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ONTOLOGY REPORT - ANNOTATIONS


Term:calcitriol
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Accession:CHEBI:17823 term browser browse the term
Definition:A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Synonyms:related_synonym: (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol;   (1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol;   (5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol;   1,25-DHCC;   1-alpha-25-Dihydroxyvitamin D3;   1alpha,25(OH)2D3;   1alpha,25-dihydroxycholecalciferol;   1alpha,25-dihydroxyvitamin D3;   5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL;   Calcijex;   Decostriol;   Formula=C27H44O3;   InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1;   InChIKey=GMRQFYUYWCNGIN-NKMMMXOESA-N;   Rocaltrol;   SMILES=[H][C@@]1(CC[C@@]2([H])\\C(CCC[C@]12C)=C\\C=C1\\C[C@@H](O)C[C@H](O)C1=C)[C@H](C)CCCC(C)(C)O;   calcitriolum
 alt_id: CHEBI:13932;   CHEBI:19209;   CHEBI:3307;   CHEBI:46435
 xref: Beilstein:2227647;   CAS:32222-06-3;   DrugBank:DB00136;   Drug_Central:466;   KEGG:C01673;   KEGG:D00129;   LIPID_MAPS_instance:LMST03020258
 xref_mesh: MESH:D002117
 xref: MetaCyc:CALCITRIOL;   PDBeChem:VDX;   PMID:10217585;   PMID:15928596;   PMID:19429426;   PMID:20599255;   PMID:22905919;   PMID:23103122;   PMID:23144765;   PMID:6687801;   Reaxys:2227647;   Wikipedia:Calcitriol


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21269
    role 21253
      biological role 21251
        immunomodulator 14005
          calcitriol 2418
            18-acetoxy-1alpha,25-dihydroxyvitamin D3 0
            1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 + 0
            1alpha,25-dihydroxy-2beta-(4-hydroxybutoxy)vitamin D3 0
            AMCR277A 0
            AMCR277B 0
            calcitriol 25-O-(beta-D-glucuronate) 0
            calcitriol 25-O-(beta-D-glucuronide) 0
            calcitriol 26,23-lactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21269
    subatomic particle 21265
      composite particle 21265
        hadron 21265
          baryon 21265
            nucleon 21265
              atomic nucleus 21265
                atom 21265
                  main group element atom 21134
                    p-block element atom 21134
                      carbon group element atom 20905
                        carbon atom 20795
                          organic molecular entity 20795
                            organic molecule 20677
                              organic cyclic compound 20134
                                organic polycyclic compound 16884
                                  steroid 13028
                                    hydroxy steroid 12587
                                      hydroxy seco-steroid 2671
                                        vitamin D 2666
                                          D3 vitamins 2616
                                            calciol 2616
                                              hydroxycalciol 2472
                                                calcitriol 2418
                                                  18-acetoxy-1alpha,25-dihydroxyvitamin D3 0
                                                  1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 + 0
                                                  1alpha,25-dihydroxy-2beta-(4-hydroxybutoxy)vitamin D3 0
                                                  AMCR277A 0
                                                  AMCR277B 0
                                                  calcitriol 25-O-(beta-D-glucuronate) 0
                                                  calcitriol 25-O-(beta-D-glucuronide) 0
                                                  calcitriol 26,23-lactone 0
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