Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbon monoxide
go back to main search page
Accession:CHEBI:17245 term browser browse the term
Definition:A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.
Synonyms:exact_synonym: carbon(II) oxide
 related_synonym: C#O;   CO;   Formula=CO;   InChI=1S/CO/c1-2;   InChIKey=UGFAIRIUMAVXCW-UHFFFAOYSA-N;   SMILES=[C-]#[O+];   carbon monooxide
 alt_id: CHEBI:13281;   CHEBI:23013;   CHEBI:3282;   CHEBI:41526
 xref: Beilstein:1900508;   Beilstein:3535285;   Beilstein:3587264;   CAS:630-08-0;   Gmelin:421;   HMDB:HMDB0001361;   KEGG:C00237;   KEGG:D09706
 xref_mesh: MESH:D002248
 xref: MetaCyc:CARBON-MONOXIDE;   MolBase:753;   PDBeChem:CMO;   PMID:10085152;   PMID:10679539;   PMID:11572959;   PMID:14527438;   PMID:14563665;   PMID:15127883;   PMID:15598489;   PMID:16371440;   PMID:16520836;   PMID:17041734;   PMID:18094356;   PMID:19909254;   PMID:23762709;   PMID:7022476;   PMID:8240252;   PMID:8620577;   UM-BBD_compID:c0369;   Wikipedia:Carbon_monoxide
 cyclic_relationship: is_conjugate_base_of CHEBI:58072


show annotations for term's descendants           Sort by:
 
carbon monoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases activity EXP Carbon Monoxide results in increased activity of ABCC2 protein CTD PMID:13678533 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein
[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein; Carbon Monoxide results in increased expression of ADIPOQ protein
CTD PMID:19356108 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adm adrenomedullin increases expression EXP Carbon Monoxide results in increased expression of ADM mRNA; Carbon Monoxide results in increased expression of ADM protein CTD PMID:10666155 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of AGR2 mRNA CTD PMID:29621558 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Agt angiotensinogen decreases response to substance ISO AGT protein results in decreased susceptibility to Carbon Monoxide CTD PMID:18174886 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:17179207, PMID:18037988, PMID:18215737, PMID:18845810, PMID:19356108 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase increases activity
multiple interactions
EXP Carbon Monoxide results in increased activity of ALAD protein
Carbon Monoxide inhibits the reaction [[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein]
CTD PMID:1032310, PMID:6740708 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Areg amphiregulin multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of AREG mRNA CTD PMID:29621558 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Bach1 BTB domain and CNC homolog 1 decreases phosphorylation ISO Carbon Monoxide results in decreased phosphorylation of BACH1 protein CTD PMID:18845810 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:18037988 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
EXP Carbon Monoxide results in decreased expression of and results in decreased secretion of BDNF protein
Carbon Monoxide results in decreased expression of BDNF mRNA
CTD PMID:27113706 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP3 mRNA
Carbon Monoxide results in increased activity of CASP3 protein
CTD PMID:17173083, PMID:19356108, PMID:19520142, PMID:25562542, PMID:31268311 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity EXP Carbon Monoxide results in increased activity of CASP7 protein CTD PMID:25562542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
EXP
ISO
Carbon Monoxide results in increased activity of CASP8 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA
CTD PMID:25562542, PMID:31268311 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
EXP
ISO
Carbon Monoxide results in increased activity of CASP9 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP9 mRNA
CTD PMID:25562542, PMID:31268311 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO
EXP
CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:17179207, PMID:18845810 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of CCL1 mRNA CTD PMID:29621558 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882
JBrowse link
G Cd86 CD86 molecule decreases expression EXP Carbon Monoxide results in decreased expression of CD86 protein CTD PMID:12201358 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Clca1 chloride channel accessory 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CLCA1 mRNA CTD PMID:29621558 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744
JBrowse link
G Col11a1 collagen type XI alpha 1 chain multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of COL11A1 mRNA CTD PMID:29621558 NCBI chr 2:216,863,423...217,056,523
Ensembl chr 2:216,863,428...217,056,523
JBrowse link
G Crp C-reactive protein increases expression ISO Carbon Monoxide results in increased expression of CRP protein CTD PMID:18629312 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CXCL11 mRNA CTD PMID:29621558 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Carbon Monoxide inhibits the reaction [CYP1A1 protein results in increased reduction of sodium chromate(VI)] CTD PMID:1903091 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Carbon Monoxide promotes the reaction [1-ethynylpyrene results in increased expression of CYP1B1 mRNA] CTD PMID:10581206 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Carbon Monoxide inhibits the reaction [CYP2B1 protein results in increased reduction of sodium chromate(VI)] CTD PMID:1903091 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
ISO
EXP
Carbon Monoxide results in decreased activity of CYP2E1 protein
Carbon Monoxide inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)]
CTD PMID:1903091, PMID:15036350 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Duox2 dual oxidase 2 increases expression
decreases expression
EXP Carbon Monoxide results in increased expression of DUOX2 mRNA
Carbon Monoxide results in decreased expression of DUOX2 protein
CTD PMID:29223502 NCBI chr 3:114,218,187...114,237,808
Ensembl chr 3:114,218,193...114,235,933
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
EXP
ISO
Carbon Monoxide results in increased expression of EDN1 mRNA; Carbon Monoxide results in increased expression of EDN1 protein
Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]
CTD PMID:11781074, PMID:12969895, PMID:20197249 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA]; Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]; UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]] CTD PMID:22046279 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Epo erythropoietin increases expression EXP Carbon Monoxide results in increased expression of EPO mRNA; Carbon Monoxide results in increased expression of EPO protein CTD PMID:9263988 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression EXP Carbon Monoxide results in increased expression of ERO1A mRNA CTD PMID:12752442 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] CTD PMID:19750100 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of FOXP3 promoter CTD PMID:29317916 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of GABPA mRNA
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]
CTD PMID:17179207 NCBI chr11:24,293,845...24,322,822
Ensembl chr11:24,263,281...24,322,815
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased activity of GATA4 protein] CTD PMID:18037988 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gpr182 G protein-coupled receptor 182 increases expression EXP Carbon Monoxide results in increased expression of GPR182 mRNA CTD PMID:10666155 NCBI chr 7:71,044,786...71,048,713
Ensembl chr 7:71,045,543...71,048,383
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein] CTD PMID:18037988 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein]
Carbon Monoxide results in increased phosphorylation of GSK3B protein
CTD PMID:18037988, PMID:18845810 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases chemical synthesis
increases expression
increases activity
ISO
EXP
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]; HMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased chemical synthesis of Carbon Monoxide
[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in increased expression of HMOX1 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]
CTD PMID:11880364, PMID:16365149, PMID:18037988, PMID:18845810, PMID:19520142, PMID:21444764, PMID:25348283, PMID:29165873 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions
affects chemical synthesis
affects abundance
EXP Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]
HMOX2 protein affects the chemical synthesis of Carbon Monoxide
HMOX2 protein affects the abundance of Carbon Monoxide
CTD PMID:11342580, PMID:12969895 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP
ISO
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
CTD PMID:19356108, PMID:19608869 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IFNG protein; Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein] CTD PMID:16365149, PMID:29621558 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO Carbon Monoxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]
Carbon Monoxide results in increased expression of IL10 mRNA
CTD PMID:21444764 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]] CTD PMID:16365149 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IL13 mRNA CTD PMID:29621558 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL17A protein CTD PMID:29621558 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 decreases response to substance
multiple interactions
ISO Carbon Monoxide results in decreased susceptibility to IL18 protein
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
CTD PMID:18215737 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Carbon Monoxide results in decreased expression of IL1B protein CTD PMID:21444764 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il22 interleukin 22 multiple interactions
increases expression
ISO HMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]; tin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased expression of IL22 mRNA] CTD PMID:21444764 NCBI chr 7:61,236,037...61,240,502
Ensembl chr 7:61,236,037...61,240,502
JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
ISO Carbon Monoxide results in decreased expression of IL4 protein
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL4 protein
CTD PMID:21444764, PMID:29621558 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of IL6 protein; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]; IL6 gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] CTD PMID:18629312, PMID:19608869, PMID:19750100, PMID:31268311 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf8 interferon regulatory factor 8 decreases activity ISO Carbon Monoxide results in decreased activity of IRF8 protein CTD PMID:16365149 NCBI chr19:54,314,859...54,336,643
Ensembl chr19:54,314,865...54,336,640
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:18845810 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mir1224 microRNA 1224 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR1224 mRNA CTD PMID:31268311 NCBI chr11:83,992,628...83,992,712
Ensembl chr11:83,992,628...83,992,712
JBrowse link
G Mir186 microRNA 186 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR186 mRNA CTD PMID:31268311 NCBI chr 2:263,873,759...263,873,844
Ensembl chr 2:263,873,759...263,873,844
JBrowse link
G Mir21 microRNA 21 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR21 mRNA CTD PMID:31268311 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir342 microRNA 342 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR342 mRNA CTD PMID:31268311 NCBI chr 6:132,561,169...132,561,267
Ensembl chr 6:132,561,169...132,561,267
JBrowse link
G Mir374b microRNA 374b multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR374B mRNA CTD PMID:31268311 NCBI chr  X:74,443,648...74,443,715
Ensembl chr  X:74,443,648...74,443,715
JBrowse link
G Mir615 microRNA 615 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR615 mRNA CTD PMID:31268311 NCBI chr 7:144,629,019...144,629,110
Ensembl chr 7:144,629,019...144,629,110
JBrowse link
G Mir93 microRNA 93 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR93 mRNA CTD PMID:31268311 NCBI chr12:19,307,543...19,307,629
Ensembl chr12:19,307,543...19,307,629
JBrowse link
G Mirlet7i microRNA let-7i multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7I mRNA CTD PMID:31268311 NCBI chr 7:66,802,731...66,802,815
Ensembl chr 7:66,802,732...66,802,821
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Carbon Monoxide results in increased expression of MMP9 mRNA CTD PMID:20197249 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 mRNA]; Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 protein] CTD PMID:11006124 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
increases localization
decreases phosphorylation
ISO
EXP
Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]; CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of NFE2L2 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein]
Carbon Monoxide results in increased expression of NFE2L2 mRNA
Carbon Monoxide results in decreased phosphorylation of NFE2L2 protein
CTD PMID:18845810, PMID:25348283 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor affects expression
multiple interactions
EXP Carbon Monoxide affects the expression of NGF mRNA
Carbon Monoxide results in decreased expression of and affects the secretion of NGF protein
CTD PMID:27113706 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO
EXP
Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Carbon Monoxide results in decreased expression of NOS2 protein
CTD PMID:12201358, PMID:22046279 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein CTD PMID:19356108 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Carbon Monoxide results in increased expression of NPPA mRNA CTD PMID:11781074 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression
increases localization
ISO
EXP
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]
Carbon Monoxide results in increased expression of NRF1 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
Carbon Monoxide results in increased expression of NRF1 mRNA
CTD PMID:17179207, PMID:18845810 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Ntf3 neurotrophin 3 decreases expression
multiple interactions
EXP Carbon Monoxide results in decreased expression of NTF3 mRNA
Carbon Monoxide results in decreased expression of and results in decreased secretion of NTF3 protein
CTD PMID:27113706 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression EXP [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein CTD PMID:19356108 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pla2g7 phospholipase A2 group VII affects expression ISO Carbon Monoxide affects the expression of PLA2G7 CTD PMID:21356620 NCBI chr 9:19,935,754...19,978,013
Ensembl chr 9:19,935,768...19,978,013
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit increases expression ISO Carbon Monoxide results in increased expression of POLG mRNA; Carbon Monoxide results in increased expression of POLG protein CTD PMID:17179207 NCBI chr 1:141,172,117...141,188,893
Ensembl chr 1:141,172,531...141,188,031
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein; Acetylcysteine inhibits the reaction [[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] CTD PMID:22046279 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of PPARGC1A mRNA
Carbon Monoxide results in increased expression of PPARGC1A protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]
CTD PMID:17179207 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prg2 proteoglycan 2 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of PRG2 mRNA CTD PMID:29621558 NCBI chr 3:72,385,678...72,389,245
Ensembl chr 3:72,385,666...72,389,276
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Selp selectin P increases expression ISO Carbon Monoxide results in increased expression of SELP protein modified form CTD PMID:18629312 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Carbon Monoxide results in decreased expression of SOD1 protein CTD PMID:18629312 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO
EXP
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of SOD2 protein
CTD PMID:17179207, PMID:18037988, PMID:18845810 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sostdc1 sclerostin domain containing 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of SOSTDC1 mRNA CTD PMID:29621558 NCBI chr 6:55,812,820...55,816,994
Ensembl chr 6:55,812,747...55,817,066
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of TFAM mRNA; Carbon Monoxide results in increased expression of TFAM protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
CTD PMID:17179207 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases response to substance
EXP
ISO
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
Carbon monoxide decreases expression of Tnf mRNA in reperfused liver nonparenchymal cells
Carbon Monoxide results in decreased susceptibility to TNF protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of TNF protein; [HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in decreased expression of TNF protein
CTD PMID:11880364, PMID:17173083, PMID:19356108, PMID:19608869, PMID:21444764, PMID:31268311, PMID:18972563 RGD:15023490 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO Carbon Monoxide results in increased expression of TNFRSF1B protein modified form CTD PMID:18629312 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Tnfsf4 TNF superfamily member 4 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of TNFSF4 mRNA CTD PMID:29621558 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]; UCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] CTD PMID:22046279 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein decreases phosphorylation ISO Carbon Monoxide results in decreased phosphorylation of VASP protein CTD PMID:26582457 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO
EXP
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:19356108, PMID:19608869 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Xdh xanthine dehydrogenase increases activity
increases metabolic processing
EXP Carbon Monoxide results in increased activity of XDH protein
Carbon Monoxide results in increased metabolism of XDH protein
CTD PMID:1447108 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        probe 484
          carbon monoxide 95
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  carbon oxide 113
                                    carbon monoxide 95
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.