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ONTOLOGY REPORT - ANNOTATIONS


Term:calcitriol
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Accession:CHEBI:17823 term browser browse the term
Definition:A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Synonyms:related_synonym: (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol;   (1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol;   (5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol;   1,25-DHCC;   1-alpha-25-Dihydroxyvitamin D3;   1alpha,25(OH)2D3;   1alpha,25-dihydroxycholecalciferol;   1alpha,25-dihydroxyvitamin D3;   5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL;   Calcijex;   Decostriol;   Formula=C27H44O3;   InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1;   InChIKey=GMRQFYUYWCNGIN-NKMMMXOESA-N;   Rocaltrol;   SMILES=[H][C@@]1(CC[C@@]2([H])\\C(CCC[C@]12C)=C\\C=C1\\C[C@@H](O)C[C@H](O)C1=C)[C@H](C)CCCC(C)(C)O;   calcitriolum
 alt_id: CHEBI:13932;   CHEBI:19209;   CHEBI:3307;   CHEBI:46435
 xref: Beilstein:2227647 "Beilstein";   CAS:32222-06-3 "ChemIDplus";   CAS:32222-06-3 "KEGG COMPOUND";   DrugBank:DB00136;   Drug_Central:466 "DrugCentral";   KEGG:C01673;   KEGG:D00129;   LIPID_MAPS_instance:LMST03020258 "LIPID MAPS"
 xref_mesh: MESH:D002117
 xref: MetaCyc:CALCITRIOL;   PDBeChem:VDX;   PMID:10217585 "Europe PMC";   PMID:15928596 "Europe PMC";   PMID:19429426 "Europe PMC";   PMID:20599255 "Europe PMC";   PMID:22905919 "Europe PMC";   PMID:23103122 "Europe PMC";   PMID:23144765 "Europe PMC";   PMID:6687801 "Europe PMC";   Reaxys:2227647 "Reaxys";   Wikipedia:Calcitriol


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23758
    role 23647
      biological role 23610
        immunomodulator 14922
          calcitriol 2501
            18-acetoxy-1alpha,25-dihydroxyvitamin D3 0
            1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 0
            1alpha,25-dihydroxy-2beta-(4-hydroxybutoxy)vitamin D3 0
            AMCR277A 0
            AMCR277B 0
            calcitriol 25-O-(beta-D-glucuronate) 0
            calcitriol 25-O-(beta-D-glucuronide) 0
            calcitriol 26,23-lactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23758
    subatomic particle 23707
      composite particle 23707
        hadron 23707
          baryon 23707
            nucleon 23707
              atomic nucleus 23707
                atom 23707
                  main group element atom 23527
                    p-block element atom 23527
                      carbon group element atom 23238
                        carbon atom 23215
                          organic molecular entity 23215
                            organic molecule 23077
                              organic cyclic compound 22097
                                organic polycyclic compound 17330
                                  steroid 13513
                                    hydroxy steroid 13025
                                      hydroxy seco-steroid 2747
                                        vitamin D 2742
                                          D3 vitamins 2694
                                            calciol 2694
                                              hydroxycalciol 2556
                                                calcitriol 2501
                                                  18-acetoxy-1alpha,25-dihydroxyvitamin D3 0
                                                  1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 0
                                                  1alpha,25-dihydroxy-2beta-(4-hydroxybutoxy)vitamin D3 0
                                                  AMCR277A 0
                                                  AMCR277B 0
                                                  calcitriol 25-O-(beta-D-glucuronate) 0
                                                  calcitriol 25-O-(beta-D-glucuronide) 0
                                                  calcitriol 26,23-lactone 0
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