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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alkylating agent
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Accession:CHEBI:22333 term browser browse the term
Definition:Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.


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  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          genotoxin 16978
            mutagen 16794
              alkylating agent 13415
                1,2-dimethylhydrazine 9968
                2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                2,5-bis(aziridin-1-yl)-1,4-benzoquinone 1
                2-aminoacrylic acid + 0
                2-chloroethyl methanesulfonate 0
                2-fluoroethyl methanesulfonate 0
                3-bromopyruvic acid 17
                4-hydroperoxycyclophosphamide 74
                4-hydroxycyclophosphamide 9
                D-mannitol 1,6-bis(methanesulfonate) 0
                L-mannitol 1,6-bis(methanesulfonate) 0
                MTIC 0
                N-ethyl-N-nitrosourea 506
                N-methyl-N'-nitro-N-nitrosoguanidine 289
                N-methyl-N-nitrosourea 354
                N-tosyl-L-phenylalanyl chloromethyl ketone 53
                S-(chloromethyl)glutathione 0
                acrylamide 3796
                anthramycin 0
                aziridine + 0
                bis(2-chloroethyl) sulfide 1284
                bis(chloromethyl) ether 0
                busulfan 61
                carmustine 467
                chlorambucil 50
                chloroacetic acid + 28
                colibactin 0
                cyclophosphamide + 729
                cyclophosphamide hydrate 0
                dacarbazine 22
                diaziquone 3
                diazomethane 0
                dimethyl sulfate 5
                dimethyl sulfoxide + 311
                dimethylmyleran 0
                esperamicin A1 0
                estramustine + 3
                etanidazole 1
                ethyl methanesulfonate 2169
                fotemustine 10
                hex-3-yne-2,5-diyl bis(methanesulfonate) 0
                hexane-2,5-diyl bis(methanesulfonate) 0
                hycanthone mesylate 0
                ifosfamide 244
                iodoacetic acid 27
                lomustine 9
                mechlorethamine + 88
                melphalan 271
                methyl methanesulfonate 3641
                mitomycin A 0
                mitomycin C 403
                nimustine 24
                nitrogen mustard + 1259
                pipobroman 0
                semustine 2
                temozolomide 212
                tilimycin 0
                tomaymycin 0
                tretamine 0
                triaziquone 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.