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ONTOLOGY REPORT - ANNOTATIONS


Term:alkylating agent
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Accession:CHEBI:22333 term browser browse the term
Definition:Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.


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  CHEBI ontology 19679
    role 19623
      biological role 19621
        aetiopathogenetic role 18776
          genotoxin 16051
            mutagen 15669
              alkylating agent 9018
                1,2-dimethylhydrazine 503
                2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
                2-aminoacrylic acid + 0
                2-chloroethyl methanesulfonate 0
                2-fluoroethyl methanesulfonate 0
                3-bromopyruvic acid 17
                4-hydroperoxycyclophosphamide 74
                4-hydroxycyclophosphamide 9
                D-mannitol 1,6-bis(methanesulfonate) 0
                L-mannitol 1,6-bis(methanesulfonate) 0
                MTIC 0
                N-ethyl-N-nitrosourea 509
                N-methyl-N'-nitro-N-nitrosoguanidine 271
                N-methyl-N-nitrosourea 349
                N-tosyl-L-phenylalanyl chloromethyl ketone 53
                S-(chloromethyl)glutathione 0
                acrylamide 3781
                aziridine + 0
                bis(2-chloroethyl) sulfide 1276
                bis(chloromethyl) ether 0
                busulfan 57
                carmustine 466
                chlorambucil 50
                chloroacetic acid + 25
                cyclophosphamide + 703
                cyclophosphamide hydrate 0
                dacarbazine 22
                diaziquone 3
                diazomethane 0
                dimethyl sulfate 5
                dimethyl sulfoxide + 305
                dimethylmyleran 0
                esperamicin A1 0
                estramustine + 3
                etanidazole 1
                ethyl methanesulfonate 2170
                fotemustine 10
                hex-3-yne-2,5-diyl bis(methanesulfonate) 0
                hexane-2,5-diyl bis(methanesulfonate) 0
                hycanthone mesylate 0
                ifosfamide 237
                iodoacetic acid 9
                lomustine 9
                mechlorethamine + 82
                melphalan 270
                methyl methanesulfonate 3640
                mitomycin A 0
                mitomycin C 404
                nimustine 23
                nitrogen mustard + 1232
                pipobroman 0
                semustine 2
                temozolomide 211
                tretamine 0
                triaziquone 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.