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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphocholine
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Accession:CHEBI:18132 term browser browse the term
Definition:The phosphate of choline; and the parent compound of the phosphocholine family.
Synonyms:exact_synonym: N,N,N-trimethyl-2-(phosphonooxy)ethanaminium
 related_synonym: ChoP;   Choline phosphate;   Formula=C5H15NO4P;   InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p+1;   InChIKey=YHHSONZFOIEMCP-UHFFFAOYSA-O;   N-Trimethyl-2-aminoethylphosphonate;   O-phosphocholine;   Phosphoryl-choline;   Phosphorylcholine;   SMILES=C[N+](C)(C)CCOP(O)(O)=O;   Trimethyl(2-(phosphonooxy)ethyl)ammonium
 alt_id: CHEBI:12720;   CHEBI:13986;   CHEBI:23214;   CHEBI:3667;   CHEBI:44707
 xref: Beilstein:1784889;   CAS:107-73-3;   DrugBank:DB03945;   Gmelin:2594827;   HMDB:HMDB0001565;   KEGG:C00588;   KNApSAcK:C00007299
 xref_mesh: MESH:D010767
 xref: PDBeChem:PC;   PMID:10456913;   PMID:10596404;   PMID:10811914;   PMID:11437497;   PMID:11908950;   PMID:15267227;   PMID:15583011;   PMID:18684852;   PMID:19369878;   PMID:19748321;   PMID:19758165;   PMID:23572077;   PMID:24012478;   PMID:6420466;   PMID:6790611;   PMID:7450902;   Reaxys:1784889
 cyclic_relationship: is_conjugate_acid_of CHEBI:295975


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phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene decreases chemical synthesis ISO DEK protein results in decreased chemical synthesis of Phosphorylcholine CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine CTD PMID:18723500 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] CTD PMID:15878362 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Phosphorylcholine analog results in increased expression of TIMP1 mRNA
Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]
CTD PMID:15878362 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Phosphorylcholine analog results in increased expression of TNF mRNA CTD PMID:15878362 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
phosphorylcholine chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene decreases chemical synthesis ISO DEK protein results in decreased chemical synthesis of Phosphorylcholine CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine CTD PMID:18723500 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] CTD PMID:15878362 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Phosphorylcholine analog results in increased expression of TIMP1 mRNA
Genistein inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]
CTD PMID:15878362 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Phosphorylcholine analog results in increased expression of TNF mRNA CTD PMID:15878362 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        epitope 6835
          phosphocholine 5
            phosphocholine group 0
            phosphorylcholine chloride 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  ammonium 8213
                                    ammonium ion derivative 8209
                                      quaternary ammonium ion 5079
                                        cholines 4780
                                          choline 3531
                                            choline ester 123
                                              phosphocholines 123
                                                phosphocholine 5
                                                  phosphocholine group 0
                                                  phosphorylcholine chloride 5
paths to the root

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