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Accession:CHEBI:247956 term browser browse the term
Definition:A monocarboxylic acid amide that is the 2-(diethylamino)ethyl amide of 2-butoxyquinoline-4-carboxylic acid. One of the most potent and toxic of the long-acting local anesthetics, its parenteral use was restricted to spinal anesthesia. It is now generally only used (usually as the hydrochloride) in creams and ointments and in suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.
Synonyms:exact_synonym: 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
 related_synonym: 2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide;   2-N-butoxy-N-(2-diethylaminoethyl)cinchoninamide;   2-butoxy-N-(2-(diethylamino)ethyl)cinchoninamide;   2-butoxy-N-(alpha-diethylaminoethyl)cinchoninamide;   2-butoxy-N-(beta-diethylaminoethyl)cinchoninamide;   2-butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide;   2-butoxyquinoline-4-carboxylic acid diethylaminoethylamide;   Dibucaine;   Formula=C20H29N3O2;   InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24);   InChIKey=PUFQVTATUTYEAL-UHFFFAOYSA-N;   N-(2-(diethylamino)ethyl)-2-butoxycinchoninamide;   SMILES=CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1;   alpha-butyloxycinchonic acid-gamma-diethylethylenediamine;   alpha-butyloxycinchoninic acid diethylethylenediamide;   cinchocainum;   cincocainio;   dibucaine base
 alt_id: CHEBI:4500
 xref: Beilstein:275489 "Beilstein";   CAS:85-79-0 "ChemIDplus";   CAS:85-79-0 "KEGG COMPOUND";   CAS:85-79-0 "NIST Chemistry WebBook";   DrugBank:DB00527;   Drug_Central:859 "DrugCentral";   HMDB:HMDB0014668;   KEGG:C07879;   KEGG:D00733;   LINCS:LSM-6018
 xref_mesh: MESH:D003992
 xref: PMID:23953476 "Europe PMC";   PMID:2873227 "Europe PMC";   Patent:US1825623;   Reaxys:275489 "Reaxys";   Wikipedia:Dibucaine

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cinchocaine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Diablo diablo, IAP-binding mitochondrial protein JBrowse link 12 38,490,230 38,503,344 RGD:6480464
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link 15 56,666,152 56,732,469 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      application 19362
        refrigerant 17253
          ammonia 16699
            organic amino compound 16698
              tertiary amino compound 8583
                cinchocaine 7
                  cinchocaine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    p-block element atom 19646
                      carbon group element atom 19540
                        carbon atom 19529
                          organic molecular entity 19529
                            organic group 18432
                              organic divalent group 18423
                                organodiyl group 18423
                                  carbonyl group 18311
                                    carbonyl compound 18311
                                      carboxylic acid 17978
                                        carboacyl group 17095
                                          univalent carboacyl group 17095
                                            carbamoyl group 16817
                                              carboxamide 16817
                                                monocarboxylic acid amide 14173
                                                  cinchocaine 7
                                                    cinchocaine hydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.