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Accession:CHEBI:240107 term browser browse the term
Definition:Amfenac in which the the hydrogen at the 4 position of the benzoyl group is substituted by bromine. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction. It was withdrawn from the US market in 1998, following concerns over off-label abuse and hepatic failure.
Synonyms:exact_synonym: [2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
 related_synonym: 2-amino-3-(4-bromobenzoyl)benzeneacetic acid;   Formula=C15H12BrNO3;   InChI=1S/C15H12BrNO3/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19/h1-7H,8,17H2,(H,18,19);   InChIKey=ZBPLOVFIXSTCRZ-UHFFFAOYSA-N;   SMILES=Nc1c(CC(O)=O)cccc1C(=O)c1ccc(Br)cc1;   [2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid;   bromfenaco;   bromfenacum
 xref: Beilstein:8335547 "Beilstein";   CAS:91714-94-2 "ChemIDplus";   DrugBank:DB00963;   Drug_Central:401 "DrugCentral";   KEGG:D07541;   LINCS:LSM-5585
 xref_mesh: MESH:C053083
 xref: Patent:EP221753;   Patent:US4683242;   Wikipedia:Bromfenac
 cyclic_relationship: is_conjugate_acid_of CHEBI:59175

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bromfenac term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        anti-inflammatory agent 14935
          anti-inflammatory drug 13586
            non-steroidal anti-inflammatory drug 12671
              bromfenac 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    main group molecular entity 19610
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18278
                            inorganic hydride 17205
                              pnictogen hydride 17167
                                nitrogen hydride 17003
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        aromatic amine 13592
                                          anilines 12302
                                            substituted aniline 11797
                                              amfenac 2
                                                bromfenac 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.