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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diiodine
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Accession:CHEBI:17606 term browser browse the term
Definition:Molecule comprising two covalently bonded iodine atoms with overall zero charge..
Synonyms:related_synonym: Formula=I2;   I2;   InChI=1S/I2/c1-2;   InChIKey=PNDPGZBMCMUPRI-UHFFFAOYSA-N;   Iodine;   Jod;   SMILES=II;   molecular iodine
 alt_id: CHEBI:14461;   CHEBI:5947
 xref: Beilstein:3587194;   CAS:7553-56-2;   Drug_Central:4446;   Gmelin:1160;   KEGG:C01382;   KEGG:D00108
 xref_mesh: MESH:D007455
 xref: PMID:15206581;   PMID:19672279;   PMID:20045605;   PMID:24504625


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diiodine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of ALDH1L1 protein CTD PMID:30090431 NCBI chr 4:123,516,553...123,564,067
Ensembl chr 4:123,516,788...123,557,501
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of ALDH5A1 protein CTD PMID:30090431 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BAX protein CTD PMID:17173243 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BCL2 protein CTD PMID:17173243 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased activity of CASP3 protein CTD PMID:17173243 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cd86 CD86 molecule increases expression EXP Iodine results in increased expression of CD86 mRNA CTD PMID:19035182 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 decreases expression EXP Iodine deficiency results in decreased expression of CDK5R1 protein CTD PMID:22987596 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Clcn5 chloride voltage-gated channel 5 increases abundance
increases uptake
ISO CLCN5 gene mutant form results in increased abundance of Iodine
CLCN5 gene mutant form results in increased uptake of Iodine
CTD PMID:16306076 NCBI chr  X:16,170,585...16,196,691
Ensembl chr  X:16,050,780...16,196,789
JBrowse link
G Cldn5 claudin 5 multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of CLDN5 protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein; [Selenium co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein; Iodine results in increased expression of and results in increased localization of CLDN5 protein CTD PMID:16514648 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Iodine results in increased expression of COL1A1 mRNA CTD PMID:22083529 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of CTH protein CTD PMID:30090431 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in decreased expression of CYB5A protein CTD PMID:30090431 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [Iodine deficiency co-treated with Propylthiouracil] results in increased expression of CYP2B10 mRNA CTD PMID:22503787 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity
multiple interactions
increases expression
decreases expression
ISO
EXP
Iodine results in decreased activity of DIO1 protein
Methylnitrosourea inhibits the reaction [Iodine results in increased expression of DIO1 mRNA]
Selenium inhibits the reaction [Iodine results in decreased activity of DIO1 protein]; Selenium inhibits the reaction [Iodine results in decreased expression of DIO1 mRNA]
CTD PMID:15922087, PMID:17044649 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Iodine results in increased expression of FOS mRNA; Iodine results in increased expression of FOS protein
[Selenium co-treated with Iodine] results in increased expression of FOS mRNA; [Selenium co-treated with Iodine] results in increased expression of FOS protein
CTD PMID:12475444, PMID:12666833 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in decreased expression of FTCD protein CTD PMID:30090431 NCBI chr20:12,806,957...12,820,466
Ensembl chr20:12,806,957...12,820,466
JBrowse link
G Gamt guanidinoacetate N-methyltransferase multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of GAMT protein CTD PMID:30090431 NCBI chr 7:12,314,848...12,317,998
Ensembl chr 7:12,314,848...12,317,998
JBrowse link
G Ifng interferon gamma multiple interactions EXP [Iodine co-treated with Dibutyl Phthalate] results in increased expression of IFNG protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IFNG protein] CTD PMID:29385629 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il17a interleukin 17A multiple interactions EXP [Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein] CTD PMID:29385629 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL1B protein CTD PMID:29385629 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 increases expression EXP Iodine results in increased expression of IL2 protein CTD PMID:19035182 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL6 protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL6 protein] CTD PMID:29385629 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Iodine results in increased expression of JUN mRNA; Iodine results in increased expression of JUN protein
[Iodine co-treated with Dibutyl Phthalate] results in increased phosphorylation of and results in increased activity of JUN protein; [Selenium co-treated with Iodine] results in increased expression of JUN mRNA; [Selenium co-treated with Iodine] results in increased expression of JUN protein
CTD PMID:12475444, PMID:12666833, PMID:29385629 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Krt18 keratin 18 multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of KRT18 protein CTD PMID:30090431 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Lep leptin multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased secretion of LHB protein CTD PMID:30090431 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Map1b microtubule-associated protein 1B decreases expression EXP Iodine deficiency results in decreased expression of MAP1B protein CTD PMID:27444543 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Mbp myelin basic protein decreases expression
multiple interactions
ISO Iodine results in decreased expression of MBP mRNA
Selenium inhibits the reaction [Iodine results in decreased expression of MBP mRNA]
CTD PMID:16229266 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Iodine deficiency results in increased expression of and results in decreased phosphorylation of NFKBIA protein CTD PMID:27444543 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [[Iodine deficiency co-treated with Propylthiouracil] results in decreased expression of CYP3A11 mRNA] CTD PMID:22503787 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ocln occludin multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of OCLN protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of OCLN protein; [Selenium co-treated with Iodine] results in increased expression of and results in increased localization of OCLN protein; Iodine results in increased expression of and results in increased localization of OCLN protein CTD PMID:16514648 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON1 protein; [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of PON1 protein CTD PMID:30090431 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pon2 paraoxonase 2 multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON2 protein CTD PMID:30090431 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Iodine deficiency results in decreased expression of and results in decreased phosphorylation of RELA protein CTD PMID:27444543 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Serpina7 serpin family A member 7 multiple interactions EXP [Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein] CTD PMID:29385629 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Slc26a4 solute carrier family 26 member 4 increases expression
multiple interactions
EXP Iodine results in increased expression of SLC26A4 mRNA
Methylnitrosourea promotes the reaction [Iodine results in increased expression of SLC26A4 mRNA]
CTD PMID:15922087 NCBI chr 6:50,809,103...50,848,443
Ensembl chr 6:50,808,923...50,846,965
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions
increases uptake
affects transport
ISO
EXP
2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; [[Butyrates co-treated with decitabine] results in increased expression of SLC5A5 mRNA] which results in increased uptake of Iodine; captax inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; cypermethrin inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; decamethrin inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; Dibutyl Phthalate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; Indomethacin inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; polymarcine inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; potassium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; sodium thiocyanate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; triclocarban inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]
SLC5A5 protein affects the transport of Iodine
CTD PMID:12602914, PMID:17332617, PMID:17408651, PMID:17967635, PMID:27979590 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Tf transferrin multiple interactions ISO [ferric pyrophosphate co-treated with Iodine] results in increased expression of TF protein CTD PMID:16772442 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [ferric pyrophosphate co-treated with Iodine] results in increased expression of TFRC protein CTD PMID:16772442 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Thra thyroid hormone receptor alpha increases expression
multiple interactions
ISO Iodine results in increased expression of THRA mRNA
Selenium inhibits the reaction [Iodine results in increased expression of THRA mRNA]
CTD PMID:17555094 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta increases expression
multiple interactions
ISO Iodine results in increased expression of THRB mRNA
Selenium inhibits the reaction [Iodine results in increased expression of THRB mRNA]
CTD PMID:17555094 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of TJP1 protein; Iodine results in increased expression of and results in increased localization of TJP1 protein CTD PMID:16514648 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Iodine inhibits the reaction [Mustard Gas results in increased expression of TNF protein] CTD PMID:16001271 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
increases secretion
affects abundance
ISO
EXP
efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]; Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]; sodium perchlorate inhibits the reaction [efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]]; sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]]
[Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of TSHB protein
Iodine deficiency results in increased secretion of TSHB protein
CTD PMID:16030158, PMID:20882593, PMID:30090431 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        physiological role 19757
          food component 19757
            nutrient 19752
              diiodine 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      molecular entity 19814
        elemental molecular entity 16247
          elemental halogen 9213
            elemental iodine 134
              diatomic iodine 44
                diiodine 44
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.