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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyridoxal 5'-phosphate
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Accession:CHEBI:18405 term browser browse the term
Definition:The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Synonyms:exact_synonym: (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
 related_synonym: 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde;   3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate;   Formula=C8H10NO6P;   InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14);   InChIKey=NGVDGCNFYWLIFO-UHFFFAOYSA-N;   PLP;   Phosphoric acid mono-(4-formyl-5-hydroxy-6-methyl-pyridin-3-ylmethyl) ester;   Pyridoxal phosphate;   SMILES=[H]C(=O)c1c(COP(O)(O)=O)cnc(C)c1O;   codecarboxylase;   pyridoxal 5'-(dihydrogen phosphate);   pyridoxal 5-monophosphoric acid ester
 alt_id: CHEBI:14977;   CHEBI:234571;   CHEBI:26424;   CHEBI:358848;   CHEBI:45145;   CHEBI:8668
 xref: Beilstein:234749;   CAS:54-47-7;   COMe:MOL000108;   DrugBank:DB00114;   Drug_Central:3506;   Gmelin:465416;   HMDB:HMDB0001491;   KEGG:C00018;   KNApSAcK:C00007503
 xref_mesh: MESH:D011732
 xref: PDBeChem:PLP;   PMID:14651974;   PMID:16277678;   PMID:18491919;   PMID:6339724;   PMID:7284379;   PMID:9866693;   Reaxys:234749;   Wikipedia:Pyridoxal_phosphate
 cyclic_relationship: is_conjugate_acid_of CHEBI:597326


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pyridoxal 5'-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases abundance ISO ALPL gene mutant form results in increased abundance of Pyridoxal Phosphate CTD PMID:7550313 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Pyridoxal Phosphate results in decreased expression of BCL2 protein CTD PMID:16690808 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Pyridoxal Phosphate inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] CTD PMID:8151099 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fut8 fucosyltransferase 8 multiple interactions
decreases activity
ISO Fucose analog inhibits the reaction [Pyridoxal Phosphate results in decreased activity of FUT8 protein] CTD PMID:12770769 NCBI chr 6:100,305,957...100,537,208
Ensembl chr 6:100,337,226...100,537,224
JBrowse link
G Gad1 glutamate decarboxylase 1 affects binding
decreases activity
increases activity
ISO
EXP
Pyridoxal Phosphate binds to GAD1 protein modified form
Pyridoxal Phosphate results in decreased activity of GAD1 protein
Pyridoxal Phosphate results in increased activity of GAD1 protein
CTD PMID:171340, PMID:7463050, PMID:15686475 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gad2 glutamate decarboxylase 2 affects binding ISO Pyridoxal Phosphate binds to GAD2 protein; Pyridoxal Phosphate binds to GAD2 protein modified form CTD PMID:15686475, PMID:15690345, PMID:15836621 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gh1 growth hormone 1 decreases secretion EXP Pyridoxal Phosphate results in decreased secretion of GH1 protein CTD PMID:16690808 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO Pyridoxal Phosphate binds to and results in increased activity of NRIP1 protein CTD PMID:17277785 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Pdxk pyridoxal kinase decreases activity EXP Pyridoxal Phosphate results in decreased activity of PDXK protein CTD PMID:7463050 NCBI chr20:10,930,651...10,952,194
Ensembl chr20:10,930,518...10,952,391
JBrowse link
G Pomc proopiomelanocortin decreases secretion ISO Pyridoxal Phosphate results in decreased secretion of POMC protein CTD PMID:16690808 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Pyridoxal Phosphate inhibits the reaction [Ethanol results in decreased activity of PPARA protein] CTD PMID:11022051 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Prl prolactin decreases secretion EXP Pyridoxal Phosphate results in decreased secretion of PRL protein CTD PMID:16690808 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein] CTD PMID:11102496 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid results in decreased expression of FN1 mRNA CTD PMID:18210741 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Il6 interleukin 6 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein] CTD PMID:24793913 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]] CTD PMID:24912985 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein] CTD PMID:11102496 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein] CTD PMID:21638035 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [zinc chloride results in increased expression of PARP1 protein] CTD PMID:22253048 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          cofactor 15548
            pyridoxal 5'-phosphate 18
              (2R,3R,4S,5R,6R)-3,4-dihydroxy-5-\{[(1E)-\{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl\}methylidene]amino\}-6-methyltetrahydro-2H-pyran-2-yl [(2R,3S,5R)-3-hydroxy-5-(thymin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate 0
              5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            formyl group 7851
                                              aldehyde 7851
                                                heteroarenecarbaldehyde 18
                                                  pyridinecarbaldehyde 18
                                                    pyridoxal 18
                                                      pyridoxal 5'-phosphate 18
                                                        (2R,3R,4S,5R,6R)-3,4-dihydroxy-5-\{[(1E)-\{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl\}methylidene]amino\}-6-methyltetrahydro-2H-pyran-2-yl [(2R,3S,5R)-3-hydroxy-5-(thymin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate 0
                                                        5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.