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ONTOLOGY REPORT - ANNOTATIONS


Term:7,9-dihydro-1H-purine-2,6,8(3H)-trione
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Accession:CHEBI:17775 term browser browse the term
Definition:An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Synonyms:related_synonym: 2,6,8-trioxopurine;   2,6,8-trioxypurine;   Formula=C5H4N4O3;   InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12);   InChIKey=LEHOTFFKMJEONL-UHFFFAOYSA-N;   SMILES=O=c1[nH]c2[nH]c(=O)[nH]c(=O)c2[nH]1;   URIC ACID;   Urate;   purine-2,6,8(1H,3H,9H)-trione
 alt_id: CHEBI:46455;   CHEBI:9885
 xref: Beilstein:156158 "Beilstein";   CAS:69-93-2 "KEGG COMPOUND";   CAS:69-93-2 "NIST Chemistry WebBook";   DrugBank:DB01696;   Gmelin:241332 "Gmelin";   HMDB:HMDB0000289;   KEGG:C00366;   KNApSAcK:C00007301
 xref_mesh: MESH:D014527
 xref: MetaCyc:URATE;   PDBeChem:URC;   PMID:22770225 "Europe PMC";   Reaxys:156158 "Reaxys";   Wikipedia:Uric_acid
 cyclic_relationship: is_tautomer_of CHEBI:46811;   is_tautomer_of CHEBI:46814;   is_tautomer_of CHEBI:46817;   is_tautomer_of CHEBI:46823;   is_tautomer_of CHEBI:49051


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7,9-dihydro-1H-purine-2,6,8(3H)-trione term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A1cf APOBEC1 complementation factor JBrowse link 1 250,426,027 250,514,245 RGD:6480464
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:6480464
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:6480464
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:6480464
G Aldh16a1 aldehyde dehydrogenase 16 family, member A1 JBrowse link 1 101,138,237 101,151,320 RGD:6480464
G Alpk1 alpha-kinase 1 JBrowse link 2 231,997,360 232,117,471 RGD:6480464
G Apln apelin JBrowse link X 134,856,719 134,866,210 RGD:6480464
G Aplnr apelin receptor JBrowse link 3 72,540,538 72,544,183 RGD:6480464
G Aqp1 aquaporin 1 (Colton blood group) JBrowse link 4 85,551,503 85,563,683 RGD:6480464
G Aqp9 aquaporin 9 JBrowse link 8 77,559,621 77,599,781 RGD:6480464
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6480464
G Atr ATR serine/threonine kinase JBrowse link 8 103,673,578 103,770,886 RGD:6480464
G Atxn2 ataxin 2 JBrowse link 12 40,264,601 40,335,637 RGD:6480464
G B3gnt4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 JBrowse link 12 38,503,361 38,506,793 RGD:6480464
G Baz1b bromodomain adjacent to zinc finger domain, 1B JBrowse link 12 24,478,882 24,536,851 RGD:6480464
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:6480464
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:6480464
G Cp ceruloplasmin JBrowse link 2 104,744,249 104,803,034 RGD:6480464
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:6480464
G Cyba cytochrome b-245 alpha chain JBrowse link 19 55,249,634 55,257,824 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:6480464
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:6480464
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Hlf HLF transcription factor, PAR bZIP family member JBrowse link 10 77,836,352 77,918,656 RGD:6480464
G Hnf4g hepatocyte nuclear factor 4, gamma JBrowse link 2 100,225,880 100,372,710 RGD:6480464
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Inhbb inhibin subunit beta B JBrowse link 13 35,436,532 35,442,222 RGD:6480464
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:6480464
G Maf MAF bZIP transcription factor JBrowse link 19 48,179,826 48,200,995 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Nfat5 nuclear factor of activated T-cells 5 JBrowse link 19 38,446,059 38,533,735 RGD:6480464
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Ogg1 8-oxoguanine DNA glycosylase JBrowse link 4 145,282,828 145,289,367 RGD:6480464
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:6480464
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:6480464
G Polb DNA polymerase beta JBrowse link 16 74,237,001 74,260,272 RGD:6480464
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:6480464
G Prdx1 peroxiredoxin 1 JBrowse link 5 135,536,413 135,551,986 RGD:6480464
G Prim1 DNA primase subunit 1 JBrowse link 7 2,435,524 2,451,169 RGD:6480464
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 JBrowse link 4 6,559,153 6,799,888 RGD:6480464
G Prkg2 protein kinase cGMP-dependent 2 JBrowse link 14 12,217,121 12,313,616 RGD:6480464
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:6480464
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:6480464
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rfc3 replication factor C subunit 3 JBrowse link 12 1,460,581 1,471,344 RGD:6480464
G Rfc4 replication factor C subunit 4 JBrowse link 11 81,358,592 81,373,044 RGD:6480464
G Sfmbt1 Scm-like with four mbt domains 1 JBrowse link 16 6,775,648 6,896,155 RGD:6480464
G Slc12a2 solute carrier family 12 member 2 JBrowse link 18 52,917,124 52,985,281 RGD:6480464
G Slc17a3 solute carrier family 17 member 3 JBrowse link 17 43,518,760 43,545,160 RGD:6480464
G Slc22a12 solute carrier family 22 member 12 JBrowse link 1 221,910,787 221,919,277 RGD:6480464
G Slc22a20 solute carrier family 22, member 20 JBrowse link 1 221,327,608 221,344,367 RGD:6480464
G Slc22a6 solute carrier family 22 member 6 JBrowse link 1 224,824,809 224,833,284 RGD:6480464
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464
G Slc2a9 solute carrier family 2 member 9 JBrowse link 14 77,067,537 77,192,702 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Stc1 stanniocalcin 1 JBrowse link 15 50,891,137 50,901,791 RGD:6480464
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tmem171 transmembrane protein 171 JBrowse link 2 28,791,831 28,802,135 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Trim46 tripartite motif-containing 46 JBrowse link 2 188,548,608 188,561,617 RGD:6480464
G Ttk Ttk protein kinase JBrowse link 8 91,368,065 91,405,995 RGD:6480464
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464
G Ube2q2 ubiquitin conjugating enzyme E2 Q2 JBrowse link 8 59,709,972 59,754,102 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:6480464
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:6480464
1-methyluric acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        biochemical role 19130
          metabolite 19098
            prokaryotic metabolite 18225
              bacterial metabolite 18225
                Escherichia coli metabolite 18120
                  7,9-dihydro-1H-purine-2,6,8(3H)-trione 85
                    1,3-dimethyluric acid 0
                    1,7-dimethyluric acid 0
                    1-methyluric acid 1
                    3,7-dimethyluric acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic molecule 19332
                              organic cyclic compound 19083
                                organic heterocyclic compound 18154
                                  organic heteropolycyclic compound 17419
                                    organic heterobicyclic compound 15891
                                      imidazopyrimidine 5336
                                        purines 5334
                                          oxopurine 3933
                                            uric acid 85
                                              7,9-dihydro-1H-purine-2,6,8(3H)-trione 85
                                                1,3-dimethyluric acid 0
                                                1,7-dimethyluric acid 0
                                                1-methyluric acid 1
                                                3,7-dimethyluric acid 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.