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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cobamamide
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Accession:CHEBI:18408 term browser browse the term
Definition:A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.
Synonyms:exact_synonym: Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide
 related_synonym: (5,6-Dimethylbenzimidazolyl)cobamide coenzyme;   5'-Deoxy-5'-adenosyl vitamin B12;   5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide;   5'-Deoxy-5'-adenosylcobalamin;   5'-deoxyadenosyl vitamin B12;   5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide;   5'-deoxyadenosylcobalamin;   5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide;   5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide;   AdoCbl;   Calomide;   Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide;   Cobalamin coenzyme;   Coenzyme B12;   DBC coenzyme;   DMBC coenzyme;   Deoxyadenosylcobalamin;   Dibencozide;   Formula=C72H100CoN18O17P;   Funacomide;   InChI=1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;4-,6-,7-,10-;/m11./s1;   InChIKey=ZIHHMGTYZOSFRC-OUCXYWSSSA-L;   SMILES=[H][C@]12[C@H](CC(N)=O)[C@@]3(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@@H]4[C@@H](CO)O[C@@H]([C@@H]4O)n4c[n+](c5cc(C)c(C)cc45)[Co-3]456(C[C@H]7O[C@H]([C@H](O)[C@@H]7O)n7cnc8c(N)ncnc78)N1C3=C(C)C1=[N+]4C(=CC3=[N+]5C(=C(C)C4=[N+]6[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O;   Vitamin B12 coenzyme;   adenosylcob(III)alamin;   adenosylcobalamin;   alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme;   cobamamid;   cobamamida;   cobamamidum;   cobamide coenzyme;   coenzyme B-12
 alt_id: CHEBI:13739;   CHEBI:23340;   CHEBI:3797
 xref: Beilstein:4122932;   CAS:13870-90-1;   DrugBank:DB11191;   Gmelin:439994;   HMDB:HMDB0002086;   KEGG:C00194
 xref_mesh: MESH:C000913
 xref: MetaCyc:ADENOSYLCOBALAMIN;   PDBeChem:B1Z;   PMID:11792214;   PMID:12093296;   PMID:17011224;   Reaxys:4122932;   Wikipedia:Cobamamide


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cobamamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO cobamamide inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          cofactor 15531
            cobamamide 1
              adenosylcobalamin 5'-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organonitrogen heterocyclic compound 17461
                                    polypyrrole 609
                                      tetrapyrrole 497
                                        cyclic tetrapyrrole 368
                                          metallotetrapyrrole 336
                                            cobalt corrinoid 39
                                              cobalt-corrinoid hexaamide 39
                                                cobamides 39
                                                  cobalamins 39
                                                    cobamamide 1
                                                      adenosylcobalamin 5'-phosphate 0
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