Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-phenylethylamine
go back to main search page
Accession:CHEBI:18397 term browser browse the term
Definition:A phenylethylamine having the phenyl substituent at the 2-position.
Synonyms:related_synonym: 2-phenylethanamine;   Formula=C8H11N;   InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2;   InChIKey=BHHGXPLMPWCGHP-UHFFFAOYSA-N;   Phenethylamine;   Phenylethylamine;   SMILES=NCCc1ccccc1;   benzeneethanamine;   beta-Phenylethylamine;   beta-aminoethylbenzene;   beta-phenethylamine
 alt_id: CHEBI:14782;   CHEBI:25965;   CHEBI:8063
 xref: Beilstein:507488;   CAS:64-04-0;   DrugBank:DB04325;   ECMDB:ECMDB02654;   Gmelin:50120;   HMDB:HMDB0012275;   KEGG:C05332;   KNApSAcK:C00001426
 xref_mesh: MESH:C029261
 xref: PDBeChem:PEA;   PMID:20390105;   PMID:21191624;   PMID:23225177;   PMID:23564683;   PMID:7906896;   Reaxys:507488;   Wikipedia:2-phenylethylamine
 cyclic_relationship: is_conjugate_base_of CHEBI:225237


show annotations for term's descendants           Sort by:
 
2-phenylethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions ISO phenethylamine binds to and results in decreased activity of ADRA1A protein CTD PMID:20217639 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra2a adrenoceptor alpha 2A affects binding ISO phenethylamine binds to ADRA2A protein CTD PMID:20217639 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2c adrenoceptor alpha 2C affects binding ISO phenethylamine binds to ADRA2C protein CTD PMID:20217639 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Maob monoamine oxidase B multiple interactions ISO Phenylpropanolamine inhibits the reaction [MAOB protein results in increased degradation of phenethylamine] CTD PMID:3961266 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Slc18a1 solute carrier family 18 member A1 multiple interactions ISO phenethylamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] CTD PMID:8245983 NCBI chr16:22,358,646...22,395,183
Ensembl chr16:22,361,998...22,395,183
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO SLC6A2 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases transport
ISO Cocaine inhibits the reaction [SLC6A3 protein results in increased transport of phenethylamine]; SLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] CTD PMID:15764732, PMID:17234900 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO SLC6A4 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions
increases activity
ISO [phenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; SLC6A2 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] CTD PMID:17234900, PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
4-methoxyphenylethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO O-methyltyramine results in increased activity of TAAR1 protein
[O-methyltyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
compound 48/80 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gusb glucuronidase, beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases activity EXP p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Kng2 kininogen 2 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity
EXP atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein] CTD PMID:29402411 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein] CTD PMID:29402411 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
N,O-dimethyltyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gusb glucuronidase, beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases activity EXP p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Kng2 kininogen 2 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity
EXP atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein
epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein]
CTD PMID:29402411 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein] CTD PMID:29402411 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            alkaloid 5350
              2-phenylethylamine 16
                (2R)-4-(2-ammonio-1-hydroxyethyl)phenol 0
                2-hydroxy-5-[(1E)-(2-phenylethylidene)amino]-L-tyrosine 0
                3,4-dimethoxyphenylethylamine 0
                3-\{(3E)-4-hydroxy-6-oxo-3-[(2-phenylethyl)imino]cyclohexa-1,4-dien-1-yl\}-L-alanine 0
                4-methoxyphenylethylamine + 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        amine 7602
                                          alkylamines 183
                                            aralkylamine 163
                                              2-phenylethylamine 16
                                                (2R)-4-(2-ammonio-1-hydroxyethyl)phenol 0
                                                2-hydroxy-5-[(1E)-(2-phenylethylidene)amino]-L-tyrosine 0
                                                3,4-dimethoxyphenylethylamine 0
                                                3-\{(3E)-4-hydroxy-6-oxo-3-[(2-phenylethyl)imino]cyclohexa-1,4-dien-1-yl\}-L-alanine 0
                                                4-methoxyphenylethylamine + 8
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.