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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acyclovir
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Accession:CHEBI:2453 term browser browse the term
Definition:An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.
Synonyms:exact_synonym: 2-amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one
 related_synonym: Formula=C8H11N5O3;   InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15);   InChIKey=MKUXAQIIEYXACX-UHFFFAOYSA-N;   SMILES=Nc1nc2n(COCCO)cnc2c(=O)[nH]1;   Zovir;   aciclovir;   aciclovirum;   acycloguanosine
 alt_id: CHEBI:40459
 xref: Beilstein:1219402;   CAS:59277-89-3;   DrugBank:DB00787;   Drug_Central:85;   HMDB:HMDB0014925;   KEGG:C06810;   KEGG:D00222;   LINCS:LSM-5459
 xref_mesh: MESH:D000212
 xref: PDBeChem:AC2;   PMID:11687127;   PMID:11994034;   PMID:24346595;   PMID:26024233;   PMID:28166217;   PMID:8308511;   Patent:DE2539963;   Patent:US4199574;   Reaxys:1219402;   Wikipedia:Acyclovir


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acyclovir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
multiple interactions
ISO ABCG2 protein affects the transport of Acyclovir
tryptoquivaline inhibits the reaction [ABCG2 protein affects the transport of Acyclovir]
CTD PMID:21859328 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Aqp2 aquaporin 2 decreases expression EXP Acyclovir results in decreased expression of AQP2 protein CTD PMID:14675048 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase decreases activity ISO Acyclovir results in decreased activity of HAAO protein CTD PMID:17174341 NCBI chr 6:7,045,145...7,059,227
Ensembl chr 6:7,045,152...7,058,314
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 decreases activity ISO Acyclovir results in decreased activity of IDO1 protein CTD PMID:17174341 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Acyclovir affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Slc12a1 solute carrier family 12 member 1 decreases expression EXP Acyclovir results in decreased expression of SLC12A1 mRNA; Acyclovir results in decreased expression of SLC12A1 protein CTD PMID:14675048 NCBI chr 3:117,421,531...117,498,372
Ensembl chr 3:117,421,604...117,498,367
JBrowse link
G Slc17a1 solute carrier family 17 member 1 decreases expression EXP Acyclovir results in decreased expression of SLC17A1 mRNA; Acyclovir results in decreased expression of SLC17A1 protein CTD PMID:14675048 NCBI chr17:43,473,048...43,504,645 JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity EXP Acyclovir results in decreased activity of TDO2 protein CTD PMID:18665439 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          antimetabolite 8494
            acyclovir 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterobicyclic compound 16765
                                      imidazopyrimidine 5443
                                        purines 5441
                                          aminopurine 4398
                                            2-aminopurines 4008
                                              guanine 3972
                                                acyclovir 8
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