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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glutathione
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Accession:CHEBI:16856 term browser browse the term
Definition:A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
Synonyms:related_synonym: 5-L-Glutamyl-L-cysteinylglycine;   Formula=C10H17N3O6S;   GSH;   Glutathione-SH;   InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1;   InChIKey=RWSXRVCMGQZWBV-WDSKDSINSA-N;   L-gamma-glutamyl-L-cysteinylglycine;   N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine;   Reduced glutathione;   SMILES=N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O;   gamma-L-Glutamyl-L-cysteinyl-glycine
 alt_id: CHEBI:12402;   CHEBI:14327;   CHEBI:24334;   CHEBI:42873;   CHEBI:43049;   CHEBI:5437
 xref: CAS:70-18-8;   DrugBank:DB00143;   Drug_Central:1312;   HMDB:HMDB0000125;   KEGG:C00051;   KEGG:D00014;   KNApSAcK:C00001518
 xref_mesh: MESH:D005978
 xref: MetaCyc:GLUTATHIONE;   PDBeChem:GSH;   PMID:17439666;   PMID:4200890;   PMID:4745654;   Reaxys:1729812;   Wikipedia:Glutathione
 cyclic_relationship: is_conjugate_acid_of CHEBI:57925


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glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO Glutathione promotes the reaction [Quercetin results in increased expression of ABCA1 mRNA]; Quercetin promotes the reaction [Glutathione results in increased expression of ABCA1 mRNA] CTD PMID:25204422 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 affects export ISO ABCB4 protein affects the export of Glutathione CTD PMID:11302927 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects export
increases uptake
multiple interactions
increases export
affects transport
ISO
EXP
ABCC1 protein affects the export of Glutathione
ABCC1 protein results in increased uptake of Glutathione
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to monomethylarsonous acid analog]; [Glutathione binds to 10-nitro-oleic acid] promotes the reaction [ABCC1 protein results in increased export of 10-nitro-oleic acid metabolite]; [Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; ABCC1 protein affects the reaction [chrysin results in increased transport of Glutathione]; ABCC1 protein affects the transport of [arsenite co-treated with Glutathione]; Apigenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]; Genistein promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Glutathione affects the reaction [ABCC1 protein results in increased secretion of Antimony Potassium Tartrate]; Glutathione affects the reaction [ABCC1 protein results in increased secretion of arsenic trioxide]; Glutathione binds to and affects the folding of and affects the activity of ABCC1 protein; Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]; Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [Genistein affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin results in increased activity of ABCC1 protein]; Glutathione results in increased stability of and results in decreased degradation of and affects the localization of ABCC1 protein mutant form; naringenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; PAK 104P promotes the reaction [ABCC1 protein affects the export of Glutathione]; Quercetin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the export of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the transport of Glutathione]; Verapamil promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Vincristine inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]
[verlukast results in decreased activity of ABCC1 protein] inhibits the reaction [Arsenates results in increased export of Glutathione]
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione]; ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Glutathione]; buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]
ABCC1 protein affects the transport of Glutathione; ABCC1 protein affects the transport of Glutathione analog
CTD PMID:11278867, PMID:11306701, PMID:12018890, PMID:12485947, PMID:12504668, PMID:15161912, PMID:15245331, PMID:15498506, PMID:15561710, PMID:15579473, PMID:15581632, PMID:15766272, PMID:16679408, PMID:17272743, PMID:20584751, PMID:21856323, PMID:21918036, PMID:23542460, PMID:29158255 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
affects abundance
affects transport
ISO
EXP
ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione]; Glutathione promotes the reaction [ABCC2 protein affects the export of phenethyl isothiocyanate]
ABCC2 protein affects the abundance of Glutathione
ABCC2 protein affects the transport of Glutathione
ABCC2 protein affects the transport of Glutathione analog
CTD PMID:16002050, PMID:16049127, PMID:16611851, PMID:20584751, PMID:25450747 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO ABCC3 protein affects the reaction [chrysin results in increased transport of Glutathione]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM] CTD PMID:15210835, PMID:21856323 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
affects transport
ISO ABCC4 protein results in increased export of [2,6-dibromobenzoquinone binds to Glutathione]; ABCC4 protein results in increased export of [2,6-dichloro-(1,4)benzoquinone binds to Glutathione]; Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM]
ABCC4 protein affects the transport of Glutathione analog
CTD PMID:15210835, PMID:20584751, PMID:28885828 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
affects transport
ISO ABCC5 protein affects the reaction [chrysin results in increased transport of Glutathione]
ABCC5 protein affects the transport of Glutathione analog
CTD PMID:20584751, PMID:21856323 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions ISO Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases export
ISO 2',5'-dihydroxychalcone promotes the reaction [ABCG2 protein results in increased export of Glutathione]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of Glutathione] CTD PMID:20332504 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP Glutathione deficiency results in increased expression of ACOX1 mRNA CTD PMID:15345336 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression EXP Glutathione deficiency results in increased expression of ACSL4 mRNA CTD PMID:15345336 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO Glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] CTD PMID:19428350 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Agt angiotensinogen multiple interactions
decreases abundance
ISO ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione]; AGT protein promotes the reaction [GSR protein affects the chemical synthesis of Glutathione]; FNDC5 protein inhibits the reaction [AGT protein modified form results in decreased abundance of Glutathione]
AGT protein modified form results in increased chemical synthesis of [4-oxo-2-nonenal binds to Glutathione]
AGT protein modified form results in decreased abundance of Glutathione; AGT protein results in decreased abundance of Glutathione
CTD PMID:17272743, PMID:30703374, PMID:31144504 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased abundance of Glutathione] CTD PMID:12398935 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO AIFM1 protein inhibits the reaction [arsenic acid results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [Nitroprusside results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [Paraquat results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Glutathione] CTD PMID:15316071 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akap1 A-kinase anchoring protein 1 increases expression EXP Glutathione deficiency results in increased expression of AKAP1 mRNA CTD PMID:15345336 NCBI chr10:76,151,013...76,183,987
Ensembl chr10:76,151,038...76,166,276
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases glutathionylation
increases reduction
affects binding
ISO Glutathione results in increased glutathionylation of AKR1B1 protein modified form
Glutathione results in increased reduction of AKR1B1 protein modified form
AKR1B1 protein binds to Glutathione
CTD PMID:11306073, PMID:19061876 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP Glutathione inhibits the reaction [arsenite results in increased expression of AKR1B8 protein] CTD PMID:15175009 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases expression EXP Glutathione deficiency results in increased expression of AKR1D1 mRNA CTD PMID:15345336 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 increases expression
multiple interactions
EXP
ISO
Glutathione deficiency results in increased expression of AKR7A2 mRNA
AKR7A2 protein inhibits the reaction [Vitamin K 3 results in decreased abundance of Glutathione]
CTD PMID:15345336, PMID:22001351 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Glutathione deficiency results in increased expression of AKR7A3 mRNA CTD PMID:15345336, PMID:20621112 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] CTD PMID:17640567, PMID:24015256 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions EXP Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein] CTD PMID:21620807 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alb albumin multiple interactions ISO [4,4'-diphenylmethane diisocyanate co-treated with Glutathione] binds to and results in increased metabolism of ALB protein CTD PMID:23791970 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Glutathione deficiency results in increased expression of ALDH1A1 mRNA CTD PMID:20621112 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 increases expression EXP Glutathione deficiency results in increased expression of AP2M1 mRNA CTD PMID:15345336 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Aplp2 amyloid beta precursor like protein 2 increases expression EXP Glutathione deficiency results in increased expression of APLP2 mRNA CTD PMID:15345336 NCBI chr 8:32,298,526...32,328,821
Ensembl chr 8:32,298,532...32,328,839
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [Glutathione co-treated with Quercetin] promotes the reaction [APOA1 protein results in increased export of Cholesterol] CTD PMID:25204422 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoe apolipoprotein E decreases abundance
multiple interactions
ISO APOE gene mutant form results in decreased abundance of Glutathione
notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased abundance of Glutathione]
CTD PMID:24933211 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein decreases abundance
multiple interactions
EXP
ISO
APP protein modified form results in decreased abundance of Glutathione
vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]
resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]
CTD PMID:25654502, PMID:29545167 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G As3mt arsenite methyltransferase multiple interactions
affects folding
EXP
ISO
Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenic acid]; Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenous acid]; Glutathione affects the reaction [AS3MT protein affects the metabolism of dimethylarsine]; Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine oxide]; Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine]
Glutathione affects the folding of AS3MT protein
Glutathione promotes the reaction [[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]; Glutathione promotes the reaction [AS3MT protein results in increased methylation of arsenite]; Glutathione results in increased reduction of and affects the folding of AS3MT protein
CTD PMID:15606138, PMID:22868225, PMID:22955273, PMID:25349987 NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of ATF4 protein]; Glutathione inhibits the reaction [Camptothecin results in increased expression of ATF4 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of ATF4 protein] CTD PMID:24515801, PMID:30266318 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of ATF6 protein modified form] CTD PMID:27349771 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atg5 autophagy related 5 multiple interactions
affects abundance
ISO [ATG5 gene mutant form results in increased activity of NFE2L2 protein] affects the reaction [Acetaminophen affects the abundance of Glutathione]; [ATG5 gene mutant form results in increased activity of NFE2L2 protein] which affects the abundance of Glutathione; ATG5 protein affects the reaction [Acetaminophen affects the abundance of Glutathione]
ATG5 protein affects the abundance of Glutathione
CTD PMID:22491424 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO Glutathione inhibits the reaction [Apigenin results in increased expression of ATG7 protein] CTD PMID:29247770 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression EXP Glutathione deficiency results in increased expression of ATP1B1 mRNA CTD PMID:20621112 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Atp7b ATPase copper transporting beta decreases abundance
multiple interactions
ISO ATP7B gene mutant form results in decreased abundance of Glutathione
Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]; Zinc Sulfate inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]
CTD PMID:24368744 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Glutathione results in increased expression of BAX protein
Glutathione inhibits the reaction [Acrolein results in increased expression of BAX protein]
[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]
CTD PMID:10897038, PMID:21621595, PMID:24036456, PMID:24376112 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases export
ISO Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of BCL2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA; Glutathione inhibits the reaction [Acrolein results in decreased expression of BCL2 protein]
BCL2 protein results in decreased export of Glutathione
CTD PMID:15561710, PMID:17640567, PMID:22564015, PMID:24036456, PMID:24376112 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]] CTD PMID:17640567 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl3 BCL3, transcription coactivator decreases expression EXP Glutathione deficiency results in decreased expression of BCL3 mRNA CTD PMID:20621112 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase 2 increases expression EXP Glutathione deficiency results in increased expression of BDH2 mRNA CTD PMID:20621112 NCBI chr 2:240,461,505...240,482,149
Ensembl chr 2:240,461,505...240,482,145
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]] CTD PMID:17640567 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Glutathione inhibits the reaction [Thimerosal results in decreased expression of BIRC3 protein] CTD PMID:12140745 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases abundance ISO BMI1 protein results in increased abundance of Glutathione CTD PMID:21445297 NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Glutathione inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein] CTD PMID:19442826 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression EXP Glutathione deficiency results in decreased expression of BST2 mRNA CTD PMID:20621112 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G C5 complement C5 decreases expression EXP Glutathione deficiency results in decreased expression of C5 mRNA CTD PMID:20621112 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; Glutathione inhibits the reaction [aristolochic acid I results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP3 protein]
Glutathione results in increased activity of CASP3 protein
Glutathione inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [JP8 aviation fuel results in increased activity of CASP3 protein]
Glutathione inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; Glutathione promotes the reaction [FAS protein results in increased activity of CASP3 protein]
CTD PMID:10385654, PMID:11969376, PMID:12140745, PMID:14660655, PMID:15683462, PMID:17640567, PMID:21300145, PMID:21621595, PMID:24036456, PMID:24376112 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases expression EXP Glutathione deficiency results in increased expression of CASP6 mRNA CTD PMID:15345336 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP7 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP7 protein] CTD PMID:24515801 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Glutathione inhibits the reaction [Acrolein results in increased expression of CASP8 protein]
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP8 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP8 protein]
CTD PMID:24376112, PMID:24515801 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Glutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP9 protein] CTD PMID:12140745, PMID:18594523 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases response to substance
ISO
EXP
[INS1 protein co-treated with Glutathione] affects the activity of CAT protein; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of CAT mRNA; CAT inhibits the reaction [Buthionine Sulfoximine results in decreased abundance of Glutathione]; CAT protein inhibits the reaction [casiopeina II results in decreased abundance of Glutathione]
CAT protein results in decreased susceptibility to Glutathione
Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of CAT protein]; Glutathione inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Glutathione inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein]
CTD PMID:19419996, PMID:20580664, PMID:21354300, PMID:21620807, PMID:25362599, PMID:26187465, PMID:27718046 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav2 caveolin 2 increases expression EXP Glutathione deficiency results in increased expression of CAV2 mRNA CTD PMID:20621112 NCBI chr 4:44,573,264...44,580,640
Ensembl chr 4:44,573,264...44,580,638
JBrowse link
G Cbr3 carbonyl reductase 3 multiple interactions ISO [GCLM gene mutant form results in decreased abundance of Glutathione] which results in increased expression of CBR3 protein CTD PMID:25446851 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Cbs cystathionine beta synthase decreases abundance ISO CBS gene mutant form results in decreased abundance of Glutathione CTD PMID:15016621 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Glutathione inhibits the reaction [[Particulate Matter analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL2 protein]; Glutathione inhibits the reaction [[Vehicle Emissions analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL2 protein] CTD PMID:10919993 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Glutathione results in decreased expression of CCL20 mRNA CTD PMID:22385246 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Glutathione inhibits the reaction [[Particulate Matter analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [[Vehicle Emissions analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Particulate Matter analog results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Vehicle Emissions analog results in increased secretion of CCL5 protein] CTD PMID:10919993 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]] CTD PMID:17640567 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd14 CD14 molecule increases expression EXP Glutathione deficiency results in increased expression of CD14 mRNA CTD PMID:15345336 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd36 CD36 molecule multiple interactions
decreases expression
ISO [GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein
Glutathione results in decreased expression of CD36 protein
CTD PMID:26187465 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein] CTD PMID:27634759 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Thimerosal results in increased expression of CD86 protein] CTD PMID:20457211 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc25b cell division cycle 25B multiple interactions ISO [CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate CTD PMID:20025242 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate CTD PMID:20025242 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Glutathione deficiency results in increased expression of CDK4 mRNA CTD PMID:15345336 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Glutathione inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein] CTD PMID:22927544 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdo1 cysteine dioxygenase type 1 increases abundance EXP CDO1 protein results in increased abundance of Glutathione CTD PMID:23665415 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Glutathione inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA] CTD PMID:21220312 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
affects export
decreases activity
ISO [Bicarbonates co-treated with Glutathione co-treated with Ascorbic Acid] results in increased activity of CFTR protein; [Glutathione co-treated with Diamide] results in decreased activity of CFTR protein; Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein]; Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein]
CFTR protein affects the export of Glutathione
Glutathione analog results in decreased activity of CFTR protein
CTD PMID:15561710, PMID:15657297, PMID:15857825, PMID:32374624 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Glutathione inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] CTD PMID:17067557 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cldn4 claudin 4 multiple interactions EXP Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Clu clusterin increases expression EXP Glutathione deficiency results in increased expression of CLU mRNA CTD PMID:15345336 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]] CTD PMID:16896058 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Glutathione deficiency results in increased expression of CPT1A mRNA CTD PMID:15345336 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression EXP Glutathione deficiency results in increased expression of CREG1 mRNA CTD PMID:20621112 NCBI chr13:83,972,186...83,984,675
Ensembl chr13:83,972,212...83,984,675
JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP Glutathione inhibits the reaction [arsenite results in increased expression of CRYAB protein] CTD PMID:15175009 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Ctps1 CTP synthase 1 increases expression EXP Glutathione deficiency results in increased expression of CTPS mRNA CTD PMID:20621112 NCBI chr 5:139,475,934...139,505,065
Ensembl chr 5:139,475,934...139,505,065
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Glutathione deficiency results in decreased expression of CXCL1 mRNA CTD PMID:20621112 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Glutathione deficiency promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of CXCL1 protein] CTD PMID:26149495 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein CTD PMID:21621595 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of CYP1A1 mRNA; Glutathione affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Glutathione affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
[CYP1A1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac
CTD PMID:18078826, PMID:21094198, PMID:24246759 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP1A2 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP1A2 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [myristicin results in decreased activity of CYP1A2 protein] CTD PMID:20825217, PMID:24246759, PMID:26091900, PMID:31102647, PMID:32198085 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [CYP1B1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; CYP1B1 protein affects the metabolism of [2-hydroxyestradiol co-treated with Glutathione]; CYP1B1 protein affects the metabolism of [4-hydroxyestradiol co-treated with Glutathione] CTD PMID:14679015, PMID:24246759 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 multiple interactions EXP [CYP2A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine CTD PMID:20825217 NCBI chr 1:83,744,229...83,766,490
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] CTD PMID:24246759, PMID:32198085 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP2C19 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] CTD PMID:24246759, PMID:31102647, PMID:32198085 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO [CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac CTD PMID:24246759 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP2D6 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP2D6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein] CTD PMID:20825217, PMID:24246759, PMID:31102647, PMID:32198085 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO
EXP
[CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2E1 protein results in increased metabolism of Ethanol] which results in decreased abundance of Glutathione; [CYP2E1 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]
Glutathione inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein]
1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]; [[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde; [Glutathione co-treated with [CYP2E1 protein results in increased metabolism of Phenol]] results in increased chemical synthesis of [Glutathione binds to hydroquinone metabolite]
CTD PMID:8211999, PMID:10573527, PMID:16872732, PMID:21842885, PMID:24246759, PMID:28803762, PMID:32198085 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO [CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac CTD PMID:24246759 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [CYP3A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine CTD PMID:20825217 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP [CYP3A23-3A1 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine CTD PMID:20825217 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; CYP3A5 protein promotes the reaction [tetrandrine results in decreased abundance of Glutathione] CTD PMID:24246759, PMID:26302866 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of DDIT3 protein]
Glutathione inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]
CTD PMID:17171638, PMID:20493918, PMID:24515801 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 increases expression EXP Glutathione deficiency results in increased expression of DECR1 mRNA CTD PMID:15345336 NCBI chr 5:29,573,893...29,601,731
Ensembl chr 5:29,573,898...29,601,748
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 increases expression EXP Glutathione deficiency results in increased expression of DECR2 mRNA CTD PMID:15345336 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Defb4 defensin beta 4 decreases expression ISO Glutathione results in decreased expression of DEFB4A mRNA CTD PMID:22385246 NCBI chr16:75,634,598...75,637,789
Ensembl chr16:75,634,598...75,637,789
JBrowse link
G Dek DEK proto-oncogene decreases chemical synthesis ISO DEK protein results in decreased chemical synthesis of Glutathione CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO Glutathione inhibits the reaction [Alcohols results in increased expression of DGAT1 protein] CTD PMID:28803762 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dio1 iodothyronine deiodinase 1 increases expression EXP Glutathione deficiency results in increased expression of DIO1 mRNA CTD PMID:15345336 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] CTD PMID:27624276, PMID:28153600 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions EXP Glutathione inhibits the reaction [Cadmium results in increased expression of DUSP1 mRNA]; Glutathione inhibits the reaction [Cadmium results in increased expression of DUSP1 protein] CTD PMID:18573614 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Egf epidermal growth factor affects abundance EXP EGF protein affects the abundance of Glutathione CTD PMID:10544272 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased phosphorylation of EGFR protein]
[Acetaminophen results in decreased abundance of Glutathione] which results in increased phosphorylation of and results in increased activity of EGFR protein; [phorone results in decreased abundance of Glutathione] which results in increased phosphorylation of and results in increased activity of EGFR protein
CTD PMID:14660655, PMID:28123000 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression EXP Glutathione deficiency results in decreased expression of EIF2AK2 mRNA CTD PMID:20621112 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein] CTD PMID:24515801, PMID:30266318 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein] CTD PMID:30266318 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO Glutathione inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:23958427 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP Glutathione deficiency results in increased expression of EPHX1 mRNA CTD PMID:15345336 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Epo erythropoietin multiple interactions EXP
ISO
EPO protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione]
EPO protein inhibits the reaction [Cisplatin results in decreased abundance of Glutathione]
CTD PMID:16405037, PMID:22013135 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Extl1 exostosin-like glycosyltransferase 1 decreases expression EXP Glutathione deficiency results in decreased expression of EXTL1 mRNA CTD PMID:20621112 NCBI chr 5:152,573,755...152,588,956
Ensembl chr 5:152,573,758...152,589,719
JBrowse link
G F3 coagulation factor III, tissue factor increases activity ISO Glutathione results in increased activity of F3 protein CTD PMID:17726162 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fahd1 fumarylacetoacetate hydrolase domain containing 1 decreases expression EXP Glutathione deficiency results in decreased expression of FAHD1 mRNA CTD PMID:20621112 NCBI chr10:14,214,518...14,215,957
Ensembl chr10:14,214,519...14,215,957
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
affects chemical synthesis
ISO [FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione; [FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; FAS protein affects the reaction [Acetaminophen affects the chemical synthesis of Glutathione]; Glutathione promotes the reaction [FAS protein results in increased activity of CASP3 protein]
FAS protein affects the chemical synthesis of Glutathione
CTD PMID:10385654, PMID:23628456 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand decreases abundance
multiple interactions
ISO FASL protein results in decreased abundance of Glutathione
Glutathione inhibits the reaction [Acrolein results in increased expression of FASL protein]
verlukast promotes the reaction [FASL protein results in decreased abundance of Glutathione]
CTD PMID:17724027, PMID:24376112 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions
EXP
ISO
Glutathione deficiency results in decreased expression of FASN mRNA
Glutathione inhibits the reaction [Alcohols results in increased expression of FASN protein]
CTD PMID:20621112, PMID:28803762 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP 2-tert-butylhydroquinone promotes the reaction [FGF1 protein results in increased abundance of and results in increased secretion of Glutathione]; FGF1 protein results in increased abundance of and results in increased secretion of Glutathione CTD PMID:16524372 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] CTD PMID:19524604 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fndc5 fibronectin type III domain containing 5 multiple interactions ISO FNDC5 protein inhibits the reaction [AGT protein modified form results in decreased abundance of Glutathione] CTD PMID:30703374 NCBI chr 5:147,323,240...147,330,266
Ensembl chr 5:147,323,240...147,330,266
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Glutathione affects the reaction [Sodium Selenite results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA] CTD PMID:15105052, PMID:15520183, PMID:18449455 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA] CTD PMID:15520183 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Glutathione inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein] CTD PMID:20580664 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA] CTD PMID:16631525 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions EXP Glutathione inhibits the reaction [arsenite results in increased expression of FTL1 protein] CTD PMID:15175009 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein] CTD PMID:14572611 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO
EXP
Glutathione inhibits the reaction [Quartz results in decreased activity of G6PDX protein]
Glutathione inhibits the reaction [Asbestos, Amosite results in decreased activity of G6PD protein]
Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA]
CTD PMID:14613721, PMID:15225644, PMID:18370412 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO
EXP
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]; [GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog; Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Glutathione results in increased metabolism of and results in increased activity of GAPDH protein modified form; NAD analog inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; NADP inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]
Glutathione inhibits the reaction [arsenite results in decreased expression of GAPDH protein]
CTD PMID:15175009, PMID:15788719, PMID:21827172 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression EXP Glutathione deficiency results in increased expression of GCH1 mRNA CTD PMID:15345336 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases abundance
increases expression
affects chemical synthesis
ISO
EXP
[[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [Chenodeoxycholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [GCLC results in increased abundance of Glutathione] which results in decreased susceptibility to Cadmium Chloride; [Ginkgo biloba extract results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione; [Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]
GCLC mRNA results in increased abundance of Glutathione; GCLC protein results in increased abundance of Glutathione
[2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione; [Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]; [Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione; [FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein; [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; GCLC protein affects the reaction [RXRA protein affects the abundance of Glutathione]; GCLC protein inhibits the reaction [Hydrogen Peroxide results in decreased abundance of Glutathione]; GCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]
Glutathione deficiency results in increased expression of GCLC mRNA
GCLC polymorphism affects the chemical synthesis of Glutathione
[HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione
CTD PMID:7955076, PMID:10544272, PMID:11673643, PMID:12504668, PMID:14978233, PMID:15282320, PMID:15345336, PMID:15707499, PMID:16599007, PMID:17724089, PMID:18556457, PMID:19914271, PMID:20159942, PMID:20621112, PMID:21728338, PMID:21833590, PMID:22762311, PMID:23628456, PMID:26187465 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases abundance
increases chemical synthesis
affects response to substance
affects metabolic processing
decreases abundance
increases expression
ISO
EXP
[Chenodeoxycholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; [Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]; GCLM gene SNP results in decreased chemical synthesis of and results in decreased abundance of Glutathione
GCLM gene SNP results in increased abundance of Glutathione
GCLM protein results in increased chemical synthesis of Glutathione
GCLM protein affects the susceptibility to Glutathione
GCLM protein affects the metabolism of Glutathione
GCLM gene mutant form results in decreased abundance of Glutathione; GCLM protein mutant form results in decreased abundance of Glutathione
Glutathione deficiency results in increased expression of GCLM mRNA
[GCLM gene mutant form results in decreased abundance of Glutathione] which results in decreased susceptibility to Benzo(a)pyrene; [GCLM gene mutant form results in decreased abundance of Glutathione] which results in increased expression of CBR3 protein; GCLM protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]
CTD PMID:12975258, PMID:15345336, PMID:17584759, PMID:17724089, PMID:20159942, PMID:20417186, PMID:20621112, PMID:22253057, PMID:23135907, PMID:23704229, PMID:24107266, PMID:25446851, PMID:32715377 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO [acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione; [hexylglutathione results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione; GGT1 protein affects the reaction [acetaminophen cysteine results in decreased abundance of Glutathione] CTD PMID:15629191, PMID:19419996 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Glrx glutaredoxin multiple interactions ISO
EXP
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]]
[GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]
CTD PMID:12680778, PMID:20025242, PMID:24451382 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Glrx3 glutaredoxin 3 multiple interactions ISO [frenolicin B results in decreased activity of GLRX3 protein] which results in decreased abundance of Glutathione CTD PMID:30661989 NCBI chr 1:209,768,696...209,799,912
Ensembl chr 1:209,768,696...209,799,903
JBrowse link
G Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase decreases expression EXP Glutathione deficiency results in decreased expression of GNE mRNA CTD PMID:20621112 NCBI chr 5:59,511,738...59,553,421
Ensembl chr 5:59,512,872...59,553,416
JBrowse link
G Gnl3 G protein nucleolar 3 increases expression EXP Glutathione deficiency results in increased expression of GNL3 mRNA CTD PMID:20621112 NCBI chr16:7,097,580...7,103,518
Ensembl chr16:7,097,507...7,103,604
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; GPX1 protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] CTD PMID:16636302 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases abundance ISO GSK3B protein mutant form results in increased abundance of Glutathione CTD PMID:25246272 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
affects activity
increases expression
ISO
EXP
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate
Glutathione results in decreased activity of GSR protein
Glutathione inhibits the reaction [Chlorpyrifos results in decreased activity of GSR protein]
Glutathione deficiency affects the activity of GSR protein
Glutathione deficiency results in increased expression of GSR mRNA
1'-acetoxychavicol acetate analog inhibits the reaction [GSR protein results in increased reduction of Glutathione]; AGT protein promotes the reaction [GSR protein affects the chemical synthesis of Glutathione]; Glutathione inhibits the reaction [Alcohols results in decreased expression of GSR protein]
CTD PMID:15345336, PMID:15707499, PMID:17272743, PMID:20025242, PMID:20230805, PMID:23172834, PMID:24038001, PMID:28803762 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gss glutathione synthetase multiple interactions ISO [Arsenic results in increased expression of GSS protein] which results in increased chemical synthesis of Glutathione CTD PMID:18487201 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
affects binding
affects metabolic processing
ISO
EXP
GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Chlorambucil co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Cyclophosphamide metabolite co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]; GSTA1 protein binds to and affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione]
Glutathione binds to GSTA1 protein
[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione; Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]]; GSTA1 protein affects the metabolism of [2-hydroxymenthofuran co-treated with Glutathione]
GSTA1 protein affects the metabolism of Glutathione
CTD PMID:3783048, PMID:7712478, PMID:8886613, PMID:9084911, PMID:9877184, PMID:10437668, PMID:10496977, PMID:10751412, PMID:11115505, PMID:11368548, PMID:11849043, PMID:12147362, PMID:12516103, PMID:14690442, PMID:16890185 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
affects metabolic processing
ISO
EXP
[GSTA2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTA2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine
GSTA2 protein affects the metabolism of Glutathione
[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione; GSTA2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]
CTD PMID:8973562, PMID:9084911, PMID:9877184, PMID:28478157 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects binding
multiple interactions
increases expression
affects metabolic processing
ISO
EXP
Glutathione binds to GSTA3 protein
Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]]
Glutathione deficiency results in increased expression of GSTA3 mRNA
GSTA3 protein affects the metabolism of Glutathione
CTD PMID:3783048, PMID:6095330, PMID:8910329, PMID:15345336 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 affects metabolic processing
multiple interactions
ISO
EXP
GSTA4 protein affects the metabolism of Glutathione
[GSTA4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTA4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine
CTD PMID:14727915, PMID:28478157 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Glutathione deficiency results in increased expression of GSTA5 mRNA CTD PMID:15345336 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA CTD PMID:22564015 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
affects metabolic processing
decreases abundance
increases expression
affects binding
ISO
EXP
4-O-decyl-gabosine D inhibits the reaction [Glutathione binds to GSTM1 protein]; [GSTM1 protein co-treated with 4-hydroxy-2-nonenal] results in decreased abundance of Glutathione; GSTM1 protein affects the metabolism of [1,2,5,6-dibenzanthracene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Glutathione]; GSTM1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTM1 protein affects the metabolism of [Benzo(a)pyrene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [chrysene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTM1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTM1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]
GSTM5 protein affects the metabolism of Glutathione
GSTM1 gene mutant form results in decreased abundance of Glutathione
Glutathione analog binds to and results in decreased activity of GSTM1 protein; GSTM1 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]; GSTM1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione analog]; GSTM1 protein affects the metabolism of [styrene oxide co-treated with Glutathione]
GSTM1 protein affects the metabolism of Glutathione
Glutathione deficiency results in increased expression of GSTM1 mRNA
CTD PMID:1883342, PMID:2604743, PMID:2904809, PMID:6095330, PMID:7826396, PMID:8886613, PMID:8973562, PMID:9084911, PMID:9403173, PMID:9545290, PMID:11368548, PMID:11849043, PMID:14979731, PMID:15345336, PMID:21925487, PMID:22085405, PMID:25420021 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects metabolic processing
multiple interactions
ISO
EXP
GSTM2 protein affects the metabolism of Glutathione
[GSTM2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTM2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine
Dinitrochlorobenzene promotes the reaction [GSTM2 protein affects the metabolism of Glutathione]; GSTM2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]; GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione]
CTD PMID:2604743, PMID:8924604, PMID:8973562, PMID:9794801, PMID:10858281, PMID:28478157 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm3 glutathione S-transferase mu 3 affects metabolic processing ISO GSTM3 protein affects the metabolism of Glutathione CTD PMID:9545290 NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstm3l glutathione S-transferase mu 3-like affects metabolic processing EXP GSTM5 protein affects the metabolism of Glutathione CTD PMID:9545290 NCBI chr 2:210,761,729...210,766,501
Ensembl chr 2:210,761,729...210,766,501
JBrowse link
G Gstm4 glutathione S-transferase mu 4 multiple interactions ISO [GSTM4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTM4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine; GSTM4 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione] CTD PMID:8203914, PMID:28478157 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 affects metabolic processing ISO GSTM3 protein affects the metabolism of Glutathione CTD PMID:9545290 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity
multiple interactions
increases expression
affects metabolic processing
ISO
EXP
Glutathione analog results in decreased activity of GSTP1 protein
GSTP1 protein affects the metabolism of [Atrazine co-treated with Glutathione]
Glutathione deficiency results in increased expression of GSTP1 mRNA
GSTP1 protein affects the metabolism of Glutathione
Glutathione inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein]; GSTP1 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1B1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2A6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; [GSTP1 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTP1 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine; GSTP1 gene affects the reaction [Glutathione affects the metabolism of Thiotepa]; GSTP1 protein affects the metabolism of [4-oxo-2-nonenal co-treated with Glutathione]; GSTP1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTP1 protein affects the metabolism of [acrylodan co-treated with Glutathione]; GSTP1 protein affects the metabolism of [Atrazine co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(c)chrysene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(c)phenanthrene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(g)chrysene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTP1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]; GSTP1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTP1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]; GSTP1 protein promotes the reaction [Glutathione binds to Atrazine]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]
CTD PMID:7712478, PMID:7826396, PMID:8886613, PMID:8973562, PMID:9403173, PMID:9877184, PMID:10334868, PMID:11196146, PMID:11368548, PMID:11849043, PMID:12470677, PMID:13679171, PMID:15115887, PMID:15528046, PMID:18607078, PMID:20570720, PMID:20621112, PMID:24246759, PMID:28478157 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects metabolic processing
multiple interactions
ISO
EXP
GSTT1 protein affects the metabolism of Glutathione
GSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione]
GSTT1 protein polymorphism affects the metabolism of [Benzene co-treated with Glutathione]
CTD PMID:14727918, PMID:14998683, PMID:15533900 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects metabolic processing
affects binding
multiple interactions
ISO GSTZ1 protein affects the metabolism of Glutathione
Glutathione binds to GSTZ1 protein
GSTZ1 protein binds to and affects the metabolism of Glutathione
CTD PMID:1846734, PMID:9396740, PMID:11327815, PMID:12852784, PMID:15173170 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of H2AX protein] CTD PMID:21722719 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression EXP Glutathione deficiency results in increased expression of HADHA mRNA CTD PMID:15345336 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Has2 hyaluronan synthase 2 multiple interactions ISO Glutathione inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA] CTD PMID:21220312 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Hfe homeostatic iron regulator increases expression EXP Glutathione deficiency results in increased expression of HFE mRNA CTD PMID:15345336 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Hgf hepatocyte growth factor increases abundance
multiple interactions
EXP HGF protein results in increased abundance of Glutathione
[HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione
CTD PMID:10544272 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [Vanadates results in increased expression of HIF1A protein] CTD PMID:11641398, PMID:16678800, PMID:17658243 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP Glutathione deficiency results in increased expression of HMGCR mRNA CTD PMID:15345336 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
affects expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; [Acetylcysteine results in increased abundance of Glutathione] inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]; [Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Air Pollutants results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]]
[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [resveratrol results in increased abundance of Glutathione]; Glutathione inhibits the reaction [arsenite results in increased expression of HMOX1 protein]
Glutathione deficiency results in increased expression of HMOX1 mRNA; Glutathione results in increased expression of HMOX1 mRNA
Glutathione affects the expression of HMOX1 mRNA
CTD PMID:8743975, PMID:12420312, PMID:15175009, PMID:15602829, PMID:16631525, PMID:18078826, PMID:18332044, PMID:20020861, PMID:20621112, PMID:20888885, PMID:20934533, PMID:20961405, PMID:21971136, PMID:23649983, PMID:23691207, PMID:26945724 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases expression EXP Glutathione deficiency results in increased expression of HNF4A mRNA CTD PMID:15345336 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene; Dactinomycin promotes the reaction [[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene] CTD PMID:9345283 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions EXP Glutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD17B1 protein] CTD PMID:20580664 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions EXP Glutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD3B1 protein] CTD PMID:20580664
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions EXP Glutathione inhibits the reaction [arsenite results in increased expression of HSPA1B protein] CTD PMID:15175009 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Glutathione inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] CTD PMID:20493918 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions EXP Glutathione inhibits the reaction [arsenite results in increased expression of HSPB1 protein] CTD PMID:15175009 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Iapp islet amyloid polypeptide multiple interactions ISO IAPP protein inhibits the reaction [[Copper co-treated with Glutathione] results in increased abundance of Hydrogen Peroxide] CTD PMID:23793354 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:20351055 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of Glutathione
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Glutathione]
CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Ifng interferon gamma multiple interactions ISO Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]
[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IFNG protein; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]]
CTD PMID:12847270, PMID:16896058, PMID:17079650, PMID:18214930 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
ISO deoxynivalenol promotes the reaction [Glutathione results in increased expression of IGF1 mRNA] CTD PMID:19805407 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit multiple interactions
increases expression
ISO deoxynivalenol inhibits the reaction [Glutathione results in increased expression of IGFALS mRNA] CTD PMID:19805407 NCBI chr10:14,240,308...14,243,554
Ensembl chr10:14,240,219...14,243,597
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions
increases expression
ISO deoxynivalenol promotes the reaction [Glutathione results in increased expression of IGFBP3 mRNA] CTD PMID:19805407 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
affects abundance
ISO GCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]; GCLM protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]; Glutathione inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]
IKBKB protein affects the abundance of Glutathione
CTD PMID:17067557, PMID:20159942 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL10 protein CTD PMID:18214930 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein; Glutathione inhibits the reaction [[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein] CTD PMID:17079650, PMID:18214930 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta increases abundance
decreases expression
multiple interactions
ISO IL1B protein results in increased abundance of Glutathione
Glutathione results in decreased expression of IL1B mRNA
Glutathione deficiency promotes the reaction [Phenol results in increased secretion of IL1B protein]; Glutathione deficiency promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of IL1B protein]
CTD PMID:10802230, PMID:17922553, PMID:22385246, PMID:26149495 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il33 interleukin 33 increases expression EXP Glutathione deficiency results in increased expression of IL33 mRNA CTD PMID:20621112 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [IL4 gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased abundance of Glutathione
[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]
CTD PMID:18214930, PMID:22107450, PMID:27634759 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Glutathione analog promotes the reaction [Ozone results in increased expression of IL6 protein]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]] CTD PMID:15379216, PMID:17079650 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO INS protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] CTD PMID:26739624 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression EXP Glutathione deficiency results in increased expression of ISG20 mRNA CTD PMID:20621112 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Glutathione inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA] CTD PMID:16357311 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein] CTD PMID:12847270 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
ISO Glutathione affects the reaction [Sodium Selenite results in increased expression of JUN mRNA]; Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA]
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of JUN protein]
Glutathione deficiency results in increased phosphorylation of JUN protein
CTD PMID:12774022, PMID:15105052, PMID:15520183, PMID:18449455, PMID:30266318 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA] CTD PMID:15520183 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
increases abundance
ISO
EXP
[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione; [Plant Extracts results in decreased expression of KEAP1 protein] which results in increased chemical synthesis of Glutathione; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]
KEAP1 gene mutant form results in increased abundance of Glutathione
Glutathione inhibits the reaction [falcarindiol binds to and results in increased alkylation of KEAP1 protein]
[KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; Glutathione inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein]; Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased glutathionylation of KEAP1 protein]; KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]
CTD PMID:19608619, PMID:20026152, PMID:20800667, PMID:21972102, PMID:22762311, PMID:25807370, PMID:26827822 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Klf4 Kruppel like factor 4 increases abundance
multiple interactions
ISO KLF4 results in increased abundance of Glutathione
[KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione
CTD PMID:21833590 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Klkb1 kallikrein B1 increases expression EXP Glutathione deficiency results in increased expression of KLKB1 mRNA CTD PMID:15345336 NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
JBrowse link
G Krt18 keratin 18 increases expression EXP Glutathione deficiency results in increased expression of KRT18 mRNA CTD PMID:15345336 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LCK protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LCK protein] CTD PMID:14572611 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Lepr leptin receptor multiple interactions EXP LEPR gene mutant form results in increased oxidation of and results in decreased abundance of Glutathione CTD PMID:29743445 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP
ISO
Glutathione inhibits the reaction [sodium arsenite results in decreased expression of LHB protein]
Glutathione inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA]
CTD PMID:20580664, PMID:21220312 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression EXP Glutathione deficiency results in decreased expression of LRP1 mRNA CTD PMID:20621112 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] CTD PMID:14572611 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Maob monoamine oxidase B multiple interactions ISO Glutathione inhibits the reaction [MAOB protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole] CTD PMID:26686552 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
EXP
ISO
Glutathione deficiency results in increased expression of MAP1LC3B mRNA
Glutathione inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form]
CTD PMID:15345336, PMID:29247770 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Glutathione inhibits the reaction [Particulate Matter results in decreased expression of MAP2 mRNA] CTD PMID:28153600 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Glutathione inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of MAPK1 protein]
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [ciglitazone results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK1 protein; Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]
CTD PMID:10658192, PMID:12083801, PMID:15252869, PMID:21971136, PMID:22767315, PMID:23370007, PMID:24015256 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
Glutathione inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK3 protein]
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [ciglitazone results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK3 protein; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]
CTD PMID:12083801, PMID:15252869, PMID:21971136, PMID:22767315, PMID:24015256 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO
EXP
Glutathione deficiency promotes the reaction [antimony trioxide results in increased activity of MAPK8 protein]
Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK8 protein]
Glutathione inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Dopamine results in increased phosphorylation of MAPK8 protein]
CTD PMID:16112521, PMID:17481858, PMID:20423716, PMID:22767315 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO
EXP
Glutathione inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK9 protein]
Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK9 protein]
CTD PMID:20423716, PMID:22767315 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Glutathione deficiency results in increased expression of ME1 mRNA CTD PMID:15345336 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO MET gene mutant form promotes the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased oxidation of Glutathione] CTD PMID:27394961 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO Glutathione affects the reaction [MGMT protein results in increased susceptibility to Mitomycin] CTD PMID:16039682 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP [Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Glutathione binds to and results in increased activity of MGST1 protein; Leukotriene C4 inhibits the reaction [Glutathione binds to and results in increased activity of MGST1 protein]; MGST1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]; MGST1 protein affects the metabolism of [acrylodan co-treated with Glutathione]; sodium arsenite inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein] CTD PMID:9890956, PMID:12470677, PMID:16386761 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases secretion ISO Glutathione results in decreased secretion of MMP2 protein CTD PMID:15147517 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding
multiple interactions
decreases secretion
ISO Glutathione binds to MMP9 protein
Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of MMP9 protein]
Glutathione results in decreased secretion of MMP9 protein
Glutathione inhibits the reaction [4-aminophenylmercuriacetate results in increased activity of MMP9 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glutathione binds to MMP9 protein]
CTD PMID:15147517, PMID:17015178, PMID:17640567, PMID:21722719 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; [[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione] which results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione; [MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in decreased abundance of Glutathione; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; Glutathione promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Glutathione promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile] CTD PMID:19462961, PMID:25614581, PMID:28754375, PMID:31288001 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mst1r macrophage stimulating 1 receptor multiple interactions ISO MST1R protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] CTD PMID:22575169 NCBI chr 8:116,686,601...116,700,132
Ensembl chr 8:116,686,601...116,700,132
JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
ISO
EXP
[MT1 protein co-treated with MT2 protein] affects the reaction [Glutathione affects the susceptibility to Doxorubicin]
Glutathione deficiency results in increased expression of MT1A mRNA
CTD PMID:15345336, PMID:20600803 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [MT1 protein co-treated with MT2 protein] affects the reaction [Glutathione affects the susceptibility to Doxorubicin] CTD PMID:20600803 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO Glutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]] CTD PMID:9507026 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] CTD PMID:26989453 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects abundance
multiple interactions
ISO
EXP
MYC protein affects the abundance of Glutathione
Glutathione inhibits the reaction [arsenite results in increased expression of MYC mRNA]
CTD PMID:9848127, PMID:12226097 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases abundance
decreases abundance
affects abundance
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased abundance of Glutathione; [[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein; [Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein; [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]; Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid affects the localization of NFE2L2 protein]; Glutathione inhibits the reaction [Air Pollutants results in increased expression of NFE2L2 protein]; NFE2L2 promotes the reaction [Chalcone analog results in increased abundance of Glutathione]; NFE2L2 protein affects the reaction [Silver results in increased abundance of Glutathione]
NFE2L2 protein results in increased abundance of Glutathione
NFE2L2 gene mutant form results in decreased abundance of Glutathione
NFE2L2 protein affects the abundance of Glutathione
NFE2L2 protein inhibits the reaction [triptolide results in decreased abundance of Glutathione]
[ATG5 gene mutant form results in increased activity of NFE2L2 protein] affects the reaction [Acetaminophen affects the abundance of Glutathione]; [ATG5 gene mutant form results in increased activity of NFE2L2 protein] which affects the abundance of Glutathione; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased abundance of Glutathione; Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form promotes the reaction [Diquat results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [Dinitrochlorobenzene results in decreased abundance of Glutathione]; sulforafan affects the reaction [NFE2L2 affects the abundance of Glutathione]
NFE2L2 affects the abundance of Glutathione; NFE2L2 protein affects the abundance of Glutathione
CTD PMID:11287661, PMID:16524372, PMID:16631525, PMID:19303893, PMID:19608619, PMID:20124447, PMID:20800667, PMID:21728338, PMID:21971136, PMID:22491424, PMID:22546375, PMID:22762311, PMID:22820427, PMID:23649983, PMID:23764462, PMID:24211276, PMID:27633142, PMID:28219650, PMID:29618784, PMID:31299238 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]] CTD PMID:16219905, PMID:17640567 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] CTD PMID:17067557 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions
affects reduction
affects oxidation
affects activity
EXP
ISO
N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein]
NGF protein affects the reduction of Glutathione
NGF protein affects the oxidation of Glutathione
CTD PMID:12381813, PMID:23472850 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nlgn3 neuroligin 3 multiple interactions ISO Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] CTD PMID:27624276 NCBI chr  X:71,199,390...71,227,460
Ensembl chr  X:71,199,491...71,222,732
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases abundance ISO NNMT protein results in increased abundance of Glutathione CTD PMID:31909875 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]
Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of NOS2 protein]; Glutathione inhibits the reaction [orazipone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
CTD PMID:17640567, PMID:18039960, PMID:21722719 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
decreases expression
EXP
ISO
Glutathione deficiency results in increased expression of NQO1 mRNA
Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased expression of NQO1 protein]
Glutathione results in decreased expression of NQO1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA; NQO1 protein inhibits the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; NQO1 protein polymorphism promotes the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]
CTD PMID:15345336, PMID:20800667, PMID:21034357, PMID:21971136 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression EXP Glutathione deficiency results in increased expression of NR0B2 mRNA CTD PMID:15345336 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 gene mutant form inhibits the reaction [pyrene results in decreased abundance of Glutathione] CTD PMID:26160115 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of ATF4 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP7 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP8 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of PARP protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of DDIT3 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of SESN2 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of XBP1 protein alternative form]; Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein] CTD PMID:24515801, PMID:26035713 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions EXP Glutathione inhibits the reaction [Permethrin results in increased expression of NR4A2 mRNA] CTD PMID:28943456 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nrxn1 neurexin 1 multiple interactions ISO Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] CTD PMID:27624276 NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660
JBrowse link
G Oaf out at first homolog decreases expression EXP Glutathione deficiency results in decreased expression of OAF mRNA CTD PMID:20621112 NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO Glutathione inhibits the reaction [mezerein results in increased activity of ODC1 protein]; Glutathione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] CTD PMID:3098411 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP [GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]; Glutathione promotes the reaction [Diamide results in decreased activity of OGDH protein] CTD PMID:12680778 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA CTD PMID:22564015 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Panx1 Pannexin 1 decreases oxidation ISO PANX1 gene mutant form results in decreased oxidation of Glutathione CTD PMID:29246445 NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
JBrowse link
G Park7 Parkinsonism associated deglycase increases abundance ISO PARK7 protein results in increased abundance of Glutathione CTD PMID:18331584 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Glutathione deficiency promotes the reaction [antimony trioxide results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [N-methylisoindigotin results in increased cleavage of PARP1 protein] CTD PMID:14660655, PMID:16112521, PMID:24036456, PMID:24515801, PMID:26887594 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression EXP Glutathione deficiency results in decreased expression of PCSK9 mRNA CTD PMID:20621112 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta increases abundance ISO PDGFRB protein results in increased abundance of Glutathione CTD PMID:29857117 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein] CTD PMID:17171638 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Glutathione inhibits the reaction [LHB protein results in increased abundance of PGR mRNA] CTD PMID:21220312 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plin2 perilipin 2 multiple interactions ISO SOD1 gene mutant form promotes the reaction [Glutathione results in increased expression of PLIN2 protein modified form] CTD PMID:27349771 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO PON1 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione] CTD PMID:20079818 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pon3 paraoxonase 3 multiple interactions ISO PON3 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione] CTD PMID:20079818 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679
JBrowse link
G Ppan peter pan homolog increases expression EXP Glutathione deficiency results in increased expression of PPAN mRNA CTD PMID:20621112 NCBI chr 8:21,905,865...21,909,845
Ensembl chr 8:21,905,865...21,909,842
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions
ISO Glutathione results in increased expression of PPARA mRNA
Glutathione inhibits the reaction [Alcohols results in decreased expression of PPARA protein]; Quercetin promotes the reaction [Glutathione results in increased expression of PPARA mRNA]
CTD PMID:25204422, PMID:28803762 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Glutathione analog results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppat phosphoribosyl pyrophosphate amidotransferase increases expression EXP Glutathione deficiency results in increased expression of PPAT mRNA CTD PMID:20621112 NCBI chr14:33,580,541...33,614,919
Ensembl chr14:33,580,541...33,614,919
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C increases expression EXP Glutathione deficiency results in increased expression of PPP1R3C mRNA CTD PMID:20621112 NCBI chr 1:255,371,830...255,376,833
Ensembl chr 1:255,371,810...255,376,833
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO [frenolicin B results in decreased activity of PRDX1 protein] which results in decreased abundance of Glutathione CTD PMID:30661989 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions ISO SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of PRDX2 protein] CTD PMID:27349771 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prdx6 peroxiredoxin 6 increases expression EXP Glutathione deficiency results in increased expression of PRDX6 mRNA CTD PMID:15345336 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Prim2 DNA primase subunit 2 increases expression EXP Glutathione deficiency results in increased expression of PRIM2 mRNA CTD PMID:20621112 NCBI chr 9:38,535,435...38,745,058
Ensembl chr 9:38,536,920...38,745,099
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
affects abundance
ISO Glutathione inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of PRKCD protein]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
PRKCD protein affects the abundance of Glutathione
CTD PMID:15131007, PMID:15707588, PMID:17171638 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase affects abundance ISO PRKN protein affects the abundance of Glutathione CTD PMID:12915482 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Prnp prion protein multiple interactions ISO PRNP protein inhibits the reaction [manganese chloride results in decreased abundance of Glutathione] CTD PMID:17483122 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Procr protein C receptor multiple interactions ISO Glutathione inhibits the reaction [Doxorubicin results in decreased expression of PROCR protein] CTD PMID:17172434 NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
JBrowse link
G Ptbp1 polypyrimidine tract binding protein 1 increases expression EXP Glutathione deficiency results in increased expression of PTBP1 mRNA CTD PMID:15345336 NCBI chr 7:12,663,965...12,673,723
Ensembl chr 7:12,663,965...12,673,718
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]
Glutathione inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 mRNA]; Glutathione inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]
Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGS2 protein]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]
CTD PMID:17640567, PMID:21220312, PMID:21722719, PMID:22767315 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptma prothymosin alpha increases abundance
multiple interactions
decreases abundance
ISO PTMA protein alternative form results in increased abundance of Glutathione
PTMA protein inhibits the reaction [Dexamethasone results in decreased abundance of Glutathione]
PTMA protein alternative form results in decreased abundance of Glutathione
CTD PMID:9147362, PMID:19442654 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions ISO Glutathione inhibits the reaction [quinone results in decreased activity of PTPN2 protein] CTD PMID:31248982 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F decreases expression EXP Glutathione deficiency results in decreased expression of PTPRF mRNA CTD PMID:20621112 NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927
JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S decreases expression EXP Glutathione deficiency results in decreased expression of PTPRS mRNA CTD PMID:20621112 NCBI chr 9:10,585,360...10,646,205
Ensembl chr 9:10,603,813...10,645,939
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Glutathione inhibits the reaction [Doxorubicin results in decreased phosphorylation of RB1 protein]; Glutathione inhibits the reaction [Levamisole results in decreased expression of RB1 protein] CTD PMID:11139434, PMID:22927544 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbm27 RNA binding motif protein 27 decreases expression EXP Glutathione deficiency results in decreased expression of RBM27 mRNA CTD PMID:20621112 NCBI chr18:36,596,568...36,657,157
Ensembl chr18:36,596,585...36,656,314
JBrowse link
G Rdh16 retinol dehydrogenase 16 increases expression EXP Glutathione deficiency results in increased expression of RDH2 mRNA CTD PMID:15345336 NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases glutathionylation
affects abundance
ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; [cinnamic aldehyde results in increased abundance of Glutathione] which results in increased glutathionylation of RELA protein; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein affects the localization of RELA protein]; [Glutathione co-treated with Hydrogen Peroxide] results in increased glutathionylation of RELA protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]
Glutathione results in increased glutathionylation of RELA protein
RELA protein affects the abundance of Glutathione
Glutathione affects the reaction [Sodium Selenite results in increased expression of RELA mRNA]; Glutathione inhibits the reaction [Alcohols results in increased expression of RELA protein]
CTD PMID:16219905, PMID:17640567, PMID:18449455, PMID:20116392, PMID:20159942, PMID:20351055, PMID:28803762 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Reln reelin decreases expression EXP Glutathione deficiency results in decreased expression of RELN mRNA CTD PMID:20621112 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Retreg1 reticulophagy regulator 1 increases expression EXP Glutathione deficiency results in increased expression of RETREG1 mRNA CTD PMID:20621112 NCBI chr 2:78,391,921...78,401,569
Ensembl chr 2:78,391,921...78,399,987
JBrowse link
G Rfk riboflavin kinase increases abundance ISO RFK protein results in increased abundance of Glutathione CTD PMID:21308351 NCBI chr 1:236,494,221...236,501,733
Ensembl chr 1:236,494,221...236,501,733
JBrowse link
G RGD1309808 similar to apolipoprotein L2; apolipoprotein L-II decreases expression EXP Glutathione deficiency results in decreased expression of RGD1309808 mRNA CTD PMID:20621112 NCBI chr 7:118,700,952...118,719,160
Ensembl chr 7:118,692,851...118,719,156
JBrowse link
G Rps6 ribosomal protein S6 increases expression EXP Glutathione deficiency results in increased expression of RPS6 mRNA CTD PMID:15345336 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases expression EXP Glutathione deficiency results in increased expression of RPS6KB1 mRNA CTD PMID:15345336 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rreb1 ras responsive element binding protein 1 decreases expression EXP Glutathione deficiency results in decreased expression of RREB1 mRNA CTD PMID:20621112 NCBI chr17:27,539,137...27,718,878
Ensembl chr17:27,539,133...27,665,266
JBrowse link
G Rup2 urinary protein 2 increases expression EXP Glutathione deficiency results in increased expression of RUP2 mRNA CTD PMID:15345336 NCBI chr 8:41,657,662...41,661,223
Ensembl chr 8:41,657,566...41,661,238
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
affects abundance
ISO GCLC protein affects the reaction [RXRA protein affects the abundance of Glutathione] CTD PMID:14978233 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Samd4a sterile alpha motif domain containing 4A increases expression EXP Glutathione deficiency results in increased expression of SAMD4A mRNA CTD PMID:20621112 NCBI chr15:23,666,543...23,879,067
Ensembl chr15:23,665,202...23,878,539
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Glutathione deficiency results in decreased expression of SCD1 mRNA CTD PMID:20621112 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression EXP Glutathione deficiency results in increased expression of SDF2L1 mRNA CTD PMID:20621112 NCBI chr11:88,122,271...88,124,513
Ensembl chr11:88,122,271...88,124,513
JBrowse link
G Sele selectin E multiple interactions ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:21971136 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Selenow selenoprotein W multiple interactions ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased expression of SELENOW mRNA; Glutathione deficiency promotes the reaction [Methylmercury Compounds results in decreased expression of SELENOW mRNA] CTD PMID:15823556 NCBI chr 1:77,530,692...77,535,765
Ensembl chr 1:77,533,148...77,535,681
Ensembl chr 1:77,533,148...77,535,681
JBrowse link
G Sesn2 sestrin 2 increases expression
multiple interactions
EXP
ISO
Glutathione deficiency results in increased expression of SESN2 mRNA
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of SESN2 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of SESN2 protein]; Glutathione inhibits the reaction [p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in increased expression of SESN2 protein]
CTD PMID:20621112, PMID:26035713 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Sfxn1 sideroflexin 1 increases expression EXP Glutathione deficiency results in increased expression of SFXN1 mRNA CTD PMID:15345336 NCBI chr17:11,046,588...11,082,219
Ensembl chr17:11,045,761...11,082,047
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 increases expression EXP Glutathione deficiency results in increased expression of SGK2 mRNA CTD PMID:20621112 NCBI chr 3:159,361,313...159,385,843
Ensembl chr 3:159,368,273...159,384,775
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases abundance
ISO [Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]]
SIRT1 protein results in decreased abundance of Glutathione
CTD PMID:24451382, PMID:29134718 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Glutathione] CTD PMID:12606766 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc25a10 solute carrier family 25 member 10 multiple interactions
increases uptake
EXP [SLC25A10 protein co-treated with Glutathione] results in decreased susceptibility to S-(1,2-dichlorovinyl)cysteine; [SLC25A10 protein co-treated with Glutathione] results in decreased susceptibility to tert-Butylhydroperoxide
SLC25A10 protein results in increased uptake of Glutathione
CTD PMID:12388626 NCBI chr10:109,665,682...109,674,782
Ensembl chr10:109,665,682...109,673,143
JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions ISO Glutathione inhibits the reaction [Mercuric Chloride results in decreased activity of SLC25A20 protein]; Glutathione inhibits the reaction [methylmercuric chloride results in decreased activity of SLC25A20 protein] CTD PMID:25849418 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
G Slc25a33 solute carrier family 25 member 33 increases expression EXP Glutathione deficiency results in increased expression of SLC25A33 mRNA CTD PMID:20621112 NCBI chr 5:166,701,463...166,726,794
Ensembl chr 5:166,701,465...166,726,794
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [SLC31A1 protein results in increased import of Copper] CTD PMID:23426973 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Slc39a2 solute carrier family 39 member 2 multiple interactions ISO [SLC39A2 protein co-treated with zinc chloride] results in increased abundance of Glutathione CTD PMID:18385089 NCBI chr15:28,295,044...28,297,688
Ensembl chr15:28,295,368...28,297,684
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione CTD PMID:22216172 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc5a6 solute carrier family 5 member 6 increases expression EXP Glutathione deficiency results in increased expression of SLC5A6 mRNA CTD PMID:15345336 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases abundance
multiple interactions
ISO SLC7A11 results in increased abundance of Glutathione
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione
[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [SLC7A11 gene mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Glutathione; [SLC7A11 results in increased abundance of Glutathione] which results in decreased abundance of Reactive Oxygen Species; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione
CTD PMID:19015640, PMID:22216172, PMID:23085521 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slc9a9 solute carrier family 9 member A9 increases expression EXP Glutathione deficiency results in increased expression of SLC9A9 mRNA CTD PMID:20621112 NCBI chr 8:102,304,095...103,022,619
Ensembl chr 8:102,304,095...103,022,619
JBrowse link
G Snca synuclein alpha multiple interactions
decreases abundance
EXP
ISO
Glutathione inhibits the reaction [manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]]
Dopamine inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; ferrous sulfate inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; geraniol inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]
CTD PMID:23353026, PMID:27026137, PMID:27424009 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases abundance
affects activity
affects abundance
ISO [Glutathione results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Glutathione results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]; Glutathione results in increased reduction of and results in decreased activity of SOD1 protein
SOD1 gene mutant form results in increased abundance of Glutathione
Glutathione deficiency affects the activity of SOD1 protein
[GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of ATF6 protein modified form]; SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of PRDX2 protein]; SOD1 gene mutant form promotes the reaction [Glutathione results in increased expression of PLIN2 protein modified form]; Thioacetamide promotes the reaction [SOD1 gene mutant form results in increased abundance of Glutathione]
SOD1 protein affects the abundance of Glutathione
CTD PMID:15707499, PMID:16101137, PMID:16377630, PMID:16636302, PMID:22867017, PMID:27349771 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases abundance
multiple interactions
ISO SOD2 protein results in increased abundance of Glutathione
[Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of SOD2 mRNA
Glutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin]; Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]
CTD PMID:15130278, PMID:16101137, PMID:18594523, PMID:25362599 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
decreases expression
ISO Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein]
Glutathione results in decreased expression of SP1
CTD PMID:18556457, PMID:20435036 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp3 Sp3 transcription factor multiple interactions ISO Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein] CTD PMID:20435036 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
JBrowse link
G Sp4 Sp4 transcription factor multiple interactions ISO Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP4 protein] CTD PMID:20435036 NCBI chr 6:146,135,877...146,201,344
Ensembl chr 6:146,135,877...146,195,819
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Glutathione inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein] CTD PMID:22927544 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Glutathione inhibits the reaction [Alcohols results in increased expression of SREBF1 protein] CTD PMID:28803762 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srek1ip1 SREK1-interacting protein 1 decreases expression EXP Glutathione deficiency results in decreased expression of SREK1IP1 mRNA CTD PMID:20621112 NCBI chr 2:34,923,187...34,940,410 JBrowse link
G Srxn1 sulfiredoxin 1 increases expression EXP Glutathione deficiency results in increased expression of SRXN1 mRNA CTD PMID:20621112 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]
Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]
CTD PMID:12847270, PMID:16896058 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
affects abundance
ISO Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]
STAT3 protein affects the abundance of Glutathione
CTD PMID:16896058, PMID:20224768 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sult1c2a sulfotransferase family, cytosolic, 1C, member 2a increases expression EXP Glutathione deficiency results in increased expression of SULT1C2 mRNA CTD PMID:15345336 NCBI chr 9:4,152,588...4,168,355
Ensembl chr 9:4,152,589...4,168,221
JBrowse link
G Syn1 synapsin I multiple interactions ISO Glutathione inhibits the reaction [Particulate Matter results in decreased expression of SYN1 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] CTD PMID:27624276, PMID:28153600 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Taldo1 transaldolase 1 multiple interactions
decreases abundance
ISO Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased abundance of Glutathione] CTD PMID:19436114 NCBI chr 1:214,375,555...214,385,886
Ensembl chr 1:214,375,515...214,385,885
JBrowse link
G Tert telomerase reverse transcriptase increases expression
multiple interactions
ISO Glutathione results in increased expression of TERT protein
Glutathione inhibits the reaction [Camptothecin results in increased expression of TERT protein]
CTD PMID:30851366 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tes testin LIM domain protein increases expression EXP Glutathione deficiency results in increased expression of TES mRNA CTD PMID:20621112 NCBI chr 4:44,321,883...44,360,407
Ensembl chr 4:44,321,883...44,360,405
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 multiple interactions ISO Glutathione inhibits the reaction [Particulate Matter results in increased expression of TET1 mRNA] CTD PMID:28153600 NCBI chr20:27,359,122...27,438,039
Ensembl chr20:27,366,213...27,437,427
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases abundance
EXP diphenyleneiodonium inhibits the reaction [TGFB1 protein results in decreased abundance of Glutathione]; Rotenone inhibits the reaction [TGFB1 protein results in decreased abundance of Glutathione] CTD PMID:11260395, PMID:14732287 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thpo thrombopoietin decreases expression EXP Glutathione deficiency results in decreased expression of THPO mRNA CTD PMID:20621112 NCBI chr11:82,845,676...82,853,439
Ensembl chr11:83,868,655...83,873,910
Ensembl chr11:83,868,655...83,873,910
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Glutathione results in decreased expression of TLR2 mRNA CTD PMID:22385246 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO Glutathione results in decreased expression of TLR4 mRNA CTD PMID:22385246 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tmcc1 transmembrane and coiled-coil domain family 1 increases expression EXP Glutathione deficiency results in increased expression of TMCC1 mRNA CTD PMID:20621112 NCBI chr 4:147,920,987...148,048,852
Ensembl chr 4:147,921,724...148,048,726
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases abundance
decreases expression
increases chemical synthesis
affects abundance
increases abundance
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein]; [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein affects the localization of RELA protein]; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in decreased abundance of Glutathione]; cyanidin 3-O-glucoside inhibits the reaction [TNF protein results in decreased abundance of Glutathione]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]
Glutathione affects the reaction [Alcohols results in increased expression of TNF protein]
Glutathione results in decreased expression of TNF mRNA
TNF protein results in increased chemical synthesis of Glutathione
TNF protein affects the abundance of Glutathione
TNF protein results in increased abundance of Glutathione
CTD PMID:9374527, PMID:9535218, PMID:10802230, PMID:16219905, PMID:16271621, PMID:17079650, PMID:17640567, PMID:19900513, PMID:20351055, PMID:20626112, PMID:21971136, PMID:22385246, PMID:27793764, PMID:28803762 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions ISO Glutathione inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA] CTD PMID:21220312 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A affects abundance ISO TNFRSF1A protein affects the abundance of Glutathione CTD PMID:20159942 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of TOP2A protein] CTD PMID:21497582 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases glutathionylation
decreases abundance
increases expression
ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [Benzo(a)pyrene results in increased activity of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]; Glutathione inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; Glutathione inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]
TP53 protein results in decreased abundance of Glutathione
Glutathione results in increased expression of TP53 protein
CTD PMID:10897038, PMID:12807757, PMID:12967322, PMID:17555331, PMID:19202565, PMID:22927544, PMID:27634759 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpo thyroid peroxidase multiple interactions
decreases activity
ISO arsenic trioxide promotes the reaction [Glutathione results in decreased activity of TPO protein]; Glutathione promotes the reaction [arsenic trioxide results in decreased activity of TPO protein] CTD PMID:25595679 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression EXP Glutathione deficiency results in increased expression of TRIB3 mRNA CTD PMID:20621112 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO Glutathione inhibits the reaction [agathic acid results in increased activity of TRPA1 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased activity of TRPA1 protein]; Glutathione inhibits the reaction [phenalen-1-one results in increased activity of TRPA1 protein] CTD PMID:23541125, PMID:30945539 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan increases expression EXP Glutathione deficiency results in increased expression of TSKU mRNA CTD PMID:20621112 NCBI chr 1:163,317,281...163,328,697
Ensembl chr 1:163,317,282...163,328,591
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions ISO Glutathione inhibits the reaction [Particulate Matter results in decreased expression of TUBB3 mRNA] CTD PMID:28153600 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions EXP Glutathione affects the reaction [arsenic trioxide results in decreased activity of TXNRD1 protein]; Glutathione inhibits the reaction [[Mitomycin co-treated with NADP] results in decreased activity of TXNRD1 protein]; Glutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein] CTD PMID:17640917, PMID:22694104, PMID:24661219 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Tyr tyrosinase multiple interactions ISO [TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Glutathione; [TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of 3-phenylpropionic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of cinnamic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of ferulic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of trans-3-(4'-hydroxyphenyl)-2-propenoic acid] which results in decreased abundance of Glutathione; Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]; Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]; Glutathione inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester] CTD PMID:20685355 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO Glutathione inhibits the reaction [1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein] CTD PMID:24582816 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP Glutathione inhibits the reaction [alitretinoin results in increased expression of UCP1 mRNA]; Glutathione inhibits the reaction [rosiglitazone results in increased expression of UCP1 mRNA] CTD PMID:12414803 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP Glutathione inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide] CTD PMID:19361538 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression EXP Glutathione deficiency results in increased expression of UGT1A2 mRNA; Glutathione deficiency results in increased expression of UGT1A3 mRNA CTD PMID:15345336 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression EXP Glutathione deficiency results in increased expression of UGT1A5 mRNA CTD PMID:15345336 NCBI chr 9:95,274,707...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP Glutathione deficiency results in increased expression of UGT1A6 mRNA CTD PMID:15345336 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases expression EXP Glutathione deficiency results in increased expression of UGT1A10 mRNA; Glutathione deficiency results in increased expression of UGT1A7 mRNA CTD PMID:15345336 NCBI chr 9:95,233,957...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases expression EXP Glutathione deficiency results in increased expression of UGT1A8 mRNA CTD PMID:15345336 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B increases expression EXP Glutathione deficiency results in increased expression of UGT2B4 mRNA CTD PMID:15345336 Ensembl chr14:22,375,955...22,534,720 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Glutathione deficiency results in increased expression of UGT2B1 mRNA CTD PMID:15345336 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G UST4r integral membrane transport protein UST4r increases expression EXP Glutathione deficiency results in increased expression of UST4R mRNA CTD PMID:20621112 NCBI chr 1:224,319,927...224,389,499
Ensembl chr 1:224,319,077...224,389,499
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:16271621, PMID:21971136 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Glutathione inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA] CTD PMID:11641398 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vnn1 vanin 1 affects abundance ISO VNN1 affects the abundance of Glutathione CTD PMID:15282320 NCBI chr 1:22,614,832...22,625,134
Ensembl chr 1:22,614,783...22,625,204
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of XBP1 protein alternative form]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of XBP1 protein alternative form] CTD PMID:24515801 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [Xanthine co-treated with XDH protein] results in increased abundance of Glutathione CTD PMID:7743507 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO Glutathione inhibits the reaction [Thimerosal results in decreased expression of XIAP protein] CTD PMID:12140745 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Xk X-linked Kx blood group decreases expression EXP Glutathione deficiency results in decreased expression of XK mRNA CTD PMID:20621112 NCBI chr  X:14,497,376...14,534,479
Ensembl chr  X:14,498,119...14,534,473
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma increases expression EXP Glutathione deficiency results in increased expression of YWHAG mRNA CTD PMID:15345336 NCBI chr12:23,789,547...23,817,884
Ensembl chr12:23,789,638...23,817,883
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B decreases expression EXP Glutathione deficiency results in decreased expression of ZBTB7B mRNA CTD PMID:20621112 NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704
JBrowse link
G Zfp367 zinc finger protein 367 increases expression EXP Glutathione deficiency results in increased expression of ZFP367 mRNA CTD PMID:20621112 NCBI chr17:1,652,892...1,672,021
Ensembl chr17:1,652,895...1,672,021
JBrowse link
8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta3 glutathione S-transferase alpha 3 affects binding ISO 8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1 binds to GSTA3 protein CTD PMID:8910329 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
gamma-glutamyl-glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta4 glutathione S-transferase alpha 4 multiple interactions EXP GSTA4 protein binds to and affects the metabolism of gamma-glutamyl-glutathione CTD PMID:2619714 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP GSTP1 protein binds to and affects the metabolism of gamma-glutamyl-glutathione CTD PMID:2619714 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
glutathione disulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 increases export
increases activity
multiple interactions
ISO
EXP
ABCC1 protein results in increased export of Glutathione Disulfide
Glutathione Disulfide results in increased activity of ABCC1 protein
[Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide]
Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein]
CTD PMID:11306701, PMID:15628876, PMID:17272743, PMID:19053318, PMID:21918036 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases transport
multiple interactions
EXP ABCC2 protein results in increased transport of Glutathione Disulfide
Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of Glutathione Disulfide]
CTD PMID:15276087 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Agt angiotensinogen multiple interactions
increases export
decreases abundance
ISO ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide]
AGT protein results in increased export of Glutathione Disulfide
CTD PMID:17272743 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type affects response to substance
increases activity
increases glutathionylation
ISO ALOX12 protein affects the susceptibility to Glutathione Disulfide
Glutathione Disulfide results in increased activity of ALOX12 protein
Glutathione Disulfide results in increased glutathionylation of ALOX12 protein
CTD PMID:19373248 NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
JBrowse link
G Ar androgen receptor affects localization
multiple interactions
ISO Glutathione Disulfide affects the localization of AR protein
Glutathione Disulfide binds to and results in increased activity of AR protein
CTD PMID:28478275 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Glutathione Disulfide results in increased expression of CDKN1A protein CTD PMID:15993333 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Glutathione Disulfide results in decreased activity of CFTR protein CTD PMID:15657297 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Crygd crystallin, gamma D increases oxidation ISO Glutathione Disulfide results in increased oxidation of CRYGD protein mutant form CTD PMID:30242128 NCBI chr 9:71,776,568...71,778,323
Ensembl chr 9:71,764,318...71,778,323
JBrowse link
G Fas Fas cell surface death receptor decreases activity ISO Glutathione Disulfide results in decreased activity of FAS protein CTD PMID:10385654 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Glrx glutaredoxin affects response to substance ISO GLRX protein affects the susceptibility to Glutathione Disulfide CTD PMID:19373248 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP
Glutathione Disulfide inhibits the reaction [Carmustine results in decreased activity of GSR protein]
arsenic trioxide inhibits the reaction [GSR protein results in increased reduction of Glutathione Disulfide]; arsenic trioxide promotes the reaction [GSR protein binds to Glutathione Disulfide]; GSR protein binds to and results in increased reduction of Glutathione Disulfide
[[Carmustine results in decreased activity of GSR protein] which co-treated with Oligodeoxyribonucleotides analog] results in increased abundance of Glutathione Disulfide; [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide
CTD PMID:12114195, PMID:12477282, PMID:19668867, PMID:24634002 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Glutathione Disulfide analog promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; Glutathione Disulfide analog promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein] CTD PMID:19374849 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in increased abundance of Glutathione Disulfide CTD PMID:31288001 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]]
Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein]
CTD PMID:12433058, PMID:12477282 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ngf nerve growth factor affects abundance ISO NGF protein affects the abundance of Glutathione Disulfide CTD PMID:23472850 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases abundance ISO NNMT protein results in increased abundance of Glutathione Disulfide CTD PMID:31909875 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]]
Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein]
CTD PMID:12433058, PMID:12477282 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
increases abundance
ISO manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [SLC2A4 gene mutant form results in increased abundance of Glutathione Disulfide] CTD PMID:22221582 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Snca synuclein alpha decreases abundance ISO SNCA protein results in decreased abundance of Glutathione Disulfide CTD PMID:27424009 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod2 superoxide dismutase 2 increases abundance ISO SOD2 protein results in increased abundance of Glutathione Disulfide CTD PMID:15130278 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions EXP Glutathione Disulfide affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog binds to SULT1A1 protein] CTD PMID:21130751 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases glutathionylation
ISO Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Glutathione Disulfide results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein CTD PMID:15993333, PMID:17555331 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
phytochelatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a17 solute carrier family 22, member 17 increases uptake ISO SLC22A17 protein results in increased uptake of Phytochelatins CTD PMID:24518829 NCBI chr15:33,569,824...33,576,972
Ensembl chr15:33,569,843...33,576,331
JBrowse link
S-(2,4-dinitrophenyl)glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export
affects transport
increases export
multiple interactions
ISO ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione
ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione
ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione
flavone inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Mefloquine inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]; naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Quercetin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; resveratrol inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; verlukast inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]
CTD PMID:15041478, PMID:16004972, PMID:16156793 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases transport
affects transport
increases export
EXP
ISO
[Benzbromarone results in decreased activity of ABCC2 protein] inhibits the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; [Furosemide results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-(2,4-dinitrophenyl)glutathione; [sulfanitran results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of S-(2,4-dinitrophenyl)glutathione]; S-(2,4-dinitrophenyl)glutathione inhibits the reaction [ABCC2 protein results in increased transport of temocaprilat]; temocaprilat inhibits the reaction [ABCC2 protein results in increased transport of S-(2,4-dinitrophenyl)glutathione]; Ursodeoxycholic Acid promotes the reaction [ABCC2 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
ABCC2 protein affects the transport of S-(2,4-dinitrophenyl)glutathione
CTD PMID:9067317, PMID:9430713, PMID:9525973, PMID:15276087, PMID:15652244, PMID:15846474, PMID:15901347, PMID:19067394, PMID:19766108, PMID:19782883 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO S-(2,4-dinitrophenyl)glutathione inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate] CTD PMID:11856762 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
S-(hydroxymethyl)glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions
increases oxidation
ISO Cimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione] CTD PMID:23220590 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
S-hexylglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO [hexylglutathione results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione CTD PMID:19419996 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects binding ISO hexylglutathione binds to GSTA1 protein CTD PMID:12211029, PMID:15893769 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity ISO hexylglutathione results in decreased activity of GSTM2 protein CTD PMID:10858281 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO hexylglutathione inhibits the reaction [captafol results in decreased activity of GSTP1 protein]; hexylglutathione inhibits the reaction [Captan results in decreased activity of GSTP1 protein] CTD PMID:8678907 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
S-methylglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO S-methyl glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] CTD PMID:19428350 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Casp3 caspase 3 multiple interactions ISO S-methyl glutathione inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein] CTD PMID:26124276 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
S-nitrosoglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 affects the transport of S-Nitrosoglutathione CTD PMID:20683964 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions
increases reduction
ISO [SPL-334 results in decreased activity of ADH5 protein] which results in decreased metabolism of S-Nitrosoglutathione
decanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; dodecanedioic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; Glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; lauric acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; octanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; pelargonic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; S-methyl glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Ethanol]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Formaldehyde]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Octanols]; sebacic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; undecanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]
CTD PMID:19038239, PMID:19428350, PMID:26209236 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Atm ATM serine/threonine kinase increases response to substance ISO ATM results in increased susceptibility to S-Nitrosoglutathione CTD PMID:8958160 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of BAX protein CTD PMID:10828028 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased expression of BCL2 protein CTD PMID:10828028 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO S-Nitrosoglutathione results in decreased expression of BNIP3 mRNA CTD PMID:11592958 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein; [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]
Cyclosporine inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]
CTD PMID:10205001, PMID:10828028, PMID:20153346 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO S-Nitrosoglutathione results in increased activity of CASP8 protein CTD PMID:20153346 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions
increases reduction
ISO [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 1,4-naphthoquinone]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 2,3-hexanedione]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 4-benzoylpyridine]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Vitamin K 3]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 1,2-naphthoquinone]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin]; Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]]; S-Nitrosoglutathione binds to and results in decreased activity of CBR1 protein; S-Nitrosoglutathione binds to and results in increased activity of CBR1 protein; S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione] CTD PMID:21256830, PMID:23295225 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of CCL5 protein CTD PMID:13678430 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 multiple interactions ISO CCT7 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased abundance of Cyclic GMP] CTD PMID:24213632 NCBI chr 4:117,235,023...117,252,265
Ensembl chr 4:117,235,023...117,252,265
JBrowse link
G Cd86 CD86 molecule decreases expression ISO S-Nitrosoglutathione results in decreased expression of CD86 protein CTD PMID:13678430 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases expression
decreases expression
decreases activity
ISO acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA]; DDT inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein
S-Nitrosoglutathione results in decreased expression of CFTR mRNA
S-Nitrosoglutathione results in decreased activity of CFTR protein
CTD PMID:14766015, PMID:15657297 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of CXCL10 protein CTD PMID:13678430 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Faslg Fas ligand multiple interactions ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] CTD PMID:10811113 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO GUCY1A1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased abundance of Cyclic GMP] CTD PMID:24213632 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO S-Nitrosoglutathione results in increased expression of HIF1A mRNA CTD PMID:11514583 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [linsidomine co-treated with S-Nitrosoglutathione] results in increased expression of HMOX1 mRNA; Nitroprusside promotes the reaction [S-Nitrosoglutathione results in increased expression of HMOX1 mRNA]; S-Nitrosoglutathione promotes the reaction [Nitroprusside results in increased expression of HMOX1 mRNA] CTD PMID:8764571, PMID:10423162 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions
affects localization
ISO [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] CTD PMID:20153346 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Ifng interferon gamma increases secretion ISO S-Nitrosoglutathione results in increased secretion of IFNG protein CTD PMID:13678430 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of IL10 protein CTD PMID:13678430 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B decreases expression ISO S-Nitrosoglutathione results in decreased expression of IL12B protein CTD PMID:13678430 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il5 interleukin 5 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of IL5 protein CTD PMID:13678430 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 affects metabolic processing
multiple interactions
EXP S-Nitrosoglutathione affects the metabolism of MGST1 protein
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]
CTD PMID:16386761, PMID:16899233 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [NOS2 protein results in increased chemical synthesis of S-Nitrosoglutathione] which results in decreased susceptibility to Carmustine CTD PMID:15110396 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases nitrosation EXP S-Nitrosoglutathione results in increased nitrosation of P4HB protein CTD PMID:28823167 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein binds to TP53 promoter]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione inhibits the reaction [PRKN protein binds to TP53 promoter]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione results in increased nitrosation of and affects the localization of PRKN protein CTD PMID:23985028 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rasd1 ras related dexamethasone induced 1 multiple interactions EXP S-Nitrosoglutathione results in increased nitrosation of and results in increased activity of RASD1 protein CTD PMID:16908409 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO S-Nitrosoglutathione promotes the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein] CTD PMID:21464294 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sp1 Sp1 transcription factor increases activity ISO S-Nitrosoglutathione results in increased activity of SP1 protein CTD PMID:14766015 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp3 Sp3 transcription factor decreases activity
increases activity
ISO S-Nitrosoglutathione results in decreased activity of SP3 protein
S-Nitrosoglutathione results in increased activity of SP3 protein
CTD PMID:14766015 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO S-Nitrosoglutathione results in increased secretion of TNF protein CTD PMID:13678430 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP
ISO
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein
[S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein binds to TP53 promoter]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione inhibits the reaction [PRKN protein binds to TP53 promoter]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]
CTD PMID:8982730, PMID:23985028 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
trypanothione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 decreases activity ISO trypanothione results in decreased activity of ARG1 protein CTD PMID:21232540 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
trypanothione disulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 decreases activity ISO trypanothione results in decreased activity of ARG1 protein CTD PMID:21232540 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        antioxidant 14209
          glutathione 373
            DON-10-glutathione 0
            N-(4-oxoglutaryl)-L-cysteinylglycine 0
            S-(2,4-dinitrophenyl)glutathione 3
            S-(2-hydroxyethyl)glutathione 0
            S-acylglutathione + 0
            S-sulfanylglutathione 0
            eoxin C4 0
            glutathione derivative + 58
            phytochelatin + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                peptide 9391
                                                  oligopeptide 1196
                                                    tripeptide 881
                                                      glutathione 373
                                                        DON-10-glutathione 0
                                                        N-(4-oxoglutaryl)-L-cysteinylglycine 0
                                                        S-(2,4-dinitrophenyl)glutathione 3
                                                        S-(2-hydroxyethyl)glutathione 0
                                                        S-acylglutathione + 0
                                                        S-sulfanylglutathione 0
                                                        eoxin C4 0
                                                        glutathione derivative + 58
                                                        phytochelatin + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.