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ONTOLOGY REPORT - ANNOTATIONS


Term:riboflavin
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Accession:CHEBI:17015 term browser browse the term
Definition:D-Ribitol in which the hydroxy group at position 5 is substituted by a 7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl moiety. It is a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables, but the richest natural source is yeast. The free form occurs only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.
Synonyms:exact_synonym: 5-deoxy-5-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-D-ribitol
 related_synonym: 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol;   6,7-dimethyl-9-D-ribitylisoalloxazine;   7,8-Dimethyl-10-ribitylisoalloxazine;   7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione;   7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine;   E101;   Formula=C17H20N4O6;   InChI=1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1;   InChIKey=AUNGANRZJHBGPY-SCRDCRAPSA-N;   Lactoflavin;   SMILES=Cc1cc2nc3c(nc(=O)[nH]c3=O)n(C[C@H](O)[C@H](O)[C@H](O)CO)c2cc1C;   riboflavina;   riboflavine;   riboflavinum;   vitamin B2;   vitamin G
 alt_id: CHEBI:15044;   CHEBI:27299;   CHEBI:45214;   CHEBI:529204;   CHEBI:8843
 xref: Beilstein:97831 "Beilstein";   CAS:83-88-5 "ChemIDplus";   CAS:83-88-5 "KEGG COMPOUND";   CAS:83-88-5 "NIST Chemistry WebBook";   DrugBank:DB00140;   Drug_Central:2834 "DrugCentral";   HMDB:HMDB0000244;   KEGG:C00255;   KEGG:D00050;   KNApSAcK:C00001552;   LINCS:LSM-4084
 xref_mesh: MESH:D012256
 xref: MetaCyc:RIBOFLAVIN;   PDBeChem:RBF;   PMID:16658098 "Europe PMC";   PMID:22770225 "Europe PMC";   PMID:24643482 "Europe PMC";   PMID:25108762 "Europe PMC";   Patent:US2807611;   Patent:US2876169;   Reaxys:97831 "Reaxys";   Wikipedia:Riboflavin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57986


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riboflavin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Aspm abnormal spindle microtubule assembly JBrowse link 13 56,546,021 56,591,793 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Kif23 kinesin family member 23 JBrowse link 8 66,866,043 66,893,241 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Plagl1 PLAG1 like zinc finger 1 JBrowse link 1 7,219,587 7,270,169 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Runx2 RUNX family transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:6480464
G Slc52a3 solute carrier family 52 member 3 JBrowse link 3 147,503,266 147,517,935 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          cofactor 15860
            riboflavin 30
              7,8-didemethyl-8-hydroxy-5-deazariboflavin + 0
              8-amino-8-demethylriboflavin + 0
              8-demethyl-8-(methylamino)riboflavin 0
              dihydroriboflavins + 0
              riboflavin cyclic 4',5'-phosphate 0
              riboflavin sodium phosphate 0
              roseoflavin 0
              vitamin B complex 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic heterocyclic compound 18164
                                  organic heteropolycyclic compound 17427
                                    organic heterotricyclic compound 13734
                                      benzopteridine 34
                                        benzo[g]pteridine-2,4-dione 34
                                          isoalloxazine 33
                                            7,8-dimethylisoalloxazine 33
                                              flavin 33
                                                riboflavin 30
                                                  7,8-didemethyl-8-hydroxy-5-deazariboflavin + 0
                                                  8-amino-8-demethylriboflavin + 0
                                                  8-demethyl-8-(methylamino)riboflavin 0
                                                  dihydroriboflavins + 0
                                                  riboflavin cyclic 4',5'-phosphate 0
                                                  riboflavin sodium phosphate 0
                                                  roseoflavin 0
                                                  vitamin B complex 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.