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ONTOLOGY REPORT - ANNOTATIONS


Term:ferroheme b
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Accession:CHEBI:17627 term browser browse the term
Definition:Heme b in which the iron has oxidation state +2.
Synonyms:exact_synonym: (protoporphyrinato)iron(II)
 related_synonym: Fe(ppIX);   Formula=C34H32FeN4O4;   Haem;   Heme;   InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;   InChIKey=KABFMIBPWCXCRK-RGGAHWMASA-L;   Protoheme;   SMILES=CC1=C(CCC(O)=O)C2=[N+]3C1=Cc1c(C)c(C=C)c4C=C5C(C)=C(C=C)C6=[N+]5[Fe--]3(n14)n1c(=C6)c(C)c(CCC(O)=O)c1=C2;   [3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2-)]iron(II);   ferroprotoheme;   ferroprotoporphyrin IX;   ferrous protoheme;   ferrous protoheme IX;   iron(II) protoporphyrin IX;   protoferroheme
 alt_id: CHEBI:14957;   CHEBI:5651
 xref: Beilstein:953574 "Beilstein";   CAS:14875-96-8 "ChemIDplus";   CAS:14875-96-8 "KEGG COMPOUND";   Gmelin:95291 "Gmelin";   KEGG:C00032
 xref_mesh: MESH:D006418
 xref: PDB:3KS0;   PDBeChem:HEM;   PMID:20546754 "Europe PMC";   YMDB:YMDB00041
 cyclic_relationship: is_conjugate_acid_of CHEBI:60344


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ferroheme b term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb6 ATP binding cassette subfamily B member 6 JBrowse link 9 82,373,950 82,382,228 RGD:6480464
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:6480464
G Alas1 5'-aminolevulinate synthase 1 JBrowse link 8 114,927,704 114,941,038 RGD:6480464
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Ambp alpha-1-microglobulin/bikunin precursor JBrowse link 5 78,975,690 78,986,021 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Arhgap31 Rho GTPase activating protein 31 JBrowse link 11 64,600,968 64,714,114 RGD:6480464
G Asb1 ankyrin repeat and SOCS box-containing 1 JBrowse link 9 98,668,231 98,689,471 RGD:6480464
G Asxl2 ASXL transcriptional regulator 2 JBrowse link 6 27,835,346 27,919,285 RGD:6480464
G Atp7b ATPase copper transporting beta JBrowse link 16 74,865,516 74,944,935 RGD:6480464
G Bcar3 BCAR3 adaptor protein, NSP family member JBrowse link 2 226,563,050 226,679,449 RGD:6480464
G Blvra biliverdin reductase A JBrowse link 3 119,552,550 119,577,796 RGD:6480464
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:6480464
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:6480464
G Camk2g calcium/calmodulin-dependent protein kinase II gamma JBrowse link 15 3,936,721 3,995,740 RGD:6480464
G Car1 carbonic anhydrase 1 JBrowse link 2 88,185,204 88,227,486 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Ccl6 chemokine (C-C motif) ligand 6 JBrowse link 10 70,798,118 70,802,750 RGD:6480464
G Ccs copper chaperone for superoxide dismutase JBrowse link 1 220,075,251 220,096,319 RGD:6480464
G Cd2 Cd2 molecule JBrowse link 2 203,666,706 203,680,073 RGD:6480464
G Cel carboxyl ester lipase JBrowse link 3 7,134,021 7,141,522 RGD:6480464
G Clca1 chloride channel accessory 1 JBrowse link 2 250,897,980 250,923,711 RGD:6480464
G Cnot9 CCR4-NOT transcription complex subunit 9 JBrowse link 9 81,783,349 81,808,815 RGD:6480464
G Cops5 COP9 signalosome subunit 5 JBrowse link 5 8,876,090 8,894,345 RGD:6480464
G Cpox coproporphyrinogen oxidase JBrowse link 11 44,039,665 44,049,648 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Cxcl2 C-X-C motif chemokine ligand 2 JBrowse link 14 18,731,346 18,733,391 RGD:6480464
G Cyb5a cytochrome b5 type A JBrowse link 18 81,694,818 81,726,821 RGD:6480464
G Dgcr8 DGCR8 microprocessor complex subunit JBrowse link 11 86,852,682 86,885,233 RGD:6480464
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 JBrowse link 10 88,498,271 88,533,730 RGD:6480464
G Dner delta/notch-like EGF repeat containing JBrowse link 9 91,965,866 92,291,172 RGD:6480464
G Dusp14 dual specificity phosphatase 14 JBrowse link 10 71,363,688 71,383,602 RGD:6480464
G Dusp2 dual specificity phosphatase 2 JBrowse link 3 119,776,925 119,779,110 RGD:6480464
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma JBrowse link X 63,268,106 63,291,125 RGD:6480464
G Eno2 enolase 2 JBrowse link 4 157,285,192 157,294,090 RGD:6480464
G Ereg epiregulin JBrowse link 14 18,577,620 18,591,395 RGD:6480464
G Esrra estrogen related receptor, alpha JBrowse link 1 222,168,729 222,178,842 RGD:6480464
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Fabp2 fatty acid binding protein 2 JBrowse link 2 227,080,912 227,083,654 RGD:6480464
G Fabp3 fatty acid binding protein 3 JBrowse link 5 148,528,854 148,535,597 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Fxyd4 FXYD domain-containing ion transport regulator 4 JBrowse link 4 149,984,206 149,988,744 RGD:6480464
G Gfod1 glucose-fructose oxidoreductase domain containing 1 JBrowse link 17 23,818,370 23,924,393 RGD:6480464
G Gipc1 GIPC PDZ domain containing family, member 1 JBrowse link 19 24,786,604 24,798,231 RGD:6480464
G Gpr176 G protein-coupled receptor 176 JBrowse link 3 110,042,853 110,140,756 RGD:6480464
G Gprc5a G protein-coupled receptor, class C, group 5, member A JBrowse link 4 168,832,937 168,851,650 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 JBrowse link 2 181,045,694 181,103,321 RGD:6480464
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 JBrowse link 2 180,976,939 181,026,001 RGD:6480464
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 JBrowse link 5 135,860,578 135,870,535 RGD:6480464
G Hk3 hexokinase 3 JBrowse link 17 10,134,726 10,152,976 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hpx hemopexin JBrowse link 1 170,423,558 170,431,066 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il1rl1 interleukin 1 receptor-like 1 JBrowse link 9 47,133,483 47,184,316 RGD:6480464
G Il20 interleukin 20 JBrowse link 13 47,644,071 47,651,487 RGD:6480464
G Il7r interleukin 7 receptor RGD:6480464
G Irf3 interferon regulatory factor 3 JBrowse link 1 100,992,244 100,997,202 RGD:6480464
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:6480464
G Itln1 intelectin 1 JBrowse link 13 89,919,570 89,929,774 RGD:6480464
G Krt20 keratin 20 JBrowse link 10 87,342,514 87,351,045 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:6480464
G Lyz2 lysozyme 2 JBrowse link 7 60,335,968 60,341,264 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Mptx1 mucosal pentraxin 1 JBrowse link 13 91,772,927 91,827,231 RGD:6480464
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6480464
G Mtf1 metal-regulatory transcription factor 1 JBrowse link 5 142,797,340 142,843,896 RGD:6480464
G Mtmr10 myotubularin related protein 10 JBrowse link 1 125,124,743 125,175,857 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Ngb neuroglobin JBrowse link 6 111,126,259 111,131,699 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Pars2 prolyl-tRNA synthetase 2, mitochondrial JBrowse link 5 126,254,090 126,259,204 RGD:6480464
G Pcsk2 proprotein convertase subtilisin/kexin type 2 JBrowse link 3 137,618,891 137,923,385 RGD:6480464
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6480464
G Pgap2 post-GPI attachment to proteins 2 JBrowse link 1 167,309,021 167,335,550 RGD:6480464
G Phlda1 pleckstrin homology-like domain, family A, member 1 JBrowse link 7 54,247,460 54,249,664 RGD:6480464
G Pja2 praja ring finger ubiquitin ligase 2 JBrowse link 9 111,998,204 112,048,847 RGD:6480464
G Plekhm1 pleckstrin homology and RUN domain containing M1 JBrowse link 10 91,451,890 91,500,675 RGD:6480464
G Plekho1 pleckstrin homology domain containing O1 JBrowse link 2 198,112,104 198,120,202 RGD:6480464
G Plk2 polo-like kinase 2 JBrowse link 2 41,911,143 41,916,901 RGD:6480464
G Plxna2 plexin A2 JBrowse link 13 113,373,569 113,570,774 RGD:6480464
G Pomt1 protein-O-mannosyltransferase 1 JBrowse link 3 11,253,424 11,271,873 RGD:6480464
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:6480464
G Ppie peptidylprolyl isomerase E JBrowse link 5 140,822,141 140,835,244 RGD:6480464
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 JBrowse link 18 74,173,809 74,291,188 RGD:6480464
G Rab33a RAB33A, member RAS oncogene family JBrowse link X 135,348,799 135,360,204 RGD:6480464
G Rab3a RAB3A, member RAS oncogene family JBrowse link 16 20,435,098 20,439,206 RGD:6480464
G Rbm39 RNA binding motif protein 39 JBrowse link 3 151,691,498 151,724,723 RGD:6480464
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rhebl1 RHEB like 1 JBrowse link 7 140,552,704 140,556,980 RGD:6480464
G Rpap1 RNA polymerase II associated protein 1 JBrowse link 3 111,565,646 111,587,184 RGD:6480464
G Rps6ka2 ribosomal protein S6 kinase A2 JBrowse link 1 53,219,346 53,499,445 RGD:6480464
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:6480464
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:6480464
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 JBrowse link 2 196,495,867 196,527,412 RGD:6480464
G Slamf7 SLAM family member 7 JBrowse link 13 90,056,726 90,075,159 RGD:6480464
G Slc46a1 solute carrier family 46 member 1 JBrowse link 10 65,728,508 65,741,708 RGD:6480464
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 JBrowse link 20 13,679,955 13,702,821 RGD:6480464
G Smc4 structural maintenance of chromosomes 4 JBrowse link 2 165,600,934 165,629,415 RGD:6480464
G Srp9 signal recognition particle 9 JBrowse link 13 100,551,307 100,559,447 RGD:6480464
G Stard4 StAR-related lipid transfer domain containing 4 JBrowse link 18 25,982,210 25,997,555 RGD:6480464
G Taf7 TATA-box binding protein associated factor 7 JBrowse link 18 30,779,149 30,781,297 RGD:6480464
G Tdo2 tryptophan 2,3-dioxygenase JBrowse link 2 180,897,059 180,914,919 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfsf13b TNF superfamily member 13b JBrowse link 16 85,275,690 85,306,419 RGD:6480464
G Tollip toll interacting protein JBrowse link 1 214,823,993 214,844,861 RGD:6480464
G Tuba4a tubulin, alpha 4A JBrowse link 9 82,415,599 82,419,918 RGD:6480464
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 JBrowse link 11 88,047,186 88,088,477 RGD:6480464
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 JBrowse link 5 57,472,315 57,530,973 RGD:6480464
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 JBrowse link 10 81,936,156 81,943,142 RGD:6480464
G Yeats2 YEATS domain containing 2 JBrowse link 11 84,330,064 84,595,296 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        biochemical role 19138
          cofactor 15848
            ferroheme b 121
              ferrocytochrome b + 0
              heme d cis-diol + 0
              heme d trans-diol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organonitrogen heterocyclic compound 16961
                                    polypyrrole 590
                                      tetrapyrrole 478
                                        cyclic tetrapyrrole 347
                                          porphyrins 328
                                            metalloporphyrin 303
                                              heme 202
                                                heme b 202
                                                  ferroheme b 121
                                                    ferrocytochrome b + 0
                                                    heme d cis-diol + 0
                                                    heme d trans-diol 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.