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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoeugenol
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Accession:CHEBI:18224 term browser browse the term
Definition:A phenylpropanoid that is an isomer of eugenol in which the allyl substituent is replaced by a prop-1-enyl group.
Synonyms:exact_synonym: 2-methoxy-4-(prop-1-en-1-yl)phenol
 related_synonym: 1-Hydroxy-2-methoxy-4-propen-1-ylbenzene;   1-Hydroxy-2-methoxy-4-propenylbenzene;   2-Methoxy-4-propenylphenol;   3-Methoxy-4-hydroxypropenylbenzene;   4-Hydroxy-3-methoxypropenylbenzene;   4-Propenylguaiacol;   Formula=C10H12O2;   InChI=1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3-7,11H,1-2H3;   InChIKey=BJIOGJUNALELMI-UHFFFAOYSA-N;   Propenylguaiacol;   SMILES=COc1cc(C=CC)ccc1O
 alt_id: CHEBI:14466;   CHEBI:6007
 xref: Beilstein:1909602;   CAS:97-54-1;   Gmelin:2235523;   KEGG:C10469
 xref_mesh: MESH:C036643
 xref: PMID:11033063;   PMID:17573874;   PMID:17698059;   PMID:18416757;   PMID:21969073;   PMID:21989800;   PMID:22613214;   PMID:22671430;   PMID:22686307;   PMID:22827268;   PMID:23047101;   PMID:23161090;   PMID:23281757;   PMID:23286982;   PMID:23306890;   PMID:23391906;   PMID:23627552;   PMID:29079364;   PMID:9084914;   Reaxys:1909602;   Wikipedia:Isoeugenol


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isoeugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
affects localization
multiple interactions
ISO isoeugenol results in increased activity of AHR protein
isoeugenol affects the localization of AHR protein
3'-methoxy-4'-nitroflavone inhibits the reaction [isoeugenol results in increased activity of AHR protein]
CTD PMID:16972787, PMID:22686307 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO isoeugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO isoeugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression
increases activity
ISO isoeugenol results in increased expression of AKR1C2 mRNA
isoeugenol results in increased activity of AKR1C2 promoter
CTD PMID:20491607, PMID:21195160 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO isoeugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Ar androgen receptor affects binding EXP isoeugenol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO isoeugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Cat catalase increases expression ISO isoeugenol results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases secretion ISO isoeugenol results in decreased secretion of CCL2 protein CTD PMID:20488241 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl27 C-C motif chemokine ligand 27 increases expression ISO isoeugenol results in increased expression of CCL27 mRNA CTD PMID:17936526 NCBI chr 5:58,159,066...58,166,182
Ensembl chr 5:58,159,066...58,163,584
JBrowse link
G Cd274 CD274 molecule increases expression ISO isoeugenol results in increased expression of CD274 protein CTD PMID:20488241 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO isoeugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO isoeugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO isoeugenol results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO isoeugenol results in increased expression of CYP1A1 mRNA CTD PMID:20491607, PMID:22686307 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO isoeugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Fech ferrochelatase increases expression ISO isoeugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO isoeugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO isoeugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO isoeugenol results in increased expression of GCLM mRNA CTD PMID:20566472, PMID:23999411, PMID:27965148 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO isoeugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO isoeugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isoeugenol results in increased expression of HMOX1 mRNA CTD PMID:20491607, PMID:20566472, PMID:23445166 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO isoeugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ifng interferon gamma increases secretion ISO isoeugenol results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il18 interleukin 18 increases expression ISO isoeugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO isoeugenol results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il2 interleukin 2 multiple interactions
increases secretion
ISO isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]
isoeugenol results in increased secretion of IL2 protein
CTD PMID:17630204, PMID:22245253 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 increases secretion ISO isoeugenol results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G LOC100912605 olfactory receptor 5D14-like multiple interactions ISO isoeugenol binds to and results in decreased activity of OLFR73 protein; isoeugenol binds to and results in increased activity of OLFR73 protein CTD PMID:15574817, PMID:21142015 NCBI chr 3:76,255,179...76,256,129
Ensembl chr 3:76,255,179...76,256,129
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO isoeugenol results in increased expression of MAFF mRNA CTD PMID:20491607, PMID:20566472 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO isoeugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO isoeugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr12:16,923,989...16,934,706
Ensembl chr12:16,923,990...16,934,706
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Me1 malic enzyme 1 increases expression ISO isoeugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO isoeugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO isoeugenol results in increased expression of NQO1 mRNA CTD PMID:20491607, PMID:20566472 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO isoeugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO isoeugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO isoeugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD PMID:10871845, PMID:17698059 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression
multiple interactions
ISO isoeugenol results in increased expression of SOCS3 mRNA; isoeugenol results in increased expression of SOCS3 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA]
CTD PMID:21969073 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO isoeugenol results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO isoeugenol results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 increases expression ISO isoeugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO isoeugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO isoeugenol results in increased expression of TLR2 mRNA CTD PMID:17936526 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol results in increased secretion of TNF protein
CTD PMID:10871845, PMID:22245253 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trim16 tripartite motif-containing 16 multiple interactions
increases expression
ISO [Indomethacin co-treated with isoeugenol] results in increased expression of TRIM16 mRNA
isoeugenol results in increased expression of TRIM16 mRNA
CTD PMID:21284934 NCBI chr10:49,231,660...49,254,653
Ensembl chr10:49,231,730...49,254,621
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO isoeugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO isoeugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472, PMID:23445166 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO isoeugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO isoeugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Zfp36 zinc finger protein 36 increases expression
multiple interactions
ISO isoeugenol results in increased expression of ZFP36 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]
CTD PMID:21969073 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
trans-isoeugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects localization
increases activity
multiple interactions
ISO isoeugenol affects the localization of AHR protein
isoeugenol results in increased activity of AHR protein
3'-methoxy-4'-nitroflavone inhibits the reaction [isoeugenol results in increased activity of AHR protein]
CTD PMID:16972787, PMID:22686307 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO isoeugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO isoeugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression
increases activity
ISO isoeugenol results in increased expression of AKR1C2 mRNA
isoeugenol results in increased activity of AKR1C2 promoter
CTD PMID:20491607, PMID:21195160 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO isoeugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Ar androgen receptor affects binding EXP isoeugenol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO isoeugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Cat catalase increases expression ISO isoeugenol results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases secretion ISO isoeugenol results in decreased secretion of CCL2 protein CTD PMID:20488241 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl27 C-C motif chemokine ligand 27 increases expression ISO isoeugenol results in increased expression of CCL27 mRNA CTD PMID:17936526 NCBI chr 5:58,159,066...58,166,182
Ensembl chr 5:58,159,066...58,163,584
JBrowse link
G Cd274 CD274 molecule increases expression ISO isoeugenol results in increased expression of CD274 protein CTD PMID:20488241 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO isoeugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO isoeugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO isoeugenol results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO isoeugenol results in increased expression of CYP1A1 mRNA CTD PMID:20491607, PMID:22686307 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO isoeugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Fech ferrochelatase increases expression ISO isoeugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO isoeugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO isoeugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO isoeugenol results in increased expression of GCLM mRNA CTD PMID:20566472, PMID:23999411, PMID:27965148 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO isoeugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO isoeugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isoeugenol results in increased expression of HMOX1 mRNA CTD PMID:20491607, PMID:20566472, PMID:23445166 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO isoeugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ifng interferon gamma increases secretion ISO isoeugenol results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il18 interleukin 18 increases expression ISO isoeugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO isoeugenol results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il2 interleukin 2 multiple interactions
increases secretion
ISO isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]
isoeugenol results in increased secretion of IL2 protein
CTD PMID:17630204, PMID:22245253 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 increases secretion ISO isoeugenol results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G LOC100912605 olfactory receptor 5D14-like multiple interactions ISO isoeugenol binds to and results in decreased activity of OLFR73 protein; isoeugenol binds to and results in increased activity of OLFR73 protein CTD PMID:15574817, PMID:21142015 NCBI chr 3:76,255,179...76,256,129
Ensembl chr 3:76,255,179...76,256,129
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO isoeugenol results in increased expression of MAFF mRNA CTD PMID:20491607, PMID:20566472 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO isoeugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO isoeugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr12:16,923,989...16,934,706
Ensembl chr12:16,923,990...16,934,706
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Me1 malic enzyme 1 increases expression ISO isoeugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO isoeugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO isoeugenol results in increased expression of NQO1 mRNA CTD PMID:20491607, PMID:20566472 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO isoeugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO isoeugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO isoeugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD PMID:10871845, PMID:17698059 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression
multiple interactions
ISO isoeugenol results in increased expression of SOCS3 mRNA; isoeugenol results in increased expression of SOCS3 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA]
CTD PMID:21969073 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO isoeugenol results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO isoeugenol results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 increases expression ISO isoeugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO isoeugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO isoeugenol results in increased expression of TLR2 mRNA CTD PMID:17936526 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol results in increased secretion of TNF protein
CTD PMID:10871845, PMID:22245253 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trim16 tripartite motif-containing 16 multiple interactions
increases expression
ISO [Indomethacin co-treated with isoeugenol] results in increased expression of TRIM16 mRNA
isoeugenol results in increased expression of TRIM16 mRNA
CTD PMID:21284934 NCBI chr10:49,231,660...49,254,653
Ensembl chr10:49,231,730...49,254,621
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO isoeugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO isoeugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472, PMID:23445166 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO isoeugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO isoeugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Zfp36 zinc finger protein 36 increases expression
multiple interactions
ISO isoeugenol results in increased expression of ZFP36 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]
CTD PMID:21969073 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          sensitiser 9731
            isoeugenol 60
              3-methylisoeugenol 0
              5-methylisoeugenol 0
              6-methylisoeugenol 0
              cis-isoeugenol 0
              isoeugenol sulfate 0
              trans-isoeugenol + 60
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                carbocyclic compound 18222
                                  benzenoid aromatic compound 17254
                                    benzenes 17010
                                      methoxybenzenes 1835
                                        monomethoxybenzene 1741
                                          guaiacols 1355
                                            guaiacol 1308
                                              isoeugenol 60
                                                3-methylisoeugenol 0
                                                5-methylisoeugenol 0
                                                6-methylisoeugenol 0
                                                cis-isoeugenol 0
                                                isoeugenol sulfate 0
                                                trans-isoeugenol + 60
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.