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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17alpha-hydroxyprogesterone
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Accession:CHEBI:17252 term browser browse the term
Definition:A 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone.
Synonyms:exact_synonym: 17-hydroxypregn-4-ene-3,20-dione
 related_synonym: 17-Hydroxypregn-4-en-3,20-dione;   17-hydroxyprogesterone;   17alpha-Hydroxy-4-pregnene-3,20-dione;   17alpha-Hydroxy-progesterone;   Formula=C21H30O3;   InChI=1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1;   InChIKey=DBPWSSGDRRHUNT-CEGNMAFCSA-N;   Pregn-4-ene-3,20-dione-17-ol;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(C)=O;   delta(4)-Pregnene-17alpha-ol-3,20-dione;   hidroxiprogesterona;   hydroxyprogesterone;   hydroxyprogesteronum
 alt_id: CHEBI:11339;   CHEBI:11340;   CHEBI:19173;   CHEBI:790
 xref: Beilstein:2062088;   CAS:68-96-2;   KEGG:C01176;   KEGG:D08052;   LIPID_MAPS_instance:LMST02030161
 xref_mesh: MESH:D019326
 xref: MetaCyc:17-ALPHA-HYDROXYPROGESTERONE;   PMID:1167988;   PMID:12915667;   PMID:14999215;   PMID:15863951;   PMID:17066953;   PMID:17096820;   PMID:17128559;   PMID:18573861;   PMID:19390483;   PMID:4339047;   PMID:4343782;   PMID:4628727;   PMID:4678211;   PMID:4678212;   PMID:5061166;   PMID:5065810;   PMID:5098538;   PMID:518278;   PMID:5571099;   PMID:6632812;   PMID:72488;   PMID:8496956;   PMID:9931518;   Reaxys:2062088;   Wikipedia:Hydroxyprogesterone


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17alpha-hydroxyprogesterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO 17-alpha-Hydroxyprogesterone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Ar androgen receptor increases activity ISO 17-alpha-Hydroxyprogesterone results in increased activity of AR protein CTD PMID:21543282 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP [Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of 17-alpha-Hydroxyprogesterone CTD PMID:23873838 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects abundance
increases metabolic processing
affects chemical synthesis
affects metabolic processing
multiple interactions
ISO CYP17A1 protein affects the abundance of 17-alpha-Hydroxyprogesterone
CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone
CYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxyprogesterone
CYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesterone
[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone; [CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone; [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]; TNF protein inhibits the reaction [CYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]
CTD PMID:16030167, PMID:17194026, PMID:21427057, PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [17-alpha-Hydroxyprogesterone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Ins2 insulin 2 multiple interactions ISO 17-alpha-Hydroxyprogesterone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; [17-alpha-Hydroxyprogesterone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 17-alpha-Hydroxyprogesterone analog binds to and results in increased activity of NR3C1 protein CTD PMID:18060946 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Pgr progesterone receptor multiple interactions ISO 17-alpha-Hydroxyprogesterone analog binds to and results in increased activity of PGR protein CTD PMID:18060946 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO 17-alpha-Hydroxyprogesterone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein inhibits the reaction [CYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesterone] CTD PMID:16030167 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            17alpha-hydroxyprogesterone 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        oxyketone 8631
                                          alpha-oxyketone 8631
                                            alpha-hydroxy ketone 8631
                                              tertiary alpha-hydroxy ketone 8357
                                                17alpha-hydroxyprogesterone 10
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