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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,5-dihydroxybenzoic acid
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Accession:CHEBI:17189 term browser browse the term
Definition:A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.
Synonyms:related_synonym: 2,5-Dihydroxybenzoate;   5-hydroxysalicylic acid;   Formula=C7H6O4;   Gentisate;   Gentisic acid;   Hydroquinonecarboxylic acid;   InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11);   InChIKey=WXTMDXOMEHJXQO-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(O)ccc1O
 alt_id: CHEBI:11451;   CHEBI:19381;   CHEBI:19382;   CHEBI:936
 xref: CAS:490-79-9;   Drug_Central:3260;   HMDB:HMDB0000152;   KEGG:C00628;   KNApSAcK:C00002648;   LINCS:LSM-19031
 xref_mesh: MESH:C010925
 xref: MetaCyc:CPD-633;   PDBeChem:GTQ;   PMID:15862799;   PMID:18314336;   PMID:22770225;   PMID:24547933;   Reaxys:2209119;   Wikipedia:Gentisic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58044


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2,5-dihydroxybenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]; Gallic Acid inhibits the reaction [2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]] CTD PMID:22129351 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Cat catalase multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CAT protein] CTD PMID:15454305 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cryz crystallin zeta multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CRYZ protein] CTD PMID:15454305 NCBI chr 2:260,884,315...260,911,827
Ensembl chr 2:260,884,337...260,911,792
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity
multiple interactions
ISO 2,5-dihydroxybenzoic acid results in decreased activity of G6PD protein mutant form
2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]
CTD PMID:5432368, PMID:15454305 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein] CTD PMID:15454305 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein] CTD PMID:15454305 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases activity
increases expression
ISO
EXP
2,5-dihydroxybenzoic acid results in increased activity of SULT1A1 protein
2,5-dihydroxybenzoic acid results in increased expression of SULT1A1 mRNA
CTD PMID:16308312, PMID:16443358 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP 2,5-dihydroxybenzoic acid results in increased expression of SULT2A1 mRNA CTD PMID:16443358 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        MALDI matrix material 932
          2,5-dihydroxybenzoic acid 8
            2,5-dihydroxybenzoic acid 2-O-beta-D-glucoside 0
            2,5-dihydroxybenzoic acid 5-O-beta-D-glucoside 0
            2,5-dihydroxybenzoyl-CoA 0
            benzyl 2,5-dihydroxybenzoate 0
            mygalin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        aromatic carboxylic acid 10889
                                          benzoic acids 10858
                                            benzoic acid 3839
                                              hydroxybenzoic acid 3227
                                                dihydroxybenzoic acid 48
                                                  2,5-dihydroxybenzoic acid 8
                                                    2,5-dihydroxybenzoic acid 2-O-beta-D-glucoside 0
                                                    2,5-dihydroxybenzoic acid 5-O-beta-D-glucoside 0
                                                    2,5-dihydroxybenzoyl-CoA 0
                                                    benzyl 2,5-dihydroxybenzoate 0
                                                    mygalin 0
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