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ONTOLOGY REPORT - ANNOTATIONS


Term:calcidiol
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Accession:CHEBI:17933 term browser browse the term
Definition:A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3.
Synonyms:related_synonym: (3S,5Z,7E)-9,10-secocholesta-5,7,10-triene-3,25-diol;   (3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol;   (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol;   25(OH)D3;   25-Hydroxyvitamin D3;   25-hydroxycholecalciferol;   3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL;   Calcifediol;   Calcifediol anhydrous;   Formula=C27H44O2;   InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1;   InChIKey=JWUBBDSIWDLEOM-DTOXIADCSA-N;   Rayaldee;   SMILES=[H][C@@]1(CC[C@]2([H])[C@]1(C)CCC\\C2=C/C=C1/C[C@@H](O)CCC1=C)[C@H](C)CCCC(C)(C)O;   calcifediolum
 alt_id: CHEBI:13931;   CHEBI:19815;   CHEBI:3304;   CHEBI:46387
 xref: Beilstein:4270041 "Beilstein";   CAS:19356-17-3 "ChemIDplus";   CAS:19356-17-3 "KEGG COMPOUND";   DrugBank:DB00146;   Drug_Central:464 "DrugCentral";   KEGG:C01561;   LIPID_MAPS_instance:LMST03020246 "LIPID MAPS"
 xref_mesh: MESH:D002112
 xref: PDBeChem:VDY;   PMID:16549446 "Europe PMC";   PMID:18689406 "Europe PMC";   PMID:22487892 "Europe PMC";   PMID:22536761 "Europe PMC";   PMID:23090338 "Europe PMC";   PMID:23566108 "Europe PMC";   PMID:9080330 "Europe PMC";   Reaxys:4270041 "Reaxys";   Wikipedia:Calcifediol


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calcidiol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aard alanine and arginine rich domain containing protein JBrowse link 7 91,588,458 91,593,299 RGD:6480464
G Actb actin, beta JBrowse link 12 13,715,843 13,718,813 RGD:6480464
G Aldoa aldolase, fructose-bisphosphate A JBrowse link 1 198,228,387 198,233,988 RGD:6480464
G Alpl alkaline phosphatase, biomineralization associated JBrowse link 5 156,086,496 156,141,513 RGD:6480464
G Apob apolipoprotein B JBrowse link 6 33,176,826 33,216,381 RGD:6480464
G Aqp4 aquaporin 4 JBrowse link 18 6,766,009 6,782,757 RGD:6480464
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 JBrowse link 2 204,003,742 204,032,023 RGD:6480464
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 JBrowse link 1 81,852,423 81,881,565 RGD:6480464
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 JBrowse link 13 82,737,161 82,757,681 RGD:6480464
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 JBrowse link 16 22,326,537 22,350,143 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcat1 branched chain amino acid transaminase 1 JBrowse link 4 179,259,305 179,340,021 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Canx calnexin JBrowse link 10 35,800,942 35,833,939 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cd247 Cd247 molecule JBrowse link 13 83,996,045 84,071,408 RGD:6480464
G Cd28 Cd28 molecule JBrowse link 9 67,546,408 67,573,858 RGD:6480464
G Cd3d CD3d molecule JBrowse link 8 49,282,502 49,287,095 RGD:6480464
G Cd3e CD3e molecule JBrowse link 8 49,297,604 49,309,370 RGD:6480464
G Cd3g CD3g molecule JBrowse link 8 49,274,553 49,280,943 RGD:6480464
G Cdh2 cadherin 2 JBrowse link 18 8,146,971 8,366,037 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Ckb creatine kinase B JBrowse link 6 136,142,956 136,145,838 RGD:6480464
G Clta clathrin, light chain A JBrowse link 5 59,490,689 59,509,139 RGD:6480464
G Cplx2 complexin 2 JBrowse link 17 10,756,871 10,828,811 RGD:6480464
G Cspg5 chondroitin sulfate proteoglycan 5 JBrowse link 8 118,333,695 118,348,040 RGD:6480464
G Cyb5a cytochrome b5 type A JBrowse link 18 81,694,818 81,726,821 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 JBrowse link 3 168,097,484 168,111,920 RGD:6480464
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 JBrowse link 7 70,333,150 70,340,006 RGD:6480464
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 JBrowse link 5 134,508,728 134,526,103 RGD:6480464
G Dctn4 dynactin subunit 4 JBrowse link 18 55,797,188 55,824,195 RGD:6480464
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:6480464
G Dpp6 dipeptidyl peptidase like 6 JBrowse link 4 4,021,021 4,943,675 RGD:6480464
G Eif4h eukaryotic translation initiation factor 4H JBrowse link 12 25,093,119 25,109,805 RGD:6480464
G Fgf23 fibroblast growth factor 23 JBrowse link 4 159,622,404 159,630,082 RGD:6480464
G Fkbp1a FKBP prolyl isomerase 1A JBrowse link 3 147,042,944 147,062,725 RGD:6480464
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 JBrowse link 20 1,955,344 1,984,907 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G Gas5 growth arrest specific 5 JBrowse link 13 78,852,523 78,855,844 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:6480464
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:6480464
G Glul glutamate-ammonia ligase JBrowse link 13 71,331,052 71,340,207 RGD:6480464
G Gna12 G protein subunit alpha 12 JBrowse link 12 15,890,202 15,971,212 RGD:6480464
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:6480464
G Gnrhr gonadotropin releasing hormone receptor JBrowse link 14 23,480,462 23,498,450 RGD:6480464
G Guca2b guanylate cyclase activator 2B JBrowse link 5 138,695,591 138,697,641 RGD:6480464
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 JBrowse link 18 44,810,462 44,897,677 RGD:6480464
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:6480464
G Ibsp integrin-binding sialoprotein JBrowse link 14 6,801,200 6,813,987 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6480464
G Klc1 kinesin light chain 1 JBrowse link 6 136,330,151 136,373,716 RGD:6480464
G Krt14 keratin 14 JBrowse link 10 88,118,029 88,122,233 RGD:6480464
G Lre3 LINE retrotransposable element 3 RGD:6480464
G Map2 microtubule-associated protein 2 JBrowse link 9 73,204,753 73,462,965 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Marcks myristoylated alanine rich protein kinase C substrate JBrowse link 20 42,966,140 42,971,838 RGD:6480464
G Mobp myelin-associated oligodendrocyte basic protein JBrowse link 8 128,824,420 128,854,492 RGD:6480464
G Nckap1 NCK-associated protein 1 JBrowse link 3 67,725,180 67,804,680 RGD:6480464
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase JBrowse link 10 91,879,608 91,986,242 RGD:6480464
G P4hb prolyl 4-hydroxylase subunit beta JBrowse link 10 109,736,459 109,748,070 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Pdia3 protein disulfide isomerase family A, member 3 JBrowse link 3 113,376,983 113,400,707 RGD:6480464
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6480464
G Pmch pro-melanin-concentrating hormone JBrowse link 7 28,655,206 28,656,522 RGD:6480464
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B JBrowse link 6 8,219,385 8,280,127 RGD:6480464
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:6480464
G Psap prosaposin JBrowse link 20 29,831,302 29,856,876 RGD:6480464
G Psat1 phosphoserine aminotransferase 1 JBrowse link 1 233,124,089 233,145,941 RGD:6480464
G Psma2 proteasome 20S subunit alpha 2 JBrowse link 17 53,091,937 53,102,324 RGD:6480464
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:6480464
G Pygb glycogen phosphorylase B JBrowse link 3 146,581,063 146,629,504 RGD:6480464
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:6480464
G Rasl11a RAS-like family 11 member A JBrowse link 12 9,986,150 9,990,284 RGD:6480464
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6480464
G Runx2 RUNX family transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:6480464
G Scd2 stearoyl-Coenzyme A desaturase 2 JBrowse link 1 264,059,374 264,072,433 RGD:6480464
G Sdc4 syndecan 4 JBrowse link 3 160,872,503 160,891,190 RGD:6480464
G Slc1a3 solute carrier family 1 member 3 JBrowse link 2 57,860,881 57,935,363 RGD:6480464
G Snrk SNF related kinase JBrowse link 8 130,749,806 130,805,225 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:6480464
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:6480464
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:6480464
G Vdac1 voltage-dependent anion channel 1 JBrowse link 10 37,724,915 37,752,827 RGD:6480464
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:6480464
G Ybx1 Y box binding protein 1 JBrowse link 5 138,319,754 138,336,721 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          metabolite 19101
            calcidiol 92
              calcidiol 25-O-(beta-D-glucuronate) 0
              calcidiol 25-O-(beta-D-glucuronide) 0
              calcidiol 3-O-(beta-D-glucuronate) 0
              calcidiol 3-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic polycyclic compound 16028
                                  steroid 12769
                                    hydroxy steroid 12359
                                      hydroxy seco-steroid 2643
                                        vitamin D 2639
                                          D3 vitamins 2591
                                            calciol 2591
                                              hydroxycalciol 2454
                                                calcidiol 92
                                                  calcidiol 25-O-(beta-D-glucuronate) 0
                                                  calcidiol 25-O-(beta-D-glucuronide) 0
                                                  calcidiol 3-O-(beta-D-glucuronate) 0
                                                  calcidiol 3-O-(beta-D-glucuronide) 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.