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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:xylitol
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Accession:CHEBI:17151 term browser browse the term
Definition:A pentitol (five-carbon sugar alcohol) having meso-configuration, being derived from xylose by reduction of the carbonyl group.
Synonyms:exact_synonym: (2R,3r,4S)-pentane-1,2,3,4,5-pentol
 related_synonym: (2R,3R,4S)-Pentane-1,2,3,4,5-pentaol;   D-XYLITOL;   Formula=C5H12O5;   InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+;   InChIKey=HEBKCHPVOIAQTA-SCDXWVJYSA-N;   L-xylitol;   Meso-xylitol;   SMILES=OC[C@H](O)[C@@H](O)[C@H](O)CO;   Xylit;   xylite
 alt_id: CHEBI:10078;   CHEBI:15328;   CHEBI:253147;   CHEBI:27339;   CHEBI:46522;   CHEBI:60939
 xref: Beilstein:1720523;   CAS:87-99-0;   DrugBank:DB01904;   Drug_Central:4604;   Gmelin:82893;   HMDB:HMDB0002917;   KEGG:C00379;   KEGG:D00061
 xref_mesh: MESH:D014993
 xref: MetaCyc:XYLITOL;   PDBeChem:XYL;   PMID:11154411;   PMID:11163479;   PMID:12061879;   PMID:15377394;   PMID:16708791;   PMID:16901854;   PMID:17216457;   PMID:17216458;   PMID:17336832;   PMID:17979222;   PMID:18316079;   PMID:20030329;   PMID:22735334;   PMID:22791282;   PMID:23247825;   PMID:23287496;   PMID:23338824;   PMID:23589387;   PMID:23597921;   PMID:23615861;   PMID:23796483;   PMID:23916161;   PMID:23957303;   PMID:24012734;   PMID:24643482;   PMID:25108762;   Reaxys:1720523;   Wikipedia:Xylitol


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xylitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase increases expression ISO Xylitol results in increased expression of ABL2 mRNA CTD PMID:32275922 NCBI chr13:74,154,533...74,333,244
Ensembl chr13:74,154,835...74,333,244
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 increases expression ISO Xylitol results in increased expression of ARHGEF2 mRNA CTD PMID:32275922 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Ash1l ASH1 like histone lysine methyltransferase increases expression ISO Xylitol results in increased expression of ASH1L mRNA CTD PMID:32275922 NCBI chr 2:188,252,592...188,389,251
Ensembl chr 2:188,253,220...188,389,250
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Xylitol results in increased expression of ATF4 protein CTD PMID:32275922 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Bcap29 B-cell receptor-associated protein 29 decreases expression ISO Xylitol results in decreased expression of BCAP29 mRNA CTD PMID:32275922 NCBI chr 6:50,883,758...50,923,743
Ensembl chr 6:50,883,787...50,923,510
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 increases expression ISO Xylitol results in increased expression of BIRC6 mRNA CTD PMID:32275922 NCBI chr 6:21,900,763...22,092,484
Ensembl chr 6:21,950,100...22,092,346
JBrowse link
G Casp3 caspase 3 increases expression ISO Xylitol results in increased expression of CASP3 protein modified form CTD PMID:32275922 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cep250 centrosomal protein 250 increases expression ISO Xylitol results in increased expression of CEP250 mRNA CTD PMID:32275922 NCBI chr 3:151,508,366...151,544,631
Ensembl chr 3:151,508,361...151,544,674
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 multiple interactions
increases expression
ISO tauroursodeoxycholic acid inhibits the reaction [Xylitol results in increased expression of CHAC1 protein]
Xylitol results in increased expression of CHAC1 mRNA; Xylitol results in increased expression of CHAC1 protein
CTD PMID:32275922 NCBI chr 3:111,160,205...111,163,425
Ensembl chr 3:111,160,205...111,163,425
JBrowse link
G Cit citron rho-interacting serine/threonine kinase increases expression ISO Xylitol results in increased expression of CIT mRNA CTD PMID:32275922 NCBI chr12:46,334,669...46,494,152
Ensembl chr12:46,334,665...46,494,174
JBrowse link
G Cycs cytochrome c, somatic decreases expression ISO Xylitol results in decreased expression of CYCS mRNA CTD PMID:32275922 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Dct dopachrome tautomerase decreases expression ISO Xylitol results in decreased expression of DCT mRNA CTD PMID:32275922 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase increases chemical synthesis
multiple interactions
ISO DCXR protein results in increased chemical synthesis of Xylitol
[DCXR protein results in increased metabolism of Xylulose] which results in increased chemical synthesis of Xylitol
CTD PMID:28595002 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715
JBrowse link
G Flna filamin A increases expression ISO Xylitol results in increased expression of FLNA mRNA CTD PMID:32275922 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245
JBrowse link
G Fmn1 formin 1 increases expression ISO Xylitol results in increased expression of FMN1 mRNA CTD PMID:32275922 NCBI chr 3:104,783,093...105,170,761
Ensembl chr 3:104,816,987...105,086,436
JBrowse link
G Foxk1 forkhead box K1 increases expression ISO Xylitol results in increased expression of FOXK1 mRNA CTD PMID:32275922 NCBI chr12:14,183,436...14,244,634
Ensembl chr12:14,180,029...14,244,316
JBrowse link
G Gpm6b glycoprotein m6b decreases expression ISO Xylitol results in decreased expression of GPM6B mRNA CTD PMID:32275922 NCBI chr  X:29,604,607...29,751,174
Ensembl chr  X:29,607,075...29,648,403
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 increases expression ISO Xylitol results in increased expression of HIPK2 mRNA CTD PMID:32275922 NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912
JBrowse link
G Hmcn1 hemicentin 1 increases expression ISO Xylitol results in increased expression of HMCN1 mRNA CTD PMID:32275922 NCBI chr13:67,799,791...68,360,664
Ensembl chr13:67,799,791...68,360,664
JBrowse link
G Hnrnpul2 heterogeneous nuclear ribonucleoprotein U-like 2 increases expression ISO Xylitol results in increased expression of HNRNPUL2 mRNA CTD PMID:32275922 NCBI chr 1:225,015,722...225,027,640
Ensembl chr 1:225,015,616...225,027,710
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO Xylitol results in increased expression of HSPA5 protein
tauroursodeoxycholic acid inhibits the reaction [Xylitol results in increased expression of HSPA5 protein]
CTD PMID:32275922 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Inhba inhibin subunit beta A increases expression ISO Xylitol results in increased expression of INHBA mRNA CTD PMID:32275922 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 increases expression ISO Xylitol results in increased expression of IQGAP3 mRNA CTD PMID:32275922 NCBI chr 2:187,447,477...187,489,630
Ensembl chr 2:187,447,501...187,489,630
JBrowse link
G Kmt2d lysine methyltransferase 2D increases expression ISO Xylitol results in increased expression of KMT2D mRNA CTD PMID:32275922 NCBI chr 7:140,507,137...140,542,479
Ensembl chr 7:140,489,492...140,546,908
JBrowse link
G Lsm5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO Xylitol results in decreased expression of LSM5 mRNA CTD PMID:32275922 NCBI chr 4:87,016,003...87,019,219
Ensembl chr 4:87,016,003...87,019,219
Ensembl chr 6:87,016,003...87,019,219
JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 increases expression ISO Xylitol results in increased expression of MACF1 mRNA CTD PMID:32275922 NCBI chr 5:141,039,455...141,363,524
Ensembl chr 5:141,039,468...141,363,524
JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO Xylitol results in increased expression of MAFK mRNA CTD PMID:32275922 NCBI chr12:16,923,989...16,934,706
Ensembl chr12:16,923,990...16,934,706
JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO Xylitol results in increased expression of MAP1B mRNA CTD PMID:32275922 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Mrpl34 mitochondrial ribosomal protein L34 decreases expression ISO Xylitol results in decreased expression of MRPL34 mRNA CTD PMID:32275922 NCBI chr16:19,874,034...19,874,769
Ensembl chr16:19,874,034...19,874,768
JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO Xylitol results in decreased expression of MSMO1 mRNA CTD PMID:32275922 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 increases expression ISO Xylitol results in increased expression of NKD1 mRNA CTD PMID:32275922 NCBI chr19:19,434,720...19,509,087
Ensembl chr19:19,436,333...19,509,087
JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 increases expression ISO Xylitol results in increased expression of WHSC1 mRNA CTD PMID:32275922 NCBI chr14:82,119,210...82,196,501
Ensembl chr14:82,119,210...82,171,480
JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Xylitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Pir pirin decreases expression ISO Xylitol results in decreased expression of PIR mRNA CTD PMID:32275922 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting increases expression ISO Xylitol results in increased expression of PKD1 mRNA CTD PMID:32275922 NCBI chr10:13,914,057...13,962,008
Ensembl chr10:13,915,214...13,962,008
JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit increases expression ISO Xylitol results in increased expression of POLE mRNA CTD PMID:32275922 NCBI chr12:52,403,533...52,452,075
Ensembl chr12:52,403,529...52,452,040
JBrowse link
G Prrc2b proline-rich coiled-coil 2B increases expression ISO Xylitol results in increased expression of PRRC2B mRNA CTD PMID:32275922 NCBI chr 3:11,165,687...11,252,401
Ensembl chr 3:11,198,401...11,248,558
JBrowse link
G Rab5if RAB5 interacting factor decreases expression ISO Xylitol results in decreased expression of RAB5IF mRNA CTD PMID:32275922 NCBI chr 3:152,933,771...152,943,780
Ensembl chr 3:152,933,771...152,943,777
JBrowse link
G Rere arginine-glutamic acid dipeptide repeats increases expression ISO Xylitol results in increased expression of RERE mRNA CTD PMID:32275922 NCBI chr 5:167,330,966...167,664,506
Ensembl chr 5:167,331,035...167,664,505
JBrowse link
G Rpp21 ribonuclease P/MRP subunit p21 decreases expression ISO Xylitol results in decreased expression of RPP21 mRNA CTD PMID:32275922 NCBI chr20:2,515,541...2,517,471
Ensembl chr20:2,515,520...2,517,498
JBrowse link
G Slc45a2 solute carrier family 45, member 2 decreases expression ISO Xylitol results in decreased expression of SLC45A2 mRNA CTD PMID:32275922 NCBI chr 2:60,966,671...60,999,398
Ensembl chr 2:60,966,789...60,999,398
JBrowse link
G Slco5a1 solute carrier organic anion transporter family, member 5A1 increases expression ISO Xylitol results in increased expression of SLCO5A1 mRNA CTD PMID:32275922 NCBI chr 5:5,866,362...5,994,748
Ensembl chr 5:5,866,897...5,989,667
JBrowse link
G Socs4 suppressor of cytokine signaling 4 decreases expression ISO Xylitol results in decreased expression of SOCS4 mRNA CTD PMID:32275922 NCBI chr15:24,056,383...24,070,868
Ensembl chr15:24,056,383...24,070,857
JBrowse link
G Spcs3 signal peptidase complex subunit 3 decreases expression ISO Xylitol results in decreased expression of SPCS3 mRNA CTD PMID:32275922 NCBI chr16:40,050,862...40,056,296
Ensembl chr16:40,050,734...40,058,822
JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 increases expression ISO Xylitol results in increased expression of SRRM2 mRNA CTD PMID:32275922 NCBI chr10:13,128,820...13,162,956
Ensembl chr10:13,145,099...13,162,343
JBrowse link
G Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 increases expression ISO Xylitol results in increased expression of TANC2 mRNA CTD PMID:32275922 NCBI chr10:93,811,350...94,132,418
Ensembl chr10:93,811,350...94,127,697
JBrowse link
G Tmed5 transmembrane p24 trafficking protein 5 decreases expression ISO Xylitol results in decreased expression of TMED5 mRNA CTD PMID:32275922 NCBI chr14:2,613,318...2,624,773
Ensembl chr14:2,613,406...2,633,950
JBrowse link
G Tmem59 transmembrane protein 59 decreases expression ISO Xylitol results in decreased expression of TMEM59 mRNA CTD PMID:32275922 NCBI chr 5:126,783,061...126,804,177
Ensembl chr 5:126,783,061...126,804,175
JBrowse link
G Tmem64 transmembrane protein 64 decreases expression ISO Xylitol results in decreased expression of TMEM64 mRNA CTD PMID:32275922 NCBI chr 5:28,850,864...28,898,203
Ensembl chr 5:28,850,950...28,867,227
JBrowse link
G Tnks tankyrase increases expression ISO Xylitol results in increased expression of TNKS mRNA CTD PMID:32275922 NCBI chr16:60,925,093...61,067,192
Ensembl chr16:60,925,093...61,067,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        hapten 3006
          xylitol 50
            xylitol 5-phosphate 0
            xylitol 5-phosphate(2-) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  carbohydrates and carbohydrate derivatives 12178
                                    carbohydrate 12178
                                      alditol 1871
                                        pentitol 51
                                          xylitol 50
                                            xylitol 5-phosphate 0
                                            xylitol 5-phosphate(2-) 0
paths to the root

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