaction [NDRG1 protein binds to CTNNB1 protein]; [Corticosterone results in increased phosphorylation of NDRG1 protein] which results in increased expression of and results in increased localization of CTNNB1 protein CTD PMID:21655274 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctss cathepsin S increases expression EXP Corticosterone results in increased expression of CTSS mRNA CTD PMID:15755911 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases chemical synthesis ISO CYP11B1 protein results in increased chemical synthesis of Corticosterone CTD PMID:16054388 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects metabolic processing
multiple interactions
increases hydroxylation
increases chemical synthesis
ISO CYP11B2 protein affects the metabolism of Corticosterone
[CYP11B2 protein results in increased hydroxylation of Corticosterone] which results in increased chemical synthesis of Aldosterone; [CYP11B2 protein results in increased hydroxylation of Desoxycorticosterone] which results in increased chemical synthesis of Corticosterone
CYP11B2 protein results in increased chemical synthesis of Corticosterone
CTD PMID:16054388, PMID:21384875 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression EXP Corticosterone results in increased expression of CYP2D4 mRNA CTD PMID:15755911 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO Corticosterone results in increased metabolism of CYP3A5 protein CTD PMID:20032461 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein increases expression ISO Corticosterone results in increased expression of DBI mRNA CTD PMID:16963002 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase increases expression EXP Corticosterone results in increased expression of DCXR mRNA CTD PMID:15755911 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases expression EXP Corticosterone results in decreased expression of DDIT3 mRNA CTD PMID:15755911 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddt D-dopachrome tautomerase increases expression EXP Corticosterone results in increased expression of DDT mRNA CTD PMID:15755911 NCBI chr20:13,827,153...13,829,624
Ensembl chr20:13,827,132...13,831,588
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression
multiple interactions
ISO Corticosterone results in increased expression of DKK1 protein
Mifepristone inhibits the reaction [Corticosterone results in increased expression of DKK1 protein]; NR3C1 protein promotes the reaction [Corticosterone results in increased expression of DKK1 protein]
CTD PMID:21304589 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression EXP Corticosterone results in decreased expression of DNMT3A mRNA CTD PMID:30423288 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dpep1 dipeptidase 1 increases expression EXP Corticosterone results in increased expression of DPEP1 mRNA CTD PMID:15755911 NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
JBrowse link
G Dpt dermatopontin decreases expression EXP Corticosterone results in decreased expression of DPT mRNA CTD PMID:15755911 NCBI chr13:83,073,307...83,102,404
Ensembl chr13:83,073,544...83,102,401
JBrowse link
G Ecrg4 ECRG4 augurin precursor decreases expression EXP Corticosterone results in decreased expression of ECRG4 mRNA CTD PMID:15755911 NCBI chr 9:50,526,811...50,548,056
Ensembl chr 9:50,526,811...50,548,046
JBrowse link
G Edn1 endothelin 1 increases secretion EXP EDN1 results in increased secretion of Corticosterone CTD PMID:1659878 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn2 endothelin 2 increases secretion EXP EDN2 results in increased secretion of Corticosterone CTD PMID:1659878 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Edn3 endothelin 3 increases secretion EXP EDN3 results in increased secretion of Corticosterone CTD PMID:1659878 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase increases expression EXP Corticosterone results in increased expression of EEF2K mRNA CTD PMID:15755911 NCBI chr 1:190,780,211...190,839,926
Ensembl chr 1:190,780,236...190,842,324
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression EXP Corticosterone results in increased expression of EFEMP1 mRNA CTD PMID:15755911 NCBI chr14:113,202,382...113,294,993
Ensembl chr14:113,202,419...113,295,014
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP Corticosterone results in increased expression of EGLN3 mRNA CTD PMID:15755911 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [ESR1 protein binds to TRAF6 protein] CTD PMID:29625166 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression EXP Corticosterone results in decreased expression of EZH2 mRNA CTD PMID:15755911 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Faah fatty acid amide hydrolase increases activity
multiple interactions
EXP Corticosterone results in increased activity of FAAH protein
antalarmin inhibits the reaction [Corticosterone results in increased activity of FAAH protein]
CTD PMID:26821211 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression EXP Corticosterone results in decreased expression of FABP3 mRNA CTD PMID:15755911 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Corticosterone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein; Corticosterone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fabp7 fatty acid binding protein 7 affects expression EXP Corticosterone affects the expression of FABP7 mRNA CTD PMID:18363858 NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP [Corticosterone co-treated with oleoyl-estrone] affects the expression of FASN mRNA CTD PMID:19545626 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbln2 fibulin 2 decreases expression EXP Corticosterone results in decreased expression of FBLN2 mRNA CTD PMID:15755911 NCBI chr 4:122,835,237...122,895,127
Ensembl chr 4:122,835,436...122,895,121
JBrowse link
G Fbn2 fibrillin 2 increases expression EXP Corticosterone results in increased expression of FBN2 mRNA CTD PMID:15755911 NCBI chr18:53,068,495...53,272,254
Ensembl chr18:53,068,495...53,181,503
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression
multiple interactions
ISO Corticosterone results in decreased expression of FKBP5 mRNA
Edaravone inhibits the reaction [Corticosterone results in decreased expression of FKBP5 mRNA]
CTD PMID:31344373 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression EXP Corticosterone results in increased expression of FLT1 mRNA CTD PMID:15755911 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression EXP Corticosterone results in increased expression of FMO1 mRNA CTD PMID:15755911 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Corticosterone results in increased expression of FOS protein CTD PMID:28186389 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxs1 forkhead box S1 decreases expression EXP Corticosterone results in decreased expression of FOXS1 mRNA CTD PMID:15755911 NCBI chr 3:148,406,509...148,407,778
Ensembl chr 3:148,406,513...148,407,778
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression ISO Corticosterone results in increased expression of FSHB mRNA CTD PMID:16675544 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fstl3 follistatin like 3 increases expression EXP Corticosterone results in increased expression of FSTL3 mRNA CTD PMID:15755911 NCBI chr 7:12,806,031...12,810,556
Ensembl chr 7:12,804,919...12,810,570
JBrowse link
G Fxyd6 FXYD domain-containing ion transport regulator 6 decreases expression EXP Corticosterone results in decreased expression of FXYD6 mRNA CTD PMID:15755911 NCBI chr 8:49,676,520...49,703,419
Ensembl chr 8:49,676,540...49,703,419
JBrowse link
G G6pc2 glucose-6-phosphatase catalytic subunit 2 increases expression ISO Corticosterone results in increased expression of G6PC2 mRNA CTD PMID:27300767 NCBI chr 3:55,464,528...55,467,170 JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions
increases expression
ISO
EXP
GAD1 affects the reaction [2,5-dihydro-2,4,5-trimethylthiazoline results in increased secretion of Corticosterone]
Corticosterone results in increased expression of GAD1 mRNA
CTD PMID:21219938, PMID:32437893 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression EXP Corticosterone results in increased expression of GAL mRNA CTD PMID:15755911 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gas6 growth arrest specific 6 increases expression EXP Corticosterone results in increased expression of GAS6 mRNA CTD PMID:15755911 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gatm glycine amidinotransferase decreases expression EXP Corticosterone results in decreased expression of GATM mRNA CTD PMID:15755911 NCBI chr 3:114,711,570...114,728,155
Ensembl chr 3:114,711,562...114,728,410
JBrowse link
G Gcnt1 glucosaminyl (N-acetyl) transferase 1 increases expression EXP Corticosterone results in increased expression of GCNT1 mRNA CTD PMID:15755911 NCBI chr 1:236,547,729...236,585,037
Ensembl chr 1:236,580,034...236,585,035
JBrowse link
G Gja5 gap junction protein, alpha 5 increases expression EXP Corticosterone results in increased expression of GJA5 mRNA CTD PMID:15755911 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Glt8d1 glycosyltransferase 8 domain containing 1 decreases expression EXP Corticosterone results in decreased expression of GLT8D1 mRNA CTD PMID:15755911 NCBI chr16:7,082,450...7,097,405
Ensembl chr16:7,082,450...7,097,401
JBrowse link
G Glul glutamate-ammonia ligase increases expression EXP Corticosterone results in increased expression of GLUL mRNA CTD PMID:15755911 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression
multiple interactions
ISO Corticosterone results in decreased expression of GNAI2 mRNA
Fluoxetine inhibits the reaction [Corticosterone results in decreased expression of GNAI2 mRNA]
CTD PMID:19477151 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression EXP Corticosterone results in increased expression of GPX3 mRNA CTD PMID:15755911 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist decreases expression EXP Corticosterone results in decreased expression of GREM1 mRNA CTD PMID:15755911 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 increases expression EXP Corticosterone results in increased expression of GRK5 mRNA CTD PMID:15755911 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP Corticosterone results in increased expression of GSTA3 mRNA; Corticosterone results in increased expression of GSTA3 protein CTD PMID:15755911 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Corticosterone results in increased expression of GSTM2 mRNA; Corticosterone results in increased expression of GSTM2 protein CTD PMID:15755911 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 multiple interactions ISO [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in decreased expression of HCAR2 protein; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in decreased expression of HCAR2 protein] CTD PMID:29751049 NCBI chr12:38,160,464...38,161,546
Ensembl chr12:38,160,464...38,161,546
JBrowse link
G Hdac7 histone deacetylase 7 multiple interactions
increases expression
EXP HDAC7 protein affects the reaction [Corticosterone results in decreased expression of KLF4 mRNA]; HDAC7 protein affects the reaction [Corticosterone results in decreased expression of KLF4 protein]; HDAC7 protein affects the reaction [Corticosterone results in decreased expression of NPHS1 mRNA]; HDAC7 protein affects the reaction [Corticosterone results in decreased expression of NPHS1 protein]; Mifepristone inhibits the reaction [Corticosterone results in increased expression of HDAC7 mRNA]; Mifepristone inhibits the reaction [Corticosterone results in increased expression of HDAC7 protein]
Corticosterone results in increased expression of HDAC7 mRNA; Corticosterone results in increased expression of HDAC7 protein
CTD PMID:31306741 NCBI chr 7:139,280,396...139,319,108
Ensembl chr 7:139,281,187...139,318,455
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of HMGB1 protein; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of HMGB1 protein] CTD PMID:29751049 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmgb2 high mobility group box 2 decreases expression EXP Corticosterone results in decreased expression of HMGB2 mRNA CTD PMID:15755911 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression EXP Corticosterone results in increased expression of HMGCS2 mRNA CTD PMID:15755911 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmgn2 high mobility group nucleosomal binding domain 2 decreases expression EXP Corticosterone results in decreased expression of HMGN2 mRNA CTD PMID:15755911 NCBI chr 5:152,195,359...152,198,813
Ensembl chr 5:152,195,361...152,198,813
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression EXP Corticosterone results in decreased expression of HNRNPA1 mRNA CTD PMID:15755911 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
JBrowse link
G Hs3st1 heparan sulfate-glucosamine 3-sulfotransferase 1 increases expression EXP Corticosterone results in increased expression of HS3ST1 mRNA CTD PMID:15755911 NCBI chr14:75,880,410...75,881,346
Ensembl chr14:75,852,060...75,882,693
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases chemical synthesis
multiple interactions
increases oxidation
decreases abundance
increases expression
ISO
EXP
HSD11B1 protein results in increased chemical synthesis of Corticosterone
[[trimethyltin chloride results in increased abundance of trimethyltin] which co-treated with Corticosterone] results in increased expression of HSD11B1 mRNA; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; Mifepristone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]
HSD11B1 protein results in increased oxidation of Corticosterone
HSD11B1 gene mutant form results in decreased abundance of Corticosterone
[HSD11B1 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone; resveratrol inhibits the reaction [HSD11B1 protein results in increased chemical synthesis of Corticosterone]; Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]
Corticosterone results in increased expression of HSD11B1 mRNA
CTD PMID:15755911, PMID:16751407, PMID:23814014, PMID:25061560, PMID:26859423, PMID:30993381 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
increases oxidation
increases metabolic processing
affects metabolic processing
EXP
ISO
[HSD11B2 protein results in increased metabolism of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; Betamethasone inhibits the reaction [HSD11B2 protein affects the metabolism of Corticosterone]; Dexamethasone inhibits the reaction [HSD11B2 protein affects the metabolism of Corticosterone]; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone]; Ziram inhibits the reaction [HSD11B2 protein results in increased oxidation of Corticosterone] CTD PMID:19490994, PMID:22796344, PMID:26859423, PMID:32243540 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Corticosterone results in increased expression of HSPB1 mRNA; Corticosterone results in increased expression of HSPB1 protein CTD PMID:15755911 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspb6 heat shock protein family B (small) member 6 increases expression EXP Corticosterone results in increased expression of HSPB6 mRNA CTD PMID:15755911 NCBI chr 1:89,008,117...89,010,256
Ensembl chr 1:89,008,117...89,010,256
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases secretion
increases expression
EXP [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [HTR2A protein results in increased secretion of Corticosterone]; [Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in increased secretion of Corticosterone]
Corticosterone results in increased expression of HTR2A mRNA
CTD PMID:15755911, PMID:18363858, PMID:19304867, PMID:19879056 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Ier3 immediate early response 3 decreases expression EXP Corticosterone results in decreased expression of IER3 mRNA CTD PMID:15755911 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
multiple interactions
increases expression
EXP Corticosterone results in decreased expression of IGF1 mRNA; Corticosterone results in decreased expression of IGF1 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [IGF1 protein inhibits the reaction [Corticosterone results in decreased expression of IGF1 mRNA]]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [IGF1 protein inhibits the reaction [Corticosterone results in decreased expression of PCNA mRNA]]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [IGF1 protein inhibits the reaction [Corticosterone results in decreased phosphorylation of MAPK1 protein]]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [IGF1 protein inhibits the reaction [Corticosterone results in decreased phosphorylation of MAPK3 protein]]; IGF1 protein inhibits the reaction [Corticosterone results in decreased expression of IGF1 mRNA]; IGF1 protein inhibits the reaction [Corticosterone results in decreased expression of PCNA mRNA]; IGF1 protein inhibits the reaction [Corticosterone results in decreased phosphorylation of MAPK1 protein]; IGF1 protein inhibits the reaction [Corticosterone results in decreased phosphorylation of MAPK3 protein]
Corticosterone results in increased expression of IGF1 mRNA
CTD PMID:12807724, PMID:15755911, PMID:29343424, PMID:29966748 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression
multiple interactions
EXP Corticosterone results in decreased expression of IGF1R mRNA; Corticosterone results in decreased expression of IGF1R protein
[IGF2R protein co-treated with IGF1R protein] affects the reaction [IGF2 protein inhibits the reaction [Corticosterone results in decreased expression of SOD2 protein]]
CTD PMID:12807724, PMID:24667322, PMID:29966748 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions EXP [IGF2R protein co-treated with IGF1R protein] affects the reaction [IGF2 protein inhibits the reaction [Corticosterone results in decreased expression of SOD2 protein]]; IGF2 protein inhibits the reaction [Corticosterone results in decreased expression of SOD2 protein] CTD PMID:24667322 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Igf2r insulin-like growth factor 2 receptor multiple interactions EXP [IGF2R protein co-treated with IGF1R protein] affects the reaction [IGF2 protein inhibits the reaction [Corticosterone results in decreased expression of SOD2 protein]] CTD PMID:24667322 NCBI chr 1:48,176,095...48,264,482
Ensembl chr 1:48,176,106...48,264,477
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression EXP Corticosterone results in decreased expression of IGFBP5 mRNA CTD PMID:15755911 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 increases expression EXP Corticosterone results in increased expression of IGFBP6 mRNA CTD PMID:15755911 NCBI chr 7:143,749,385...143,754,018
Ensembl chr 7:143,749,221...143,754,054
JBrowse link
G Il15 interleukin 15 increases expression EXP Corticosterone results in increased expression of IL15 mRNA CTD PMID:15755911 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il1b interleukin 1 beta increases chemical synthesis
increases expression
multiple interactions
increases secretion
ISO
EXP
IL1B protein results in increased chemical synthesis of Corticosterone
Corticosterone results in increased expression of IL1B mRNA
[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of and results in increased secretion of IL1B protein; [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of IL1B mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of and results in increased secretion of IL1B protein]; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of IL1B mRNA]
Corticosterone promotes the reaction [Isoflurophate results in increased expression of IL1B mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased secretion of Corticosterone]
[Finasteride results in increased susceptibility to IL1B protein] which results in increased secretion of Corticosterone
CTD PMID:10800959, PMID:12773775, PMID:19458216, PMID:28782715, PMID:29751049 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression EXP Corticosterone results in decreased expression of IL1RL1 mRNA CTD PMID:15755911 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP
ISO
Corticosterone inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]
Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]]
Corticosterone results in increased expression of IL6 mRNA
CTD PMID:28782715, PMID:30993381 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Corticosterone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [Corticosterone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein; Corticosterone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Itga1 integrin subunit alpha 1 decreases expression EXP Corticosterone results in decreased expression of ITGA1 mRNA CTD PMID:15755911 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421
JBrowse link
G Itga8 integrin subunit alpha 8 increases expression EXP Corticosterone results in increased expression of ITGA8 mRNA CTD PMID:15755911 NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
JBrowse link
G Itgb1bp2 integrin subunit beta 1 binding protein 2 increases expression EXP Corticosterone results in increased expression of ITGB1BP2 mRNA CTD PMID:15755911 NCBI chr  X:71,342,770...71,347,623
Ensembl chr  X:71,342,775...71,347,619
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [HTR2A protein results in increased secretion of Corticosterone] CTD PMID:19304867 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP JUN protein affects the reaction [Corticosterone results in increased expression of BCL2L1 mRNA] CTD PMID:26915917 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 increases expression EXP Corticosterone results in increased expression of KCNH2 mRNA CTD PMID:18835572 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 increases expression EXP Corticosterone results in increased expression of KCNJ5 mRNA CTD PMID:15755911 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kdr kinase insert domain receptor multiple interactions
decreases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Corticosterone results in decreased expression of KDR protein]; Calcium promotes the reaction [Corticosterone results in decreased expression of KDR protein]; Corticosterone inhibits the reaction [KDR protein binds to NR3C1 protein]; Mifepristone inhibits the reaction [Corticosterone results in decreased expression of KDR protein]; NR3C1 protein promotes the reaction [Corticosterone results in decreased expression of KDR protein] CTD PMID:21647420 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kif15 kinesin family member 15 decreases expression EXP Corticosterone results in decreased expression of KIF15 mRNA CTD PMID:15755911 NCBI chr 8:132,033,117...132,103,528
Ensembl chr 8:132,032,944...132,103,927
JBrowse link
G Kifc1 kinesin family member C1 decreases expression EXP Corticosterone results in decreased expression of KIFC1 mRNA CTD PMID:15755911 NCBI chr20:5,509,059...5,526,175
Ensembl chr20:5,509,059...5,526,175
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
decreases expression
EXP HDAC7 protein affects the reaction [Corticosterone results in decreased expression of KLF4 mRNA]; HDAC7 protein affects the reaction [Corticosterone results in decreased expression of KLF4 protein]; KLF4 protein inhibits the reaction [Corticosterone results in decreased expression of NPHS1 mRNA]; KLF4 protein inhibits the reaction [Corticosterone results in decreased expression of NPHS1 protein]; Mifepristone inhibits the reaction [Corticosterone results in decreased expression of KLF4 mRNA]; Mifepristone inhibits the reaction [Corticosterone results in decreased expression of KLF4 protein]; trichostatin A inhibits the reaction [Corticosterone results in decreased expression of KLF4 mRNA]; trichostatin A inhibits the reaction [Corticosterone results in decreased expression of KLF4 protein]
Corticosterone results in decreased expression of KLF4 mRNA; Corticosterone results in decreased expression of KLF4 protein
CTD PMID:31306741 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Klf9 Kruppel-like factor 9 increases expression EXP Corticosterone results in increased expression of KLF9 mRNA CTD PMID:15755911 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Lep leptin multiple interactions
decreases expression
ISO 1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein]; 8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione inhibits the reaction [1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein]]; [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:28186389, PMID:29751049 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions EXP [Corticosterone co-treated with Isoflurophate] results in increased expression of LIF mRNA CTD PMID:28782715 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Lmnb1 lamin B1 decreases expression EXP Corticosterone results in decreased expression of LMNB1 mRNA CTD PMID:15755911 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 increases expression EXP Corticosterone results in increased expression of LPAR1 mRNA CTD PMID:15755911 NCBI chr 5:75,557,038...75,678,067
Ensembl chr 5:75,557,042...75,676,584
JBrowse link
G Maged2 MAGE family member D2 decreases expression EXP Corticosterone results in decreased expression of MAGED2 mRNA CTD PMID:15755911 NCBI chr 5:33,174,539...33,182,715
Ensembl chr 5:33,174,542...33,182,715
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions
increases phosphorylation
EXP 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol inhibits the reaction [Corticosterone results in increased phosphorylation of MAP3K7 protein]]; Estradiol inhibits the reaction [Corticosterone results in increased phosphorylation of MAP3K7 protein]; Flutamide inhibits the reaction [Estradiol inhibits the reaction [Corticosterone results in increased phosphorylation of MAP3K7 protein]]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased phosphorylation of MAP3K7 protein]] CTD PMID:29625166 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases phosphorylation
multiple interactions
decreases activity
EXP
ISO
Corticosterone results in increased phosphorylation of MAPK1 protein
Corticosterone results in decreased phosphorylation of MAPK1 protein
2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]; KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]]
Corticosterone results in decreased activity of MAPK1 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [IGF1 protein inhibits the reaction [Corticosterone results in decreased phosphorylation of MAPK1 protein]]; Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]; IGF1 protein inhibits the reaction [Corticosterone results in decreased phosphorylation of MAPK1 protein]
CTD PMID:19175364, PMID:19733225, PMID:22850435, PMID:29343424 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
decreases phosphorylation
multiple interactions
decreases activity
EXP
ISO
Corticosterone results in increased phosphorylation of MAPK3 protein
Corticosterone results in decreased phosphorylation of MAPK3 protein
2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]; KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]]
Corticosterone results in decreased activity of MAPK3 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [IGF1 protein inhibits the reaction [Corticosterone results in decreased phosphorylation of MAPK3 protein]]; Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]; IGF1 protein inhibits the reaction [Corticosterone results in decreased phosphorylation of MAPK3 protein]
CTD PMID:19175364, PMID:19733225, PMID:22850435, PMID:29343424 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mb myoglobin decreases expression EXP Corticosterone results in decreased expression of MB mRNA CTD PMID:15755911 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link
G Mc2r melanocortin 2 receptor multiple interactions
increases secretion
EXP MC2R protein promotes the reaction [PRL protein results in increased secretion of Corticosterone]; PRL protein promotes the reaction [MC2R protein results in increased secretion of Corticosterone] CTD PMID:18609294 NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression EXP Corticosterone results in decreased expression of MCM3 mRNA CTD PMID:15755911 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression EXP Corticosterone results in decreased expression of MCM4 mRNA CTD PMID:15755911 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression EXP Corticosterone results in decreased expression of MCM6 mRNA CTD PMID:15755911 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression EXP Corticosterone results in decreased expression of MCM7 mRNA CTD PMID:15755911 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Me1 malic enzyme 1 decreases expression EXP Corticosterone results in decreased expression of ME1 mRNA CTD PMID:15755911 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Melk maternal embryonic leucine zipper kinase decreases expression EXP Corticosterone results in decreased expression of MELK mRNA CTD PMID:15755911 NCBI chr 5:59,783,835...59,844,356
Ensembl chr 5:59,783,890...59,844,356
JBrowse link
G Mfn1 mitofusin 1 decreases expression EXP Corticosterone results in decreased expression of MFN1 mRNA CTD PMID:22244747 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
JBrowse link
G Mfn2 mitofusin 2 decreases expression EXP Corticosterone results in decreased expression of MFN2 mRNA CTD PMID:22244747 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 increases expression EXP Corticosterone results in increased expression of MGST2 mRNA CTD PMID:15755911 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression EXP Corticosterone results in decreased expression of MMP12 mRNA CTD PMID:15755911 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mt1 metallothionein 1 increases expression EXP Corticosterone results in increased expression of MT1 mRNA; Corticosterone results in increased expression of MT1A mRNA CTD PMID:15755911, PMID:31520820 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Corticosterone results in decreased phosphorylation of MTOR protein CTD PMID:21647420 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mustn1 musculoskeletal, embryonic nuclear protein 1 increases expression EXP Corticosterone results in increased expression of MUSTN1 mRNA CTD PMID:15755911 NCBI chr16:6,962,737...6,964,987
Ensembl chr16:6,962,722...6,964,989
JBrowse link
G Myh11 myosin heavy chain 11 increases expression EXP Corticosterone results in increased expression of MYH11 mRNA CTD PMID:15755911 NCBI chr10:764,421...859,184
Ensembl chr10:764,421...859,184
JBrowse link
G Ncapd2 non-SMC condensin I complex, subunit D2 decreases expression EXP Corticosterone results in decreased expression of NCAPD2 mRNA CTD PMID:15755911 NCBI chr 4:157,682,855...157,705,903
Ensembl chr 4:157,683,077...157,704,596
JBrowse link
G Ncaph2 non-SMC condensin II complex, subunit H2 decreases expression EXP Corticosterone results in decreased expression of NCAPH2 mRNA CTD PMID:15755911 NCBI chr 7:130,326,597...130,343,655
Ensembl chr 7:130,326,600...130,342,493
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Corticosterone promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:11581012 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncs1 neuronal calcium sensor 1 increases expression ISO Corticosterone results in increased expression of NCS1 protein CTD PMID:21647420 NCBI chr 3:10,556,250...10,602,672
Ensembl chr 3:10,553,589...10,602,672
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions
increases phosphorylation
ISO [Corticosterone results in increased phosphorylation of NDRG1 protein] promotes the reaction [NDRG1 protein binds to CTNNB1 protein]; [Corticosterone results in increased phosphorylation of NDRG1 protein] which results in increased expression of and results in increased localization of CDH2 protein; [Corticosterone results in increased phosphorylation of NDRG1 protein] which results in increased expression of and results in increased localization of CTNNA1 protein; [Corticosterone results in increased phosphorylation of NDRG1 protein] which results in increased expression of and results in increased localization of CTNNB1 protein
[Corticosterone results in increased phosphorylation of SGK1 protein] which results in increased phosphorylation of NDRG1 protein
CTD PMID:21655274 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Ndrg2 NDRG family member 2 increases expression EXP Corticosterone results in increased expression of NDRG2 mRNA CTD PMID:15755911 NCBI chr15:28,305,820...28,314,459
Ensembl chr15:28,305,821...28,314,459
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression EXP Corticosterone results in increased expression of NFKBIA mRNA CTD PMID:15755911 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nppa natriuretic peptide A increases expression
multiple interactions
EXP Corticosterone results in increased expression of NPPA mRNA
Corticosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:16533503 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Npy neuropeptide Y decreases expression EXP Corticosterone results in decreased expression of NPY mRNA CTD PMID:15755911 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Corticosterone binds to and results in increased activity of NR1I2 protein; Corticosterone promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] CTD PMID:11581012, PMID:12072427, PMID:16054614 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Corticosterone binds to and results in increased activity of NR1I3 protein; Corticosterone inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein] CTD PMID:18832183 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases expression
affects localization
decreases expression
affects abundance
increases activity
affects binding
ISO
EXP
Corticosterone binds to and results in increased activity of NR3C1 protein
Corticosterone results in increased expression of NR3C1 mRNA; Corticosterone results in increased expression of NR3C1 protein
Corticosterone affects the localization of NR3C1 protein
Corticosterone results in decreased expression of NR3C1 protein
[Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [Corticosterone results in increased expression of PTGS2 mRNA]; [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [Corticosterone results in increased expression of PTGS2 protein]; Corticosterone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA]; Corticosterone promotes the reaction [NR3C1 protein binds to PTGS2 promoter]; Lead inhibits the reaction [Corticosterone binds to NR3C1 protein]; Mifepristone inhibits the reaction [Corticosterone promotes the reaction [NR3C1 protein binds to PTGS2 promoter]]
NR3C1 protein affects the abundance of Corticosterone
Corticosterone results in increased activity of NR3C1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Carbamazepine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Lithium inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Valproic Acid inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]]; Carbamazepine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]; Chlorpromazine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]; Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]; Corticosterone inhibits the reaction [KDR protein binds to NR3C1 protein]; Lithium inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]; Mifepristone inhibits the reaction [Corticosterone results in decreased expression of NR3C1 protein]; Mifepristone inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]; NR3C1 protein promotes the reaction [Corticosterone results in decreased expression of KDR protein]; NR3C1 protein promotes the reaction [Corticosterone results in increased expression of DKK1 protein]; Pregnanolone analog inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]; Pregnanolone inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]; pyrazolanthrone inhibits the reaction [Valproic Acid inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]]; Valproic Acid inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]
CTD PMID:10509797, PMID:11861974, PMID:15249158, PMID:15705660, PMID:16049266, PMID:16581232, PMID:18650268, PMID:21304589, PMID:21647420, PMID:22465009, PMID:25056680, PMID:30423288, PMID:31306741 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding ISO Corticosterone binds to NR3C2 protein CTD PMID:16061183 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 increases expression EXP Corticosterone results in increased expression of NTRK3 mRNA CTD PMID:18363858 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Ocln occludin multiple interactions ISO [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in decreased expression of OCLN protein; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in decreased expression of OCLN protein] CTD PMID:29751049 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Omd osteomodulin increases expression EXP Corticosterone results in increased expression of OMD mRNA CTD PMID:15755911 NCBI chr17:15,476,100...15,484,324
Ensembl chr17:15,475,710...15,484,269
JBrowse link
G Oplah 5-oxoprolinase (ATP-hydrolysing) increases expression EXP Corticosterone results in increased expression of OPLAH mRNA CTD PMID:15755911 NCBI chr 7:117,353,951...117,394,205
Ensembl chr 7:117,353,786...117,369,159
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Corticosterone results in increased expression of ORM1 mRNA CTD PMID:15755911 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Osm oncostatin M multiple interactions EXP [Corticosterone co-treated with Isoflurophate] results in increased expression of OSM mRNA CTD PMID:28782715 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G P3h1 prolyl 3-hydroxylase 1 decreases expression EXP Corticosterone results in decreased expression of P3H1 mRNA CTD PMID:15755911 NCBI chr 5:138,279,597...138,294,280
Ensembl chr 5:138,279,506...138,294,262
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) decreases expression EXP Corticosterone results in decreased expression of PCK2 mRNA CTD PMID:15755911 NCBI chr15:34,216,735...34,224,357
Ensembl chr15:34,216,833...34,224,193
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions
EXP Corticosterone results in decreased expression of PCNA mRNA; Corticosterone results in decreased expression of PCNA protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [IGF1 protein inhibits the reaction [Corticosterone results in decreased expression of PCNA mRNA]]; IGF1 protein inhibits the reaction [Corticosterone results in decreased expression of PCNA mRNA]
CTD PMID:15755911, PMID:29343424 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pde2a phosphodiesterase 2A increases expression
multiple interactions
ISO
EXP
Corticosterone results in increased expression of PDE2A mRNA; Corticosterone results in increased expression of PDE2A mRNA alternative form; Corticosterone results in increased expression of PDE2A protein
Mifepristone inhibits the reaction [Corticosterone results in increased expression of PDE2A protein]
CTD PMID:22850435 NCBI chr 1:166,534,643...166,626,158
Ensembl chr 1:166,534,643...166,626,158
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO [Corticosterone results in increased phosphorylation of and results in increased activity of PDK1 protein] which results in increased phosphorylation of and results in increased activity of SGK1 protein; Corticosterone results in increased phosphorylation of and results in increased activity of PDK1 protein CTD PMID:21655274 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pdlim5 PDZ and LIM domain 5 increases expression EXP Corticosterone results in increased expression of PDLIM5 mRNA CTD PMID:15755911 NCBI chr 2:247,815,214...247,989,198
Ensembl chr 2:247,818,243...247,988,462
JBrowse link
G Pdlim7 PDZ and LIM domain 7 increases expression EXP Corticosterone results in increased expression of PDLIM7 mRNA CTD PMID:15755911 NCBI chr17:9,653,510...9,668,715
Ensembl chr17:9,653,561...9,668,712
JBrowse link
G Pdyn prodynorphin multiple interactions EXP
ISO
Corticosterone inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]
PDYN protein promotes the reaction [Cocaine results in increased abundance of Corticosterone]
CTD PMID:17532787, PMID:18687386 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Penk proenkephalin multiple interactions EXP Corticosterone inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PENK mRNA] CTD PMID:18687386 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Pfkl phosphofructokinase, liver type increases expression EXP Corticosterone results in increased expression of PFKL mRNA CTD PMID:15755911 NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882
JBrowse link
G Pfkp phosphofructokinase, platelet multiple interactions ISO [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PFKP mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PFKP mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PFKP mRNA] CTD PMID:29751049 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
G Pfn2 profilin 2 decreases expression EXP Corticosterone results in decreased expression of PFN2 mRNA CTD PMID:15755911 NCBI chr 2:147,953,858...147,959,692
Ensembl chr 2:147,955,196...148,050,438
JBrowse link
G Pim3 Pim-3 proto-oncogene, serine/threonine kinase increases expression EXP Corticosterone results in increased expression of PIM3 mRNA CTD PMID:15755911 NCBI chr 7:129,856,467...129,863,441
Ensembl chr 7:129,860,114...129,863,441
JBrowse link
G Pla1a phospholipase A1 member A increases expression EXP Corticosterone results in increased expression of PLA1A mRNA CTD PMID:15755911 NCBI chr11:64,882,024...64,919,714
Ensembl chr11:64,882,288...64,919,579
JBrowse link
G Plk1 polo-like kinase 1 decreases expression EXP Corticosterone results in decreased expression of PLK1 mRNA CTD PMID:15755911 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Plk2 polo-like kinase 2 decreases expression EXP Corticosterone results in decreased expression of PLK2 mRNA CTD PMID:15755911 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Plk4 polo-like kinase 4 decreases expression EXP Corticosterone results in decreased expression of PLK4 mRNA CTD PMID:15755911 NCBI chr 2:127,686,911...127,705,518
Ensembl chr 2:127,686,925...127,705,518
JBrowse link
G Podxl podocalyxin-like increases expression EXP Corticosterone results in increased expression of PODXL mRNA CTD PMID:15755911 NCBI chr 4:58,829,049...58,893,353
Ensembl chr 4:58,829,060...58,893,170
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
increases abundance
decreases abundance
decreases secretion
EXP
ISO
Bromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone]; Corticosterone inhibits the reaction [Nitroprusside results in increased secretion of POMC protein]; Cromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone]; Fulvestrant inhibits the reaction [nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]]; Nitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]; nonylphenol inhibits the reaction [Nitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]]; nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]; oxophenylarsine inhibits the reaction [POMC protein results in increased abundance of Corticosterone]; pervanadate inhibits the reaction [POMC protein results in increased abundance of Corticosterone]; SB 203580 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]
lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]; resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]]
POMC protein results in decreased abundance of Corticosterone
POMC protein modified form results in increased secretion of Corticosterone; POMC protein results in increased secretion of Corticosterone; POMC results in increased secretion of Corticosterone
Corticosterone results in decreased secretion of POMC protein; POMC protein results in decreased secretion of Corticosterone
CTD PMID:1659878, PMID:3015567, PMID:7588239, PMID:10518784, PMID:11132610, PMID:11518849, PMID:12742521, PMID:20837582, PMID:27052214 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PPARA mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PPARA mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PPARA mRNA] CTD PMID:29751049 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in decreased expression of PPARG mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in decreased expression of PPARG mRNA] CTD PMID:29751049 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO Cocaine promotes the reaction [PPP1R1B protein results in increased abundance of Corticosterone] CTD PMID:10516482 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression EXP Corticosterone results in decreased expression of PPP2R2B mRNA CTD PMID:15755911 NCBI chr18:36,985,709...37,421,383
Ensembl chr18:36,985,714...37,245,809
JBrowse link
G Prim1 DNA primase subunit 1 decreases expression EXP Corticosterone results in decreased expression of PRIM1 mRNA CTD PMID:15755911 NCBI chr 7:2,435,524...2,451,169
Ensembl chr 7:2,435,553...2,451,165
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha multiple interactions ISO [Androgens deficiency affects the activity of PRKAR1A gene mutant form] which results in increased secretion of Corticosterone; [PRKAR1A gene mutant form results in increased susceptibility to Androgens deficiency] which results in increased secretion of Corticosterone; Dexamethasone inhibits the reaction [[PRKAR1A gene mutant form results in increased susceptibility to Androgens deficiency] which results in increased secretion of Corticosterone]; Dexamethasone inhibits the reaction [PRKAR1A gene mutant form results in increased secretion of Corticosterone]; Dihydrotestosterone inhibits the reaction [[Androgens deficiency affects the activity of PRKAR1A gene mutant form] which results in increased secretion of Corticosterone]; Dihydrotestosterone inhibits the reaction [[PRKAR1A gene mutant form results in increased susceptibility to Androgens deficiency] which results in increased secretion of Corticosterone] CTD PMID:29367455 NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [Corticosterone results in increased activity of PRKCA protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Corticosterone results in increased activity of PRKCA protein] CTD PMID:16581232 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prl prolactin multiple interactions EXP MC2R protein promotes the reaction [PRL protein results in increased secretion of Corticosterone]; PRL protein promotes the reaction [MC2R protein results in increased secretion of Corticosterone] CTD PMID:18609294 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Pten phosphatase and tensin homolog increases phosphorylation ISO Corticosterone results in increased phosphorylation of PTEN protein CTD PMID:21647420 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgds prostaglandin D2 synthase increases expression EXP Corticosterone results in increased expression of PTGDS mRNA CTD PMID:15755911 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression EXP Corticosterone results in increased expression of PTGS1 mRNA; Corticosterone results in increased expression of PTGS1 protein CTD PMID:15755911 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [Corticosterone results in increased expression of PTGS2 mRNA]; [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [Corticosterone results in increased expression of PTGS2 protein]; CEBPB protein affects the reaction [Corticosterone results in increased expression of PTGS2 mRNA]; CEBPB protein affects the reaction [Corticosterone results in increased expression of PTGS2 protein]; Corticosterone promotes the reaction [CEBPB protein binds to PTGS2 promoter]; Corticosterone promotes the reaction [NR3C1 protein binds to PTGS2 promoter]; Dactinomycin inhibits the reaction [Corticosterone results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Corticosterone results in increased expression of PTGS2 protein]; Mifepristone inhibits the reaction [Corticosterone promotes the reaction [NR3C1 protein binds to PTGS2 promoter]]
Corticosterone results in increased expression of PTGS2 mRNA; Corticosterone results in increased expression of PTGS2 protein
CTD PMID:15755911, PMID:18650268 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pth parathyroid hormone multiple interactions EXP [Corticosterone co-treated with PTH protein] results in decreased expression of TNFRSF11B mRNA; [Corticosterone co-treated with PTH protein] results in decreased expression of TNFSF11 mRNA CTD PMID:17476578 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 decreases expression EXP Corticosterone results in decreased expression of PTPN3 mRNA CTD PMID:15755911 NCBI chr 5:74,248,996...74,368,167
Ensembl chr 5:74,248,996...74,368,186
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression EXP Corticosterone results in decreased expression of PTTG1 mRNA CTD PMID:15755911 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 increases expression EXP Corticosterone results in increased expression of QSOX1 mRNA CTD PMID:15755911 NCBI chr13:73,423,396...73,460,890
Ensembl chr13:73,423,397...73,460,935
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 increases expression EXP Corticosterone results in increased expression of RAPGEF4 mRNA CTD PMID:15755911 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038
JBrowse link
G Rbp1 retinol binding protein 1 decreases expression EXP Corticosterone results in decreased expression of RBP1 mRNA CTD PMID:15755911 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842
JBrowse link
G Reg3b regenerating family member 3 beta decreases expression EXP Corticosterone results in decreased expression of REG3B mRNA CTD PMID:15755911 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Retn resistin increases expression ISO Corticosterone results in increased expression of RETN mRNA CTD PMID:15809511 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Rfc3 replication factor C subunit 3 decreases expression EXP Corticosterone results in decreased expression of RFC3 mRNA CTD PMID:15755911 NCBI chr12:1,460,581...1,471,344
Ensembl chr12:1,460,538...1,471,357
JBrowse link
G Rfc4 replication factor C subunit 4 decreases expression EXP Corticosterone results in decreased expression of RFC4 mRNA CTD PMID:15755911 NCBI chr11:81,358,592...81,373,044
Ensembl chr11:81,358,592...81,373,043
JBrowse link
G Rgcc regulator of cell cycle increases expression EXP Corticosterone results in increased expression of RGCC mRNA CTD PMID:15755911 NCBI chr15:61,551,861...61,564,695
Ensembl chr15:61,551,861...61,564,695
JBrowse link
G RGD1562067 similar to cell division cycle associated 3 decreases expression EXP Corticosterone results in decreased expression of RGD1562067 mRNA CTD PMID:15755911 NCBI chr 9:51,128,614...51,130,082 JBrowse link
G Rhoj ras homolog family member J increases expression EXP Corticosterone results in increased expression of RHOJ mRNA CTD PMID:15755911 NCBI chr 6:98,284,361...98,367,122
Ensembl chr 6:98,284,170...98,367,756
JBrowse link
G Rpa2 replication protein A2 decreases expression EXP Corticosterone results in decreased expression of RPA2 mRNA CTD PMID:15755911 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 decreases expression EXP Corticosterone results in decreased expression of RRM1 mRNA CTD PMID:15755911 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions
decreases expression
EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of RUNX2 mRNA] CTD PMID:30423288 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Corticosterone results in decreased expression of SCD1 mRNA CTD PMID:15755911 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sdc1 syndecan 1 decreases expression EXP Corticosterone results in decreased expression of SDC1 mRNA CTD PMID:15755911 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Sdc2 syndecan 2 decreases expression EXP Corticosterone results in decreased expression of SDC2 mRNA CTD PMID:15755911 NCBI chr 7:71,572,731...71,686,139
Ensembl chr 7:71,572,941...71,686,044
JBrowse link
G Sdc4 syndecan 4 increases expression EXP Corticosterone results in increased expression of SDC4 mRNA CTD PMID:15755911 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Selenop selenoprotein P increases expression EXP Corticosterone results in increased expression of SELENOP mRNA CTD PMID:15755911 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression EXP Corticosterone results in increased expression of SERPINA3N mRNA CTD PMID:15755911 NCBI chr 6:128,073,344...128,080,878
Ensembl chr 6:127,941,526...128,080,889
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
increases phosphorylation
multiple interactions
EXP
ISO
Corticosterone results in increased expression of SGK1 mRNA
[Corticosterone results in increased phosphorylation of SGK1 protein] which results in increased phosphorylation of NDRG1 protein
[Corticosterone results in increased phosphorylation of and results in increased activity of PDK1 protein] which results in increased phosphorylation of and results in increased activity of SGK1 protein
Corticosterone results in increased expression of SGK1 mRNA; Corticosterone results in increased expression of SGK1 protein
CTD PMID:15755911, PMID:21655274, PMID:31520820 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Corticosterone binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression
ISO Corticosterone inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC1A2 protein]; Vitamin A promotes the reaction [Corticosterone results in increased expression of SLC1A2 protein] CTD PMID:17138558 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions EXP Corticosterone inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:9830022 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 decreases activity
multiple interactions
EXP
ISO
Corticosterone results in decreased activity of SLC22A3 protein
[Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite]; [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased abundance of Epinephrine; [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Phenylephrine; [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Synephrine; Corticosterone inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Corticosterone inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Corticosterone inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]
CTD PMID:9830022, PMID:12110607, PMID:12181285, PMID:12411423, PMID:16928864, PMID:17920670, PMID:19053318, PMID:20858707, PMID:21140131, PMID:30189235 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression
multiple interactions
EXP
ISO
Corticosterone results in increased expression of SLC2A1 mRNA
[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SLC2A1 mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SLC2A1 mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SLC2A1 mRNA]
CTD PMID:15755911, PMID:29751049 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
multiple interactions
EXP
ISO
Corticosterone results in increased expression of SLC2A4 mRNA
[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SLC2A4 mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SLC2A4 mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SLC2A4 mRNA]
CTD PMID:15755911, PMID:29751049 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions
decreases expression
ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of SLC6A15 mRNA]; Paroxetine inhibits the reaction [Corticosterone results in decreased expression of SLC6A15 mRNA] CTD PMID:31344373 NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229
JBrowse link
G Smad2 SMAD family member 2 decreases expression EXP Corticosterone results in decreased expression of SMAD2 mRNA; Corticosterone results in decreased expression of SMAD2 protein CTD PMID:29660438, PMID:32663519 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 decreases expression EXP Corticosterone results in decreased expression of SMAD3 mRNA CTD PMID:29660438, PMID:32663519 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smarcd2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 increases expression EXP Corticosterone results in increased expression of SMARCD2 mRNA CTD PMID:15755911 NCBI chr10:94,451,866...94,460,732
Ensembl chr10:94,451,866...94,460,732
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP Corticosterone results in decreased expression of SOD1 mRNA CTD PMID:22244747 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases activity
decreases expression
EXP [IGF2R protein co-treated with IGF1R protein] affects the reaction [IGF2 protein inhibits the reaction [Corticosterone results in decreased expression of SOD2 protein]]; IGF2 protein inhibits the reaction [Corticosterone results in decreased expression of SOD2 protein]
Corticosterone results in decreased activity of SOD2 protein
Corticosterone results in decreased expression of SOD2 mRNA; Corticosterone results in decreased expression of SOD2 protein
CTD PMID:22244747, PMID:24667322 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sorbs2 sorbin and SH3 domain containing 2 increases expression EXP Corticosterone results in increased expression of SORBS2 mRNA CTD PMID:15755911 NCBI chr16:49,626,205...49,820,223
Ensembl chr16:49,626,205...49,820,235
JBrowse link
G Sox4 SRY-box transcription factor 4 decreases expression EXP Corticosterone results in decreased expression of SOX4 mRNA CTD PMID:15755911 NCBI chr17:37,615,022...37,619,728 JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Corticosterone results in decreased expression of SOX9 mRNA; Corticosterone results in decreased expression of SOX9 protein CTD PMID:29660438, PMID:32663519 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
decreases expression
EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of SPP1 mRNA] CTD PMID:30423288 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP
ISO
[Corticosterone co-treated with oleoyl-estrone] affects the expression of SREBF1 mRNA
[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SREBF1 mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SREBF1 mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SREBF1 mRNA]
CTD PMID:19545626, PMID:29751049 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stmn1 stathmin 1 decreases expression EXP Corticosterone results in decreased expression of STMN1 mRNA CTD PMID:15755911 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Corticosterone results in increased expression of SULT1A1 mRNA CTD PMID:15755911 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Synm synemin increases expression EXP Corticosterone results in increased expression of SYNM mRNA CTD PMID:15755911 NCBI chr 1:128,692,112...128,722,048
Ensembl chr 1:128,692,112...128,722,048
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP [Mirex co-treated with Corticosterone] results in increased activity of TAT protein; Corticosterone promotes the reaction [[NR3C1 protein binds to TAT promoter] which results in increased expression of TAT mRNA] CTD PMID:2893471, PMID:22465009 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tcf21 transcription factor 21 increases expression EXP Corticosterone results in increased expression of TCF21 mRNA CTD PMID:15755911 NCBI chr 1:23,906,717...23,909,576
Ensembl chr 1:23,906,717...23,909,566
JBrowse link
G Tcp1 t-complex 1 decreases expression EXP Corticosterone results in decreased expression of TCP1 mRNA CTD PMID:15755911 NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase increases activity EXP Corticosterone results in increased activity of TDO2 protein CTD PMID:7306070 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tf transferrin increases expression EXP Corticosterone results in increased expression of TF mRNA CTD PMID:15755911 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
EXP Corticosterone inhibits the reaction [TGFB1 protein results in increased secretion of VEGFA protein]
Corticosterone results in decreased expression of TGFB1 mRNA
CTD PMID:16598785, PMID:29660438, PMID:32663519 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression
multiple interactions
EXP Corticosterone results in decreased expression of TGFBR1 mRNA; Corticosterone results in decreased expression of TGFBR1 protein
Mifepristone inhibits the reaction [Corticosterone results in decreased expression of TGFBR1 mRNA]
CTD PMID:29660438, PMID:32663519 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgm2 transglutaminase 2 increases expression EXP Corticosterone results in increased expression of TGM2 mRNA CTD PMID:15755911 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Th tyrosine hydroxylase increases expression ISO Corticosterone results in increased expression of TH protein CTD PMID:28186389 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tinagl1 tubulointerstitial nephritis antigen-like 1 increases expression EXP Corticosterone results in increased expression of TINAGL1 mRNA CTD PMID:15755911 NCBI chr 5:148,382,702...148,392,729
Ensembl chr 5:148,382,706...148,392,697
JBrowse link
G Tk1 thymidine kinase 1 decreases expression EXP Corticosterone results in decreased expression of TK1 mRNA CTD PMID:15755911 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR4 protein; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR4 protein]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PFKP mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PPARA mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SLC2A1 mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SLC2A4 mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SREBF1 mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR5 protein] CTD PMID:29751049 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tlr5 toll-like receptor 5 multiple interactions ISO [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR5 protein; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR5 protein]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR5 protein] CTD PMID:29751049 NCBI chr13:101,364,784...101,385,764
Ensembl chr13:101,381,510...101,385,764
JBrowse link
G Tnc tenascin C decreases expression EXP Corticosterone results in decreased expression of TNC mRNA CTD PMID:15755911 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TNF mRNA; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TNF mRNA]
[Corticosterone co-treated with Isoflurophate] results in increased expression of TNF mRNA
CTD PMID:28782715, PMID:29751049 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression
increases expression
multiple interactions
EXP Corticosterone results in decreased expression of TNFRSF11B mRNA
Corticosterone results in increased expression of TNFRSF11B mRNA
[Corticosterone co-treated with PTH protein] results in decreased expression of TNFRSF11B mRNA; Mifepristone inhibits the reaction [Corticosterone results in increased expression of TNFRSF11B mRNA]
CTD PMID:17476578, PMID:29981921 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases expression
increases expression
EXP [Corticosterone co-treated with PTH protein] results in decreased expression of TNFSF11 mRNA; Mifepristone inhibits the reaction [Corticosterone results in decreased expression of TNFSF11 mRNA]
Corticosterone results in increased expression of TNFSF11 mRNA
CTD PMID:17476578, PMID:29981921 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression EXP Corticosterone results in decreased expression of TOP2A mRNA CTD PMID:15755911 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tpbg trophoblast glycoprotein decreases expression EXP Corticosterone results in decreased expression of TPBG mRNA CTD PMID:15755911 NCBI chr 8:93,491,761...93,495,132
Ensembl chr 8:93,491,761...93,495,130
JBrowse link
G Tpd52l1 TPD52 like 1 increases expression EXP Corticosterone results in increased expression of TPD52L1 mRNA CTD PMID:15755911 NCBI chr 1:28,454,949...28,578,736
Ensembl chr 1:28,454,966...28,576,553
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO
EXP
[Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [AR protein binds to TRAF6 protein]; [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [ESR1 protein binds to TRAF6 protein]
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol inhibits the reaction [Corticosterone results in increased expression of TRAF6 protein]]; Corticosterone results in increased expression of and results in increased ubiquitination of TRAF6 protein; Estradiol inhibits the reaction [Corticosterone results in increased expression of and results in increased ubiquitination of TRAF6 protein]; Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in increased ubiquitination of TRAF6 protein]]; Flutamide inhibits the reaction [Estradiol inhibits the reaction [Corticosterone results in increased expression of TRAF6 protein]]; Testosterone inhibits the reaction [Corticosterone results in increased ubiquitination of TRAF6 protein]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased expression of and results in increased ubiquitination of TRAF6 protein]]
CTD PMID:29625166 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Trhr thyrotropin releasing hormone receptor increases expression EXP Corticosterone results in increased expression of TRHR mRNA CTD PMID:15755911 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Trim54 tripartite motif-containing 54 increases expression EXP Corticosterone results in increased expression of TRIM54 mRNA CTD PMID:15755911 NCBI chr 6:26,603,364...26,623,950
Ensembl chr 6:26,603,369...26,624,092
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 increases expression
multiple interactions
EXP Corticosterone results in increased expression of TSC22D3 mRNA; Corticosterone results in increased expression of TSC22D3 protein
TSC22D3 protein affects the reaction [Corticosterone results in decreased susceptibility to Doxorubicin]
CTD PMID:24480152, PMID:31520820 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906
JBrowse link
G Tspo translocator protein increases expression EXP Corticosterone results in increased expression of TSPO mRNA CTD PMID:15755911 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Corticosterone results in decreased expression of TUBB5 mRNA CTD PMID:15755911 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression EXP Corticosterone results in decreased expression of UBE2C mRNA CTD PMID:15755911 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Vcan versican decreases expression EXP Corticosterone results in decreased expression of VCAN mRNA CTD PMID:15755911 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
affects expression
EXP
ISO
Corticosterone inhibits the reaction [TGFB1 protein results in increased secretion of VEGFA protein]
Corticosterone results in increased expression of VEGFA protein
Corticosterone affects the expression of VEGFA protein
CTD PMID:16598785, PMID:21647420 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 decreases expression EXP Corticosterone results in decreased expression of WARS1 mRNA CTD PMID:15755911 NCBI chr 6:132,771,026...132,802,262
Ensembl chr 6:132,771,021...132,802,210
JBrowse link
G Wt1 WT1 transcription factor decreases expression EXP Corticosterone results in decreased expression of WT1 mRNA; Corticosterone results in decreased expression of WT1 protein CTD PMID:31306741 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link
G Xpo1 exportin 1 decreases expression EXP Corticosterone results in decreased expression of XPO1 mRNA CTD PMID:15755911 NCBI chr14:108,007,421...108,049,088
Ensembl chr14:108,007,724...108,049,660
JBrowse link
G Zfp36 zinc finger protein 36 increases expression EXP Corticosterone results in increased expression of ZFP36 mRNA CTD PMID:15755911 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
11-dehydrocorticosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases metabolic processing
increases reduction
affects abundance
multiple interactions
affects response to substance
ISO
EXP
HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone
HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone
HSD11B1 gene mutant form affects the abundance of 11-dehydrocorticosterone
[HSD11B1 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone; Resveratrol inhibits the reaction [HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone]; Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]; Ziram inhibits the reaction [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone]
HSD11B1 gene affects the susceptibility to 11-dehydrocorticosterone
CTD PMID:16751407, PMID:23814014, PMID:25061560, PMID:26859423 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions EXP [HSD11B2 protein results in increased metabolism of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone] CTD PMID:26859423, PMID:32243540 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 11-dehydrocorticosterone results in increased expression of IL6 mRNA
11-dehydrocorticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]
CTD PMID:30993381 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression
EXP Carbenoxolone inhibits the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA] CTD PMID:16533503 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      group 19696
        organic group 18493
          3-oxo-Delta(4)-steroid group 7934
            3-oxo-Delta(4) steroid 7934
              corticosterone 328
                11-dehydrocorticosterone 4
                11-deoxycorticosterone pivalate 0
                18-hydroxycorticosterone 0
                5beta-dihydrocorticosterone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        oxyketone 8629
                                          alpha-oxyketone 8629
                                            alpha-hydroxy ketone 8629
                                              primary alpha-hydroxy ketone 7514
                                                corticosterone 328
                                                  11-dehydrocorticosterone 4
                                                  11-deoxycorticosterone pivalate 0
                                                  18-hydroxycorticosterone 0
                                                  5beta-dihydrocorticosterone 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.