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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cerulenin
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Accession:CHEBI:171741 term browser browse the term
Definition:An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.
Synonyms:related_synonym: (2R,3S)-3-((4E,7E)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide;   (2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)oxirane-2-carboxamide;   Formula=C12H17NO3;   InChI=1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1;   InChIKey=GVEZIHKRYBHEFX-NQQPLRFYSA-N;   SMILES=[H][C@]1(O[C@]1([H])C(=O)CC\\C=C\\C\\C=C\\C)C(N)=O
 alt_id: CHEBI:29552
 xref: Beilstein:4807182;   CAS:17397-89-6;   DrugBank:DB01034;   Drug_Central:578;   KEGG:C12058;   KNApSAcK:C00018711
 xref_mesh: MESH:D002569


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cerulenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide increases expression ISO Cerulenin results in increased expression of AGRP mRNA CTD PMID:11289036 NCBI chr19:37,525,941...37,584,875
Ensembl chr19:37,526,419...37,528,011
JBrowse link
G Asip agouti signaling protein affects response to substance ISO A protein affects the susceptibility to Cerulenin CTD PMID:11289036 NCBI chr 3:150,492,010...150,579,870
Ensembl chr 3:150,574,473...150,579,870
JBrowse link
G Casp3 caspase 3 increases activity ISO Cerulenin results in increased activity of CASP3 protein CTD PMID:20805790 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO Cerulenin results in increased activity of CASP9 protein CTD PMID:20805790 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Cerulenin results in decreased expression of CEBPA mRNA CTD PMID:15707987 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Cerulenin results in increased phosphorylation of EIF2A protein CTD PMID:17283163 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Cerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases activity
decreases expression
ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine
Cerulenin results in decreased expression of FASN mRNA
CTD PMID:12798352, PMID:15707987, PMID:18723500 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Cerulenin inhibits the reaction [Glucose results in decreased expression of HNF4A mRNA] CTD PMID:17992261 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Lep leptin affects response to substance ISO LEP protein affects the susceptibility to Cerulenin CTD PMID:11289036 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Cerulenin results in decreased expression of PPARG mRNA CTD PMID:15707987 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Shbg sex hormone binding globulin multiple interactions ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]; Cerulenin inhibits the reaction [Glucose results in decreased expression of SHBG protein] CTD PMID:17992261 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Cerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          cerulenin 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  cerulenin 13
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