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Accession:CHEBI:247956 term browser browse the term
Definition:A monocarboxylic acid amide that is the 2-(diethylamino)ethyl amide of 2-butoxyquinoline-4-carboxylic acid. One of the most potent and toxic of the long-acting local anesthetics, its parenteral use was restricted to spinal anesthesia. It is now generally only used (usually as the hydrochloride) in creams and ointments and in suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.
Synonyms:exact_synonym: 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
 related_synonym: 2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide;   2-N-butoxy-N-(2-diethylaminoethyl)cinchoninamide;   2-butoxy-N-(2-(diethylamino)ethyl)cinchoninamide;   2-butoxy-N-(alpha-diethylaminoethyl)cinchoninamide;   2-butoxy-N-(beta-diethylaminoethyl)cinchoninamide;   2-butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide;   2-butoxyquinoline-4-carboxylic acid diethylaminoethylamide;   Dibucaine;   Formula=C20H29N3O2;   InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24);   InChIKey=PUFQVTATUTYEAL-UHFFFAOYSA-N;   N-(2-(diethylamino)ethyl)-2-butoxycinchoninamide;   SMILES=CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1;   alpha-butyloxycinchonic acid-gamma-diethylethylenediamine;   alpha-butyloxycinchoninic acid diethylethylenediamide;   cinchocainum;   cincocainio;   dibucaine base
 alt_id: CHEBI:4500
 xref: Beilstein:275489 "Beilstein";   CAS:85-79-0 "ChemIDplus";   CAS:85-79-0 "KEGG COMPOUND";   CAS:85-79-0 "NIST Chemistry WebBook";   DrugBank:DB00527;   Drug_Central:859 "DrugCentral";   HMDB:HMDB0014668;   KEGG:C07879;   KEGG:D00733;   LINCS:LSM-6018
 xref_mesh: MESH:D003992
 xref: PMID:23953476 "Europe PMC";   PMID:2873227 "Europe PMC";   Patent:US1825623;   Reaxys:275489 "Reaxys";   Wikipedia:Dibucaine

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cinchocaine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Diablo diablo, IAP-binding mitochondrial protein JBrowse link 12 38,490,230 38,503,344 RGD:6480464
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link 15 56,666,152 56,732,469 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        refrigerant 16977
          ammonia 16548
            organic amino compound 16547
              tertiary amino compound 8517
                cinchocaine 7
                  cinchocaine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      carboxylic acid 17908
                                        carboacyl group 16930
                                          univalent carboacyl group 16930
                                            carbamoyl group 16610
                                              carboxamide 16610
                                                monocarboxylic acid amide 13174
                                                  cinchocaine 7
                                                    cinchocaine hydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.