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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cysteamine
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Accession:CHEBI:17141 term browser browse the term
Definition:An amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.
Synonyms:related_synonym: 2-AMINO-ETHANETHIOL;   2-Aminoethanethiol;   2-amino-1-ethanethiol;   Formula=C2H7NS;   InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2;   InChIKey=UFULAYFCSOUIOV-UHFFFAOYSA-N;   MEA;   SMILES=NCCS;   Thioethanolamine;   beta-Aminoethanethiol;   beta-MEA;   beta-Mercaptoethylamine;   beta-aminoethylthiol;   mercaptamina;   mercaptamine;   mercaptaminum
 alt_id: CHEBI:14060;   CHEBI:15235;   CHEBI:23506;   CHEBI:4049;   CHEBI:41923
 xref: Beilstein:635649;   CAS:60-23-1;   DrugBank:DB00847;   Drug_Central:768;   Gmelin:25385;   HMDB:HMDB0002991;   KEGG:C01678;   KEGG:D03634
 xref_mesh: MESH:D003543
 xref: MetaCyc:CPD-239;   PDBeChem:DHL;   PMID:17581819;   PMID:22735334;   Reaxys:635649;   Wikipedia:Cysteamine
 cyclic_relationship: is_conjugate_base_of CHEBI:58029


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cysteamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor2 adiponectin receptor 2 increases expression EXP dietary cysteamine increases expression of adipor2 mRNA in soleus muscle and retroperitoneal adipose tissue RGD PMID:17696487 RGD:21079417 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
JBrowse link
G Ctsd cathepsin D increases expression
multiple interactions
EXP Cysteamine results in increased expression of CTSD protein
Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein]; thamira parpam inhibits the reaction [Cysteamine results in increased expression of CTSD protein]
CTD PMID:20165931 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases activity EXP Cysteamine results in increased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases activity
multiple interactions
ISO Cysteamine results in decreased activity of GCLC protein
[Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione
CTD PMID:15282320 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide decreases expression
multiple interactions
EXP Cysteamine results in decreased expression of GHRL mRNA; Cysteamine results in decreased expression of GHRL protein
Cysteamine results in increased expression of and results in increased secretion of GHRL protein
CTD PMID:15778430 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP [Cysteamine results in increased expression of HMOX1] which results in increased expression of SOD2; Cysteamine results in increased expression of HMOX1 mRNA; Cysteamine results in increased expression of HMOX1 protein
[stannous mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Cysteamine results in increased expression of SOD2 protein]
CTD PMID:10942521 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression ISO Cysteamine results in increased expression of MMP12 mRNA; Cysteamine results in increased expression of MMP12 protein CTD PMID:22532830 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp14 matrix metallopeptidase 14 increases expression ISO Cysteamine results in increased expression of MMP14 mRNA; Cysteamine results in increased expression of MMP14 protein CTD PMID:22532830 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
multiple interactions
increases expression
ISO Cysteamine results in decreased activity of MMP9 protein
Cysteamine results in increased expression of and results in decreased activity of MMP9 protein
Cysteamine results in increased expression of MMP9 mRNA
CTD PMID:22532830 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases expression
EXP geraniol inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; thamira parpam inhibits the reaction [Cysteamine results in increased expression of MPO protein] CTD PMID:20165931, PMID:24337826 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
EXP [Cysteamine results in increased expression of HMOX1] which results in increased expression of SOD2; Cysteamine results in increased expression of SOD2 mRNA; Cysteamine results in increased expression of SOD2 protein
[stannous mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Cysteamine results in increased expression of SOD2 protein]
CTD PMID:10942521 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sst somatostatin decreases expression EXP Cysteamine results in decreased expression of SST protein CTD PMID:15778430 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link
G Vnn1 vanin 1 increases chemical synthesis
multiple interactions
ISO VNN1 results in increased chemical synthesis of Cysteamine
Cysteamine inhibits the reaction [VNN1 gene mutant form results in decreased susceptibility to Paraquat]
CTD PMID:11042271, PMID:15282320 NCBI chr 1:22,614,832...22,625,134
Ensembl chr 1:22,614,783...22,625,204
JBrowse link
amifostine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Amifostine co-treated with Doxorubicin] results in increased expression of BAX mRNA CTD PMID:15985719 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Amifostine co-treated with Doxorubicin] results in decreased expression of BCL2 mRNA CTD PMID:15985719 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Amifostine co-treated with Doxorubicin] results in increased activity of CASP3 protein; Amifostine inhibits the reaction [Idarubicin results in increased activity of CASP3 protein]; Amifostine promotes the reaction [Idarubicin results in increased activity of CASP3 protein] CTD PMID:15985719, PMID:18438337 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation
multiple interactions
ISO Amifostine results in decreased phosphorylation of CDK1 protein
olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]
CTD PMID:16628227 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
ISO Amifostine results in decreased expression of CDKN1A mRNA
Amifostine results in increased expression of CDKN1A protein
CTD PMID:12618886, PMID:14555708 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein decreases expression ISO Amifostine results in decreased expression of EI24 mRNA CTD PMID:14555708 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Amifostine inhibits the reaction [IL6 protein results in increased phosphorylation of MYL2 protein] CTD PMID:19010997 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Amifostine inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased phosphorylation of MAPK14 protein] CTD PMID:19010997 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO Amifostine results in decreased expression of MDM2 mRNA CTD PMID:14555708 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Amifostine inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:19010997 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Amifostine co-treated with TP53] results in increased expression of MYC mRNA CTD PMID:14555708 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl2 myosin light chain 2 multiple interactions ISO Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL2 protein]
Amifostine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MYL2 protein]; Amifostine inhibits the reaction [IL6 protein results in increased phosphorylation of MYL2 protein]
CTD PMID:19010997 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression
multiple interactions
ISO Amifostine results in decreased expression of NFKBIA protein
Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
CTD PMID:10590050, PMID:19010997 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Amifostine inhibits the reaction [Benzene results in decreased expression of PCNA protein] CTD PMID:17661222 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases localization
ISO Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
Amifostine results in increased localization of RELA protein
CTD PMID:10590050, PMID:19010997 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
affects response to substance
increases activity
ISO [Amifostine co-treated with TP53] results in increased expression of MYC mRNA; olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]
Amifostine results in increased expression of TP53 protein
TP53 affects the susceptibility to Amifostine
Amifostine results in increased activity of TP53 protein
CTD PMID:12618886, PMID:14555708, PMID:16628227 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 decreases expression ISO Amifostine results in decreased expression of TP53I3 mRNA CTD PMID:14555708 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
cystamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:17708605 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] CTD PMID:17708605 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions EXP Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 mRNA]; Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 protein] CTD PMID:17708605 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] CTD PMID:17708605 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
N-acetylcysteamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor decreases phosphorylation ISO 2-acetamidoethanethiol analog results in decreased phosphorylation of EGFR protein CTD PMID:20058253 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO 2-acetamidoethanethiol analog results in decreased activity of and results in decreased phosphorylation of ERBB2 protein CTD PMID:20058253 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases phosphorylation ISO 2-acetamidoethanethiol analog results in decreased phosphorylation of ERBB3 protein CTD PMID:20058253 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
WR-1065 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases expression ISO WR 1065 results in increased expression of CAT protein CTD PMID:17388698 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO WR 1065 results in increased expression of CCL5 mRNA CTD PMID:12007958 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO WR 1065 results in decreased expression of GSTP1 mRNA CTD PMID:12007958 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression ISO WR 1065 results in increased expression of IL2RA mRNA CTD PMID:12007958 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO WR 1065 results in increased expression of MYB mRNA CTD PMID:12007958 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO WR 1065 results in decreased expression of MYC mRNA CTD PMID:12007958 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO WR 1065 results in increased activity of [NFKB1 protein binds to RELA protein]; WR 1065 results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:11390188, PMID:11917294, PMID:12007958 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO WR 1065 results in increased activity of [NFKB1 protein binds to RELA protein]; WR 1065 results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:11390188, PMID:11917294, PMID:12007958 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
increases activity
multiple interactions
ISO WR 1065 results in increased expression of SOD2 mRNA; WR 1065 results in increased expression of SOD2 protein
WR 1065 results in increased activity of SOD2
[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [WR 1065 results in increased activity of SOD2]
helenalin inhibits the reaction [WR 1065 results in increased expression of SOD2 protein]; WR 1065 results in increased expression of and results in increased activity of SOD2 protein
CTD PMID:11390188, PMID:11917294, PMID:12007958, PMID:16540396, PMID:17388698, PMID:21945096 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO [TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2]; TNFRSF1A protein affects the reaction [WR 1065 results in increased activity of SOD2] CTD PMID:21945096 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO [TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2] CTD PMID:21945096 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      group 19696
        inorganic group 19146
          thiol group 1938
            thiol 1938
              cysteamine 44
                N-acetylcysteamine 3
                S-acetylcysteamine 0
                WR-1065 11
                amifostine 17
                cystamine 4
                cysteamine S-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        primary amino compound 7858
                                          primary amine 5663
                                            primary aliphatic amine 137
                                              ethylamine 45
                                                cysteamine 44
                                                  N-acetylcysteamine 3
                                                  S-acetylcysteamine 0
                                                  WR-1065 11
                                                  amifostine 17
                                                  cystamine 4
                                                  cysteamine S-phosphate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.