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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glyoxylic acid
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Accession:CHEBI:16891 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom.
Synonyms:exact_synonym: oxoacetic acid
 related_synonym: Formula=C2H2O3;   Glyoxalate;   Glyoxalsaeure;   Glyoxylate;   Glyoxylsaeure;   InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5);   InChIKey=HHLFWLYXYJOTON-UHFFFAOYSA-N;   SMILES=[H]C(=O)C(O)=O;   alpha-ketoacetic acid;   formylformic acid;   oxalaldehydic acid;   oxoethanoic acid
 alt_id: CHEBI:24421;   CHEBI:42767;   CHEBI:5509
 xref: Beilstein:741891;   CAS:298-12-4;   DrugBank:DB04343;   Gmelin:25752;   HMDB:HMDB0000119;   KEGG:C00048;   KNApSAcK:C00001186
 xref_mesh: MESH:C031150
 xref: MetaCyc:GLYOX;   PDBeChem:GLV;   PMID:11479160;   PMID:16396466;   PMID:22580421;   PMID:23790896;   Reaxys:741891;   Wikipedia:Glyoxylic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:36655


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glyoxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP glyoxylic acid results in decreased activity of G6PD protein CTD PMID:15144222 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in decreased abundance of glyoxylic acid analog CTD PMID:26820058 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
EXP [glyoxylic acid co-treated with Calcitriol] results in increased expression of SPP1 mRNA
glyoxylic acid results in increased expression of SPP1 protein
CTD PMID:7571189, PMID:8325891 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
phenylglyoxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        solvent 16489
          formic acid 7885
            formyl group 7851
              aldehyde 7851
                aldehydic acid 10
                  glyoxylic acid 5
                    2-aminophenylglyoxylic acid 0
                    3,5-dihydroxyphenylglyoxylic acid 0
                    4-hydroxyphenylglyoxylic acid 0
                    glyoxylate ester + 0
                    phenylglyoxylic acid + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            formyl group 7851
                                              aldehyde 7851
                                                aldehydic acid 10
                                                  glyoxylic acid 5
                                                    2-aminophenylglyoxylic acid 0
                                                    3,5-dihydroxyphenylglyoxylic acid 0
                                                    4-hydroxyphenylglyoxylic acid 0
                                                    glyoxylate ester + 0
                                                    phenylglyoxylic acid + 2
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