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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:linalool
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Accession:CHEBI:17580 term browser browse the term
Definition:A monoterpenoid that is octa-1,6-diene substituted by methyl groups at positions 3 and 7 and a hydroxy group at position 3. It has been isolated from plants like Ocimum canum.
Synonyms:related_synonym: 2,6-dimethylocta-2,7-dien-6-ol;   3,7-Dimethylocta-1,6-dien-3-ol;   Formula=C10H18O;   InChI=1S/C10H18O/c1-5-10(4,11)8-6-7-9(2)3/h5,7,11H,1,6,8H2,2-4H3;   InChIKey=CDOSHBSSFJOMGT-UHFFFAOYSA-N;   SMILES=CC(C)=CCCC(C)(O)C=C;   beta-linalool;   linalyl alcohol
 alt_id: CHEBI:11712;   CHEBI:1417;   CHEBI:19917
 xref: BPDB:2150;   Beilstein:1362385;   CAS:78-70-6;   Gmelin:406448;   HMDB:HMDB0036100;   KEGG:C03985;   KNApSAcK:C00003047;   LIPID_MAPS_instance:LMPR0102010004
 xref_mesh: MESH:C018584
 xref: PMID:18695915;   PMID:24570447;   PMID:24758511;   Reaxys:1362385;   VSDB:2150;   Wikipedia:Linalool


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linalool term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 increases expression ISO linalool results in increased expression of ACO1 mRNA CTD PMID:24752549 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Aco2 aconitase 2 increases expression ISO linalool results in increased expression of ACO2 mRNA CTD PMID:24752549 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
increases expression
ISO PPARA protein promotes the reaction [linalool results in increased expression of ACOX1 protein]
linalool results in increased expression of ACOX1 mRNA; linalool results in increased expression of ACOX1 protein
PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACOX1 protein]
CTD PMID:24752549 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions
increases expression
ISO PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACSL1 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACSL1 protein]
linalool results in increased expression of ACSL1 mRNA; linalool results in increased expression of ACSL1 protein
PPARA protein promotes the reaction [linalool results in increased expression of ACSL1 protein]
CTD PMID:24752549 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO linalool results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression ISO linalool results in increased expression of AKT1 mRNA CTD PMID:19922762 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression EXP linalool results in decreased expression of ALAS2 mRNA CTD PMID:20536181 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit decreases expression EXP linalool results in decreased expression of APH1B mRNA CTD PMID:20536181 NCBI chr 8:72,508,008...72,598,921
Ensembl chr 8:72,476,425...72,629,265
JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO linalool results in increased expression of APOA1 mRNA CTD PMID:24752549 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression ISO linalool results in decreased expression of APOC3 mRNA; linalool results in decreased expression of APOC3 protein CTD PMID:24752549 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Ar androgen receptor multiple interactions ISO linalool inhibits the reaction [Testosterone results in increased activity of AR protein] CTD PMID:31393563 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atf2 activating transcription factor 2 increases expression ISO linalool results in increased expression of ATF2 mRNA CTD PMID:19922762 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO linalool results in increased expression of BAK1 mRNA CTD PMID:28567457 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO linalool results in increased expression of BAX mRNA CTD PMID:26703569, PMID:28567457 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO linalool results in decreased expression of BCL2 mRNA CTD PMID:28567457 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO linalool results in decreased expression of BCL2L1 mRNA CTD PMID:28567457 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO linalool results in increased expression of BIRC2 mRNA CTD PMID:19922762 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO linalool results in increased expression of BIRC3 mRNA CTD PMID:19922762 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
ISO linalool results in increased expression of CASP3 mRNA
linalool results in increased activity of CASP3 protein
CTD PMID:26703569, PMID:28567457 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases expression ISO linalool results in increased expression of CASP8 mRNA CTD PMID:26703569 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases expression
increases activity
ISO linalool results in increased expression of CASP9 mRNA
linalool results in increased activity of CASP9 protein
CTD PMID:26703569, PMID:28567457 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of CAT protein] CTD PMID:30466616 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd86 CD86 molecule increases expression ISO linalool metabolite results in increased expression of CD86 protein CTD PMID:29029310 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdh1 cadherin 1 increases expression ISO linalool results in increased expression of CDH1 mRNA CTD PMID:26703569 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO linalool results in increased expression of CDKN1A mRNA CTD PMID:19922762, PMID:26703569 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO linalool results in increased expression of CDKN1B mRNA CTD PMID:19922762 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO linalool results in increased expression of CDKN1C mRNA CTD PMID:19922762 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO linalool results in increased expression of CDKN2A mRNA CTD PMID:26703569 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO linalool results in increased expression of CDKN2B mRNA CTD PMID:19922762 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C increases expression ISO linalool results in increased expression of CDKN2C mRNA CTD PMID:26703569 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP linalool results in increased expression of CEBPB mRNA CTD PMID:20536181 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP linalool results in increased expression of CEBPD mRNA CTD PMID:20536181 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression EXP linalool results in increased expression of COL10A1 mRNA CTD PMID:20536181 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633
JBrowse link
G Csn2 casein beta increases expression ISO linalool results in increased expression of CSN2 mRNA CTD PMID:19922762 NCBI chr14:21,972,274...21,979,511
Ensembl chr14:21,972,274...21,979,510
JBrowse link
G Ctsd cathepsin D increases expression
multiple interactions
ISO linalool results in increased expression of CTSD mRNA
Fulvestrant inhibits the reaction [linalool results in increased expression of CTSD mRNA]
CTD PMID:19922762, PMID:31393563 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO linalool results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO linalool results in increased expression of CYP27A1 mRNA CTD PMID:24752549 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression ISO linalool results in increased expression of DHCR7 mRNA CTD PMID:24752549 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression EXP linalool results in increased expression of DNAJB1 mRNA CTD PMID:20536181 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 increases expression ISO linalool results in increased expression of ECHS1 mRNA CTD PMID:24752549 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Edn1 endothelin 1 increases expression ISO linalool results in increased expression of EDN1 mRNA CTD PMID:19922762 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO linalool results in increased expression of EGFR mRNA CTD PMID:19922762 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 decreases expression ISO linalool results in decreased expression of ELOVL3 mRNA CTD PMID:24752549 NCBI chr 1:265,883,353...265,887,181
Ensembl chr 1:265,883,355...265,887,226
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO linalool results in increased activity of ESR1 protein CTD PMID:31393563 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO linalool results in increased expression of FABP1 mRNA CTD PMID:24752549 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fn1 fibronectin 1 increases expression ISO linalool results in increased expression of FN1 mRNA CTD PMID:19922762 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP linalool results in increased expression of FOS mRNA CTD PMID:20536181 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 increases expression EXP linalool results in increased expression of GABBR1 mRNA CTD PMID:20536181 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO linalool results in increased expression of GADD45A mRNA; linalool results in increased expression of GADD45A protein CTD PMID:19922762 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO linalool results in increased expression of GCLC mRNA CTD PMID:20491607 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [linalool results in increased expression of GREB1 mRNA] CTD PMID:31393563 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Hbb hemoglobin subunit beta decreases expression EXP linalool results in decreased expression of HBB mRNA CTD PMID:20536181 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression
ISO linalool inhibits the reaction [KAT2B protein binds to HMGCR promoter]; linalool inhibits the reaction [SREBF2 protein binds to HMGCR promoter]; linalool results in decreased expression of and results in increased ubiquitination of HMGCR protein
linalool results in decreased expression of HMGCR mRNA; linalool results in decreased expression of HMGCR protein
CTD PMID:21944868, PMID:24613879 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO linalool metabolite results in increased expression of HMOX1 mRNA CTD PMID:29029310 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP linalool results in increased expression of HOMER1 mRNA CTD PMID:20536181 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Hsf1 heat shock transcription factor 1 increases expression ISO linalool results in increased expression of HSF1 mRNA CTD PMID:19922762 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO linalool results in increased expression of HSP90AA1 mRNA CTD PMID:19922762 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression EXP linalool results in increased expression of HSPA1L mRNA CTD PMID:20536181 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO linalool results in increased expression of HSPA4 mRNA CTD PMID:19922762 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP linalool results in increased expression of HSPB1 mRNA CTD PMID:20536181 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspb2 heat shock protein family B (small) member 2 increases expression ISO linalool results in increased expression of HSPB2 mRNA CTD PMID:19922762 NCBI chr 8:55,176,648...55,178,227
Ensembl chr 8:55,176,847...55,177,818
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression EXP linalool results in increased expression of HSPH1 mRNA CTD PMID:20536181 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
ISO linalool metabolite results in increased expression of ICAM1 protein
linalool inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
CTD PMID:29029310, PMID:29276222 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO linalool results in increased expression of ID2 mRNA CTD PMID:19922762 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO linalool results in increased expression of INSIG1 protein CTD PMID:21944868 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insig2 insulin induced gene 2 increases expression ISO linalool results in increased expression of INSIG2 mRNA CTD PMID:24752549 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO linalool results in increased expression of JUN protein CTD PMID:19922762 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kat2b lysine acetyltransferase 2B multiple interactions ISO linalool inhibits the reaction [KAT2B protein binds to HMGCR promoter] CTD PMID:21944868 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Lipa lipase A, lysosomal acid type increases expression ISO linalool results in increased expression of LIPA mRNA CTD PMID:24752549 NCBI chr 1:252,816,536...252,959,348
Ensembl chr 1:252,816,527...252,849,904
JBrowse link
G Lpl lipoprotein lipase increases expression
multiple interactions
ISO linalool results in increased expression of LPL mRNA; linalool results in increased expression of LPL protein
PPARA gene mutant form inhibits the reaction [linalool results in increased expression of LPL mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of LPL protein]
PPARA protein promotes the reaction [linalool results in increased expression of LPL protein]
CTD PMID:24752549 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO linalool metabolite results in increased phosphorylation of MAPK1 protein CTD PMID:29029310 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO linalool metabolite results in increased phosphorylation of MAPK3 protein CTD PMID:29029310 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression EXP linalool results in increased expression of MARCKS mRNA CTD PMID:20536181 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mcee methylmalonyl CoA epimerase decreases expression ISO linalool results in decreased expression of MCEE mRNA CTD PMID:24752549 NCBI chr 1:125,229,487...125,252,692
Ensembl chr 1:125,229,469...125,252,666
JBrowse link
G Mdh2 malate dehydrogenase 2 increases expression ISO linalool results in increased expression of MDH mRNA CTD PMID:24752549 NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO linalool results in increased expression of MDM2 mRNA CTD PMID:19922762 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO linalool results in increased expression of MMP9 mRNA CTD PMID:26703569 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpz myelin protein zero decreases expression EXP linalool results in decreased expression of MPZ mRNA CTD PMID:20536181 NCBI chr13:89,524,204...89,530,070
Ensembl chr13:89,524,329...89,530,068
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO linalool results in increased expression of MYC mRNA CTD PMID:19922762 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO linalool metabolite results in increased expression of and results in increased activity of NFE2L2 protein CTD PMID:29029310 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO linalool results in increased expression of NFKB1 mRNA CTD PMID:19922762 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Npy neuropeptide Y increases expression EXP
ISO
linalool results in increased expression of NPY mRNA
linalool results in increased expression of NPY protein
CTD PMID:22757684 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO linalool metabolite results in increased expression of NQO1 mRNA CTD PMID:29029310 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO linalool results in increased expression of PCK2 mRNA CTD PMID:24752549 NCBI chr15:34,216,735...34,224,357
Ensembl chr15:34,216,833...34,224,193
JBrowse link
G Pgm1 phosphoglucomutase 1 increases expression ISO linalool results in increased expression of PGM1 mRNA CTD PMID:24752549 NCBI chr 5:118,743,632...118,803,055
Ensembl chr 5:118,743,632...118,803,055
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [linalool results in increased expression of PGR mRNA] CTD PMID:31393563 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phf1 PHD finger protein 1 decreases expression ISO linalool results in decreased expression of PHF1 mRNA CTD PMID:27683099 NCBI chr20:5,526,926...5,531,940
Ensembl chr20:5,526,961...5,531,941
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
increases response to substance
decreases response to substance
multiple interactions
ISO linalool results in increased expression of PPARA mRNA; linalool results in increased expression of PPARA protein
PPARA protein results in increased susceptibility to linalool
PPARA gene mutant form results in decreased susceptibility to linalool
linalool binds to and results in increased activity of PPARA protein; PPARA protein promotes the reaction [linalool results in increased expression of ACOX1 protein]; PPARA protein promotes the reaction [linalool results in increased expression of ACSL1 protein]; PPARA protein promotes the reaction [linalool results in increased expression of LPL protein]; PPARA protein promotes the reaction [linalool results in increased expression of SLC27A4 protein]; PPARA protein promotes the reaction [linalool results in increased expression of UCP2 protein]
PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACOX1 protein]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACSL1 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of ACSL1 protein]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of LPL mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of LPL protein]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of SLC27A4 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of SLC27A4 protein]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of UCP2 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of UCP2 protein]
CTD PMID:24752549 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Psmd9 proteasome 26S subunit, non-ATPase 9 increases expression ISO linalool results in increased expression of PSMD9 mRNA CTD PMID:26703569 NCBI chr12:38,786,539...38,805,121
Ensembl chr12:38,786,540...38,805,121
JBrowse link
G Pxmp4 peroxisomal membrane protein 4 decreases expression EXP linalool results in decreased expression of PXMP4 mRNA CTD PMID:20536181 NCBI chr 3:150,091,646...150,108,893
Ensembl chr 3:150,091,630...150,108,898
JBrowse link
G RGD1559459 similar to Expressed sequence AI788959 multiple interactions ISO linalool inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA] CTD PMID:31393563 NCBI chr14:22,932,454...22,955,663
Ensembl chr14:22,937,421...22,952,822
JBrowse link
G Rgs5 regulator of G-protein signaling 5 increases expression EXP linalool results in increased expression of RGS5 mRNA CTD PMID:20536181 NCBI chr13:87,966,820...88,002,831
Ensembl chr13:87,966,758...88,003,035
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of RUNX2 mRNA] CTD PMID:30466616 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Rusf1 RUS family member 1 increases expression EXP linalool results in increased expression of RUSF1 mRNA CTD PMID:20536181 NCBI chr 1:199,687,775...199,716,205
Ensembl chr 1:199,687,778...199,716,205
JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression ISO linalool results in decreased expression of RUVBL2 mRNA CTD PMID:27683099 NCBI chr 1:101,413,766...101,426,970
Ensembl chr 1:101,413,766...101,426,852
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression EXP linalool results in decreased expression of S100A9 mRNA CTD PMID:20536181 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO linalool inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:84,335,594...84,360,354
Ensembl chr14:84,335,597...84,355,528
JBrowse link
G Sele selectin E multiple interactions ISO linalool inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:29276222 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sirt3 sirtuin 3 decreases expression
multiple interactions
ISO linalool results in decreased expression of SIRT3 mRNA; linalool results in decreased expression of SIRT3 protein
linalool inhibits the reaction [SOD2 protein binds to SIRT3 protein]
CTD PMID:28567457 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Slc20a1 solute carrier family 20 member 1 multiple interactions EXP linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of SLC20A1 mRNA] CTD PMID:30466616 NCBI chr 3:121,725,204...121,739,160
Ensembl chr 3:121,725,859...121,739,173
JBrowse link
G Slc27a4 solute carrier family 27 member 4 multiple interactions
increases expression
ISO PPARA gene mutant form inhibits the reaction [linalool results in increased expression of SLC27A4 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of SLC27A4 protein]
linalool results in increased expression of SLC27A4 mRNA; linalool results in increased expression of SLC27A4 protein
PPARA protein promotes the reaction [linalool results in increased expression of SLC27A4 protein]
CTD PMID:24752549 NCBI chr 3:8,363,937...8,376,858
Ensembl chr 3:8,363,937...8,376,858
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression EXP linalool results in decreased expression of SLC6A3 mRNA CTD PMID:20536181 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO linalool inhibits the reaction [SOD2 protein binds to SIRT3 protein]; linalool results in decreased activity of and results in increased acetylation of SOD2 protein CTD PMID:28567457 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox11 SRY-box transcription factor 11 increases expression EXP linalool results in increased expression of SOX11 mRNA CTD PMID:20536181 NCBI chr 6:46,629,967...46,631,988
Ensembl chr 6:46,629,974...46,631,983
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of SPP1 mRNA] CTD PMID:30466616 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Sqle squalene epoxidase increases expression ISO linalool results in increased expression of SQLE mRNA CTD PMID:24752549 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions
decreases expression
ISO linalool inhibits the reaction [SREBF2 protein binds to HMGCR promoter]
linalool results in decreased expression of SREBF2 mRNA; linalool results in decreased expression of SREBF2 protein
CTD PMID:21944868 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Th tyrosine hydroxylase decreases expression EXP linalool results in decreased expression of TH mRNA CTD PMID:20536181 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO linalool inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; linalool inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; linalool inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:29276222 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression
increases response to substance
ISO linalool results in increased expression of TP53 mRNA; linalool results in increased expression of TP53 protein
TP53 results in increased susceptibility to linalool
CTD PMID:19922762, PMID:26703569 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO linalool results in increased activity of TRPA1 protein CTD PMID:27735854 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Tshb thyroid stimulating hormone subunit beta decreases expression EXP linalool results in decreased expression of TSHB mRNA CTD PMID:20536181 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO linalool results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions
increases expression
ISO PPARA protein promotes the reaction [linalool results in increased expression of UCP2 protein]
PPARA gene mutant form inhibits the reaction [linalool results in increased expression of UCP2 mRNA]; PPARA gene mutant form inhibits the reaction [linalool results in increased expression of UCP2 protein]
linalool results in increased expression of UCP2 mRNA; linalool results in increased expression of UCP2 protein
CTD PMID:24752549 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of linalool CTD PMID:7574722 NCBI chr14:22,553,633...22,591,461
Ensembl chr14:22,553,650...22,591,461
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO linalool inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:29276222 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vof16 ischemia related factor vof-16 increases expression EXP linalool results in increased expression of VOF16 mRNA CTD PMID:20536181 NCBI chr 8:45,798,356...45,800,462 JBrowse link
G Wnt1 Wnt family member 1 increases expression ISO linalool results in increased expression of WNT1 mRNA CTD PMID:19922762 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link
G Wsb1 WD repeat and SOCS box-containing 1 increases expression ISO linalool results in increased expression of WSB1 mRNA CTD PMID:19922762 NCBI chr10:66,586,905...66,602,984
Ensembl chr10:66,586,924...66,602,987
JBrowse link
(R)-linalyl acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO linalyl acetate inhibits the reaction [Testosterone results in increased activity of AR protein] CTD PMID:31393563 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ctsd cathepsin D increases expression
multiple interactions
ISO linalyl acetate results in increased expression of CTSD mRNA
Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of CTSD mRNA]
CTD PMID:31393563 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
ISO linalyl acetate results in increased activity of ESR1 protein
NCOA2 protein promotes the reaction [linalyl acetate results in increased activity of ESR1 protein]
CTD PMID:31393563 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 increases expression
multiple interactions
ISO linalyl acetate results in increased expression of GREB1 mRNA
Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of GREB1 mRNA]
CTD PMID:31393563 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] CTD PMID:29276222 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO NCOA2 protein promotes the reaction [linalyl acetate results in increased activity of ESR1 protein] CTD PMID:31393563 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO linalyl acetate results in increased expression of PGR mRNA
Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of PGR mRNA]
CTD PMID:31393563 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of and affects the localization of RELA protein modified form] CTD PMID:29276222 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G RGD1559459 similar to Expressed sequence AI788959 multiple interactions ISO linalyl acetate inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA] CTD PMID:31393563 NCBI chr14:22,932,454...22,955,663
Ensembl chr14:22,937,421...22,952,822
JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO linalyl acetate inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:84,335,594...84,360,354
Ensembl chr14:84,335,597...84,355,528
JBrowse link
G Sele selectin E multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:29276222 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Selp selectin P multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELP mRNA] CTD PMID:29276222 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of and affects the localization of RELA protein modified form]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELP mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:29276222 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:29276222 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
linalyl acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO linalyl acetate inhibits the reaction [Testosterone results in increased activity of AR protein] CTD PMID:31393563 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ctsd cathepsin D increases expression
multiple interactions
ISO linalyl acetate results in increased expression of CTSD mRNA
Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of CTSD mRNA]
CTD PMID:31393563 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
ISO NCOA2 protein promotes the reaction [linalyl acetate results in increased activity of ESR1 protein] CTD PMID:31393563 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of GREB1 mRNA] CTD PMID:31393563 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] CTD PMID:29276222 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO NCOA2 protein promotes the reaction [linalyl acetate results in increased activity of ESR1 protein] CTD PMID:31393563 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of PGR mRNA] CTD PMID:31393563 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of and affects the localization of RELA protein modified form] CTD PMID:29276222 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G RGD1559459 similar to Expressed sequence AI788959 multiple interactions ISO linalyl acetate inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA] CTD PMID:31393563 NCBI chr14:22,932,454...22,955,663
Ensembl chr14:22,937,421...22,952,822
JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO linalyl acetate inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:84,335,594...84,360,354
Ensembl chr14:84,335,597...84,355,528
JBrowse link
G Sele selectin E multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:29276222 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Selp selectin P multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELP mRNA] CTD PMID:29276222 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of and affects the localization of RELA protein modified form]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of SELP mRNA]; linalyl acetate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:29276222 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO linalyl acetate inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:29276222 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          linalool 122
            (R)-linalool 0
            (S)-linalool 0
            3,7-dimethylocta-1,6-dien-3-yl acetate + 14
            linalool hydroperoxide + 0
            linaloyl diphosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  terpene 9607
                                    monoterpene 1219
                                      monoterpenoid 1188
                                        linalool 122
                                          (R)-linalool 0
                                          (S)-linalool 0
                                          3,7-dimethylocta-1,6-dien-3-yl acetate + 14
                                          linalool hydroperoxide + 0
                                          linaloyl diphosphate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.