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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sucrose
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Accession:CHEBI:17992 term browser browse the term
Definition:A glycosyl glycoside formed by glucose and fructose units joined by an acetal oxygen bridge from hemiacetal of glucose to the hemiketal of the fructose.
Synonyms:exact_synonym: beta-D-fructofuranosyl alpha-D-glucopyranoside
 related_synonym: 1-alpha-D-Glucopyranosyl-2-beta-D-fructofuranoside;   Cane sugar;   Formula=C12H22O11;   InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1;   InChIKey=CZMRCDWAGMRECN-UGDNZRGBSA-N;   SMILES=OC[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O;   Saccharose;   Sacharose;   White sugar;   beta-D-Fruf-(2<->1)-alpha-D-Glcp;   sacarosa;   table sugar
 alt_id: CHEBI:15128;   CHEBI:26812;   CHEBI:45795;   CHEBI:9314
 xref: Beilstein:90825;   CAS:57-50-1;   DrugBank:DB02772;   Drug_Central:4610;   Gmelin:97695;   HMDB:HMDB0000258;   KEGG:C00089;   KEGG:D00025;   KEGG:D06533;   KEGG:G00370;   KNApSAcK:C00001151
 xref_mesh: MESH:D013395
 xref: MetaCyc:SUCROSE;   PDBeChem:SUC;   PMID:11021636;   PMID:11093712;   PMID:11111003;   PMID:12065720;   PMID:12706980;   PMID:13508893;   PMID:15291457;   PMID:15660210;   PMID:15792978;   PMID:15845855;   PMID:16228482;   PMID:16304615;   PMID:16313996;   PMID:16525719;   PMID:16660545;   PMID:16663947;   PMID:16665852;   PMID:17233733;   PMID:17439666;   PMID:17597061;   PMID:18625236;   PMID:19199566;   PMID:19726178;   PMID:21703290;   PMID:21972845;   PMID:22085755;   PMID:22311778;   PMID:22404833;   PMID:22751876;   Reaxys:1435311;   Reaxys:90825;   Wikipedia:Sucrose


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sucrose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO
EXP
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of ACACA mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of ACACA mRNA
[Dietary Fats co-treated with Sucrose] results in increased expression of ACACA mRNA; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of ACACA mRNA]
CTD PMID:24440342, PMID:31175915 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACADM mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACADM mRNA] CTD PMID:24440342 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acly ATP citrate lyase multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of ACLY mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of ACLY mRNA CTD PMID:24440342 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA] CTD PMID:24440342 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Agt angiotensinogen multiple interactions EXP Sucrose inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Sucrose inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP Sucrose inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Sucrose inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO [Cadmium co-treated with Sucrose] affects the activity of ALAD protein CTD PMID:15454309 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Sucrose results in increased activity of CASP3 protein
EIF2AK2 protein affects the reaction [Sucrose results in increased activity of and results in increased cleavage of CASP3 protein]; EIF2AK2 protein affects the reaction [Sucrose results in increased cleavage of CASP3 protein]; GW 506033X inhibits the reaction [Sucrose results in increased activity of CASP3 protein]; Sucrose results in increased activity of and results in increased cleavage of CASP3 protein
CTD PMID:15975986, PMID:27920257 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Sucrose co-treated with Palmitates] results in increased expression of CCL2 mRNA CTD PMID:26895660 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA; [Sucrose co-treated with Oleic Acid] results in increased expression of CPT1A mRNA; [Sucrose co-treated with Palmitates] results in increased expression of CPT1A mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA] CTD PMID:24440342, PMID:26895660 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation EXP Sucrose results in increased phosphorylation of CREB1 protein CTD PMID:12514263 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cs citrate synthase multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CS mRNA CTD PMID:24440342 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression EXP Sucrose results in decreased expression of CYP1A1 protein CTD PMID:12680239 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions EXP [Sucrose co-treated with Orotic Acid] results in increased expression of CYP4A1 mRNA CTD PMID:15670589 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 multiple interactions EXP [Sucrose co-treated with Orotic Acid] results in increased expression of CYP4A2 mRNA CTD PMID:15670589 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of DGAT1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of DGAT1 mRNA CTD PMID:24440342 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA] CTD PMID:24440342 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions
increases phosphorylation
ISO EIF2AK2 protein affects the reaction [Sucrose results in increased activity of and results in increased cleavage of CASP3 protein]; EIF2AK2 protein affects the reaction [Sucrose results in increased cleavage of CASP3 protein]; EIF2AK2 protein affects the reaction [Sucrose results in increased expression of IL6 mRNA]; EIF2AK2 protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA]; EIF2AK2 protein affects the reaction [Sucrose results in increased phosphorylation of RELA protein]; GW 506033X inhibits the reaction [Sucrose results in increased phosphorylation of EIF2AK2 protein] CTD PMID:27920257 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Sucrose co-treated with Dietary Fats] results in decreased expression of FAS mRNA; [Sucrose co-treated with Dietary Fats] results in decreased expression of FAS protein; Resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of FAS mRNA]; Resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of FAS protein] CTD PMID:23127599 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Sucrose co-treated with Oleic Acid] results in increased expression of FASN mRNA; [Sucrose co-treated with Palmitates] results in increased expression of FASN mRNA CTD PMID:26895660 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Sucrose results in increased expression of FGF2 mRNA CTD PMID:26800359 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit increases expression EXP Sucrose results in increased expression of G6PC mRNA CTD PMID:12514263 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects localization
multiple interactions
ISO Sucrose affects the localization of GAPDH protein
GW 506033X inhibits the reaction [Sucrose affects the localization of GAPDH protein]
CTD PMID:27920257 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gnat3 G protein subunit alpha transducin 3 affects response to substance ISO GNAT3 protein affects the susceptibility to Sucrose CTD PMID:16740645 NCBI chr 4:13,827,764...13,878,126
Ensembl chr 4:13,827,756...13,878,126
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of GPAM mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of GPAM mRNA CTD PMID:24440342 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of GPT protein] CTD PMID:31175915 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases phosphorylation EXP Sucrose results in decreased phosphorylation of GSK3A protein CTD PMID:12514263 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Sucrose results in increased expression of HBEGF mRNA CTD PMID:26800359 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [Dietary Fats co-treated with Sucrose] results in increased expression of HMGCR mRNA; [Dietary Fats co-treated with Sucrose] results in increased expression of HMGCR protein; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of HMGCR mRNA] CTD PMID:31175915 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon multiple interactions ISO IKBKE protein affects the reaction [Sucrose results in increased expression of NOS2 protein] CTD PMID:27920257 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Sucrose results in increased expression of IL6 mRNA
EIF2AK2 protein affects the reaction [Sucrose results in increased expression of IL6 mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of IL6 mRNA]
CTD PMID:27920257 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 increases expression ISO Sucrose results in increased expression of INS protein CTD PMID:1805284 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of IRS1 mRNA]; Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of IRS1 protein] CTD PMID:31181236 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Lct lactase increases expression EXP Sucrose results in increased expression of LCT mRNA CTD PMID:11242478 NCBI chr13:44,998,414...45,040,593
Ensembl chr13:44,998,414...45,040,593
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP [Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR mRNA; [Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR protein; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR mRNA]; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR protein] CTD PMID:23127599 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Sucrose CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
Sucrose results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
Sucrose results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD PMID:15975986, PMID:18267125 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Sucrose results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:15975986 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Sucrose results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Sucrose results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD PMID:15975986, PMID:18267125 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of MAPK8 mRNA] CTD PMID:31181236 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO [Oligosaccharides co-treated with Sucrose co-treated with Dietary Fats] affects the expression of MAPK9 mRNA CTD PMID:31181236 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases expression
ISO RELA protein affects the reaction [Sucrose results in increased expression of MCL1 mRNA] CTD PMID:27920257 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of MLXIPL mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of MLXIPL mRNA] CTD PMID:24440342 NCBI chr12:24,590,645...24,619,639 JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO Sucrose results in increased expression of NFKBIA mRNA
RELA protein affects the reaction [Sucrose results in increased expression of NFKBIA mRNA]; Sucrose results in decreased expression of and results in increased phosphorylation of NFKBIA protein
CTD PMID:27920257 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO Sucrose results in increased expression of NOS2 mRNA; Sucrose results in increased expression of NOS2 protein
EIF2AK2 protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA]; GW 506033X inhibits the reaction [Sucrose results in increased expression of NOS2 mRNA]; IKBKE protein affects the reaction [Sucrose results in increased expression of NOS2 protein]; RELA protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA]
CTD PMID:27920257 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
EXP Chromium inhibits the reaction [Sucrose results in decreased expression of NOS3 protein] CTD PMID:17215582 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nts neurotensin multiple interactions
decreases activity
ISO Sucrose promotes the reaction [bisindolylmaleimide I results in increased activity of NTS protein]; Sucrose promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]
Sucrose results in decreased activity of NTS protein
CTD PMID:18313772 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP [Dietary Fats co-treated with Sucrose] results in increased expression of PCK1 mRNA; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of PCK1 mRNA] CTD PMID:31175915 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of PIK3CA mRNA] CTD PMID:31181236 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of PKLR mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of PKLR mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of PKLR mRNA CTD PMID:24440342 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP
ISO
[Sucrose co-treated with Orotic Acid] results in decreased expression of PPARA protein
[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA]
CTD PMID:15670589, PMID:24440342 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARG mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARG mRNA] CTD PMID:24440342 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Dietary Fats co-treated with Sucrose] results in decreased expression of PRKAA2 mRNA; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in decreased expression of PRKAA2 mRNA] CTD PMID:31175915 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression EXP Sucrose results in decreased expression of PRKG1 protein CTD PMID:17215582 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Sucrose inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein] CTD PMID:18267125 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rac1 Rac family small GTPase 1 increases activity ISO Sucrose results in increased activity of RAC1 protein CTD PMID:15975986 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
ISO EIF2AK2 protein affects the reaction [Sucrose results in increased phosphorylation of RELA protein]; RELA protein affects the reaction [Sucrose results in increased expression of IL6 mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of MCL1 mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of NFKBIA mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA] CTD PMID:27920257 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP [Sucrose co-treated with Orotic Acid] results in decreased expression of RXRA protein CTD PMID:15670589 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions EXP [Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA; [Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA]; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein] CTD PMID:23127599 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
increases expression
increases activity
ISO
EXP
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SCD1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of SCD1 mRNA; [Sucrose co-treated with Oleic Acid] results in increased expression of SCD1 mRNA; [Sucrose co-treated with Palmitates] results in increased expression of SCD1 mRNA
Sucrose results in increased expression of SCD1 mRNA
Sucrose results in increased activity of SCD1 protein
CTD PMID:22413010, PMID:24440342, PMID:26895660 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Si sucrase-isomaltase increases expression EXP Sucrose results in increased expression of SI mRNA CTD PMID:10222385, PMID:11242478 NCBI chr 2:170,220,794...170,301,348
Ensembl chr 2:170,221,245...170,301,348
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression
multiple interactions
EXP
ISO
Sucrose results in increased expression of SLC2A2 mRNA
[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA]
CTD PMID:10222385, PMID:24440342 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases localization
multiple interactions
ISO Sucrose results in decreased localization of SLC2A4 protein
Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of SLC2A4 mRNA]; Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of SLC2A4 protein]
Chromium inhibits the reaction [Sucrose results in decreased localization of SLC2A4 protein]
CTD PMID:18806091, PMID:31181236 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc2a5 solute carrier family 2 member 5 increases expression EXP Sucrose results in increased expression of SLC2A5 mRNA CTD PMID:9124564, PMID:10222385 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
JBrowse link
G Slc39a4 solute carrier family 39 member 4 multiple interactions ISO Sucrose inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein] CTD PMID:17202136 NCBI chr 7:117,675,718...117,682,586
Ensembl chr 7:117,675,720...117,680,004
JBrowse link
G Slc5a1 solute carrier family 5 member 1 increases expression EXP Sucrose results in increased expression of SLC5A1 mRNA; Sucrose results in increased expression of SLC5A1 protein CTD PMID:8048533, PMID:10222385 NCBI chr14:82,910,448...82,975,303
Ensembl chr14:82,909,981...82,975,263
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Sucrose inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]] CTD PMID:22362149 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO
EXP
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SREBF1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of SREBF1 mRNA
[Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 mRNA; [Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 protein; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 mRNA]; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 protein]
CTD PMID:24440342, PMID:31175915 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Sucrose inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions EXP Sucrose inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tas1r2 taste 1 receptor member 2 multiple interactions ISO Sucrose binds to and results in increased activity of TAS1R2 protein; Sucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein] CTD PMID:20173092 NCBI chr 5:158,119,894...158,135,733
Ensembl chr 5:158,042,587...158,135,733
JBrowse link
G Tas1r3 taste 1 receptor member 3 multiple interactions ISO Sucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein] CTD PMID:20173092 NCBI chr 5:173,307,325...173,312,950
Ensembl chr 5:173,308,870...173,312,023
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Sucrose results in increased phosphorylation of and affects the localization of TRP53 protein CTD PMID:15975986 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions
decreases phosphorylation
EXP Chromium inhibits the reaction [Sucrose results in decreased phosphorylation of VASP protein] CTD PMID:17215582 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        osmolyte 2027
          sucrose 74
            1,6-kestotetraose 0
            6,6-kestotetraose 0
            6-kestotriose 0
            agrocinopine A 0
            agrocinopine C 0
            beta-D-fructofuranosyl 6-O-octanoyl-alpha-D-glucopyranoside 0
            molasses 0
            stachyose + 0
            sucrose 6(F)-phosphate 0
            sucrose 6(G)-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  carbohydrates and carbohydrate derivatives 12178
                                    carbohydrate 12178
                                      oligosaccharide 515
                                        disaccharide 425
                                          glycosyl glycoside 100
                                            sucrose 74
                                              1,6-kestotetraose 0
                                              6,6-kestotetraose 0
                                              6-kestotriose 0
                                              agrocinopine A 0
                                              agrocinopine C 0
                                              beta-D-fructofuranosyl 6-O-octanoyl-alpha-D-glucopyranoside 0
                                              molasses 0
                                              stachyose + 0
                                              sucrose 6(F)-phosphate 0
                                              sucrose 6(G)-phosphate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.