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ONTOLOGY REPORT - ANNOTATIONS


Term:calcitriol
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Accession:CHEBI:17823 term browser browse the term
Definition:A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Synonyms:related_synonym: (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol;   (1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol;   (5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol;   1,25-DHCC;   1-alpha-25-Dihydroxyvitamin D3;   1alpha,25(OH)2D3;   1alpha,25-dihydroxycholecalciferol;   1alpha,25-dihydroxyvitamin D3;   5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL;   Calcijex;   Decostriol;   Formula=C27H44O3;   InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1;   InChIKey=GMRQFYUYWCNGIN-NKMMMXOESA-N;   Rocaltrol;   SMILES=[H][C@@]1(CC[C@@]2([H])\\C(CCC[C@]12C)=C\\C=C1\\C[C@@H](O)C[C@H](O)C1=C)[C@H](C)CCCC(C)(C)O;   calcitriolum
 alt_id: CHEBI:13932;   CHEBI:19209;   CHEBI:3307;   CHEBI:46435
 xref: Beilstein:2227647 "Beilstein";   CAS:32222-06-3 "ChemIDplus";   CAS:32222-06-3 "KEGG COMPOUND";   DrugBank:DB00136;   Drug_Central:466 "DrugCentral";   KEGG:C01673;   KEGG:D00129;   LIPID_MAPS_instance:LMST03020258 "LIPID MAPS"
 xref_mesh: MESH:D002117
 xref: MetaCyc:CALCITRIOL;   PDBeChem:VDX;   PMID:10217585 "Europe PMC";   PMID:15928596 "Europe PMC";   PMID:19429426 "Europe PMC";   PMID:20599255 "Europe PMC";   PMID:22905919 "Europe PMC";   PMID:23103122 "Europe PMC";   PMID:23144765 "Europe PMC";   PMID:6687801 "Europe PMC";   Reaxys:2227647 "Reaxys";   Wikipedia:Calcitriol


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        immunomodulator 12649
          calcitriol 2398
            18-acetoxy-1alpha,25-dihydroxyvitamin D3 0
            1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 0
            1alpha,25-dihydroxy-2beta-(4-hydroxybutoxy)vitamin D3 0
            AMCR277A 0
            AMCR277B 0
            calcitriol 25-O-(beta-D-glucuronate) 0
            calcitriol 25-O-(beta-D-glucuronide) 0
            calcitriol 26,23-lactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic molecule 19402
                              organic cyclic compound 19158
                                organic polycyclic compound 16027
                                  steroid 12770
                                    hydroxy steroid 12362
                                      hydroxy seco-steroid 2644
                                        vitamin D 2640
                                          D3 vitamins 2592
                                            calciol 2592
                                              hydroxycalciol 2455
                                                calcitriol 2398
                                                  18-acetoxy-1alpha,25-dihydroxyvitamin D3 0
                                                  1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 0
                                                  1alpha,25-dihydroxy-2beta-(4-hydroxybutoxy)vitamin D3 0
                                                  AMCR277A 0
                                                  AMCR277B 0
                                                  calcitriol 25-O-(beta-D-glucuronate) 0
                                                  calcitriol 25-O-(beta-D-glucuronide) 0
                                                  calcitriol 26,23-lactone 0
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