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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:all-trans-retinol
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Accession:CHEBI:17336 term browser browse the term
Definition:A retinol in which all four exocyclic double bonds have E- (trans-) geometry.
Synonyms:related_synonym: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol;   Alphalin;   Chocola A;   Formula=C20H30O;   InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+;   InChIKey=FPIPGXGPPPQFEQ-OVSJKPMPSA-N;   Retinol;   SMILES=CC(\\C=C\\C=C(C)\\C=C\\C1=C(C)CCCC1(C)C)=C/CO;   Vitamin A;   Vitamin A1;   all-trans-retinyl alcohol;   all-trans-vitamin A alcohol
 alt_id: CHEBI:12783;   CHEBI:22349;   CHEBI:8816
 xref: Beilstein:403040;   CAS:11103-57-4;   CAS:68-26-8;   DrugBank:DB00162;   Drug_Central:2831;   Gmelin:247497;   KEGG:C00473;   KEGG:C17276;   KEGG:D00069;   KEGG:D06543;   LIPID_MAPS_instance:LMPR01090000;   LIPID_MAPS_instance:LMPR01090001
 xref_mesh: MESH:D014801
 xref: PDBeChem:RTL;   Wikipedia:Vitamin_A


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all-trans-retinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases expression
EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in decreased expression of ABCB1 mRNA]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in decreased expression of ABCB1A mRNA]; Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1 mRNA]; Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1A mRNA]
Vitamin A results in decreased expression of ABCB1 mRNA; Vitamin A results in decreased expression of ABCB1A mRNA
CTD PMID:15327746 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 decreases expression EXP Vitamin A deficiency results in decreased expression of ACSS2 mRNA CTD PMID:12163651 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Vitamin A inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:16256175 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actb actin, beta decreases expression EXP Vitamin A deficiency results in decreased expression of ACTB mRNA CTD PMID:12163651 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression
multiple interactions
EXP Vitamin A results in decreased expression of ACTG2 protein
Vitamin A results in decreased expression of [Ethanol results in increased expression of ACTG2 protein]
CTD PMID:16043492 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723
JBrowse link
G Afp alpha-fetoprotein increases expression EXP Vitamin A deficiency results in increased expression of AFP mRNA CTD PMID:7519440 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of AGER protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased expression of AGER protein]; [Vitamin A results in increased abundance of Reactive Oxygen Species] which results in increased expression of AGER protein; SB 203580 inhibits the reaction [Vitamin A results in increased expression of AGER protein] CTD PMID:18396385, PMID:21807062, PMID:22274401 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Vitamin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA] CTD PMID:15728703 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases response to substance ISO AKR1B1 protein results in decreased susceptibility to Vitamin A; AKR1B1 protein results in decreased susceptibility to Vitamin A metabolite CTD PMID:19014918 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases response to substance ISO AKR1B10 protein results in decreased susceptibility to Vitamin A; AKR1B10 protein results in decreased susceptibility to Vitamin A metabolite CTD PMID:19014918 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased phosphorylation of AKT1 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of AKT1 protein] CTD PMID:21807062 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding ISO Vitamin A binds to ALB protein CTD PMID:17184834 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Vitamin A results in decreased expression of ALDH1A2 mRNA CTD PMID:30944279 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aox1 aldehyde oxidase 1 multiple interactions ISO [Tetrachlorodibenzodioxin co-treated with Vitamin A] results in increased activity of AOX1 protein; [Tetrachlorodibenzodioxin co-treated with Vitamin A] results in increased expression of AOX1 mRNA; Vitamin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AOX1 protein]; Vitamin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AOX1 mRNA] CTD PMID:16292751 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Apod apolipoprotein D affects binding ISO Vitamin A binds to APOD protein CTD PMID:16461020 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases expression
affects expression
EXP Tretinoin inhibits the reaction [Vitamin A affects the expression of APP mRNA]
Vitamin A results in increased expression of APP protein
CTD PMID:16530976, PMID:22274401 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 increases expression EXP Vitamin A deficiency results in increased expression of ASCL1 mRNA CTD PMID:12555267 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Bace1 beta-secretase 1 multiple interactions
affects expression
EXP Tretinoin inhibits the reaction [Vitamin A affects the expression of BACE mRNA] CTD PMID:16530976 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Vitamin A results in increased expression of BAX protein CTD PMID:16216918 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Vitamin A results in decreased expression of BCL2 protein CTD PMID:16216918 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bmp4 bone morphogenetic protein 4 affects expression ISO Vitamin A affects the expression of BMP4 mRNA CTD PMID:16120438 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Vitamin A results in increased expression of BTG2 mRNA CTD PMID:17234770 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Cab39 calcium binding protein 39 decreases expression EXP Vitamin A deficiency results in decreased expression of CAB39 mRNA CTD PMID:12163651 NCBI chr 9:92,834,327...92,895,778
Ensembl chr 9:92,834,357...92,895,778
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
increases activity
ISO alpha-Tocopherol inhibits the reaction [Vitamin A results in increased activity of CASP3 protein]
Vitamin A results in decreased activity of CASP3 protein
CTD PMID:16531423, PMID:17618090 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase affects activity
decreases activity
increases expression
multiple interactions
decreases expression
ISO
EXP
Vitamin A affects the activity of CAT protein
Vitamin A results in decreased activity of CAT protein
Vitamin A results in increased expression of CAT protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased expression of CAT protein]; [Vitamin A results in decreased activity of CAT protein] which results in increased abundance of Hydrogen Peroxide; Vitamin A results in increased expression of and results in increased activity of CAT protein
Vitamin A deficiency results in decreased expression of CAT protein; Vitamin A results in decreased expression of CAT protein
CTD PMID:8602878, PMID:16036340, PMID:17673185, PMID:17727954, PMID:18440196, PMID:18533141, PMID:19842843, PMID:22274401 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
increases expression
affects expression
ISO
EXP
Vitamin A results in decreased expression of CCL2 protein
Vitamin A results in increased expression of CCL2 mRNA
Vitamin A affects the expression of CCL2 protein
CTD PMID:16988133, PMID:25051504 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Vitamin A results in decreased expression of CCND1 mRNA CTD PMID:17219422, PMID:17234770 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases expression EXP Vitamin A deficiency results in decreased expression of CCND2 mRNA CTD PMID:12163651 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Cd14 CD14 molecule increases expression ISO Vitamin A results in increased expression of CD14 mRNA CTD PMID:17033190 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Vitamin A results in increased expression of CD44 protein CTD PMID:16724877 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 affects expression ISO Vitamin A affects the expression of CDH1 mRNA CTD PMID:17034753 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions
ISO Vitamin A results in increased expression of COL1A1 mRNA
[Cryptoxanthins co-treated with Vitamin A] results in increased expression of COL1A1 mRNA
CTD PMID:15962303, PMID:17034753 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions ISO [RARA gene mutant form co-treated with Vitamin A] results in decreased expression of COL2A1 mRNA; RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of COL2A1 mRNA] CTD PMID:16397886 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Col4a2 collagen type IV alpha 2 chain increases expression ISO Vitamin A results in increased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr16:83,386,388...83,522,169
Ensembl chr16:83,387,364...83,438,561
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 multiple interactions
increases expression
ISO CRABP2 protein promotes the reaction [Vitamin A results in increased expression of TOB1 mRNA]
Vitamin A results in increased expression of CRABP2 mRNA
CTD PMID:16793012, PMID:17034753, PMID:17234770 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO
EXP
Vitamin A results in increased phosphorylation of CREB1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased phosphorylation of CREB1 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of CREB1 protein]; AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of CREB1 protein]
CTD PMID:16280361, PMID:16510265 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Vitamin A results in decreased expression of CTNNB1 protein]; MG 262 inhibits the reaction [Vitamin A results in decreased expression of CTNNB1 protein]; Vitamin A results in increased ubiquitination of and results in increased degradation of CTNNB1 protein CTD PMID:17219422 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cycs cytochrome c, somatic affects localization EXP Vitamin A affects the localization of CYCS protein CTD PMID:16202537 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Vitamin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Vitamin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:15728703 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases oxidation ISO CYP1B1 protein results in increased oxidation of Vitamin A CTD PMID:15258110 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions
increases expression
affects metabolic processing
ISO
EXP
[Vitamin A co-treated with RARA protein co-treated with RXRA protein] results in increased expression of CYP26A1 mRNA
Vitamin A results in increased expression of CYP26A1 mRNA
[R 115866 co-treated with Vitamin A] results in increased expression of CYP26A1 mRNA
CYP26A1 protein affects the metabolism of Vitamin A
CTD PMID:10557354, PMID:16194896, PMID:17244623, PMID:17510468, PMID:22542753, PMID:30944279 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 multiple interactions EXP [R 115866 co-treated with Vitamin A] results in increased expression of CYP26B1 mRNA CTD PMID:17510468 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP GH1 protein promotes the reaction [Vitamin A affects the expression of and affects the activity of CYP2C11 protein]; Vitamin A affects the expression of and affects the activity of CYP2C11 protein CTD PMID:15963505 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Dcp2 decapping mRNA 2 decreases expression EXP Vitamin A deficiency results in decreased expression of DCP2 mRNA CTD PMID:12163651 NCBI chr18:35,489,274...35,671,676
Ensembl chr18:35,489,274...35,672,291
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO DGAT1 protein results in increased metabolism of [Palmitoyl Coenzyme A co-treated with Vitamin A] CTD PMID:16214399 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 decreases abundance ISO DHRS3 gene mutant form results in decreased abundance of Vitamin A CTD PMID:24005908 NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 increases metabolic processing ISO DHRS9 protein results in increased metabolism of Vitamin A CTD PMID:11304534 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP Vitamin A results in decreased expression of DRD2 protein CTD PMID:22274401 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 decreases expression EXP Vitamin A deficiency results in decreased expression of EEF1A1 mRNA CTD PMID:12163651 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Egfr epidermal growth factor receptor increases expression EXP Vitamin A deficiency results in increased expression of EGFR mRNA CTD PMID:7519440 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 decreases expression EXP Vitamin A deficiency results in decreased expression of EIF4A2 mRNA CTD PMID:12163651 NCBI chr11:81,373,047...81,379,680
Ensembl chr11:81,373,048...81,379,871
JBrowse link
G Epo erythropoietin increases expression
multiple interactions
ISO
EXP
Vitamin A results in increased expression of EPO protein
Vitamin A inhibits the reaction [Hydrogen Peroxide results in decreased expression of EPO protein]
CTD PMID:9927288, PMID:16960172 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Vitamin A inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] CTD PMID:19340624 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Vitamin A results in decreased expression of FAS mRNA CTD PMID:17034753 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fn1 fibronectin 1 decreases secretion ISO Vitamin A results in decreased secretion of FN1 protein CTD PMID:17225872 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha multiple interactions EXP [Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein CTD PMID:15959631 NCBI chr16:70,834,957...70,854,724
Ensembl chr16:70,834,957...70,854,724
JBrowse link
G Fntb farnesyltransferase, CAAX box, beta multiple interactions
increases expression
EXP [perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA
Vitamin A results in increased expression of FNTB mRNA; Vitamin A results in increased expression of FNTB protein
CTD PMID:15959631 NCBI chr 6:99,883,959...99,966,988
Ensembl chr 6:99,883,959...99,966,988
JBrowse link
G Foxa1 forkhead box A1 increases expression ISO Vitamin A results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Foxa2 forkhead box A2 multiple interactions EXP Vitamin A inhibits the reaction [nitrofen results in decreased expression of FOXA2 protein] CTD PMID:16863852 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
decreases expression
EXP Iron deficiency promotes the reaction [Vitamin A deficiency results in decreased expression of FTH1 protein]
Vitamin A deficiency results in decreased expression of FTH1 mRNA; Vitamin A deficiency results in decreased expression of FTH1 protein
CTD PMID:22154532 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression ISO Vitamin A results in increased expression of GABRB3 mRNA CTD PMID:17225872 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO Vitamin A results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Gcg glucagon multiple interactions ISO [Vitamin A co-treated with INHBA protein] results in increased expression of GCG mRNA CTD PMID:17244017 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP GH1 protein promotes the reaction [Vitamin A affects the expression of and affects the activity of CYP2C11 protein] CTD PMID:15963505 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression
EXP Vitamin A inhibits the reaction [nitrofen results in increased expression of GJA1 mRNA]
Vitamin A results in increased expression of GJA1 mRNA
CTD PMID:12031251, PMID:16292552 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gnai1 G protein subunit alpha i1 increases expression EXP Vitamin A results in increased expression of GNAI1 protein CTD PMID:16757122 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnai2 G protein subunit alpha i2 increases expression EXP Vitamin A results in increased expression of GNAI2 protein CTD PMID:16757122 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
EXP Vitamin A results in increased activity of GPT protein
gadolinium chloride inhibits the reaction [Vitamin A results in increased activity of GPT protein]
CTD PMID:8627517 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [Vitamin A co-treated with Ascorbic Acid co-treated with Vitamin E] results in increased expression of GPX1 protein CTD PMID:17179735 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Grhl3 grainyhead-like transcription factor 3 increases response to substance ISO GRHL3 gene mutant form results in increased susceptibility to Vitamin A CTD PMID:6635991 NCBI chr 5:153,893,039...153,925,045
Ensembl chr 5:153,893,039...153,924,896
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Vitamin A inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H3f4 H3.4 histone multiple interactions
increases acetylation
ISO Vitamin A affects the reaction [H3F4 protein modified form binds to PCK1 promoter]
Vitamin A results in increased acetylation of H3F4 protein
CTD PMID:16317119 NCBI chr10:45,304,696...45,305,106 JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Vitamin A results in increased expression of HBEGF mRNA CTD PMID:19648781 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hoxa1 homeobox A1 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of HOXA1]; 3,4-methylenedioxy-beta-nitrostyrene inhibits the reaction [Vitamin A results in increased expression of HOXA1]; 4-nonylphenol inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]; BAY 11-7085 inhibits the reaction [Vitamin A results in increased expression of HOXA1]; bisphenol A inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]; Camptothecin inhibits the reaction [Vitamin A results in increased expression of HOXA1]; citral inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]; di-n-pentyl phthalate inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]; Dibutyl Phthalate inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]; Diethylstilbestrol inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]; Disulfiram inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]; Genistein inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]; N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]; nitrofen inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]
Vitamin A results in increased expression of HOXA1; Vitamin A results in increased expression of HOXA1 mRNA
CTD PMID:23696197, PMID:26820057 NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066
JBrowse link
G Hoxa3 homeobox A3 affects expression ISO Vitamin A affects the expression of HOXA3 mRNA CTD PMID:10992263 NCBI chr 4:82,137,802...82,181,836
Ensembl chr 4:82,138,683...82,141,385
JBrowse link
G Ifng interferon gamma decreases expression
affects expression
ISO
EXP
Vitamin A results in decreased expression of IFNG protein
Vitamin A affects the expression of IFNG protein
CTD PMID:14624943, PMID:17289162 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Vitamin A results in increased expression of IL1B protein CTD PMID:25051504 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 increases expression ISO Vitamin A results in increased expression of IL2 mRNA CTD PMID:15506942 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 decreases expression ISO Vitamin A results in decreased expression of IL4 protein CTD PMID:14624943 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Inhba inhibin subunit beta A multiple interactions ISO [Vitamin A co-treated with INHBA protein] results in decreased expression of SHH mRNA; [Vitamin A co-treated with INHBA protein] results in increased expression of GCG mRNA; [Vitamin A co-treated with INHBA protein] results in increased expression of INS1 mRNA; [Vitamin A co-treated with INHBA protein] results in increased expression of INS2 mRNA; [Vitamin A co-treated with INHBA protein] results in increased expression of PDX1 mRNA; [Vitamin A co-treated with INHBA protein] results in increased expression of PPY mRNA; [Vitamin A co-treated with INHBA protein] results in increased expression of PTF1A mRNA; [Vitamin A co-treated with INHBA protein] results in increased expression of SOX17 mRNA; [Vitamin A co-treated with INHBA protein] results in increased expression of SST mRNA CTD PMID:17244017 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Vitamin A co-treated with INHBA protein] results in increased expression of INS2 mRNA CTD PMID:17244017 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Ireb2 iron responsive element binding protein 2 increases expression EXP Vitamin A deficiency results in increased expression of IREB2 mRNA CTD PMID:22154532 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Itga3 integrin subunit alpha 3 increases expression ISO Vitamin A results in increased expression of ITGA3 protein CTD PMID:17241391 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itgb1 integrin subunit beta 1 affects localization
increases expression
ISO Vitamin A affects the localization of ITGB1 protein
Vitamin A results in increased expression of ITGB1 protein
CTD PMID:17241391 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Ivl involucrin increases expression ISO Vitamin A results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577
JBrowse link
G Jak2 Janus kinase 2 affects localization EXP Vitamin A affects the localization of JAK2 protein CTD PMID:15963505 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Krt18 keratin 18 increases expression ISO Vitamin A results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt19 keratin 19 increases expression
decreases expression
ISO
EXP
Vitamin A results in increased expression of KRT19 mRNA
Vitamin A deficiency results in decreased expression of KRT19 mRNA
CTD PMID:12163651, PMID:17034753 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt7 keratin 7 increases expression ISO Vitamin A results in increased expression of KRT7 mRNA CTD PMID:17034753 NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907
JBrowse link
G Krt8 keratin 8 increases expression ISO Vitamin A results in increased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lep leptin multiple interactions EXP LEP gene mutant form promotes the reaction [Vitamin A results in increased expression of UCP1 mRNA] CTD PMID:16493122 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lrat lecithin retinol acyltransferase multiple interactions
decreases expression
affects expression
increases expression
ISO
EXP
[STRA6 protein co-treated with LRAT protein] results in increased uptake of Vitamin A
Vitamin A results in decreased expression of LRAT mRNA
Vitamin A affects the expression of LRAT mRNA
Vitamin A results in increased expression of LRAT mRNA
[Vitamin A co-treated with Tetrachlorodibenzodioxin] results in increased expression of LRAT mRNA; Tetrachlorodibenzodioxin inhibits the reaction [Vitamin A results in increased expression of LRAT mRNA]
CTD PMID:12576510, PMID:16292751, PMID:18316031, PMID:30944279 NCBI chr 2:181,896,304...181,905,366
Ensembl chr 2:181,896,305...181,905,300
JBrowse link
G Lrp2 LDL receptor related protein 2 multiple interactions ISO LRP2 protein results in increased uptake of and affects the abundance of Vitamin A CTD PMID:16251603 NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions
increases phosphorylation
EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein]; AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein]; Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein] CTD PMID:16510265 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions
increases phosphorylation
EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]; AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]; Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein] CTD PMID:16510265 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased phosphorylation of MAPK1 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of MAPK1 protein]; Vitamin A results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:16043492, PMID:16510265 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased phosphorylation of MAPK3 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of MAPK3 protein]; Vitamin A results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:16043492, PMID:16510265 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mbl2 mannose binding lectin 2 multiple interactions ISO MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene] CTD PMID:16960176 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression ISO Vitamin A affects the expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Meis1 Meis homeobox 1 increases expression
multiple interactions
ISO Vitamin A results in increased expression of MEIS1 mRNA
[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS1 mRNA; RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS1 mRNA]
CTD PMID:16397886, PMID:17034753 NCBI chr14:103,182,178...103,321,809
Ensembl chr14:103,181,281...103,321,270
JBrowse link
G Meis2 Meis homeobox 2 increases expression
multiple interactions
ISO Vitamin A results in increased expression of MEIS2 mRNA
[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS2 mRNA; RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS2 mRNA]
CTD PMID:16397886, PMID:17034753 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589
JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO Vitamin A results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III decreases expression EXP Vitamin A deficiency results in decreased expression of COX3 mRNA CTD PMID:12163651 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO Vitamin A results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Vitamin A results in decreased expression of MYC mRNA CTD PMID:17219422 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Vitamin A affects the reaction [NCOA1 protein binds to PCK1 promoter] CTD PMID:16317119 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Neurog3 neurogenin 3 decreases expression ISO Vitamin A results in decreased expression of NEUROG3 mRNA CTD PMID:30944279 NCBI chr20:31,761,419...31,762,893
Ensembl chr20:31,761,405...31,762,893
JBrowse link
G Nkx2-1 NK2 homeobox 1 multiple interactions ISO
EXP
Vitamin A inhibits the reaction [nitrofen results in decreased expression of NKX2-1 mRNA]
Vitamin A inhibits the reaction [nitrofen results in decreased expression of NKX2-1 protein]
CTD PMID:16490937, PMID:16863852 NCBI chr 6:77,418,096...77,423,383
Ensembl chr 6:77,418,096...77,421,286
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Vitamin A deficiency results in increased expression of NOS2 CTD PMID:16036340 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP Vitamin A deficiency results in increased expression of NOS3 CTD PMID:16036340 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Npy1r neuropeptide Y receptor Y1 increases response to substance ISO NPY1R protein results in increased susceptibility to Vitamin A CTD PMID:17400914 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased abundance of Vitamin A] CTD PMID:31449830 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nrgn neurogranin affects expression EXP Vitamin A affects the expression of NRGN mRNA CTD PMID:14529804 NCBI chr 8:40,015,049...40,023,193
Ensembl chr 8:40,015,049...40,023,193
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression EXP Vitamin A deficiency results in decreased expression of ODC1 mRNA CTD PMID:12163651 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO Vitamin A results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Oprm1 opioid receptor, mu 1 affects expression EXP Vitamin A affects the expression of OPRM1 mRNA; Vitamin A affects the expression of OPRM1 protein CTD PMID:17289162 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pax3 paired box 3 multiple interactions EXP Vitamin A inhibits the reaction [nitrofen results in decreased expression of PAX3 mRNA] CTD PMID:16481245 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 affects expression
multiple interactions
ISO Vitamin A affects the expression of PCK1 mRNA
[Tretinoin co-treated with Alitretinoin] affects the reaction [Vitamin A affects the expression of PCK1 mRNA]; Vitamin A affects the reaction [H3F4 protein modified form binds to PCK1 promoter]; Vitamin A affects the reaction [NCOA1 protein binds to PCK1 promoter]; Vitamin A affects the reaction [PPARA protein binds to PCK1 promoter]; Vitamin A affects the reaction [PPARGC1A protein binds to PCK1 promoter]
CTD PMID:16317119, PMID:16713227 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions ISO [Vitamin A co-treated with INHBA protein] results in increased expression of PDX1 mRNA CTD PMID:17244017 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Pomc proopiomelanocortin increases expression EXP Vitamin A results in increased expression of POMC protein CTD PMID:17373634 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Vitamin A affects the reaction [PPARA protein binds to PCK1 promoter] CTD PMID:16713227 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
EXP Vitamin A inhibits the reaction [Safflower Oil results in increased expression of PPARG mRNA]
Vitamin A results in increased expression of PPARG mRNA
CTD PMID:15203375, PMID:16180333 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Vitamin A affects the reaction [PPARGC1A protein binds to PCK1 promoter] CTD PMID:16317119 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppy pancreatic polypeptide multiple interactions ISO [Vitamin A co-treated with INHBA protein] results in increased expression of PPY mRNA CTD PMID:17244017 NCBI chr10:90,041,582...90,043,316
Ensembl chr10:90,041,591...90,042,877
JBrowse link
G Prm1 protamine 1 decreases expression ISO Vitamin A results in decreased expression of PRM1 mRNA CTD PMID:30944279 NCBI chr10:4,945,995...4,946,241
Ensembl chr10:4,945,911...4,946,397
JBrowse link
G Ptf1a pancreas associated transcription factor 1a multiple interactions ISO [Vitamin A co-treated with INHBA protein] results in increased expression of PTF1A mRNA CTD PMID:17244017 NCBI chr17:86,199,623...86,201,477
Ensembl chr17:86,199,623...86,201,477
JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO Vitamin A binds to PTGDS protein CTD PMID:16461020 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Vitamin A deficiency results in increased expression of PTGS2 CTD PMID:16036340 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 multiple interactions EXP Vitamin A affects the localization of and affects the phosphorylation of PTPN6 protein CTD PMID:15963505 NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions
increases expression
ISO
EXP
[Vitamin A co-treated with RARA protein co-treated with RXRA protein] results in increased expression of CYP26A1 mRNA
[Valproic Acid co-treated with Vitamin A deficiency] affects the expression of RARA protein; [Valproic Acid co-treated with Vitamin A deficiency] affects the reaction [RARA protein binds to RET promoter]
Vitamin A results in increased expression of RARA mRNA
Vitamin A deficiency results in increased expression of RARA mRNA
[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of COL2A1 mRNA; [RARA gene mutant form co-treated with Vitamin A] results in decreased expression of SOX9 mRNA; [RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS1 mRNA; [RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS2 mRNA; RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of COL2A1 mRNA]; RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of SOX9 mRNA]; RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS1 mRNA]; RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS2 mRNA]
CTD PMID:7519440, PMID:16397886, PMID:17034753, PMID:17225872, PMID:17244623, PMID:30944279, PMID:32526256 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarb retinoic acid receptor, beta decreases expression
affects expression
multiple interactions
increases expression
ISO
EXP
Vitamin A results in decreased expression of RARB mRNA
Vitamin A affects the expression of RARB mRNA
Vitamin A deficiency results in decreased expression of RARB mRNA
[R 115866 co-treated with Vitamin A] results in increased expression of RARB mRNA; Tretinoin inhibits the reaction [Vitamin A affects the expression of RARB mRNA]; Vitamin A inhibits the reaction [Safflower Oil results in decreased expression of RARB mRNA]
Vitamin A results in increased expression of RARB mRNA
CTD PMID:7519440, PMID:14529804, PMID:15203375, PMID:15754000, PMID:16530976, PMID:17034753, PMID:17510468, PMID:30944279 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma multiple interactions ISO RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of COL2A1 mRNA]; RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of SOX9 mRNA]; RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS1 mRNA]; RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS2 mRNA] CTD PMID:16397886 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO Vitamin A results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 2:164,650,722...164,684,982
Ensembl chr 2:164,650,722...164,684,985
JBrowse link
G Rbp1 retinol binding protein 1 increases uptake
increases abundance
multiple interactions
affects expression
increases expression
ISO
EXP
RBP1 protein results in increased uptake of Vitamin A
RBP1 gene mutant form results in increased abundance of Vitamin A
[RBP1 gene mutant form results in increased abundance of Vitamin A] which results in increased expression of RBP2 mRNA
Vitamin A affects the expression of RBP1 mRNA
Vitamin A results in increased expression of RBP1 mRNA
CTD PMID:12576510, PMID:16150442, PMID:16793012, PMID:21670153 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842
JBrowse link
G Rbp2 retinol binding protein 2 multiple interactions ISO [RBP1 gene mutant form results in increased abundance of Vitamin A] which results in increased expression of RBP2 mRNA CTD PMID:21670153 NCBI chr 8:106,479,253...106,527,726
Ensembl chr 8:106,503,504...106,527,711
JBrowse link
G Rbp4 retinol binding protein 4 affects binding
multiple interactions
increases secretion
decreases secretion
ISO Vitamin A binds to RBP4 protein
Vitamin A results in decreased expression of and results in decreased secretion of RBP4 protein
Fenretinide analog inhibits the reaction [Vitamin A promotes the reaction [RBP4 protein binds to TTR protein]]; Vitamin A promotes the reaction [RBP4 protein binds to TTR protein]; Vitamin A results in decreased expression of and results in decreased secretion of RBP4 protein
Vitamin A results in increased secretion of RBP4 protein
Vitamin A deficiency results in decreased secretion of RBP4 protein
CTD PMID:16461020, PMID:16762690, PMID:18316031, PMID:21591606, PMID:22001960, PMID:22542753 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Rdh10 retinol dehydrogenase 10 increases oxidation ISO RDH10 protein results in increased oxidation of Vitamin A CTD PMID:17473173 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030
JBrowse link
G Rdh11 retinol dehydrogenase 11 increases oxidation ISO RDH11 protein results in increased oxidation of Vitamin A CTD PMID:16968212 NCBI chr 6:102,356,498...102,372,618
Ensembl chr 6:102,356,492...102,372,611
JBrowse link
G Rdh12 retinol dehydrogenase 12 increases chemical synthesis ISO RDH12 protein results in increased chemical synthesis of Vitamin A CTD PMID:16269441 NCBI chr 6:102,392,828...102,405,750
Ensembl chr 6:102,392,828...102,405,750
JBrowse link
G Rdh5 retinol dehydrogenase 5 increases oxidation ISO RDH5 protein results in increased oxidation of Vitamin A CTD PMID:16968212 NCBI chr 7:3,335,681...3,342,573
Ensembl chr 7:3,335,742...3,342,491
JBrowse link
G Ret ret proto-oncogene multiple interactions EXP [Valproic Acid co-treated with Vitamin A deficiency] affects the expression of RET protein; [Valproic Acid co-treated with Vitamin A deficiency] affects the reaction [RARA protein binds to RET promoter] CTD PMID:32526256 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Retn resistin decreases expression ISO Vitamin A results in decreased expression of RETN mRNA CTD PMID:15047602 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases expression
EXP [perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA
Vitamin A results in increased expression of RHOA mRNA
CTD PMID:15959631 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhob ras homolog family member B multiple interactions
increases expression
EXP [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein
Vitamin A results in increased expression of RHOB mRNA; Vitamin A results in increased expression of RHOB protein
CTD PMID:15959631 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 increases chemical synthesis
increases metabolic processing
ISO RPE65 protein results in increased chemical synthesis of Vitamin A
RPE65 protein results in increased metabolism of Vitamin A
CTD PMID:16150724, PMID:16828753 NCBI chr 2:266,141,581...266,169,197
Ensembl chr 2:266,141,581...266,169,197
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO [Cryptoxanthins co-treated with Vitamin A] results in increased expression of RUNX2 mRNA CTD PMID:15962303 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
increases expression
ISO
EXP
[Vitamin A co-treated with RARA protein co-treated with RXRA protein] results in increased expression of CYP26A1 mRNA
Vitamin A results in increased expression of RXRA mRNA
Vitamin A results in increased expression of RXRA protein
CTD PMID:16180333, PMID:17219422, PMID:17244623 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Rxrb retinoid X receptor beta affects expression EXP Vitamin A affects the expression of RXRB mRNA CTD PMID:14529804 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G Rxrg retinoid X receptor gamma affects expression
decreases expression
increases expression
EXP
ISO
Vitamin A affects the expression of RXRG mRNA
Vitamin A results in decreased expression of RXRG mRNA
Vitamin A results in increased expression of RXRG protein
CTD PMID:14529804, PMID:17219422, PMID:30944279 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 increases oxidation
increases metabolic processing
ISO SDR16C5 protein results in increased oxidation of Vitamin A
SDR16C5 protein results in increased metabolism of Vitamin A
CTD PMID:18926804, PMID:27793605 NCBI chr 5:16,904,926...16,930,111
Ensembl chr 5:16,904,926...16,930,075
JBrowse link
G Sftpb surfactant protein B multiple interactions EXP
ISO
Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]; Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB protein] CTD PMID:11588001, PMID:16490937, PMID:16863852 NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938
JBrowse link
G Sftpc surfactant protein C multiple interactions
decreases expression
EXP Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPC mRNA]
Vitamin A results in decreased expression of SFTPC protein
CTD PMID:11588001 NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO [Vitamin A co-treated with INHBA protein] results in decreased expression of SHH mRNA CTD PMID:17244017 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression
ISO Vitamin A promotes the reaction [Corticosterone results in increased expression of SLC1A2 protein]
Vitamin A results in increased expression of SLC1A2 protein
CTD PMID:17138558 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression EXP Vitamin A deficiency results in decreased expression of SLC30A1 protein CTD PMID:12421840 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc30a2 solute carrier family 30 member 2 multiple interactions EXP [Zinc deficiency co-treated with Vitamin A deficiency] results in increased expression of SLC30A2 mRNA CTD PMID:12421840 NCBI chr 5:152,559,577...152,571,800
Ensembl chr 5:152,559,577...152,571,799
JBrowse link
G Slc30a4 solute carrier family 30 member 4 increases expression EXP Vitamin A deficiency results in increased expression of SLC30A4 mRNA; Vitamin A deficiency results in increased expression of SLC30A4 protein CTD PMID:12421840 NCBI chr 3:114,805,919...114,828,154
Ensembl chr 3:114,805,922...114,828,154
JBrowse link
G Snca synuclein alpha increases expression EXP Vitamin A results in increased expression of SNCA protein CTD PMID:22274401 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sncb synuclein, beta decreases expression EXP Vitamin A results in decreased expression of SNCB protein CTD PMID:22274401 NCBI chr17:10,384,472...10,392,776
Ensembl chr17:10,384,511...10,392,843
JBrowse link
G Sod1 superoxide dismutase 1 increases activity EXP Vitamin A results in increased activity of SOD1 protein CTD PMID:22274401 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases activity EXP Vitamin A results in increased activity of SOD2 protein CTD PMID:22274401 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox17 SRY-box transcription factor 17 multiple interactions ISO [Vitamin A co-treated with INHBA protein] results in increased expression of SOX17 mRNA CTD PMID:17244017 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions ISO [RARA gene mutant form co-treated with Vitamin A] results in decreased expression of SOX9 mRNA; RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of SOX9 mRNA] CTD PMID:16397886 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of SRC protein]; Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of SRC protein] CTD PMID:16510265 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Sst somatostatin multiple interactions
affects expression
ISO
EXP
[Vitamin A co-treated with INHBA protein] results in increased expression of SST mRNA
Vitamin A affects the expression of SST protein
CTD PMID:16757122, PMID:17244017 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects expression EXP Vitamin A affects the expression of STAT3 protein CTD PMID:15963505 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions EXP Vitamin A affects the phosphorylation of and affects the localization of STAT5A protein CTD PMID:15963505 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 multiple interactions
increases transport
ISO [STRA6 protein co-treated with LRAT protein] results in increased uptake of Vitamin A
STRA6 protein results in increased transport of Vitamin A
CTD PMID:18316031 NCBI chr 8:62,925,364...62,944,438
Ensembl chr 8:62,925,357...62,944,437
JBrowse link
G Stra8 stimulated by retinoic acid 8 increases expression ISO Vitamin A results in increased expression of STRA8 mRNA CTD PMID:16461896 NCBI chr 4:62,447,724...62,474,802
Ensembl chr 4:62,457,694...62,473,360
JBrowse link
G Sycp3 synaptonemal complex protein 3 decreases expression ISO Vitamin A results in decreased expression of SYCP3 mRNA CTD PMID:30944279 NCBI chr 7:29,029,887...29,044,344
Ensembl chr 7:29,029,263...29,044,251
JBrowse link
G Tfrc transferrin receptor decreases expression
increases expression
ISO
EXP
Vitamin A results in decreased expression of TFRC protein
Vitamin A deficiency results in increased expression of TFRC mRNA; Vitamin A deficiency results in increased expression of TFRC protein
CTD PMID:16960172, PMID:22154532 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfa transforming growth factor alpha increases expression EXP Vitamin A deficiency results in increased expression of TGFA mRNA CTD PMID:7519440 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression ISO Vitamin A results in increased expression of TGFB3 mRNA CTD PMID:17225872 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO Vitamin A results in decreased expression of TGFBR1 mRNA CTD PMID:17225872 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression ISO Vitamin A results in increased expression of TGFBR2 mRNA CTD PMID:17225872 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tgm2 transglutaminase 2 increases expression
affects expression
ISO
EXP
Vitamin A results in increased expression of TGM2 mRNA
Vitamin A affects the expression of TGM2 mRNA
CTD PMID:14529804, PMID:17034753 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO Vitamin A results in increased expression of TLR2 mRNA CTD PMID:17033190 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 increases expression ISO Vitamin A results in increased expression of TLR4 mRNA CTD PMID:17033190 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tmem245 transmembrane protein 245 decreases expression EXP Vitamin A deficiency results in decreased expression of TMEM245 mRNA CTD PMID:12163651 NCBI chr 5:73,909,032...73,986,602
Ensembl chr 5:73,918,747...73,986,373
JBrowse link
G Tnf tumor necrosis factor affects secretion
increases expression
EXP Vitamin A affects the secretion of TNF protein
Vitamin A results in increased expression of TNF mRNA; Vitamin A results in increased expression of TNF protein
CTD PMID:15135310, PMID:17289162, PMID:22274401 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tob1 transducer of ErbB-2.1 multiple interactions
increases expression
ISO CRABP2 protein promotes the reaction [Vitamin A results in increased expression of TOB1 mRNA] CTD PMID:17234770 NCBI chr10:81,913,689...81,915,727
Ensembl chr10:81,913,689...81,915,716
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Vitamin A results in increased expression of TPI1 mRNA alternative form CTD PMID:8793052 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
JBrowse link
G Ttr transthyretin multiple interactions ISO Fenretinide analog inhibits the reaction [Vitamin A promotes the reaction [RBP4 protein binds to TTR protein]]; Vitamin A promotes the reaction [RBP4 protein binds to TTR protein] CTD PMID:21591606 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Ubc ubiquitin C increases expression EXP Vitamin A deficiency results in increased expression of UBC mRNA CTD PMID:12163651 NCBI chr12:36,638,457...36,642,734
Ensembl chr12:36,638,457...36,642,734
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP [Valproic Acid co-treated with Vitamin A deficiency] affects the expression of UCHL1 protein CTD PMID:32526256 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP LEP gene mutant form promotes the reaction [Vitamin A results in increased expression of UCP1 mRNA] CTD PMID:16493122 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP Vitamin A inhibits the reaction [Triiodothyronine results in decreased expression of UGT1A1 mRNA] CTD PMID:11299074 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
decreases expression
EXP Vitamin A inhibits the reaction [Triiodothyronine results in increased expression of UGT1A6 mRNA]
Vitamin A deficiency results in decreased expression of UGT1A6 mRNA
CTD PMID:11299074, PMID:12163651 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
all-trans-4-oxoretinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 affects expression ISO 4-oxoretinol affects the expression of CDH1 mRNA CTD PMID:17034753 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO 4-oxoretinol results in increased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col4a2 collagen type IV alpha 2 chain increases expression ISO 4-oxoretinol results in increased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr16:83,386,388...83,522,169
Ensembl chr16:83,387,364...83,438,561
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO 4-oxoretinol results in increased expression of CRABP2 mRNA CTD PMID:17034753 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 affects chemical synthesis ISO CYP26A1 protein affects the chemical synthesis of 4-oxoretinol CTD PMID:10557354 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO 4-oxoretinol results in decreased expression of FAS mRNA CTD PMID:17034753 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Foxa1 forkhead box A1 increases expression ISO 4-oxoretinol results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO 4-oxoretinol results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Ivl involucrin increases expression ISO 4-oxoretinol results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577
JBrowse link
G Krt18 keratin 18 increases expression ISO 4-oxoretinol results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt19 keratin 19 increases expression ISO 4-oxoretinol results in increased expression of KRT19 mRNA CTD PMID:17034753 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt7 keratin 7 increases expression ISO 4-oxoretinol results in increased expression of KRT7 mRNA CTD PMID:17034753 NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907
JBrowse link
G Krt8 keratin 8 increases expression ISO 4-oxoretinol results in increased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO 4-oxoretinol results in decreased expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Meis1 Meis homeobox 1 increases expression ISO 4-oxoretinol results in increased expression of MEIS1 mRNA CTD PMID:17034753 NCBI chr14:103,182,178...103,321,809
Ensembl chr14:103,181,281...103,321,270
JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO 4-oxoretinol results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589
JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO 4-oxoretinol results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO 4-oxoretinol results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO 4-oxoretinol results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO 4-oxoretinol results in increased expression of RARA mRNA CTD PMID:17034753 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO 4-oxoretinol results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 2:164,650,722...164,684,982
Ensembl chr 2:164,650,722...164,684,985
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO 4-oxoretinol results in increased expression of TGM2 mRNA CTD PMID:17034753 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
all-trans-retinyl palmitate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase increases activity EXP retinol palmitate results in increased activity of CAT protein CTD PMID:20679000 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions EXP retinol palmitate promotes the reaction [EP300 protein binds to MMP9 protein] CTD PMID:17164434 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Il10 interleukin 10 multiple interactions ISO retinol palmitate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:17377406 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO retinol palmitate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1RN protein] CTD PMID:17377406 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Lipe lipase E, hormone sensitive type increases hydrolysis
multiple interactions
ISO LIPE protein results in increased hydrolysis of retinol palmitate
PLIN3 protein inhibits the reaction [LIPE protein results in increased hydrolysis of retinol palmitate]
CTD PMID:16741517 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
EXP retinol palmitate promotes the reaction [EP300 protein binds to MMP9 protein]; retinol palmitate promotes the reaction [RARA protein binds to MMP9 protein]
retinol palmitate results in increased expression of MMP9 mRNA
CTD PMID:17164434 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Plin3 perilipin 3 multiple interactions ISO PLIN3 protein inhibits the reaction [LIPE protein results in increased hydrolysis of retinol palmitate]; PLIN3 protein inhibits the reaction [PNPLA4 protein results in increased hydrolysis of retinol palmitate] CTD PMID:16741517 NCBI chr 9:10,769,739...10,781,659
Ensembl chr 9:10,773,901...10,781,109
JBrowse link
G Pnpla4 patatin like phospholipase domain containing 4 increases hydrolysis
multiple interactions
ISO PNPLA4 protein results in increased hydrolysis of retinol palmitate
PLIN3 protein inhibits the reaction [PNPLA4 protein results in increased hydrolysis of retinol palmitate]
CTD PMID:16741517 NCBI chr  X:45,519,406...45,522,988
Ensembl chr  X:45,519,228...45,522,665
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions EXP retinol palmitate promotes the reaction [RARA protein binds to MMP9 protein] CTD PMID:17164434 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression EXP retinol palmitate results in increased expression of SCARB1 mRNA CTD PMID:17299104 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
retinyl acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B increases expression ISO retinol acetate results in increased expression of ACVR2B mRNA CTD PMID:16772331 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions
ISO retinol acetate results in decreased expression of ADIPOQ mRNA
NR1I3 protein affects the reaction [retinol acetate results in decreased expression of ADIPOQ mRNA]
CTD PMID:31449830 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Alb albumin affects binding ISO retinol acetate binds to ALB protein CTD PMID:17217919 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apoe apolipoprotein E increases expression ISO retinol acetate results in increased expression of APOE mRNA CTD PMID:16772331 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member increases expression ISO retinol acetate results in increased expression of BCAR1 mRNA CTD PMID:16772331 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO retinol acetate results in increased expression of BMP4 mRNA CTD PMID:16772331 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmp7 bone morphogenetic protein 7 increases expression ISO retinol acetate results in increased expression of BMP7 mRNA CTD PMID:16772331 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Calm1 calmodulin 1 increases expression ISO retinol acetate results in increased expression of CALM1 mRNA CTD PMID:16772331 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Cbl Cbl proto-oncogene increases expression ISO retinol acetate results in increased expression of CBL mRNA CTD PMID:16772331 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Ccnb2 cyclin B2 increases expression ISO retinol acetate results in increased expression of CCNB2 mRNA CTD PMID:16772331 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 increases expression ISO retinol acetate results in increased expression of CCND1 mRNA CTD PMID:16772331 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 increases expression ISO retinol acetate results in increased expression of CCNE1 mRNA CTD PMID:16772331 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cd36 CD36 molecule decreases expression
multiple interactions
ISO retinol acetate results in decreased expression of CD36 mRNA
NR1I3 protein affects the reaction [retinol acetate results in decreased expression of CD36 mRNA]
CTD PMID:31449830 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdx2 caudal type homeo box 2 increases expression ISO retinol acetate results in increased expression of CDX2 mRNA CTD PMID:16772331 NCBI chr12:9,464,026...9,470,565
Ensembl chr12:9,464,026...9,470,565
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO retinol acetate results in increased expression of CKS2 mRNA CTD PMID:16772331 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Crk CRK proto-oncogene, adaptor protein increases expression ISO retinol acetate results in increased expression of CRK mRNA CTD PMID:16772331 NCBI chr10:63,829,731...63,855,999
Ensembl chr10:63,829,807...63,852,780
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases expression ISO retinol acetate results in increased expression of CSNK2A1 mRNA CTD PMID:16772331 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Ctsb cathepsin B increases expression ISO retinol acetate results in increased expression of CTSB mRNA CTD PMID:16772331 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsd cathepsin D increases expression ISO retinol acetate results in increased expression of CTSD mRNA CTD PMID:16772331 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO retinol acetate results in decreased expression of CYP1A1 mRNA CTD PMID:28123100 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO [retinol acetate co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of CYP26A1 mRNA; [retinol acetate co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of CYP26A1 protein; BMS453 inhibits the reaction [retinol acetate results in increased expression of CYP26A1 mRNA]; NR1I3 protein affects the reaction [[retinol acetate co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of CYP26A1 mRNA]; NR1I3 protein affects the reaction [[retinol acetate co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of CYP26A1 protein]; NR1I3 protein affects the reaction [retinol acetate results in increased expression of CYP26A1 mRNA] CTD PMID:16322074, PMID:31449830 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression
multiple interactions
ISO retinol acetate results in decreased expression of CYP2B10 mRNA
[bisphenol A co-treated with retinol acetate] results in increased expression of CYP2B10 mRNA
CTD PMID:28123100 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of CYP2E1 mRNA CTD PMID:28123100 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dcn decorin increases expression ISO retinol acetate results in increased expression of DCN mRNA CTD PMID:16772331 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Dlx3 distal-less homeobox 3 increases expression ISO retinol acetate results in increased expression of DLX3 mRNA CTD PMID:16772331 NCBI chr10:82,937,971...82,943,367
Ensembl chr10:82,937,971...82,943,348
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO retinol acetate results in increased expression of DNAJC3 mRNA CTD PMID:16772331 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO retinol acetate results in increased expression of E2F3 mRNA CTD PMID:16772331 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO retinol acetate results in increased expression of EI24 mRNA CTD PMID:16772331 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Eng endoglin increases expression ISO retinol acetate results in increased expression of ENG mRNA CTD PMID:16772331 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor increases expression ISO retinol acetate results in increased expression of ETS2 mRNA CTD PMID:16772331 NCBI chr11:36,075,709...36,092,495
Ensembl chr11:36,075,709...36,092,495
JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 increases expression ISO retinol acetate results in increased expression of EYA2 mRNA CTD PMID:16772331 NCBI chr 3:162,285,275...162,470,642
Ensembl chr 3:162,346,490...162,470,065
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression ISO retinol acetate results in increased expression of FGFR3 mRNA CTD PMID:16772331 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions
decreases expression
ISO [bisphenol A co-treated with retinol acetate] results in decreased expression of FMO3 mRNA
retinol acetate results in decreased expression of FMO3 mRNA
CTD PMID:28123100 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Foxg1 forkhead box G1 increases expression ISO retinol acetate results in increased expression of FOXG1 mRNA CTD PMID:16772331 NCBI chr 6:69,971,227...69,974,037
Ensembl chr 6:69,971,227...69,974,037
JBrowse link
G Frzb frizzled-related protein increases expression ISO retinol acetate results in increased expression of FRZB mRNA CTD PMID:16772331 NCBI chr 3:67,635,604...67,668,772
Ensembl chr 3:67,635,607...67,668,772
JBrowse link
G Fxn frataxin increases expression ISO retinol acetate results in increased expression of FXN mRNA CTD PMID:16772331 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834
JBrowse link
G Fzd3 frizzled class receptor 3 increases expression ISO retinol acetate results in increased expression of FZD3 mRNA CTD PMID:16772331 NCBI chr15:48,601,259...48,670,257
Ensembl chr15:48,601,266...48,670,257
JBrowse link
G Fzd6 frizzled class receptor 6 increases expression ISO retinol acetate results in increased expression of FZD6 mRNA CTD PMID:16772331 NCBI chr 7:77,898,329...77,931,034
Ensembl chr 7:77,899,322...77,931,029
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO retinol acetate results in increased expression of GADD45A mRNA CTD PMID:16772331 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO retinol acetate results in increased expression of GAPDH mRNA CTD PMID:16772331 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression ISO retinol acetate results in increased expression of HES1 mRNA CTD PMID:16772331 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression ISO retinol acetate results in increased expression of HPRT1 mRNA CTD PMID:16772331 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like increases expression ISO retinol acetate results in increased expression of HSPA4L mRNA CTD PMID:16772331 NCBI chr 2:127,625,737...127,682,864
Ensembl chr 2:127,625,683...127,677,503
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO retinol acetate results in increased expression of HSPH1 mRNA CTD PMID:16772331 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO retinol acetate results in increased expression of ID3 mRNA CTD PMID:16772331 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Il4 interleukin 4 increases expression ISO retinol acetate results in increased expression of IL4 protein CTD PMID:11444878 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 affects response to substance
increases expression
ISO IL5 protein affects the susceptibility to retinol acetate
retinol acetate results in increased expression of IL5 protein
CTD PMID:11444878 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il5ra interleukin 5 receptor subunit alpha affects response to substance ISO IL5RA protein affects the susceptibility to retinol acetate CTD PMID:11444878 NCBI chr 4:138,796,165...138,834,164
Ensembl chr 4:138,795,327...138,830,117
JBrowse link
G Il6 interleukin 6 increases expression ISO retinol acetate results in increased expression of IL6 protein CTD PMID:11444878 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO retinol acetate results in increased expression of JUND mRNA CTD PMID:16772331 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kif1b kinesin family member 1B increases expression ISO retinol acetate results in increased expression of KIF1B mRNA CTD PMID:16772331 NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491
JBrowse link
G Kl Klotho increases expression ISO retinol acetate results in increased expression of KL mRNA CTD PMID:16772331 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Lama5 laminin subunit alpha 5 increases expression ISO retinol acetate results in increased expression of LAMA5 mRNA CTD PMID:16772331 NCBI chr 3:175,553,042...175,601,112
Ensembl chr 3:175,553,045...175,601,127
JBrowse link
G Laptm4a lysosomal protein transmembrane 4 alpha increases expression ISO retinol acetate results in increased expression of LAPTM4A mRNA CTD PMID:16772331 NCBI chr 6:34,042,132...34,059,960
Ensembl chr 6:34,028,936...34,059,961
JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO retinol acetate results in increased expression of LIFR mRNA CTD PMID:16772331 NCBI chr 2:56,424,910...56,489,346
Ensembl chr 2:56,426,367...56,489,415
JBrowse link
G Lrat lecithin retinol acyltransferase multiple interactions ISO [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in decreased expression of CYP2C39 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of CYP2E1 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of CYP4A10 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of MGST1 mRNA; [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of UGT1A1 mRNA; retinol acetate inhibits the reaction [LRAT gene mutant form results in decreased susceptibility to Thioacetamide] CTD PMID:24614237, PMID:28123100 NCBI chr 2:181,896,304...181,905,366
Ensembl chr 2:181,896,305...181,905,300
JBrowse link
G Ltbr lymphotoxin beta receptor increases expression ISO retinol acetate results in increased expression of LTBR mRNA CTD PMID:16772331 NCBI chr 4:157,822,838...157,829,291
Ensembl chr 4:157,822,840...157,829,241
JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 increases expression ISO retinol acetate results in increased expression of MAP3K3 mRNA CTD PMID:16772331 NCBI chr10:94,280,703...94,349,372
Ensembl chr10:94,280,703...94,349,368
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression ISO retinol acetate results in increased expression of MAPK14 mRNA CTD PMID:16772331 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases expression ISO retinol acetate results in increased expression of MAPKAPK2 mRNA CTD PMID:16772331 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO retinol acetate results in increased expression of MET mRNA CTD PMID:16772331 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression
multiple interactions
ISO retinol acetate results in increased expression of MGST1 mRNA
[LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of MGST1 mRNA
CTD PMID:28123100 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO retinol acetate results in increased expression of MMP2 mRNA CTD PMID:16772331 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Msx1 msh homeobox 1 increases expression ISO retinol acetate results in increased expression of MSX1 mRNA CTD PMID:16772331 NCBI chr14:77,712,262...77,716,061
Ensembl chr14:77,712,240...77,716,059
JBrowse link
G Msx2 msh homeobox 2 increases expression ISO retinol acetate results in increased expression of MSX2 mRNA CTD PMID:16772331 NCBI chr17:11,683,862...11,689,527
Ensembl chr17:11,683,862...11,689,527
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor increases expression ISO retinol acetate results in increased expression of MYCN mRNA CTD PMID:16772331 NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379
JBrowse link
G Myo1b myosin Ib increases expression ISO retinol acetate results in increased expression of MYO1B mRNA CTD PMID:16772331 NCBI chr 9:54,706,005...54,766,054
Ensembl chr 9:54,558,202...54,766,054
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO retinol acetate results in increased expression of NFKBIA mRNA CTD PMID:16772331 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nid1 nidogen 1 increases expression ISO retinol acetate results in increased expression of NID1 mRNA CTD PMID:16772331 NCBI chr17:90,553,161...90,627,133
Ensembl chr17:90,553,394...90,627,101
JBrowse link
G Notch1 notch receptor 1 increases expression ISO retinol acetate results in increased expression of NOTCH1 mRNA CTD PMID:16772331 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Notch2 notch receptor 2 increases expression ISO retinol acetate results in increased expression of NOTCH2 mRNA CTD PMID:16772331 NCBI chr 2:200,187,184...200,320,403
Ensembl chr 2:200,187,179...200,320,215
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [[retinol acetate co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of CYP26A1 mRNA]; NR1I3 protein affects the reaction [[retinol acetate co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of CYP26A1 protein]; NR1I3 protein affects the reaction [[retinol acetate co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of PPARG mRNA]; NR1I3 protein affects the reaction [retinol acetate results in decreased expression of ADIPOQ mRNA]; NR1I3 protein affects the reaction [retinol acetate results in decreased expression of CD36 mRNA]; NR1I3 protein affects the reaction [retinol acetate results in increased expression of CYP26A1 mRNA] CTD PMID:31449830 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 increases expression ISO retinol acetate results in increased expression of PEA15A mRNA CTD PMID:16772331 NCBI chr13:90,579,844...90,589,466
Ensembl chr13:90,579,846...90,589,466
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression ISO retinol acetate results in increased expression of PHGDH mRNA CTD PMID:16772331 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO retinol acetate results in increased expression of PIK3R1 mRNA CTD PMID:16772331 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [retinol acetate co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of PPARG mRNA; NR1I3 protein affects the reaction [[retinol acetate co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of PPARG mRNA] CTD PMID:31449830 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Psen2 presenilin 2 increases expression ISO retinol acetate results in increased expression of PSEN2 mRNA CTD PMID:16772331 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 increases expression ISO retinol acetate results in increased expression of PTPN13 mRNA CTD PMID:16772331 NCBI chr14:7,688,551...7,863,664
Ensembl chr14:7,688,551...7,863,664
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression ISO retinol acetate results in increased expression of RAD50 mRNA CTD PMID:16772331 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Rangap1 RAN GTPase activating protein 1 increases expression ISO retinol acetate results in increased expression of RANGAP1 mRNA CTD PMID:16772331 NCBI chr 7:122,939,266...122,967,178
Ensembl chr 7:122,940,376...122,967,178
JBrowse link
G Rbp4 retinol binding protein 4 increases expression ISO retinol acetate results in increased expression of RBP4 protein CTD PMID:31449830 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Ror1 receptor tyrosine kinase-like orphan receptor 1 increases expression ISO retinol acetate results in increased expression of ROR1 mRNA CTD PMID:16772331 NCBI chr 5:118,892,874...119,239,528
Ensembl chr 5:119,097,715...119,241,733
JBrowse link
G Rxra retinoid X receptor alpha increases expression ISO retinol acetate results in increased expression of RXRA mRNA CTD PMID:16772331 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Satb1 SATB homeobox 1 increases expression ISO retinol acetate results in increased expression of SATB1 mRNA CTD PMID:16772331 NCBI chr 9:2,181,135...2,277,949
Ensembl chr 9:2,190,915...2,274,629
JBrowse link
G Sdc1 syndecan 1 increases expression ISO retinol acetate results in increased expression of SDC1 mRNA CTD PMID:16772331 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Sim2 SIM bHLH transcription factor 2 increases expression ISO retinol acetate results in increased expression of SIM2 mRNA CTD PMID:16772331 NCBI chr11:34,315,739...34,355,183
Ensembl chr11:34,316,295...34,354,027
JBrowse link
G Smn1 survival of motor neuron 1, telomeric increases expression ISO retinol acetate results in increased expression of SMN1 mRNA CTD PMID:16772331 NCBI chr 2:30,360,101...30,371,147
Ensembl chr 2:30,360,100...30,371,147
JBrowse link
G Snai1 snail family transcriptional repressor 1 increases expression ISO retinol acetate results in increased expression of SNAI1 mRNA CTD PMID:16772331 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO retinol acetate results in increased expression of SNAI2 mRNA CTD PMID:16772331 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO retinol acetate results in increased expression of SQSTM1 mRNA CTD PMID:16772331 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tbx2 T-box transcription factor 2 increases expression ISO retinol acetate results in increased expression of TBX2 mRNA CTD PMID:16772331 NCBI chr10:73,278,932...73,290,764
Ensembl chr10:73,279,119...73,289,921
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression ISO retinol acetate results in increased expression of TIMP3 mRNA CTD PMID:16772331 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase increases expression ISO retinol acetate results in increased expression of TYRO3 mRNA CTD PMID:16772331 NCBI chr 3:111,597,102...111,616,142
Ensembl chr 3:111,597,102...111,616,142
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of UGT1A1 mRNA CTD PMID:28123100 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Wnt11 Wnt family member 11 increases expression ISO retinol acetate results in increased expression of WNT11 mRNA CTD PMID:16772331 NCBI chr 1:163,794,136...163,813,756
Ensembl chr 1:163,797,660...163,813,756
JBrowse link
G Wnt7b Wnt family member 7B increases expression ISO retinol acetate results in increased expression of WNT7B mRNA CTD PMID:16772331 NCBI chr 7:126,423,418...126,465,724
Ensembl chr 7:126,420,656...126,465,723
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta increases expression ISO retinol acetate results in increased expression of YWHAZ mRNA CTD PMID:16772331 NCBI chr 7:75,573,553...75,598,295
Ensembl chr 7:75,574,967...75,597,276
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          carbon atom 19563
            organic molecular entity 19563
              olefinic compound 14457
                allylic alcohol 940
                  primary allylic alcohol 655
                    all-trans-retinol 281
                      all-trans-3,4-didehydroretinol + 0
                      all-trans-3-hydroxyretinol 0
                      all-trans-4-hydroxyretinol 0
                      all-trans-4-oxoretinol 22
                      all-trans-retinyl ester + 10
                      all-trans-retinyl linoleate 0
                      all-trans-retinyl oleate 0
                      all-trans-retinyl palmitate 10
                      all-trans-retinyl stearate 0
                      retinyl acetate 97
                      vitamin A + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  terpene 9594
                                    diterpene 8426
                                      diterpenoid 8426
                                        retinoid 7850
                                          retinol 282
                                            all-trans-retinol 281
                                              all-trans-3,4-didehydroretinol + 0
                                              all-trans-3-hydroxyretinol 0
                                              all-trans-4-hydroxyretinol 0
                                              all-trans-4-oxoretinol 22
                                              all-trans-retinyl ester + 10
                                              all-trans-retinyl linoleate 0
                                              all-trans-retinyl oleate 0
                                              all-trans-retinyl palmitate 10
                                              all-trans-retinyl stearate 0
                                              retinyl acetate 97
                                              vitamin A + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.