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ONTOLOGY REPORT - ANNOTATIONS


Term:histamine
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Accession:CHEBI:18295 term browser browse the term
Definition:A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Synonyms:related_synonym: 1H-Imidazole-4-ethanamine;   2-(1H-Imidazol-4-yl)ethanamine;   2-(4-Imidazolyl)ethylamine;   Formula=C5H9N3;   InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8);   InChIKey=NTYJJOPFIAHURM-UHFFFAOYSA-N;   SMILES=NCCc1c[nH]cn1
 alt_id: CHEBI:14401;   CHEBI:24596;   CHEBI:43187;   CHEBI:817
 xref: Beilstein:2012 "Beilstein";   CAS:51-45-6 "ChemIDplus";   CAS:51-45-6 "KEGG COMPOUND";   CAS:51-45-6 "NIST Chemistry WebBook";   Drug_Central:1375 "DrugCentral";   Gmelin:2968 "Gmelin";   HMDB:HMDB0000870;   KEGG:C00388;   KEGG:D08040;   KNApSAcK:C00001414
 xref_mesh: MESH:D006632
 xref: MetaCyc:HISTAMINE;   PDBeChem:HSM;   PMID:16399866 "Europe PMC";   PMID:19547708 "Europe PMC";   PMID:19843401 "Europe PMC";   PMID:22770225 "Europe PMC";   PMID:24101735 "Europe PMC";   Reaxys:2012 "Reaxys";   Wikipedia:Histamine
 cyclic_relationship: is_conjugate_base_of CHEBI:58432


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histamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:6480464
G Adcyap1 adenylate cyclase activating polypeptide 1 JBrowse link 9 121,705,897 121,725,736 RGD:6480464
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:6480464
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:6480464
G Alox5ap arachidonate 5-lipoxygenase activating protein JBrowse link 12 6,854,930 6,879,112 RGD:6480464
G Ambp alpha-1-microglobulin/bikunin precursor JBrowse link 5 78,975,690 78,986,021 RGD:6480464
G Aoc1 amine oxidase, copper containing 1 JBrowse link 4 78,496,043 78,515,582 RGD:6480464
G Aqp5 aquaporin 5 JBrowse link 7 141,249,044 141,252,576 RGD:6480464
G Bcr BCR activator of RhoGEF and GTPase JBrowse link 20 14,421,250 14,546,406 RGD:6480464
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6480464
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:6480464
G Cd80 Cd80 molecule JBrowse link 11 64,815,201 64,855,293 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:6480464
G Clca1 chloride channel accessory 1 JBrowse link 2 250,897,980 250,923,711 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Csf1 colony stimulating factor 1 JBrowse link 2 210,522,370 210,550,546 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Fcer1a Fc fragment of IgE receptor Ia JBrowse link 13 91,727,253 91,737,106 RGD:6480464
G Fgf1 fibroblast growth factor 1 JBrowse link 18 32,273,830 32,359,831 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gast gastrin JBrowse link 10 88,245,532 88,248,485 RGD:6480464
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:6480464
G Gusb glucuronidase, beta JBrowse link 12 30,202,066 30,215,583 RGD:6480464
G Hdc histidine decarboxylase JBrowse link 3 119,057,524 119,075,599 RGD:6480464
G Hnmt histamine N-methyltransferase JBrowse link 3 905,111 937,038 RGD:6480464
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6480464
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:6480464
G Hrh3 histamine receptor H3 JBrowse link 3 175,474,310 175,479,395 RGD:6480464
G Hrh4 histamine receptor H4 JBrowse link 18 4,365,429 4,382,599 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Il16 interleukin 16 JBrowse link 1 145,781,923 145,881,538 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:6480464
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 JBrowse link 3 176,585,897 176,645,029 RGD:6480464
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 JBrowse link 7 106,714,479 107,009,639 RGD:6480464
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:6480464
G Ltc4s leukotriene C4 synthase JBrowse link 10 35,736,486 35,743,088 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Pde4b phosphodiesterase 4B JBrowse link 5 121,759,236 122,136,814 RGD:6480464
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:6480464
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6480464
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:6480464
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Slc18a1 solute carrier family 18 member A1 JBrowse link 16 22,358,646 22,395,183 RGD:6480464
G Slc18a2 solute carrier family 18 member A2 JBrowse link 1 280,397,831 280,457,968 RGD:6480464
G Slc22a3 solute carrier family 22 member 3 JBrowse link 1 48,433,079 48,521,261 RGD:6480464
G Slc29a4 solute carrier family 29 member 4 JBrowse link 12 13,914,114 13,924,511 RGD:6480464
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Sst somatostatin JBrowse link 11 80,358,172 80,359,449 RGD:6480464
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:6480464
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:6480464
G Taar1 trace-amine-associated receptor 1 JBrowse link 1 22,595,477 22,596,475 RGD:6480464
G Tac1 tachykinin, precursor 1 JBrowse link 4 33,638,853 33,646,819 RGD:6480464
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Ucp2 uncoupling protein 2 JBrowse link 1 165,506,375 165,512,744 RGD:6480464
G Vip vasoactive intestinal peptide JBrowse link 1 42,169,307 42,177,582 RGD:6480464
4-methylhistamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6480464
G Cd80 Cd80 molecule JBrowse link 11 64,815,201 64,855,293 RGD:6480464
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:6480464
G Hrh4 histamine receptor H4 JBrowse link 18 4,365,429 4,382,599 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
alpha-methylhistamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gal galanin and GMAP prepropeptide JBrowse link 1 218,653,059 218,657,922 RGD:6480464
G Gast gastrin JBrowse link 10 88,245,532 88,248,485 RGD:6480464
G Hdc histidine decarboxylase JBrowse link 3 119,057,524 119,075,599 RGD:6480464
G Hrh3 histamine receptor H3 JBrowse link 3 175,474,310 175,479,395 RGD:6480464
G Hrh4 histamine receptor H4 JBrowse link 18 4,365,429 4,382,599 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il16 interleukin 16 JBrowse link 1 145,781,923 145,881,538 RGD:6480464
histamine phosphate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
N(tele)-methylhistamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aoc1 amine oxidase, copper containing 1 JBrowse link 4 78,496,043 78,515,582 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        molecular messenger 17946
          neurotransmitter 5832
            histamine 94
              2-methylhistamine 0
              4-methylhistamine 12
              N(alpha)-gamma-L-glutamylhistamine 0
              N(tele)-methylhistamine 1
              N-acetylhistamine 0
              N-guanylhistamine 0
              alpha-methylhistamine 7
              carcinine 0
              histamine phosphate 1
              testosterone-3-CMO-Hist + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic heterocyclic compound 18164
                                  heteroarene 15170
                                    monocyclic heteroarene 11624
                                      azole 10480
                                        diazole 8045
                                          imidazoles 7596
                                            histamine 94
                                              2-methylhistamine 0
                                              4-methylhistamine 12
                                              N(alpha)-gamma-L-glutamylhistamine 0
                                              N(tele)-methylhistamine 1
                                              N-acetylhistamine 0
                                              N-guanylhistamine 0
                                              alpha-methylhistamine 7
                                              carcinine 0
                                              histamine phosphate 1
                                              testosterone-3-CMO-Hist + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.