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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cortisone
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Accession:CHEBI:16962 term browser browse the term
Definition:A C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20.
Synonyms:exact_synonym: 17,21-dihydroxypregn-4-ene-3,11,20-trione
 related_synonym: 11-dehydro-17-hydroxycorticosterone;   17-hydroxy-11-dehydrocorticosterone;   17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione;   4-pregnene-17alpha,21-diol-3,11,20-trione;   Cortison;   Delta(4)-pregnene-17alpha,21-diol-3,11,20-trione;   Formula=C21H28O5;   InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1;   InChIKey=MFYSYFVPBJMHGN-ZPOLXVRWSA-N;   Kendall's compound E;   Kortison;   Reichstein's substance Fa;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])C(=O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO;   Wintersteiner's compound F;   pregn-4-en-17alpha,21-diol-3,11,20-trione
 alt_id: CHEBI:14026;   CHEBI:23397;   CHEBI:3896
 xref: Beilstein:1356062;   CAS:53-06-5;   HMDB:HMDB0002802;   KEGG:C00762;   KEGG:D07749;   LIPID_MAPS_instance:LMST02030090
 xref_mesh: MESH:D003348
 xref: MetaCyc:CORTISONE;   PMID:11710540;   PMID:14874924;   PMID:2268561;   PMID:24391193;   PMID:8989250;   Reaxys:1356062;   Wikipedia:Cortisone


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cortisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Calcitriol co-treated with Cortisone] results in decreased expression of ADIPOQ mRNA CTD PMID:19918113 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions ISO [AKR1D1 protein co-treated with NADP] results in increased reduction of Cortisone CTD PMID:25500266 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Cortisone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:15755911 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Cortisone results in increased expression of CCL2 mRNA CTD PMID:24135201 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Cortisone CTD PMID:24246760 NCBI chr 6:95,522,577...95,541,393
Ensembl chr 6:95,522,577...95,541,393
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression
multiple interactions
ISO Cortisone results in increased expression of FABP4 mRNA
2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of FABP4 mRNA]
CTD PMID:21315688 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Glul glutamate-ammonia ligase increases activity EXP Cortisone results in increased activity of GLUL protein CTD PMID:30993381 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions
increases expression
increases reduction
affects response to substance
increases metabolic processing
affects metabolic processing
ISO
EXP
[Calcitriol co-treated with Cortisone] results in increased expression of HSD11B1 mRNA; [HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]; [HSD11B1 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone; [HSD11B1 protein results in increased reduction of Cortisone] which results in increased chemical synthesis of Hydrocortisone; [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]]
Cortisone results in increased expression of HSD11B1 mRNA
2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of and results in increased activity of HSD11B1 protein]; Cortisone results in increased expression of and results in increased activity of HSD11B1 protein
[HSD11B1 protein affects the susceptibility to Cortisone] which results in decreased activity of NFE2L2 protein; [HSD11B1 protein co-treated with Cortisone] results in decreased expression of NQO1 mRNA; Cortisone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]
HSD11B1 protein results in increased metabolism of Cortisone
HSD11B1 protein affects the metabolism of Cortisone
CTD PMID:16054388, PMID:16751407, PMID:19918113, PMID:21315688, PMID:22606287, PMID:24135201, PMID:26859423, PMID:30993381 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases chemical synthesis
multiple interactions
ISO HSD11B2 protein results in increased chemical synthesis of Cortisone
[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone]
CTD PMID:22796344, PMID:26859423 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO perfluorooctane sulfonic acid inhibits the reaction [Cortisone results in decreased expression of IL1B] CTD PMID:27288094 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO Cortisone results in decreased expression of IL6
perfluorooctane sulfonic acid inhibits the reaction [Cortisone results in decreased expression of IL6]
CTD PMID:27288094 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Cortisone results in increased phosphorylation of MAPK1 protein CTD PMID:24135201 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Cortisone results in increased phosphorylation of MAPK3 protein CTD PMID:24135201 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]; [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]]
[HSD11B1 protein affects the susceptibility to Cortisone] which results in decreased activity of NFE2L2 protein
CTD PMID:22606287 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Cortisone results in increased expression of NOS2 protein CTD PMID:24135201 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [HSD11B1 protein co-treated with Cortisone] results in decreased expression of NQO1 mRNA CTD PMID:22606287 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding
multiple interactions
increases activity
ISO Cortisone binds to NR3C1 protein
[Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]]
Cortisone results in increased activity of NR3C1 protein
CTD PMID:15705660, PMID:15780662, PMID:22606287 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Cortisone results in increased activity of NR3C2 protein CTD PMID:15780662 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of PPARG mRNA] CTD PMID:21315688 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Cortisone results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation ISO Cortisone results in increased phosphorylation of RELA protein CTD PMID:24135201 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
EXP Cortisone results in increased expression of SGK1 mRNA
Phenylephrine promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]
CTD PMID:16533503 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Cortisone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
multiple interactions
ISO Cortisone results in increased expression of SLC2A4 mRNA
2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of SLC2A4 mRNA]
CTD PMID:21315688 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Cortisone results in increased expression of TNF mRNA CTD PMID:24135201 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
17,21-dihydroxy-5beta-pregnane-3,11,20-trione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 increases reduction ISO AKR1C4 protein results in increased reduction of 5-dihydrocortisone CTD PMID:8543560 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      group 19696
        organic group 18493
          3-oxo-Delta(4)-steroid group 7934
            3-oxo-Delta(4) steroid 7934
              cortisone 26
                4,5-dihydrocortisone + 1
                6beta-hydroxycortisone 0
                hydrocortamate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        oxyketone 8629
                                          alpha-oxyketone 8629
                                            alpha-hydroxy ketone 8629
                                              primary alpha-hydroxy ketone 7514
                                                cortisone 26
                                                  4,5-dihydrocortisone + 1
                                                  6beta-hydroxycortisone 0
                                                  hydrocortamate + 0
paths to the root

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