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ONTOLOGY REPORT - ANNOTATIONS


Term:thymine
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Accession:CHEBI:17821 term browser browse the term
Definition:A pyrimidine nucleobase that is uracil in which the hydrogen at position 5 is replaced by a methyl group.
Synonyms:related_synonym: 2,4-dihydroxy-5-methylpyrimidine;   5-methyl-2,4(1H,3H)-pyrimidinedione;   5-methylpyrimidine-2,4(1H,3H)-dione;   5-methyluracil;   Formula=C5H6N2O2;   InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9);   InChIKey=RWQNBRDOKXIBIV-UHFFFAOYSA-N;   SMILES=Cc1c[nH]c(=O)[nH]c1=O;   T;   Thy;   Thymin
 alt_id: CHEBI:15247;   CHEBI:27004;   CHEBI:46017;   CHEBI:9580
 xref: Beilstein:607626 "Beilstein";   CAS:65-71-4 "ChemIDplus";   CAS:65-71-4 "KEGG COMPOUND";   CAS:65-71-4 "NIST Chemistry WebBook";   DrugBank:DB03462;   Gmelin:278790 "Gmelin";   KEGG:C00178;   KNApSAcK:C00001511
 xref_mesh: MESH:D013941
 xref: PDBeChem:TDR;   PMID:23237383 "Europe PMC";   Wikipedia:Thymine


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thymine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Tymp thymidine phosphorylase JBrowse link 7 130,342,481 130,347,845 RGD:6480464
dTDP term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gale UDP-galactose-4-epimerase JBrowse link 5 154,310,453 154,314,959 RGD:6480464
G Uxs1 UDP-glucuronate decarboxylase 1 JBrowse link 9 11,165,006 11,240,329 RGD:6480464
dTMP term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 JBrowse link 1 141,874,354 141,893,674 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464
stavudine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Atp5f1e ATP synthase F1 subunit epsilon JBrowse link 3 172,563,105 172,566,007 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6480464
G Cebpa CCAAT/enhancer binding protein alpha JBrowse link 1 91,363,492 91,366,164 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Cpt1a carnitine palmitoyltransferase 1A JBrowse link 1 218,568,157 218,629,679 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Fth1 ferritin heavy chain 1 JBrowse link 1 226,030,940 226,033,228 RGD:6480464
G Gan gigaxonin JBrowse link 19 49,692,790 49,746,178 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gpx4 glutathione peroxidase 4 JBrowse link 7 12,516,357 12,519,154 RGD:6480464
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Hfe homeostatic iron regulator JBrowse link 17 43,661,276 43,669,327 RGD:6480464
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:6480464
G Igfbp1 insulin-like growth factor binding protein 1 JBrowse link 14 87,448,716 87,453,783 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Lonp1 lon peptidase 1, mitochondrial JBrowse link 9 10,428,853 10,441,180 RGD:6480464
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Me1 malic enzyme 1 JBrowse link 8 94,256,830 94,368,834 RGD:6480464
G Mttp microsomal triglyceride transfer protein JBrowse link 2 243,366,181 243,407,608 RGD:6480464
G Nrf1 nuclear respiratory factor 1 JBrowse link 4 57,335,732 57,445,317 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Sirt3 sirtuin 3 JBrowse link 1 213,613,502 213,636,061 RGD:6480464
G Slc25a19 solute carrier family 25 member 19 JBrowse link 10 104,166,594 104,179,523 RGD:6480464
G Slc25a5 solute carrier family 25 member 5 JBrowse link X 123,404,570 123,407,637 RGD:6480464
G Slc29a3 solute carrier family 29 member 3 JBrowse link 20 30,289,527 30,327,343 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Tfap2a transcription factor AP-2 alpha JBrowse link 17 24,653,342 24,670,457 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tymp thymidine phosphorylase JBrowse link 7 130,342,481 130,347,845 RGD:6480464
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6480464
G Ucp2 uncoupling protein 2 JBrowse link 1 165,506,375 165,512,744 RGD:6480464
G Ucp3 uncoupling protein 3 JBrowse link 1 165,482,912 165,495,895 RGD:6480464
thymidine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Alpi alkaline phosphatase, intestinal JBrowse link 9 94,197,616 94,201,910 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Csf1 colony stimulating factor 1 JBrowse link 2 210,522,370 210,550,546 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Slc28a1 solute carrier family 28 member 1 JBrowse link 1 142,948,942 142,992,410 RGD:6480464
G Slc29a1 solute carrier family 29 member 1 JBrowse link 9 17,784,468 17,799,008 RGD:6480464
G Slc29a2 solute carrier family 29 member 2 JBrowse link 1 220,306,622 220,314,631 RGD:6480464
G Tymp thymidine phosphorylase JBrowse link 7 130,342,481 130,347,845 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          metabolite 19101
            prokaryotic metabolite 18236
              bacterial metabolite 18236
                Escherichia coli metabolite 18132
                  thymine 69
                    (2-O,3-C-methylene-5-O-phosphonoarabinofuranosyl)thymine 0
                    (2-O,3-ethane-1,2-diyl-5-O-phosphonoarabinofuranosyl)thymine 0
                    1-(2,3-dideoxy-6-O-phosphono-beta-D-erythro-hexopyranosyl)thymine 0
                    1-(2-O-methyl-5-O-phosphono-beta-D-arabinofuranosyl)thymine 0
                    1-(2-deoxy-2-fluoro-5-O-phosphono-beta-D-arabinofuranosyl)thymine 0
                    1-[(1S,2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)bicyclo[3.1.0]hexan-2-yl]thymine 0
                    1-[(1S,3S,4R,5S)-3-hydroxy-4-(hydroxymethyl)bicyclo[3.1.0]hexan-1-yl]thymine 0
                    1-[(2-hydroxyethoxy)methyl]-6-(phenylsulfanyl)thymine 0
                    5,6-dihydrothymine 0
                    5-formyluracil 0
                    6-(1,3-dihydroxyisobutyl)thymine 0
                    6-(3-hydroxypropyl)thymine 0
                    6-\{[(4R,5R)-4-(hydroxymethyl)thymin-5-yl]methyl\}thymine 0
                    N-[2-(methylamino)ethyl]-N-[(thymin-1-yl)acetyl]glycine 0
                    [(1R,2S,3S,5S)-5-hydroxy-2-methyl-3-(thymin-1-yl)cyclopentyl]methyl dihydrogen phosphate 0
                    [(1R,4S,6S)-6-hydroxy-4-(thymin-1-yl)cyclohex-2-en-1-yl]methyl dihydrogen phosphate 0
                    alpha-putrescinylthymine 0
                    methylthymine + 0
                    stavudine 47
                    telbivudine 0
                    thymidine + 23
                    thymin-1-yl group 0
                    thymine glycol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic heterocyclic compound 18164
                                  organic heteromonocyclic compound 16261
                                    diazines 12112
                                      pyrimidines 11927
                                        pyrimidine nucleobase 6073
                                          thymine 69
                                            (2-O,3-C-methylene-5-O-phosphonoarabinofuranosyl)thymine 0
                                            (2-O,3-ethane-1,2-diyl-5-O-phosphonoarabinofuranosyl)thymine 0
                                            1-(2,3-dideoxy-6-O-phosphono-beta-D-erythro-hexopyranosyl)thymine 0
                                            1-(2-O-methyl-5-O-phosphono-beta-D-arabinofuranosyl)thymine 0
                                            1-(2-deoxy-2-fluoro-5-O-phosphono-beta-D-arabinofuranosyl)thymine 0
                                            1-[(1S,2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)bicyclo[3.1.0]hexan-2-yl]thymine 0
                                            1-[(1S,3S,4R,5S)-3-hydroxy-4-(hydroxymethyl)bicyclo[3.1.0]hexan-1-yl]thymine 0
                                            1-[(2-hydroxyethoxy)methyl]-6-(phenylsulfanyl)thymine 0
                                            5,6-dihydrothymine 0
                                            5-formyluracil 0
                                            6-(1,3-dihydroxyisobutyl)thymine 0
                                            6-(3-hydroxypropyl)thymine 0
                                            6-\{[(4R,5R)-4-(hydroxymethyl)thymin-5-yl]methyl\}thymine 0
                                            N-[2-(methylamino)ethyl]-N-[(thymin-1-yl)acetyl]glycine 0
                                            [(1R,2S,3S,5S)-5-hydroxy-2-methyl-3-(thymin-1-yl)cyclopentyl]methyl dihydrogen phosphate 0
                                            [(1R,4S,6S)-6-hydroxy-4-(thymin-1-yl)cyclohex-2-en-1-yl]methyl dihydrogen phosphate 0
                                            alpha-putrescinylthymine 0
                                            methylthymine + 0
                                            stavudine 47
                                            telbivudine 0
                                            thymidine + 23
                                            thymin-1-yl group 0
                                            thymine glycol 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.