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ONTOLOGY REPORT - ANNOTATIONS


Term:2-hydroxyglutaric acid
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Accession:CHEBI:17084 term browser browse the term
Definition:A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.
Synonyms:exact_synonym: 2-hydroxypentanedioic acid
 related_synonym: Formula=C5H8O5;   InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10);   InChIKey=HWXBTNAVRSUOJR-UHFFFAOYSA-N;   SMILES=OC(CCC(O)=O)C(O)=O;   alpha-hydroxyglutaric acid
 alt_id: CHEBI:1160
 xref: Beilstein:1723805 "Beilstein";   CAS:2889-31-8 "ChemIDplus";   CAS:2889-31-8 "KEGG COMPOUND";   KEGG:C02630
 xref_mesh: MESH:C019417
 xref: MetaCyc:2-HYDROXYGLUTARIC_ACID;   PMID:17439666 "Europe PMC";   Reaxys:1723805 "Reaxys";   Wikipedia:Alpha-Hydroxyglutaric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:132941;   is_conjugate_acid_of CHEBI:36149


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2-hydroxyglutaric acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase JBrowse link 12 48,257,575 48,262,244 RGD:6480464
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase JBrowse link 3 82,874,242 82,907,467 RGD:6480464
G D2hgdh D-2-hydroxyglutarate dehydrogenase JBrowse link 9 100,956,570 100,974,393 RGD:6480464
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 JBrowse link 9 71,882,108 71,911,645 RGD:6480464
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 JBrowse link 1 141,874,354 141,893,674 RGD:6480464
G L2hgdh L-2-hydroxyglutarate dehydrogenase JBrowse link 6 92,016,560 92,057,643 RGD:6480464
(R)-2-hydroxyglutaric acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase JBrowse link 12 48,257,575 48,262,244 RGD:6480464
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase JBrowse link 3 82,874,242 82,907,467 RGD:6480464
G D2hgdh D-2-hydroxyglutarate dehydrogenase JBrowse link 9 100,956,570 100,974,393 RGD:6480464
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 JBrowse link 9 71,882,108 71,911,645 RGD:6480464
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 JBrowse link 1 141,874,354 141,893,674 RGD:6480464
G L2hgdh L-2-hydroxyglutarate dehydrogenase JBrowse link 6 92,016,560 92,057,643 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          metabolite 19101
            2-hydroxyglutaric acid 6
              (R)-2-hydroxyglutaric acid 6
              (S)-2-hydroxyglutaric acid + 0
              2-hydroxyglutaryl-CoA + 0
              diethyl 2-hydroxypentanedioate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      dicarboxylic acids and O-substituted derivatives 10170
                                        dicarboxylic acid 10163
                                          alpha,omega-dicarboxylic acid 2742
                                            glutaric acid 11
                                              2-hydroxyglutaric acid 6
                                                (R)-2-hydroxyglutaric acid 6
                                                (S)-2-hydroxyglutaric acid + 0
                                                2-hydroxyglutaryl-CoA + 0
                                                diethyl 2-hydroxypentanedioate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.