Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:AICA ribonucleotide
go back to main search page
Accession:CHEBI:18406 term browser browse the term
Definition:A 1-(phosphoribosyl)imidazolecarboxamide that is acadesine in which the hydroxy group at the 5' position has been converted to its monophosphate derivative.
Synonyms:related_synonym: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide;   5'-Phospho-ribosyl-5-amino-4-imidazole carboxamide;   5'-Phosphoribosyl-5-amino-4-imidazolecarboxamide;   5-Aminoimidazole-4-carboxamide ribotide;   5-Phosphoribosyl-4-carbamoyl-5-aminoimidazole;   5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide;   5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide;   AICAR;   Formula=C9H15N4O8P;   InChI=1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19)/t3-,5-,6-,9-/m1/s1;   InChIKey=NOTGFIUVDGNKRI-UUOKFMHZSA-N;   SMILES=NC(=O)c1ncn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c1N;   acadesine 5'-monophosphate
 alt_id: CHEBI:12102;   CHEBI:18966;   CHEBI:40739;   CHEBI:573
 xref: CAS:3031-94-5;   DrugBank:DB01700;   ECMDB:ECMDB01517;   HMDB:HMDB0001517;   KEGG:C04677;   KNApSAcK:C00007383
 xref_mesh: MESH:C031143
 xref: PDBeChem:AMZ;   PMID:23988673;   PMID:25078608;   PMID:8227467;   Reaxys:52565;   Wikipedia:AICA_ribonucleotide;   YMDB:YMDB01481
 cyclic_relationship: is_conjugate_acid_of CHEBI:58475


show annotations for term's descendants           Sort by:
 
AICA ribonucleotide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP AICA ribonucleotide results in decreased expression of ABCB11 mRNA CTD PMID:27090119 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP AICA ribonucleotide results in decreased expression of ABCC2 mRNA CTD PMID:27090119 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation
multiple interactions
increases expression
ISO
EXP
AICA ribonucleotide results in increased phosphorylation of ACACA protein
AICA ribonucleotide inhibits the reaction [fipronil results in increased expression of and results in decreased phosphorylation of ACACA protein]; AICA ribonucleotide results in decreased expression of and results in increased phosphorylation of ACACA protein
AICA ribonucleotide results in increased expression of ACACA protein modified form
CTD PMID:15297373, PMID:16020477, PMID:16873680, PMID:20080969, PMID:25743752, PMID:27103584 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acacb acetyl-CoA carboxylase beta increases phosphorylation ISO AICA ribonucleotide results in increased phosphorylation of ACACB protein CTD PMID:16873680 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions
increases expression
EXP
ISO
AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]
AICA ribonucleotide results in increased expression of ACADM mRNA; AICA ribonucleotide results in increased expression of ACADM protein
CTD PMID:19699196, PMID:25743752 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:27688165 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions
ISO
EXP
AICA ribonucleotide results in increased expression of ADIPOQ protein
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA]
CTD PMID:20980258, PMID:25108154 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in decreased oxidation of Fatty Acids]; AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased phosphorylation of EIF4EBP1 protein]; AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased susceptibility to Glucose deficiency]; PRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]] CTD PMID:15806154 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein decreases expression ISO AICA ribonucleotide results in decreased expression of APP protein modified form CTD PMID:20080969 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arg1 arginase 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA] CTD PMID:25108154 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Ethanol results in decreased expression of ATG5 protein] CTD PMID:24582693 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
EXP AICA ribonucleotide results in increased expression of BECN1 protein
AICA ribonucleotide promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]
CTD PMID:28041982 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP
ISO
AICA ribonucleotide results in increased activity of CASP3 protein
AICA ribonucleotide inhibits the reaction [sunitinib results in increased cleavage of CASP3 protein]
CTD PMID:16469385, PMID:21906609 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO AICA ribonucleotide inhibits the reaction [sunitinib results in increased cleavage of CASP7 protein] CTD PMID:21906609 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 increases activity EXP AICA ribonucleotide results in increased activity of CASP9 protein CTD PMID:16469385 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
increases expression
ISO AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]
AICA ribonucleotide results in increased expression of CAT mRNA; AICA ribonucleotide results in increased expression of CAT protein
CTD PMID:25065674 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP
ISO
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA]
AICA ribonucleotide results in decreased expression of CCL2 mRNA
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of CCL2 mRNA]
CTD PMID:24465016, PMID:25108154 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] CTD PMID:21745629 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]
AICA ribonucleotide results in decreased expression of CCNA2 mRNA; AICA ribonucleotide results in decreased expression of CCNA2 protein
CTD PMID:12730239 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
AICA ribonucleotide results in decreased expression of CCNB1 mRNA; AICA ribonucleotide results in decreased expression of CCNB1 protein
CTD PMID:12730239 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO AICA ribonucleotide results in increased expression of and affects the localization of CD36 protein CTD PMID:28038998 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
multiple interactions
ISO AICA ribonucleotide results in decreased expression of CEBPA protein
AICA ribonucleotide inhibits the reaction [fipronil results in increased expression of CEBPA protein]
CTD PMID:27103584 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases phosphorylation ISO AICA ribonucleotide results in increased phosphorylation of CEBPB protein CTD PMID:28038998 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions EXP AICA ribonucleotide inhibits the reaction [Colforsin results in increased activity of CFTR protein] CTD PMID:12519745 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:27688165 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression
multiple interactions
ISO AICA ribonucleotide results in increased expression of CPT1A mRNA; AICA ribonucleotide results in increased expression of CPT1A protein
dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of CPT1A mRNA]
CTD PMID:24465016, PMID:25743752 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions EXP AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein] CTD PMID:19699196 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 mRNA; [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 protein; AICA ribonucleotide inhibits the reaction [[HDAC5 protein binds to MEF2 protein] which binds to CTNNB1 promoter]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 mRNA]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 protein]
AICA ribonucleotide results in increased expression of CTNNB1 mRNA; AICA ribonucleotide results in increased expression of CTNNB1 protein
CTD PMID:21454484 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein] CTD PMID:21195169 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein] CTD PMID:21195169 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]; PRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]] CTD PMID:22815988 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO AICA ribonucleotide inhibits the reaction [EGFR protein results in increased import of Deoxyglucose] CTD PMID:19625624 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha decreases phosphorylation ISO AICA ribonucleotide results in decreased phosphorylation of EIF2S1 protein CTD PMID:22898769 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation
ISO
EXP
AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased phosphorylation of EIF4EBP1 protein]
AICA ribonucleotide results in decreased phosphorylation of EIF4EBP1 protein
AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]
CTD PMID:15806154, PMID:21195169, PMID:28041982 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions
decreases localization
ISO AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]; AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
AICA ribonucleotide results in decreased localization of ELAVL1 protein
CTD PMID:12730239 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases expression
increases phosphorylation
increases activity
ISO AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]; AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]
AICA ribonucleotide results in increased expression of FOXO1 protein
AICA ribonucleotide results in increased phosphorylation of FOXO1 protein
AICA ribonucleotide results in increased activity of FOXO1 protein
CTD PMID:25065674 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein] CTD PMID:16020477 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit decreases expression EXP AICA ribonucleotide results in decreased expression of G6PC mRNA CTD PMID:19664596 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gpr68 G protein-coupled receptor 68 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TNF protein promotes the reaction [Oxygen deficiency results in increased expression of GPR68 mRNA]]; AICA ribonucleotide inhibits the reaction [TNF protein results in increased expression of GPR68 mRNA] CTD PMID:28174749 NCBI chr 6:124,874,151...124,903,949
Ensembl chr 6:124,874,151...124,876,710
JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP GRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 increases expression ISO AICA ribonucleotide results in increased expression of GSTK1 protein CTD PMID:20980258 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions
increases phosphorylation
ISO [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 mRNA; [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 protein; AICA ribonucleotide inhibits the reaction [[HDAC5 protein binds to MEF2 protein] which binds to CTNNB1 promoter] CTD PMID:21454484 NCBI chr10:90,140,183...90,169,853
Ensembl chr10:90,140,183...90,151,042
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO AICA ribonucleotide results in decreased expression of HNF4A mRNA CTD PMID:24428821 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP AICA ribonucleotide results in decreased expression of HSD3B1 mRNA; AICA ribonucleotide results in decreased expression of HSD3B1 protein CTD PMID:16020477
G Igf1 insulin-like growth factor 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:16020477 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of IL1B mRNA] CTD PMID:24465016 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP
ISO
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]
AICA ribonucleotide results in decreased expression of IL6 mRNA
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of IL6 mRNA]
CTD PMID:24465016, PMID:25108154 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insr insulin receptor multiple interactions
decreases activity
decreases expression
ISO 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]
AICA ribonucleotide results in decreased expression of INSR mRNA; AICA ribonucleotide results in decreased expression of INSR protein
CTD PMID:15694368 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 affects response to substance ISO KCNJ11 protein affects the susceptibility to AICA ribonucleotide CTD PMID:24498880 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Klf15 Kruppel-like factor 15 decreases expression ISO AICA ribonucleotide results in decreased expression of KLF15 mRNA CTD PMID:24428821 NCBI chr 4:122,364,688...122,377,690
Ensembl chr 4:122,365,093...122,377,659
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
EXP
ISO
AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]
AICA ribonucleotide results in increased phosphorylation of MAPK1 protein
AICA ribonucleotide results in decreased phosphorylation of MAPK1 protein
CTD PMID:16020477, PMID:28038998 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation
EXP
ISO
AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of MAPK3 protein]
AICA ribonucleotide results in increased phosphorylation of MAPK3 protein
AICA ribonucleotide results in decreased phosphorylation of MAPK3 protein
CTD PMID:11978788, PMID:16020477, PMID:28038998 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mfn1 mitofusin 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of MFN1 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN1 protein] CTD PMID:27792760 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of MFN2 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN2 protein] CTD PMID:27792760 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein] CTD PMID:27688165 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO AICA ribonucleotide results in decreased activity of MMP2 protein CTD PMID:20590612 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO AICA ribonucleotide results in decreased activity of MMP9 protein CTD PMID:20590612 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases activity
decreases phosphorylation
multiple interactions
ISO
EXP
AICA ribonucleotide results in decreased activity of MTOR protein
AICA ribonucleotide results in decreased phosphorylation of MTOR protein
AICA ribonucleotide promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]
AICA ribonucleotide promotes the reaction [Cadmium results in decreased phosphorylation of MTOR protein]
CTD PMID:19625624, PMID:21767558, PMID:27363783, PMID:28041982 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF1 protein] CTD PMID:21195169 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein] CTD PMID:21195169 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Ncf4 neutrophil cytosolic factor 4 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF4 protein] CTD PMID:21195169 NCBI chr 7:119,481,711...119,499,426
Ensembl chr 7:119,482,272...119,499,425
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein] CTD PMID:22025971 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
CTD PMID:24465016, PMID:25108154 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]] CTD PMID:25108154 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO AICA ribonucleotide results in decreased expression of NR0B2 mRNA CTD PMID:24428821 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP AICA ribonucleotide results in decreased expression of NR1H4 mRNA; AICA ribonucleotide results in decreased expression of NR1H4 protein CTD PMID:27090119 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Phenobarbital results in increased localization of and results in increased activity of NR1I3 protein]; AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]; PRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]] CTD PMID:20686344, PMID:22815988 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression
EXP dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of NRF1 mRNA] CTD PMID:20438809 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of OPA1 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of OPA1 protein] CTD PMID:27792760 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA protein] CTD PMID:19699196 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]
AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]
CTD PMID:25108154, PMID:27688165 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
decreases expression
EXP
ISO
dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of PPARGC1A mRNA]
AICA ribonucleotide results in decreased expression of PPARGC1A mRNA
AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; dorsomorphin promotes the reaction [AICA ribonucleotide results in decreased expression of PPARGC1A mRNA]
AICA ribonucleotide inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]
CTD PMID:20438809, PMID:23090186, PMID:24428821, PMID:25522270 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation
multiple interactions
increases expression
increases activity
EXP
ISO
AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein]
AICA ribonucleotide promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]; Quercetin promotes the reaction [AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein]
AICA ribonucleotide results in increased expression of PRKAA1 protein modified form
[AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein] which results in decreased secretion of Progesterone; AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]; AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in increased expression of PRKAA1 mRNA]
AICA ribonucleotide results in increased activity of PRKAA1 protein
CTD PMID:12519745, PMID:16020477, PMID:16873680, PMID:19293639, PMID:20349193, PMID:21195169, PMID:21205922, PMID:23266269, PMID:24465016, PMID:25743752, PMID:28298333 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions
increases phosphorylation
ISO
EXP
AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA2 protein; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]
PRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]]
AICA ribonucleotide results in increased phosphorylation of PRKAA2 protein
PRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 mRNA]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 protein]
CTD PMID:15806154, PMID:16873680, PMID:18482975, PMID:21205922, PMID:21454484, PMID:22815988 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions
increases activity
EXP 1-Butanol inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; Genistein inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; GRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Pten phosphatase and tensin homolog increases response to substance ISO PTEN protein results in increased susceptibility to AICA ribonucleotide CTD PMID:19625624 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22025971 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PTK2B protein; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of MAPK3 protein]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of RAC1 protein] CTD PMID:21195169 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions EXP RAF1 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose] CTD PMID:11978788 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
AICA ribonucleotide inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of RELA protein]
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]; Niacinamide inhibits the reaction [AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]
CTD PMID:22058332, PMID:25108154 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO AICA ribonucleotide results in decreased phosphorylation of RPS6 protein CTD PMID:19625624 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of RPS6KB1 protein]
AICA ribonucleotide results in decreased phosphorylation of RPS6KB1 protein
CTD PMID:15342961, PMID:21195169, PMID:28041982 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
ISO
EXP
AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [Streptozocin results in decreased activity of SIRT1 protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of SIRT1 protein]
AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]
[Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to AICA ribonucleotide
CTD PMID:22058332, PMID:23090186, PMID:24465016, PMID:25108154, PMID:27688165 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP AICA ribonucleotide results in decreased expression of SLC10A1 mRNA CTD PMID:27090119 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases activity ISO AICA ribonucleotide results in decreased activity of SLC15A1 protein CTD PMID:22108913 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
increases localization
EXP
ISO
1-Butanol inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; Genistein inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; U 0126 inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; wortmannin inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]
AICA ribonucleotide inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA]
CTD PMID:11978788, PMID:21802492 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP AICA ribonucleotide results in decreased expression of SLCO1A2 mRNA CTD PMID:27090119 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]
AICA ribonucleotide results in increased expression of SOD2 mRNA; AICA ribonucleotide results in increased expression of SOD2 protein
CTD PMID:25065674 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein] CTD PMID:27688165 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Tbc1d1 TBC1 domain family member 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D1 protein] CTD PMID:26627467 NCBI chr14:45,598,753...45,797,650
Ensembl chr14:45,598,743...45,797,887
JBrowse link
G Tbc1d4 TBC1 domain family, member 4 multiple interactions ISO AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein] CTD PMID:24343960, PMID:26627467 NCBI chr15:85,927,978...86,105,829
Ensembl chr15:85,930,044...86,105,273
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein] CTD PMID:27688165 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein] CTD PMID:27688165 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
AICA ribonucleotide inhibits the reaction [TNF protein promotes the reaction [Oxygen deficiency results in increased expression of GPR68 mRNA]]; AICA ribonucleotide inhibits the reaction [TNF protein results in increased expression of GPR68 mRNA]
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]
CTD PMID:22025971, PMID:25108154, PMID:28174749 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein] CTD PMID:22025971 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [resveratrol co-treated with AICA ribonucleotide] inhibits the reaction [Glucose results in increased expression of TP53 protein] CTD PMID:26188290 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein] CTD PMID:29031535 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Indican results in decreased expression of UCP2 mRNA] CTD PMID:25703824 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO AICA ribonucleotide inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased secretion of VEGFA protein] CTD PMID:30724446 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            cardiovascular drug 7613
              AICA ribonucleotide 100
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  phosphorus oxoacid 9032
                                    phosphoric acids 7794
                                      phosphoric acid 7794
                                        phosphoric acid derivative 7473
                                          phosphate 7473
                                            organic phosphate 7472
                                              carbohydrate phosphate 1528
                                                phospho sugar 1454
                                                  aldose phosphate 1452
                                                    aldopentose phosphate 1446
                                                      ribose phosphate 1440
                                                        1-(phosphoribosyl)imidazole 101
                                                          1-(phosphoribosyl)imidazolecarboxamide 101
                                                            AICA ribonucleotide 100
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.