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ONTOLOGY REPORT - ANNOTATIONS


Term:cortisol
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Accession:CHEBI:17650 term browser browse the term
Definition:A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the 'stress hormone' as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses
Synonyms:exact_synonym: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione
 related_synonym: (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione;   11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione;   11beta-hydrocortisone;   17-hydroxycorticosterone;   4-pregnen-11beta,17alpha,21-triol-3,20-dione;   Formula=C21H30O5;   InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1;   InChIKey=JYGXADMDTFJGBT-VWUMJDOOSA-N;   Kendall's compound F;   Reichstein's substance M;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO;   hidrocortisona;   hydrocortisone;   hydrocortisonum
 alt_id: CHEBI:14023;   CHEBI:24633;   CHEBI:3893;   CHEBI:58221
 xref: Beilstein:1354819 "Beilstein";   CAS:50-23-7 "ChemIDplus";   CAS:50-23-7 "KEGG COMPOUND";   CAS:50-23-7 "NIST Chemistry WebBook";   DrugBank:DB00741;   Drug_Central:1388 "DrugCentral";   KEGG:C00735;   KEGG:D00088;   LINCS:LSM-5980;   LIPID_MAPS_instance:LMST02030001 "LIPID MAPS"
 xref_mesh: MESH:D006854
 xref: PDBeChem:HCY;   PMID:10438974 "Europe PMC";   PMID:2268561 "Europe PMC";   Patent:US2602769;   Wikipedia:Hydrocortisone


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cortisol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Acaca acetyl-CoA carboxylase alpha JBrowse link 10 71,519,392 71,719,910 RGD:6480464
G Ackr1 atypical chemokine receptor 1 JBrowse link 13 91,827,310 91,828,875 RGD:6480464
G Acly ATP citrate lyase JBrowse link 10 88,392,248 88,442,845 RGD:6480464
G Adam12 ADAM metallopeptidase domain 12 JBrowse link 1 205,951,840 206,286,294 RGD:6480464
G Adgre5 adhesion G protein-coupled receptor E5 JBrowse link 19 24,854,981 24,875,712 RGD:6480464
G Adgrg1 adhesion G protein-coupled receptor G1 JBrowse link 19 10,423,534 10,460,674 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Akr1d1 aldo-keto reductase family 1, member D1 JBrowse link 4 65,110,706 65,143,930 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6480464
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:6480464
G Apob apolipoprotein B JBrowse link 6 33,176,826 33,216,381 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Arg1 arginase 1 JBrowse link 1 21,525,421 21,537,872 RGD:6480464
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 1 178,039,002 178,137,469 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6480464
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6480464
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:6480464
G Cd80 Cd80 molecule JBrowse link 11 64,815,201 64,855,293 RGD:6480464
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:6480464
G Cdh5 cadherin 5 JBrowse link 19 1,025,122 1,074,333 RGD:6480464
G Cebpa CCAAT/enhancer binding protein alpha JBrowse link 1 91,363,492 91,366,164 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Col7a1 collagen type VII alpha 1 chain JBrowse link 8 117,694,441 117,726,844 RGD:6480464
G Cpt1a carnitine palmitoyltransferase 1A JBrowse link 1 218,568,157 218,629,679 RGD:6480464
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:6480464
G Cry1 cryptochrome circadian regulator 1 JBrowse link 7 24,534,593 24,634,098 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:6480464
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 JBrowse link 1 82,595,211 82,610,350 RGD:6480464
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 JBrowse link 12 11,641,500 11,677,818 RGD:6480464
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:6480464
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6480464
G Errfi1 ERBB receptor feedback inhibitor 1 JBrowse link 5 167,951,564 167,966,011 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Fkbp5 FKBP prolyl isomerase 5 JBrowse link 20 7,976,704 8,097,290 RGD:6480464
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gh1 growth hormone 1 JBrowse link 10 94,486,204 94,488,181 RGD:6480464
G Gnpat glyceronephosphate O-acyltransferase JBrowse link 19 57,614,813 57,640,524 RGD:6480464
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:6480464
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:6480464
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) JBrowse link 5 166,994,683 167,030,441 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6480464
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:6480464
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 JBrowse link 13 111,946,626 111,996,536 RGD:6480464
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 JBrowse link 19 37,476,083 37,481,326 RGD:6480464
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:6480464
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6480464
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:6480464
G Igfbp1 insulin-like growth factor binding protein 1 JBrowse link 14 87,448,716 87,453,783 RGD:6480464
G Igfbp5 insulin-like growth factor binding protein 5 JBrowse link 9 80,154,230 80,166,813 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Itga10 integrin subunit alpha 10 JBrowse link 2 198,772,937 198,792,253 RGD:6480464
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:6480464
G Klk1 kallikrein 1 JBrowse link 1 100,131,562 100,135,556 RGD:6480464
G Lcn11 lipocalin 11 JBrowse link 3 2,935,396 2,938,883 RGD:6480464
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:6480464
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:6480464
G Ly75 lymphocyte antigen 75 JBrowse link 3 46,369,749 46,457,182 RGD:6480464
G Maoa monoamine oxidase A JBrowse link X 6,554,698 6,620,722 RGD:6480464
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Npy neuropeptide Y JBrowse link 4 79,557,856 79,565,059 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:6480464
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 19 34,408,275 34,761,003 RGD:6480464
G Nr6a1 nuclear receptor subfamily 6, group A, member 1 JBrowse link 3 23,029,222 23,218,050 RGD:6480464
G Ocln occludin JBrowse link 2 30,527,327 30,577,218 RGD:6480464
G Oxt oxytocin/neurophysin I prepropeptide JBrowse link 3 123,106,694 123,107,534 RGD:6480464
G Pck1 phosphoenolpyruvate carboxykinase 1 JBrowse link 3 171,213,936 171,219,885 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Per1 period circadian regulator 1 JBrowse link 10 55,681,761 55,696,557 RGD:6480464
G Pnpla2 patatin-like phospholipase domain containing 2 JBrowse link 1 214,434,638 214,439,720 RGD:6480464
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Prune2 prune homolog 2 with BCH domain JBrowse link 1 236,676,963 236,947,527 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:6480464
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:6480464
G Rbbp7 RB binding protein 7, chromatin remodeling factor JBrowse link X 33,648,682 33,665,821 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G Rora RAR-related orphan receptor A JBrowse link 8 75,515,886 75,616,477 RGD:6480464
G Scarb1 scavenger receptor class B, member 1 JBrowse link 12 36,694,952 36,761,445 RGD:6480464
G Scnn1a sodium channel epithelial 1 alpha subunit JBrowse link 4 157,834,339 157,860,472 RGD:6480464
G Scnn1b sodium channel epithelial 1 beta subunit JBrowse link 1 191,829,547 191,883,991 RGD:6480464
G Scnn1g sodium channel epithelial 1 gamma subunit JBrowse link 1 191,704,397 191,738,271 RGD:6480464
G Serpinb1a serpin family B member 1A JBrowse link 17 32,903,089 32,911,498 RGD:6480464
G Serpinc1 serpin family C member 1 JBrowse link 13 78,806,107 78,820,375 RGD:6480464
G Sftpb surfactant protein B JBrowse link 4 100,166,855 100,175,941 RGD:6480464
G Sftpc surfactant protein C JBrowse link 15 52,211,538 52,214,480 RGD:6480464
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc23a2 solute carrier family 23 member 2 JBrowse link 3 124,632,491 124,842,225 RGD:6480464
G Slc5a5 solute carrier family 5 member 5 JBrowse link 16 20,297,414 20,307,401 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:6480464
G Tat tyrosine aminotransferase JBrowse link 19 41,675,639 41,686,195 RGD:6480464
G Tbx19 T-box transcription factor 19 JBrowse link 13 83,403,263 83,426,305 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tgm1 transglutaminase 1 JBrowse link 15 34,378,136 34,393,150 RGD:6480464
G Tjp1 tight junction protein 1 JBrowse link 1 126,146,489 126,515,359 RGD:6480464
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:6480464
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Treh trehalase JBrowse link 8 48,983,802 48,998,072 RGD:6480464
G Tsc22d3 TSC22 domain family, member 3 JBrowse link X 111,884,285 111,944,693 RGD:6480464
G Ucn2 urocortin 2 JBrowse link 8 117,727,216 117,728,765 RGD:6480464
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 JBrowse link 14 22,724,399 22,736,148 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:6480464
G Zfp36 zinc finger protein 36 JBrowse link 1 85,380,088 85,382,565 RGD:6480464
11-deoxycortisol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:6480464
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 JBrowse link 7 116,155,928 116,161,781 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:6480464
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 19 34,408,275 34,761,003 RGD:6480464
hydrocortisone succinate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        anti-inflammatory agent 14910
          anti-inflammatory drug 13596
            cortisol 154
              20beta-dihydrocortisol 0
              6beta-hydroxycortisol 0
              cortisol ester + 0
              deoxycortisol + 5
              hydrocortisone caproate 0
              hydrocortisone succinate 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      ketone 15784
                                        oxyketone 8440
                                          alpha-oxyketone 8440
                                            alpha-hydroxy ketone 8440
                                              primary alpha-hydroxy ketone 7436
                                                cortisol 154
                                                  20beta-dihydrocortisol 0
                                                  6beta-hydroxycortisol 0
                                                  cortisol ester + 0
                                                  deoxycortisol + 5
                                                  hydrocortisone caproate 0
                                                  hydrocortisone succinate 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.