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Term:dehydrocostus lactone
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Accession:CHEBI:244418 term browser browse the term
Definition:An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.
Synonyms:exact_synonym: (3aR,6aS,9aS,9bR)-3,6,9-tris(methylene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione;   (3aR,6aS,9aS,9bR)-3,6,9-tris(methylidene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione
 related_synonym: (3aS,6aR,9aR,9bS)-decahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one;   Formula=C15H18O2;   InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1;   InChIKey=NETSQGRTUNRXEO-XUXIUFHCSA-N;   SMILES=[H][C@@]12CCC(=C)[C@]1([H])[C@H]1OC(=O)C(=C)[C@@H]1CCC2=C;   dehydrocostuslactone
 alt_id: CHEBI:4359;   CHEBI:467325
 xref: Beilstein:4733740 "Beilstein";   CAS:477-43-0 "ChemIDplus";   CAS:477-43-0 "KEGG COMPOUND";   KEGG:C09387;   KNApSAcK:C00003245
 xref_mesh: MESH:C083030
 xref: PMID:10193198 "Europe PMC";   PMID:12419922 "Europe PMC";   PMID:14192430 "Europe PMC";   PMID:15209353 "Europe PMC";   PMID:15881118 "Europe PMC";   PMID:17391667 "Europe PMC";   PMID:19148545 "Europe PMC";   PMID:19188481 "Europe PMC";   PMID:19457452 "Europe PMC";   PMID:19700217 "Europe PMC";   PMID:21353686 "Europe PMC";   PMID:21472220 "Europe PMC";   PMID:21596031 "Europe PMC";   PMID:22359572 "Europe PMC";   PMID:23047249 "Europe PMC";   PMID:6476889 "Europe PMC";   PMID:8541643 "Europe PMC";   PMID:9784148 "Europe PMC";   PMID:9917276 "Europe PMC";   Patent:CN102058579;   Reaxys:4733740 "Reaxys"

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dehydrocostus lactone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        biochemical role 19178
          metabolite 19150
            dehydrocostus lactone 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic ester 13965
                                        lactone 5868
                                          terpene lactone 1745
                                            sesquiterpene lactone 1598
                                              dehydrocostus lactone 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.