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ONTOLOGY REPORT - ANNOTATIONS


Term:11alpha-hydroxy steroid
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Accession:CHEBI:19129 term browser browse the term
Synonyms:related_synonym: 11alpha-hydroxy steroids


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fusidic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 JBrowse link 2 69,238,282 69,342,616 RGD:6480464
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:6480464
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 JBrowse link 19 43,782,308 43,838,332 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 JBrowse link 12 80,953,185 80,968,705 RGD:6480464
G Slco1a4 solute carrier organic anion transporter family, member 1a4 JBrowse link 6 141,805,438 141,856,284 RGD:6480464
G Slco1b2 solute carrier organic anion transporter family, member 1b2 JBrowse link 6 141,629,452 141,686,646 RGD:6480464
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 JBrowse link 1 88,211,959 88,220,002 RGD:6480464
ouabain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 6 121,636,165 121,679,238 RGD:6480464
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:6480464
G Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) JBrowse link 18 74,779,212 74,806,207 RGD:6480464
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 JBrowse link 11 105,967,948 105,989,964 RGD:6480464
G Acta2 actin, alpha 2, smooth muscle, aorta JBrowse link 19 34,240,336 34,255,585 RGD:6480464
G Adh1 alcohol dehydrogenase 1 (class I) JBrowse link 3 138,277,585 138,290,698 RGD:6480464
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) JBrowse link 8 124,556,587 124,569,706 RGD:6480464
G Agtr1a angiotensin II receptor, type 1a JBrowse link 13 30,336,356 30,382,867 RGD:6480464
G Anxa1 annexin A1 JBrowse link 19 20,373,434 20,390,671 RGD:6480464
G Anxa2 annexin A2 JBrowse link 9 69,453,683 69,491,792 RGD:6480464
G Araf Araf proto-oncogene, serine/threonine kinase JBrowse link X 20,797,707 20,860,521 RGD:6480464
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 JBrowse link 9 59,388,554 59,488,186 RGD:6480464
G Arpc5 actin related protein 2/3 complex, subunit 5 JBrowse link 1 152,766,542 152,775,580 RGD:6480464
G Arrb1 arrestin, beta 1 JBrowse link 7 99,535,147 99,606,772 RGD:6480464
G Asah1 N-acylsphingosine amidohydrolase 1 JBrowse link 8 41,340,646 41,397,644 RGD:6480464
G Atp12a ATPase, H+/K+ transporting, nongastric, alpha polypeptide JBrowse link 14 56,364,669 56,388,551 RGD:6480464
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide JBrowse link 3 101,576,219 101,604,707 RGD:6480464
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide JBrowse link 1 172,271,709 172,298,064 RGD:6480464
G Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide JBrowse link 7 24,978,165 25,006,077 RGD:6480464
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide JBrowse link 1 164,437,099 164,458,355 RGD:6480464
G Atp4b ATPase, H+/K+ exchanging, beta polypeptide JBrowse link 8 13,386,209 13,396,778 RGD:6480464
G Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 JBrowse link 18 77,773,768 77,782,869 RGD:6480464
G Bahd1 bromo adjacent homology domain containing 1 JBrowse link 2 118,900,336 118,924,528 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bdnf brain derived neurotrophic factor JBrowse link 2 109,674,700 109,727,043 RGD:6480464
G Calb1 calbindin 1 JBrowse link 4 15,881,264 15,906,709 RGD:6480464
G Calm4 calmodulin 4 JBrowse link 13 3,837,757 3,838,671 RGD:6480464
G Canx calnexin JBrowse link 11 50,293,957 50,325,673 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:6480464
G Cav1 caveolin 1, caveolae protein JBrowse link 6 17,306,335 17,341,328 RGD:6480464
G Ccdc14 coiled-coil domain containing 14 JBrowse link 16 34,690,557 34,725,204 RGD:6480464
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:6480464
G Ccna1 cyclin A1 JBrowse link 3 55,045,469 55,057,634 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 3 36,564,865 36,573,038 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 7 144,929,931 144,939,937 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 8 106,603,350 106,670,247 RGD:6480464
G Cdh2 cadherin 2 JBrowse link 18 16,588,877 16,809,246 RGD:6480464
G Cdk2 cyclin-dependent kinase 2 JBrowse link 10 128,697,938 128,705,051 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) JBrowse link 17 29,090,979 29,100,722 RGD:6480464
G Ckb creatine kinase, brain JBrowse link 12 111,669,355 111,672,338 RGD:6480464
G Cldn1 claudin 1 JBrowse link 16 26,356,645 26,371,839 RGD:6480464
G Cnpy2 canopy FGF signaling regulator 2 JBrowse link 10 128,322,158 128,327,187 RGD:6480464
G Col1a1 collagen, type I, alpha 1 JBrowse link 11 94,936,224 94,953,042 RGD:6480464
G Cs citrate synthase JBrowse link 10 128,337,727 128,362,482 RGD:6480464
G Cyc1 cytochrome c-1 JBrowse link 15 76,343,513 76,346,260 RGD:6480464
G Ddost dolichyl-di-phosphooligosaccharide-protein glycotransferase JBrowse link 4 138,304,738 138,312,619 RGD:6480464
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 16 4,684,070 4,707,695 RGD:6480464
G Drd1 dopamine receptor D1 JBrowse link 13 54,051,183 54,055,658 RGD:6480464
G Dsg1a desmoglein 1 alpha JBrowse link 18 20,310,873 20,343,353 RGD:6480464
G Dut deoxyuridine triphosphatase JBrowse link 2 125,247,248 125,259,049 RGD:6480464
G Ece1 endothelin converting enzyme 1 JBrowse link 4 137,862,237 137,965,229 RGD:6480464
G Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial JBrowse link 7 140,105,710 140,116,421 RGD:6480464
G Edn1 endothelin 1 JBrowse link 13 42,301,476 42,307,990 RGD:6480464
G Ednra endothelin receptor type A JBrowse link 8 77,663,029 77,724,452 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 11 16,752,203 16,913,907 RGD:6480464
G Eif3k eukaryotic translation initiation factor 3, subunit K JBrowse link 7 28,971,372 28,981,890 RGD:6480464
G Ercc4 excision repair cross-complementing rodent repair deficiency, complementation group 4 JBrowse link 16 13,109,366 13,152,009 RGD:6480464
G Ets1 E26 avian leukemia oncogene 1, 5' domain JBrowse link 9 32,636,183 32,757,820 RGD:6480464
G Fancd2 Fanconi anemia, complementation group D2 JBrowse link 6 113,531,640 113,597,020 RGD:6480464
G Fancf Fanconi anemia, complementation group F JBrowse link 7 51,860,577 51,862,267 RGD:6480464
G Fanci Fanconi anemia, complementation group I JBrowse link 7 79,392,312 79,450,266 RGD:6480464
G Fars2 phenylalanine-tRNA synthetase 2 (mitochondrial) JBrowse link 13 36,117,428 36,537,595 RGD:6480464
G Fbxo32 F-box protein 32 JBrowse link 15 58,175,879 58,214,892 RGD:6480464
G Fh1 fumarate hydratase 1 JBrowse link 1 175,601,378 175,625,635 RGD:6480464
G Fkbp7 FK506 binding protein 7 JBrowse link 2 76,663,034 76,673,098 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 1 71,585,473 71,653,280 RGD:6480464
G Gc vitamin D binding protein JBrowse link 5 89,417,511 89,457,898 RGD:6480464
G Glrb glycine receptor, beta subunit JBrowse link 3 80,843,598 80,913,660 RGD:6480464
G Grb2 growth factor receptor bound protein 2 JBrowse link 11 115,644,045 115,708,597 RGD:6480464
G Gtpbp6 GTP binding protein 6 (putative) JBrowse link 5 110,103,976 110,108,331 RGD:6480464
G Hey1 hairy/enhancer-of-split related with YRPW motif 1 JBrowse link 3 8,663,359 8,667,038 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 5 16,553,495 16,619,439 RGD:6480464
G Hif1a hypoxia inducible factor 1, alpha subunit JBrowse link 12 73,901,324 73,947,554 RGD:6480464
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 6 51,460,434 51,470,048 RGD:6480464
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like JBrowse link 5 100,033,577 100,039,936 RGD:6480464
G Hpcal1 hippocalcin-like 1 JBrowse link 12 17,690,750 17,791,944 RGD:6480464
G Hrg histidine-rich glycoprotein JBrowse link 16 22,951,072 22,961,659 RGD:6480464
G Hspd1 heat shock protein 1 (chaperonin) JBrowse link 1 55,077,833 55,088,243 RGD:6480464
G Id2 inhibitor of DNA binding 2 JBrowse link 12 25,093,799 25,096,092 RGD:6480464
G Il2ra interleukin 2 receptor, alpha chain JBrowse link 2 11,642,792 11,693,194 RGD:6480464
G Il2rb interleukin 2 receptor, beta chain JBrowse link 15 78,479,256 78,511,621 RGD:6480464
G Ilk integrin linked kinase JBrowse link 7 105,736,590 105,742,925 RGD:6480464
G Itgav integrin alpha V JBrowse link 2 83,722,303 83,806,917 RGD:6480464
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6480464
G Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 JBrowse link 6 21,215,346 21,729,805 RGD:6480464
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 JBrowse link 5 24,319,589 24,351,684 RGD:6480464
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 3 131,110,277 131,224,357 RGD:6480464
G Lgals1 lectin, galactose binding, soluble 1 JBrowse link 15 78,926,725 78,930,465 RGD:6480464
G Limk1 LIM-domain containing, protein kinase JBrowse link 5 134,656,039 134,689,859 RGD:6480464
G Lss lanosterol synthase JBrowse link 10 76,531,565 76,557,139 RGD:6480464
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 11 110,399,102 110,525,522 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 11 61,488,812 61,494,267 RGD:6480464
G Mdh2 malate dehydrogenase 2, NAD (mitochondrial) JBrowse link 5 135,778,649 135,790,386 RGD:6480464
G Mir29b-1 microRNA 29b-1 JBrowse link 6 31,063,023 31,063,093 RGD:6480464
G Mmp13 matrix metallopeptidase 13 JBrowse link 9 7,272,514 7,283,333 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 8 92,827,290 92,853,421 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:6480464
G Mras muscle and microspikes RAS JBrowse link 9 99,385,420 99,437,700 RGD:6480464
G Mrtfa myocardin related transcription factor A JBrowse link 15 81,012,281 81,190,736 RGD:6480464
G Myc myelocytomatosis oncogene JBrowse link 15 61,985,341 61,990,361 RGD:6480464
G Myl12a myosin, light chain 12A, regulatory, non-sarcomeric JBrowse link 17 70,993,793 71,002,533 RGD:6480464
G Mylk myosin, light polypeptide kinase JBrowse link 16 34,745,199 35,002,436 RGD:6480464
G Nectin3 nectin cell adhesion molecule 3 JBrowse link 16 46,387,665 46,498,535 RGD:6480464
G Nectin4 nectin cell adhesion molecule 4 JBrowse link 1 171,370,173 171,388,287 RGD:6480464
G Nefl neurofilament, light polypeptide JBrowse link 14 68,083,863 68,089,095 RGD:6480464
G Nos1 nitric oxide synthase 1, neuronal JBrowse link 5 117,866,839 117,958,840 RGD:6480464
G Nos3 nitric oxide synthase 3, endothelial cell JBrowse link 5 24,364,816 24,384,474 RGD:6480464
G Npc2 NPC intracellular cholesterol transporter 2 JBrowse link 12 84,754,559 84,773,112 RGD:6480464
G Nppa natriuretic peptide type A JBrowse link 4 148,000,722 148,002,074 RGD:6480464
G Nras neuroblastoma ras oncogene JBrowse link 3 103,058,285 103,067,914 RGD:6480464
G Park7 Parkinson disease (autosomal recessive, early onset) 7 JBrowse link 4 150,897,133 150,909,921 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase family, member 1 JBrowse link 1 180,568,891 180,600,999 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 2 132,249,286 132,253,180 RGD:6480464
G Pdcd6 programmed cell death 6 JBrowse link 13 74,303,121 74,317,326 RGD:6480464
G Pfdn5 prefoldin 5 JBrowse link 15 102,326,116 102,331,490 RGD:6480464
G Pfn1 profilin 1 JBrowse link 11 70,651,844 70,656,799 RGD:6480464
G Plaur plasminogen activator, urokinase receptor JBrowse link 7 24,460,937 24,475,970 RGD:6480464
G Plcg1 phospholipase C, gamma 1 JBrowse link 2 160,731,310 160,775,760 RGD:6480464
G Ppt2 palmitoyl-protein thioesterase 2 JBrowse link 17 34,616,662 34,638,022 RGD:6480464
G Psmb6 proteasome (prosome, macropain) subunit, beta type 6 JBrowse link 11 70,525,324 70,527,858 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 67,665,501 67,724,632 RGD:6480464
G Rab11b RAB11B, member RAS oncogene family JBrowse link 17 33,742,484 33,760,486 RGD:6480464
G Raf1 v-raf-leukemia viral oncogene 1 JBrowse link 6 115,618,569 115,676,635 RGD:6480464
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 JBrowse link 9 89,909,508 90,026,979 RGD:6480464
G Rgs2 regulator of G-protein signaling 2 JBrowse link 1 143,999,338 144,004,149 RGD:6480464
G Rhoh ras homolog family member H JBrowse link 5 65,860,742 65,896,700 RGD:6480464
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 10,064,401 10,182,251 RGD:6480464
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 12 16,894,978 16,988,274 RGD:6480464
G Rpa3 replication protein A3 JBrowse link 6 8,255,936 8,259,141 RGD:6480464
G Rpgrip1l Rpgrip1-like JBrowse link 8 91,217,030 91,313,291 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 JBrowse link 11 86,498,869 86,544,885 RGD:6480464
G Ryr2 ryanodine receptor 2, cardiac JBrowse link 13 11,553,099 12,106,945 RGD:6480464
G S100a13 S100 calcium binding protein A13 JBrowse link 3 90,514,233 90,524,581 RGD:6480464
G S100b S100 protein, beta polypeptide, neural JBrowse link 10 76,253,836 76,261,319 RGD:6480464
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 10 21,882,184 21,999,903 RGD:6480464
G Sgk2 serum/glucocorticoid regulated kinase 2 JBrowse link 2 162,987,327 163,014,139 RGD:6480464
G Sgk3 serum/glucocorticoid regulated kinase 3 JBrowse link 1 9,798,130 9,902,570 RGD:6480464
G Shc3 src homology 2 domain-containing transforming protein C3 JBrowse link 13 51,423,389 51,569,451 RGD:6480464
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 JBrowse link 3 104,638,664 104,658,462 RGD:6480464
G Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 JBrowse link 19 6,535,854 6,543,070 RGD:6480464
G Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 JBrowse link 8 70,882,885 70,892,785 RGD:6480464
G Slc5a6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 JBrowse link 5 31,036,036 31,048,924 RGD:6480464
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 JBrowse link 17 81,373,105 81,738,387 RGD:6480464
G Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 JBrowse link 4 133,369,711 133,423,702 RGD:6480464
G Smad4 SMAD family member 4 JBrowse link 18 73,634,790 73,703,791 RGD:6480464
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 17 80,393,752 80,480,453 RGD:6480464
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 12 69,583,761 69,681,852 RGD:6480464
G Sphk1 sphingosine kinase 1 JBrowse link 11 116,530,836 116,536,675 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Tgfb2 transforming growth factor, beta 2 JBrowse link 1 186,622,787 186,709,697 RGD:6480464
G Tgfb3 transforming growth factor, beta 3 JBrowse link 12 86,056,743 86,079,041 RGD:6480464
G Tgfbr3 transforming growth factor, beta receptor III JBrowse link 5 107,106,567 107,289,629 RGD:6480464
G Tln1 talin 1 JBrowse link 4 43,531,513 43,562,583 RGD:6480464
G Tln2 talin 2 JBrowse link 9 67,217,085 67,634,045 RGD:6480464
G Tpi1 triosephosphate isomerase 1 JBrowse link 6 124,810,592 124,814,296 RGD:6480464
G Tpt1 tumor protein, translationally-controlled 1 JBrowse link 14 75,845,256 75,848,303 RGD:6480464
G Trim63 tripartite motif-containing 63 JBrowse link 4 134,315,120 134,329,629 RGD:6480464
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 JBrowse link 9 95,705,072 95,750,386 RGD:6480464
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 JBrowse link 9 8,543,867 8,680,752 RGD:6480464
G Txn1 thioredoxin 1 JBrowse link 4 57,943,373 57,956,411 RGD:6480464
G Zfhx3 zinc finger homeobox 3 JBrowse link 8 108,279,311 108,961,636 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21025
    chemical entity 21023
      molecular entity 21013
        polyatomic entity 20866
          heteroatomic molecular entity 20751
            hydroxides 19759
              organic hydroxy compound 18865
                hydroxy steroid 12583
                  11-hydroxy steroid 5329
                    11alpha-hydroxy steroid 172
                      (24R)-11alpha,20,24-trihydroxyecdysone 0
                      (25R)-11alpha,20,26-trihydroxyecdysone 0
                      (25S)-11alpha,20,26-trihydroxyecdysone 0
                      11alpha-hydroxyprogesterone + 0
                      3beta,11alpha-dihydroxyergosta-8,24(28)-dien-7-one 0
                      9alpha,11alpha-dihydroxyergosta-4,6,8(14),22-tetraen-3-one 0
                      FR171456 0
                      bipindogenin + 0
                      bryotoxin A 0
                      dihydroouabagenin 0
                      fusidic acid 8
                      lucibufagin C 0
                      ouabagenin + 0
                      ouabagenin(1-) 0
                      ouabain 165
                      ouabain(1-) 0
                      sarmentogenin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21025
    subatomic particle 21019
      composite particle 21019
        hadron 21019
          baryon 21019
            nucleon 21019
              atomic nucleus 21019
                atom 21019
                  main group element atom 20860
                    p-block element atom 20860
                      carbon group element atom 20601
                        carbon atom 20578
                          organic molecular entity 20578
                            organic molecule 20433
                              organic cyclic compound 20119
                                organic polycyclic compound 16879
                                  steroid 13014
                                    hydroxy steroid 12583
                                      11-hydroxy steroid 5329
                                        11alpha-hydroxy steroid 172
                                          (24R)-11alpha,20,24-trihydroxyecdysone 0
                                          (25R)-11alpha,20,26-trihydroxyecdysone 0
                                          (25S)-11alpha,20,26-trihydroxyecdysone 0
                                          11alpha-hydroxyprogesterone + 0
                                          3beta,11alpha-dihydroxyergosta-8,24(28)-dien-7-one 0
                                          9alpha,11alpha-dihydroxyergosta-4,6,8(14),22-tetraen-3-one 0
                                          FR171456 0
                                          bipindogenin + 0
                                          bryotoxin A 0
                                          dihydroouabagenin 0
                                          fusidic acid 8
                                          lucibufagin C 0
                                          ouabagenin + 0
                                          ouabagenin(1-) 0
                                          ouabain 165
                                          ouabain(1-) 0
                                          sarmentogenin + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.