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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:leukotriene C4
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Accession:CHEBI:16978 term browser browse the term
Definition:A leukotriene that is (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid in which a glutathionyl group is attached at position 6 via a sulfide linkage.
Synonyms:exact_synonym: L-gamma-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl]-L-cysteinylglycine
 related_synonym: (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)glycine;   5S,6R-Ltc(sub 4);   5S-hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid;   Formula=C30H47N3O9S;   InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1;   InChIKey=GWNVDXQDILPJIG-NXOLIXFESA-N;   LTC (sub 4);   LTC4;   SMILES=CCCCC\\C=C/C\\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
 alt_id: CHEBI:14504;   CHEBI:25025;   CHEBI:6422
 xref: CAS:72025-60-6;   HMDB:HMDB0001198;   KEGG:C02166;   LIPID_MAPS_instance:LMFA03020003
 xref_mesh: MESH:D017997
 xref: MetaCyc:LEUKOTRIENE-C4;   PMID:24244016;   PMID:8415814;   PMID:9042024;   PMID:9384524;   Reaxys:4732117;   Wikipedia:Leukotriene_C4
 cyclic_relationship: is_conjugate_acid_of CHEBI:57973


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leukotriene C4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 affects transport ISO ABCA8 protein affects the transport of Leukotriene C4 CTD PMID:12379217 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects transport
multiple interactions
increases uptake
decreases transport
affects binding
ISO ABCC1 protein affects the transport of Leukotriene C4
[Nimustine results in increased expression of ABCC1 protein] which results in increased transport of Leukotriene C4; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]; Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; estradiol-17 beta-glucuronide inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; Genistein affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [Genistein affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; kaempferol inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; myricetin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Quercetin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]
ABCC1 protein mutant form results in decreased transport of Leukotriene C4
CTD PMID:9393752, PMID:11278867, PMID:11306701, PMID:15245331, PMID:15355964, PMID:15459206, PMID:15628876, PMID:18336795 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases transport
multiple interactions
affects transport
EXP
ISO
ABCC2 protein modified form results in increased transport of Leukotriene C4
verlukast inhibits the reaction [ABCC2 protein results in increased transport of Leukotriene C4]
ABCC2 protein affects the transport of Leukotriene C4
CTD PMID:9430713, PMID:11500505, PMID:12388192, PMID:12395335, PMID:15507541, PMID:15904671, PMID:27676153 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO verlukast inhibits the reaction [ABCC3 protein results in increased transport of Leukotriene C4] CTD PMID:27676153 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 affects transport ISO ABCC6 protein affects the transport of Leukotriene C4 CTD PMID:11880368 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO
EXP
[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene C4
[Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene C4
ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]]
CTD PMID:9445378, PMID:9495842, PMID:10764316, PMID:12794006 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein multiple interactions ISO [2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C4; [MK-886 results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C4 CTD PMID:9113110 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases secretion EXP AMBP protein results in decreased secretion of Leukotriene C4 CTD PMID:9579392 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 increases expression ISO Leukotriene C4 results in increased expression of CCL12 mRNA CTD PMID:12388339 NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Leukotriene C4 results in increased expression of CCL2 mRNA CTD PMID:12388339 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Clec7a C-type lectin domain containing 7A multiple interactions ISO CLEC7A protein promotes the reaction [Peptidoglycan results in increased metabolism of Leukotriene C4]; CLEC7A protein promotes the reaction [Zymosan results in increased metabolism of Leukotriene C4] CTD PMID:17030235 NCBI chr 4:163,216,152...163,227,367
Ensembl chr 4:163,216,163...163,227,334
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Leukotriene C4 results in increased expression of CXCL1 mRNA CTD PMID:12388339 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions
affects binding
ISO [Leukotriene C4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; CGP 57698 inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]; Leukotriene C4 binds to and results in increased activity of CYSLTR1 protein; MEN91507 inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]; pobilukast inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]; pranlukast inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]
CYSLTR1 protein binds to and affects the susceptibility to Leukotriene C4; Leukotriene C4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]
CTD PMID:8384568, PMID:10391245, PMID:10462554, PMID:10825389, PMID:11705452, PMID:11932261, PMID:11996896, PMID:12853847 NCBI chr  X:77,671,028...77,700,491
Ensembl chr  X:77,674,150...77,700,269
JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions
increases activity
ISO [Leukotriene C4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; [Leukotriene C4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; Leukotriene C4 binds to and results in increased activity of CYSLTR2 protein CTD PMID:10851239, PMID:11093801 NCBI chr15:54,903,290...54,941,742
Ensembl chr15:54,905,274...54,906,203
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
ISO Leukotriene C4 results in increased expression of EDN1 mRNA; Leukotriene C4 results in increased expression of EDN1 protein
zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 mRNA]; zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 protein]
CTD PMID:11372388 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Leukotriene C4 results in increased expression of EGFR mRNA CTD PMID:12388339 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 multiple interactions ISO [Beclomethasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4; [Fluticasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4 CTD PMID:11447392 NCBI chr20:13,988,444...14,001,296 JBrowse link
G Gpr17 G protein-coupled receptor 17 increases activity ISO Leukotriene C4 results in increased activity of GPR17 protein CTD PMID:18974869 NCBI chr18:24,733,306...24,739,194
Ensembl chr18:24,734,330...24,735,349
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Leukotriene C4 inhibits the reaction [Zymosan results in increased expression of HMOX1 protein] CTD PMID:11454666 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il13 interleukin 13 increases expression
multiple interactions
increases abundance
ISO
EXP
Leukotriene C4 results in increased expression of IL13 mRNA
[IL13 protein results in increased abundance of Leukotriene C4] which results in increased secretion of MUC5AC protein
CTD PMID:12388339, PMID:12654629 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il5 interleukin 5 increases secretion ISO IL5 protein results in increased secretion of Leukotriene C4 CTD PMID:9378992 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Ltc4s leukotriene C4 synthase affects chemical synthesis ISO LTC4S protein affects the chemical synthesis of Leukotriene C4 CTD PMID:10666225 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Leukotriene C4 results in increased phosphorylation of MAPK1 protein CTD PMID:19837106 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Leukotriene C4 results in increased phosphorylation of MAPK3 protein CTD PMID:19837106 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP Leukotriene C4 binds to and results in decreased activity of MGST1 protein; Leukotriene C4 inhibits the reaction [Glutathione binds to and results in increased activity of MGST1 protein] CTD PMID:9890956 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene C4 results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [Leukotriene C4 results in increased expression of MMP9 protein] CTD PMID:19837106 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression
multiple interactions
EXP Leukotriene C4 results in increased expression of MUC5AC mRNA; Leukotriene C4 results in increased expression of MUC5AC protein
[IL13 protein results in increased abundance of Leukotriene C4] which results in increased secretion of MUC5AC protein
CTD PMID:12654629 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Leukotriene C4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites] CTD PMID:11454666 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pla2g5 phospholipase A2, group V multiple interactions ISO PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]
PLA2G5 protein promotes the reaction [Zymosan results in increased metabolism of Leukotriene C4]
CTD PMID:9495842, PMID:14761945 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene C4] CTD PMID:25432964 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ralbp1 ralA binding protein 1 multiple interactions
affects transport
ISO Adenosine Triphosphate promotes the reaction [RALBP1 protein affects the transport of Leukotriene C4]; Colchicine inhibits the reaction [RALBP1 protein affects the transport of Leukotriene C4] CTD PMID:15386349 NCBI chr 9:113,579,107...113,598,477
Ensembl chr 9:113,579,107...113,598,480
JBrowse link
G Selp selectin P increases expression ISO Leukotriene C4 results in increased expression of SELP protein CTD PMID:9152370 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions ISO SYK protein promotes the reaction [Peptidoglycan results in increased metabolism of Leukotriene C4]; SYK protein promotes the reaction [Zymosan results in increased metabolism of Leukotriene C4] CTD PMID:17030235 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            bronchoconstrictor agent 65
              leukotriene C4 33
                11,12-dihydro-(12R)-hydroxyleukotriene C4 0
                11,12-dihydro-12-oxoleukotriene C4 0
                leukotriene C4 methyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            unsaturated fatty acid 922
                                              polyunsaturated fatty acid 663
                                                fatty acid 20:4 313
                                                  icosatetraenoic acid 313
                                                    icosa-7,9,11,14-tetraenoic acid 44
                                                      leukotriene C4 33
                                                        11,12-dihydro-(12R)-hydroxyleukotriene C4 0
                                                        11,12-dihydro-12-oxoleukotriene C4 0
                                                        leukotriene C4 methyl ester 0
paths to the root

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