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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iodine atom
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Accession:CHEBI:24859 term browser browse the term
Definition:Chemical element with atomic number 53.
Synonyms:related_synonym: 53I;   Formula=I;   I;   InChI=1S/I;   InChIKey=ZCYVEMRRCGMTRW-UHFFFAOYSA-N;   Iod;   J;   Jod;   SMILES=[I];   iode;   iodine;   iodium;   yodo
 xref: WebElements:I


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1,1-dimethyl-4-phenylpiperazinium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein] CTD PMID:9454827 NCBI chr15:42,808,897...42,825,179
Ensembl chr15:42,808,897...42,825,179
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein] CTD PMID:9454827 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] CTD PMID:9454827, PMID:14645658 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
increases response to substance
increases activity
ISO Dimethylphenylpiperazinium Iodide inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]
CHRNA7 protein mutant form results in increased susceptibility to Dimethylphenylpiperazinium Iodide
Dimethylphenylpiperazinium Iodide results in increased activity of CHRNA7 protein
CTD PMID:10082212, PMID:10216184 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] CTD PMID:9454827 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Tnf tumor necrosis factor increases activity EXP TNF results in increased activity of Dimethylphenylpiperazinium Iodide CTD PMID:15086448 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
2,4-dinitroiodobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icam1 intercellular adhesion molecule 1 increases expression ISO 1-iodo-2,4-dinitrobenzene results in increased expression of ICAM1 protein CTD PMID:19427879 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO 1-iodo-2,4-dinitrobenzene results in increased phosphorylation of MAPK14 protein CTD PMID:19427879 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO 1-iodo-2,4-dinitrobenzene results in increased expression of NFE2L2 protein CTD PMID:19427879 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases activity ISO 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of ABCB1 protein CTD PMID:23273999 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases activity ISO 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of ABCG2 protein CTD PMID:30083819 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions
increases response to substance
ISO ADCYAP1 gene mutant form promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of FOS protein]
ADCYAP1 gene mutant form results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine
CTD PMID:24586556 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of AIFM1 protein CTD PMID:22983118 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
ISO [Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of BDNF mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of BDNF mRNA] CTD PMID:24889602 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 increases activity EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of CASP3 protein CTD PMID:22983118 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of CASP8 protein CTD PMID:22983118 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cycs cytochrome c, somatic affects localization EXP 4-iodo-2,5-dimethoxyphenylisopropylamine affects the localization of CYCS protein CTD PMID:22983118 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
ISO 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR1 mRNA
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of EGR1 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR1 mRNA]
CTD PMID:24889602 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP
ISO
4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of FOS protein
ADCYAP1 gene mutant form promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of FOS protein]
CTD PMID:12482207, PMID:24586556 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
affects binding
affects response to substance
increases response to substance
decreases response to substance
increases activity
ISO
EXP
[Alprenolol co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]; [Yohimbine co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]; Cocaine inhibits the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]
4-iodo-2,5-dimethoxyphenylisopropylamine binds to HTR2A protein
HTR2A protein affects the susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine
4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein; [4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine; Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]; Ketanserin inhibits the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]; Ketanserin inhibits the reaction [Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]]; Streptozocin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of HTR2A protein]
1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine binds to HTR2A protein]; 4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein
HTR2A gene SNP results in decreased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine
CTD PMID:8392199, PMID:9857084, PMID:10773215, PMID:12482207, PMID:16314884, PMID:18622176, PMID:22983118 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions
affects binding
ISO 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine binds to HTR2C protein] CTD PMID:9857084 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL1B protein
4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL1B protein; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL1B protein]; rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL1B protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL1B protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL1B protein]
CTD PMID:30790395, PMID:31231976 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL6 protein
4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL6 protein; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL6 protein]; rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL6 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL6 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL6 protein]
CTD PMID:30790395, PMID:31231976 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of JAK2 protein
rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of JAK2 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of JAK2 protein]
CTD PMID:31231976 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK1 protein
Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK1 protein]
CTD PMID:30790395 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK3 protein
Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK3 protein]
CTD PMID:30790395 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK8 protein
gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK8 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK8 protein]
CTD PMID:30790395 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions
increases expression
EXP gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of MYD88 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of MYD88 protein] CTD PMID:30790395 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of NFKBIA protein
rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of NFKBIA protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of NFKBIA protein]
CTD PMID:31231976 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos1 nitric oxide synthase 1 increases expression EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of NOS1 protein CTD PMID:12482207 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Pdyn prodynorphin decreases expression EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in decreased expression of PDYN mRNA CTD PMID:9526047 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B increases phosphorylation ISO 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of PPP1R1B protein CTD PMID:11880652 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of PTGS2 mRNA
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of PTGS2 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of PTGS2 mRNA]
CTD PMID:24889602 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein
gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein]; rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein]
CTD PMID:30790395, PMID:31231976 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of STAT3 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of STAT3 protein] CTD PMID:31231976 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein
gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein]
CTD PMID:30790395 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of TNF protein; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TNF protein]; rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of TNF protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of TNF protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TNF protein] CTD PMID:30790395, PMID:31231976 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
3,3',5'-triiodo-L-thyronine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases activity
EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of BCL2 protein] CTD PMID:16135673 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions
increases metabolic processing
ISO [DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine] CTD PMID:21565810 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions
decreases activity
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]; Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]] CTD PMID:26004626 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Triiodothyronine, Reverse promotes the reaction [THRA protein binds to NCOA2 protein]; Triiodothyronine, Reverse promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]; Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:16135673 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
EXP Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein
alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein]
CTD PMID:16135673 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nppb natriuretic peptide B multiple interactions
increases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA]; Vitamin E affects the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA] CTD PMID:17198541 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
affects binding
EXP 2,4-dichlorophenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; 4-nonylphenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; 4-octylphenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; bisphenol A inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; Pentachlorophenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; tetrachlorodian inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein] CTD PMID:16617682 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Triiodothyronine, Reverse results in decreased expression of PPARA mRNA CTD PMID:17198541 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]; Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:16135673 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA]; Vitamin E affects the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA] CTD PMID:17198541 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA]; Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein; Vitamin E inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Vitamin E inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA] CTD PMID:17198541 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein]; Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein CTD PMID:16135673 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO Triiodothyronine, Reverse inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] CTD PMID:15531517 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Triiodothyronine, Reverse promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta increases activity
multiple interactions
affects binding
ISO Triiodothyronine, Reverse results in increased activity of THRB protein
Triiodothyronine, Reverse promotes the reaction [THRB protein binds to NCOA2 protein]
Triiodothyronine, Reverse binds to THRB protein
CTD PMID:21543282, PMID:31566444 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased secretion of TNF protein] CTD PMID:16135673 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
3,3',5'-triiodothyronine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases activity
EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of BCL2 protein] CTD PMID:16135673 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions
increases metabolic processing
ISO [DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine] CTD PMID:21565810 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions
decreases activity
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]; Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]] CTD PMID:26004626 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Triiodothyronine, Reverse promotes the reaction [THRA protein binds to NCOA2 protein]; Triiodothyronine, Reverse promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]; Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:16135673 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
EXP Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein
alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein]
CTD PMID:16135673 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nppb natriuretic peptide B multiple interactions
increases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA]; Vitamin E affects the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA] CTD PMID:17198541 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
affects binding
EXP 2,4-dichlorophenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; 4-nonylphenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; 4-octylphenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; bisphenol A inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; Pentachlorophenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]; tetrachlorodian inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein] CTD PMID:16617682 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Triiodothyronine, Reverse results in decreased expression of PPARA mRNA CTD PMID:17198541 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]; Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:16135673 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA]; Vitamin E affects the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA] CTD PMID:17198541 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA]; Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein; Vitamin E inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Vitamin E inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA] CTD PMID:17198541 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein]; Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein CTD PMID:16135673 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO Triiodothyronine, Reverse inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] CTD PMID:15531517 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Triiodothyronine, Reverse promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta increases activity
multiple interactions
affects binding
ISO Triiodothyronine, Reverse results in increased activity of THRB protein
Triiodothyronine, Reverse promotes the reaction [THRB protein binds to NCOA2 protein]
Triiodothyronine, Reverse binds to THRB protein
CTD PMID:21543282, PMID:31566444 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
EXP alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased secretion of TNF protein]
3,3',5-triiodothyronine increases expression of Tnf protein in serum
CTD PMID:16135673, PMID:15019085 RGD:14995431 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
3,3',5,5'-tetraiodothyroacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
tetraiodothyroacetic acid inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK1 protein]
CTD PMID:17174366, PMID:17984113 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
tetraiodothyroacetic acid inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK3 protein]
CTD PMID:17174366, PMID:17984113 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO tetraiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]; tetraiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]] CTD PMID:22227104 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]] CTD PMID:22227104 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO tetraiodothyroacetic acid binds to RXRA protein CTD PMID:31566444 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO tetraiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
affects binding
increases activity
ISO tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein]
tetraiodothyroacetic acid binds to THRB protein
tetraiodothyroacetic acid results in increased activity of THRB protein
CTD PMID:22227104, PMID:31077750, PMID:31566444 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of TP53 protein modified form] CTD PMID:17984113 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
3,3',5-triiodo-L-thyronine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Triiodothyronine results in increased expression of ABCA1 mRNA CTD PMID:25172293 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Triiodothyronine results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Triiodothyronine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases expression EXP Triiodothyronine results in increased expression of ABCC5 mRNA CTD PMID:29357290 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcf3 ATP binding cassette subfamily F member 3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ABCF3 mRNA CTD PMID:14761676 NCBI chr11:84,026,206...84,037,938
Ensembl chr11:84,026,207...84,037,938
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases expression
increases activity
EXP Triiodothyronine inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]; Triiodothyronine inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]
Triiodothyronine results in increased expression of ACACA mRNA
Triiodothyronine results in increased activity of ACACA protein
CTD PMID:1973097 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acbd4 acyl-CoA binding domain containing 4 decreases expression ISO Triiodothyronine results in decreased expression of ACBD4 mRNA CTD PMID:23397585 NCBI chr10:91,186,131...91,200,081
Ensembl chr10:91,187,593...91,196,572
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Triiodothyronine results in increased expression of and results in increased activity of ACE protein CTD PMID:1659346 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression
decreases expression
EXP Triiodothyronine results in increased expression of ACOT1 mRNA
Triiodothyronine results in decreased expression of ACOT1 mRNA
CTD PMID:15953391, PMID:28299817 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO Triiodothyronine results in increased expression of ACSL1 mRNA CTD PMID:30209975 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 increases expression EXP Triiodothyronine results in increased expression of ACSL5 mRNA CTD PMID:15953391 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Acvrl1 activin A receptor like type 1 increases expression ISO Triiodothyronine results in increased expression of ACVRL1 mRNA CTD PMID:25172293 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
JBrowse link
G Adam11 ADAM metallopeptidase domain 11 increases expression ISO Triiodothyronine results in increased expression of ADAM11 mRNA CTD PMID:25172293 NCBI chr10:90,731,260...90,749,221
Ensembl chr10:90,731,148...90,749,217
JBrowse link
G Adam12 ADAM metallopeptidase domain 12 increases expression ISO Triiodothyronine results in increased expression of ADAM12 mRNA CTD PMID:23397585 NCBI chr 1:205,951,840...206,286,294
Ensembl chr 1:205,956,342...206,282,575
JBrowse link
G Adam15 ADAM metallopeptidase domain 15 decreases expression ISO Triiodothyronine results in decreased expression of ADAM15 mRNA CTD PMID:23397585 NCBI chr 2:188,661,831...188,672,337
Ensembl chr 2:188,661,699...188,672,247
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADAM19 mRNA CTD PMID:14761676 NCBI chr10:31,146,107...31,240,582
Ensembl chr10:31,146,107...31,240,582
JBrowse link
G Add2 adducin 2 increases expression ISO Triiodothyronine results in increased expression of ADD2 mRNA CTD PMID:23397585 NCBI chr 4:117,691,294...117,887,556
Ensembl chr 4:117,743,710...117,882,464
JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression EXP Triiodothyronine results in increased expression of ADRB1 mRNA; Triiodothyronine results in increased expression of ADRB1 protein CTD PMID:10217540, PMID:11090638 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases expression
ISO bicalutamide inhibits the reaction [Triiodothyronine results in increased expression of ADRB2 protein]
Triiodothyronine results in increased expression of ADRB2 mRNA; Triiodothyronine results in increased expression of ADRB2 protein
CTD PMID:18454446 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
increases expression
decreases expression
EXP Amiodarone inhibits the reaction [Triiodothyronine results in decreased expression of ADRB3 protein]
Triiodothyronine results in increased expression of ADRB3 protein
Triiodothyronine results in decreased expression of ADRB3 mRNA; Triiodothyronine results in decreased expression of ADRB3 protein
CTD PMID:8836703, PMID:10217540 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Triiodothyronine promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA] CTD PMID:28478156 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akap12 A-kinase anchoring protein 12 increases expression ISO Triiodothyronine results in increased expression of AKAP12 mRNA CTD PMID:23397585 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581
JBrowse link
G Akirin2 akirin 2 increases expression ISO Triiodothyronine results in increased expression of AKIRIN2 mRNA CTD PMID:23397585 NCBI chr 5:50,001,945...50,016,544
Ensembl chr 5:50,002,184...50,016,539
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Triiodothyronine results in increased expression of AKR1C2 mRNA CTD PMID:15507505 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO Triiodothyronine results in increased expression of AKR1C3 mRNA CTD PMID:15507505 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine results in increased phosphorylation of AKT1 protein]; AKT1 protein affects the reaction [Triiodothyronine affects the expression of TTN mRNA] CTD PMID:16021636, PMID:18096819 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding ISO Triiodothyronine binds to ALB protein CTD PMID:21517007 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH1A3 mRNA CTD PMID:14761676 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression EXP Triiodothyronine results in increased expression of ALDH3A2 mRNA CTD PMID:15953391 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Amh anti-Mullerian hormone multiple interactions EXP Triiodothyronine affects the reaction [Propylthiouracil affects the expression of AMH mRNA] CTD PMID:7819453 NCBI chr 7:11,775,155...11,777,503
Ensembl chr 7:11,775,155...11,777,503
JBrowse link
G Angptl8 angiopoietin-like 8 multiple interactions ISO [THRA protein co-treated with Triiodothyronine] promotes the reaction [ANGPTL8 protein binds to PLIN3 protein]; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 protein; [THRB protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; ANGPTL8 protein affects the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein] CTD PMID:24262987 NCBI chr 8:22,855,495...22,858,565
Ensembl chr 8:22,856,539...22,858,565
JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP Triiodothyronine results in increased expression of APOA1 protein CTD PMID:6816881 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa4 apolipoprotein A4 multiple interactions EXP Triiodothyronine results in increased expression of [APOE protein co-treated with APOA4 protein] CTD PMID:6816881 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apoe apolipoprotein E multiple interactions EXP Triiodothyronine results in increased expression of [APOE protein co-treated with APOA4 protein] CTD PMID:6816881 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein decreases expression
multiple interactions
ISO Triiodothyronine results in decreased expression of APP mRNA; Triiodothyronine results in decreased expression of APP protein
Tretinoin promotes the reaction [Triiodothyronine results in decreased secretion of APP protein]
CTD PMID:17199430 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Triiodothyronine results in increased expression of AQP1 mRNA CTD PMID:25172293 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp8 aquaporin 8 increases expression EXP Triiodothyronine results in increased expression of AQP8 mRNA CTD PMID:15953391 NCBI chr 1:193,424,818...193,430,665
Ensembl chr 1:193,424,812...193,430,676
JBrowse link
G Arhgef25 Rho guanine nucleotide exchange factor 25 decreases expression ISO Triiodothyronine results in decreased expression of ARHGEF25 mRNA CTD PMID:23397585 NCBI chr 7:70,469,304...70,476,633
Ensembl chr 7:70,469,312...70,476,340
JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D increases expression ISO Triiodothyronine results in increased expression of ARL4D mRNA CTD PMID:25172293 NCBI chr10:89,577,556...89,580,368
Ensembl chr10:89,578,212...89,580,368
JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression EXP Triiodothyronine results in increased expression of ARRDC3 mRNA CTD PMID:28299817 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
JBrowse link
G Aspg asparaginase increases expression EXP Triiodothyronine results in increased expression of ASPG mRNA CTD PMID:29357290 NCBI chr 6:136,682,279...136,701,673
Ensembl chr 6:136,682,126...136,701,628
JBrowse link
G Aspm assembly factor for spindle microtubules decreases expression ISO Triiodothyronine results in decreased expression of ASPM mRNA CTD PMID:23397585 NCBI chr13:56,546,021...56,591,793
Ensembl chr13:56,546,021...56,591,793
JBrowse link
G Atg5 autophagy related 5 increases expression
affects response to substance
ISO Triiodothyronine results in increased expression of ATG5 mRNA; Triiodothyronine results in increased expression of ATG5 protein
ATG5 protein affects the susceptibility to Triiodothyronine
CTD PMID:30209975 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 increases expression ISO Triiodothyronine results in increased expression of ATG7 mRNA CTD PMID:30209975 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 increases expression ISO Triiodothyronine results in increased expression of ATP1B2 mRNA CTD PMID:25172293 NCBI chr10:56,205,622...56,211,879
Ensembl chr10:56,205,625...56,211,891
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
increases expression
EXP THRB protein promotes the reaction [Triiodothyronine results in increased expression of ATP2A2 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA] CTD PMID:11577024 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Avp arginine vasopressin multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA] CTD PMID:11742803 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression ISO
EXP
Triiodothyronine results in decreased expression of BAD protein CTD PMID:16021636 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO
EXP
Triiodothyronine results in decreased expression of BAX protein CTD PMID:16021636 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Triiodothyronine promotes the reaction [tamibarotene results in decreased expression of BCL2 mRNA]
Triiodothyronine results in increased expression of BCL2 protein
CTD PMID:11201846, PMID:16021636 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO Triiodothyronine promotes the reaction [tamibarotene results in increased expression of BCL2A1A mRNA] CTD PMID:11201846 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO
EXP
Triiodothyronine results in increased expression of BCL2L1 protein CTD PMID:16021636 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression EXP Triiodothyronine results in increased expression of BCL3 mRNA CTD PMID:22015988 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BMP2 mRNA CTD PMID:14761676 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions
decreases expression
ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA] CTD PMID:14761676 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Capns1 calpain, small subunit 1 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of CAPNS1 mRNA CTD PMID:14761676 NCBI chr 1:91,058,528...91,064,880 JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
EXP
ISO
Triiodothyronine results in decreased expression of CASP3 protein
THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased cleavage of CASP3 protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased cleavage of CASP3 protein]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]
CTD PMID:16021636, PMID:32223187 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein; gadolinium chloride inhibits the reaction [[Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein]; Resveratrol inhibits the reaction [Triiodothyronine results in decreased activity of CAT protein] CTD PMID:12516873, PMID:23391542 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccdc71 coiled-coil domain containing 71 decreases expression ISO Triiodothyronine results in decreased expression of CCDC71 mRNA CTD PMID:23397585 NCBI chr 8:117,236,933...117,251,573
Ensembl chr 8:117,246,376...117,250,280
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of CCL5 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of CCL5 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of CCL5 mRNA] CTD PMID:14761676 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccna2 cyclin A2 increases expression ISO
EXP
Triiodothyronine results in increased expression of CCNA2 protein CTD PMID:16021636 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO
EXP
Triiodothyronine results in increased expression of CCND1 protein
Triiodothyronine results in increased expression of CCND1 mRNA; Triiodothyronine results in increased expression of CCND1 protein
THRB protein promotes the reaction [Triiodothyronine results in increased expression of CCND1 protein]; U 0126 inhibits the reaction [Triiodothyronine results in increased expression of CCND1 mRNA]
CTD PMID:16021636, PMID:20638743, PMID:28315333 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 increases expression ISO
EXP
Triiodothyronine results in increased expression of CCNE1 protein
Triiodothyronine results in increased expression of CCNE1 mRNA; Triiodothyronine results in increased expression of CCNE1 protein
CTD PMID:16021636 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdc45 cell division cycle 45 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CDC45 mRNA CTD PMID:14761676 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDKN1A mRNA; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of CDKN1A mRNA]; Triiodothyronine analog inhibits the reaction [CDKN1A protein binds to PCNA protein]; Triiodothyronine inhibits the reaction [CDKN1A protein binds to PCNA protein] CTD PMID:14761676, PMID:22383522 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
multiple interactions
EXP
ISO
Triiodothyronine results in decreased expression of CDKN1B mRNA; Triiodothyronine results in decreased expression of CDKN1B protein
THRB protein promotes the reaction [Triiodothyronine results in decreased expression of CDKN1B protein]
CTD PMID:16021636, PMID:20638743 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Ces2c carboxylesterase 2C increases expression EXP Triiodothyronine results in increased expression of CES2C mRNA CTD PMID:28299817 NCBI chr 1:282,640,752...282,648,319
Ensembl chr 1:282,638,017...282,702,424
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions
decreases expression
EXP Phenelzine inhibits the reaction [Triiodothyronine results in decreased expression of CGA mRNA]; Triiodothyronine inhibits the reaction [Phenelzine results in increased expression of CGA mRNA] CTD PMID:20148560 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO Triiodothyronine analog results in increased phosphorylation of CHEK1 protein CTD PMID:22383522 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chst1 carbohydrate sulfotransferase 1 increases expression ISO Triiodothyronine results in increased expression of CHST1 mRNA CTD PMID:25172293 NCBI chr 3:81,441,785...81,512,829
Ensembl chr 3:81,498,022...81,512,807
JBrowse link
G Clu clusterin increases expression EXP Triiodothyronine results in increased expression of CLU mRNA CTD PMID:7531505 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col10a1 collagen type X alpha 1 chain multiple interactions
increases expression
EXP ciglitazone inhibits the reaction [Triiodothyronine results in increased expression of COL10A1 mRNA]; troglitazone inhibits the reaction [Triiodothyronine results in increased expression of COL10A1 mRNA] CTD PMID:16023420 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
EXP Triiodothyronine promotes the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
Triiodothyronine results in increased expression of COL1A1 mRNA
CTD PMID:18031379 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col6a3 collagen type VI alpha 3 chain increases expression ISO Triiodothyronine results in increased expression of COL6A3 mRNA CTD PMID:15507505 NCBI chr 9:97,926,784...98,004,643
Ensembl chr 9:97,926,787...98,004,546
JBrowse link
G Coq10b coenzyme Q10B increases expression EXP Triiodothyronine results in increased expression of COQ10B mRNA CTD PMID:29357290 NCBI chr 9:61,655,963...61,675,880
Ensembl chr 9:61,655,963...61,675,873
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions
increases expression
ISO Chloroquine promotes the reaction [Triiodothyronine results in increased expression of COX4I1 protein] CTD PMID:30209975 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression
multiple interactions
ISO
EXP
Triiodothyronine results in increased expression of CPT1A mRNA
Triiodothyronine results in increased expression of CPT1A mRNA; Triiodothyronine results in increased expression of CPT1A protein
resveratrol promotes the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]
Resveratrol promotes the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A protein]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CPT1A mRNA]
CTD PMID:23209300, PMID:25048947 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression ISO Triiodothyronine results in increased expression of CPT1B mRNA CTD PMID:30209975 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cracr2b calcium release activated channel regulator 2B decreases expression ISO Triiodothyronine results in decreased expression of CRACR2B mRNA CTD PMID:23397585 NCBI chr 1:214,439,810...214,445,876
Ensembl chr 1:214,440,503...214,445,874
JBrowse link
G Crat carnitine O-acetyltransferase increases expression EXP Triiodothyronine results in increased expression of CRAT mRNA CTD PMID:15953391 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362
JBrowse link
G Csad cysteine sulfinic acid decarboxylase increases expression EXP Triiodothyronine results in increased expression of CSAD mRNA CTD PMID:15953391 NCBI chr 7:143,781,520...143,810,880
Ensembl chr 7:143,781,702...143,793,970
JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO CSK protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]] CTD PMID:9664232 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Ctse cathepsin E increases expression EXP Triiodothyronine results in increased expression of CTSE mRNA CTD PMID:15953391 NCBI chr13:48,426,833...48,449,493
Ensembl chr13:48,426,820...48,449,490
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CYCS mRNA]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CYCS mRNA] CTD PMID:32223187 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein] CTD PMID:21726595 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein]]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein] CTD PMID:21726595 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Triiodothyronine affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Triiodothyronine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Triiodothyronine results in increased expression of CYP1A1 mRNA
CTD PMID:28478156 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of CYP1A2 mRNA
Triiodothyronine affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; Triiodothyronine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 protein]
CTD PMID:28478156 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of CYP24A1 mRNA
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of CYP24A1 mRNA]
CTD PMID:21815645 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity
increases expression
EXP Triiodothyronine results in increased activity of CYP2E1 protein
Triiodothyronine results in increased expression of CYP2E1 protein
CTD PMID:14631868 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Triiodothyronine results in decreased expression of CYP8B1 mRNA CTD PMID:10393316, PMID:29357290 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression ISO Triiodothyronine results in increased expression of DBP mRNA CTD PMID:25172293 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 increases expression EXP Triiodothyronine results in increased expression of DECR2 mRNA CTD PMID:15953391 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Dio1 iodothyronine deiodinase 1 affects abundance
multiple interactions
increases expression
affects metabolic processing
increases chemical synthesis
ISO
EXP
DIO1 gene SNP affects the abundance of Triiodothyronine
2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]
[DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine; [DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine]
DIO1 protein affects the metabolism of Triiodothyronine
Arsenic affects the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]; Pentachlorophenol inhibits the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]
DIO1 protein results in increased chemical synthesis of Triiodothyronine
CTD PMID:15254343, PMID:16131326, PMID:17105838, PMID:18288313, PMID:21565810, PMID:23397585, PMID:24001430, PMID:25646720, PMID:27420076, PMID:28167136, PMID:29357290 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions
increases expression
increases chemical synthesis
ISO
EXP
2,2',4,4',5-brominated diphenyl ether inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4',5-brominated diphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; [DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine; [DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine; kaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine]
Triiodothyronine results in increased expression of DIO2 mRNA
DIO2 protein results in increased chemical synthesis of Triiodothyronine
CTD PMID:17327447, PMID:17615150, PMID:23397585, PMID:25646720, PMID:26004626 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of DIO3 mRNA
[DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine
CTD PMID:23397585 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DMBT1 mRNA CTD PMID:14761676 NCBI chr 1:201,620,642...201,689,905
NCBI chr 1:203,149,414...203,228,705
JBrowse link
G Dmpk DM1 protein kinase increases expression EXP Triiodothyronine results in increased expression of DMPK mRNA CTD PMID:15953391 NCBI chr 1:79,988,096...79,999,358
Ensembl chr 1:79,989,019...79,999,364
JBrowse link
G Dmtn dematin actin binding protein increases expression ISO Triiodothyronine results in increased expression of DMTN mRNA CTD PMID:25172293 NCBI chr15:52,292,762...52,320,385
Ensembl chr15:52,292,765...52,320,385
JBrowse link
G Dusp2 dual specificity phosphatase 2 multiple interactions
decreases expression
ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP2 mRNA; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of DUSP2 mRNA] CTD PMID:14761676 NCBI chr 3:119,776,925...119,779,110
Ensembl chr 3:119,776,925...119,779,099
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 increases expression ISO Triiodothyronine results in increased expression of DYNC1LI2 mRNA CTD PMID:23397585 NCBI chr19:740,007...762,897
Ensembl chr19:740,028...762,897
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Triiodothyronine results in increased expression of ECH1 mRNA CTD PMID:15953391 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Efcab3 EF-hand calcium binding domain 3 decreases expression ISO Triiodothyronine results in decreased expression of EFCAB3 mRNA CTD PMID:23397585 NCBI chr10:93,304,559...93,332,849
Ensembl chr10:93,305,969...93,332,702
JBrowse link
G Egf epidermal growth factor multiple interactions EXP
ISO
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]
Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:11742803, PMID:16150908 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO Triiodothyronine results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:30209975 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eml2 EMAP like 2 increases expression ISO Triiodothyronine results in increased expression of EML2 mRNA CTD PMID:23397585 NCBI chr 1:80,087,684...80,118,784
Ensembl chr 1:80,087,684...80,119,012
JBrowse link
G Eno1 enolase 1 increases expression ISO Triiodothyronine results in increased expression of ENO1 mRNA CTD PMID:15507505 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression ISO Triiodothyronine results in increased expression of EPAS1 mRNA CTD PMID:25172293 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Epb41l3 erythrocyte membrane protein band 4.1-like 3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of EPB41L3 mRNA CTD PMID:14761676 NCBI chr 9:117,314,935...117,666,408
Ensembl chr 9:117,538,009...117,666,410
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO Tamoxifen inhibits the reaction [Triiodothyronine results in decreased expression of ESR1 mRNA] CTD PMID:19942988 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP [Arsenic co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of ESR2 mRNA; [bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [bisphenol A results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in increased expression of ESR2 mRNA; [enzacamene co-treated with Estradiol co-treated with Triiodothyronine] affects the expression of ESR2 mRNA; [Estradiol co-treated with Triiodothyronine] inhibits the reaction [bisphenol A results in decreased expression of ESR2 mRNA]; [Estradiol co-treated with Triiodothyronine] promotes the reaction [Zearalenone results in decreased expression of ESR2 mRNA]; [Zearalenone co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [Zearalenone results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in decreased expression of ESR2 mRNA CTD PMID:27338438 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase increases expression EXP Triiodothyronine results in increased expression of ETHE1 mRNA CTD PMID:28299817 NCBI chr 1:81,457,008...81,472,061
Ensembl chr 1:81,456,984...81,472,097
JBrowse link
G Eva1c eva-1 homolog C increases expression ISO Triiodothyronine results in increased expression of EVA1C mRNA CTD PMID:25172293 NCBI chr11:31,001,697...31,075,784
Ensembl chr11:31,002,451...31,075,809
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression EXP Triiodothyronine results in increased expression of FABP4 mRNA CTD PMID:15953391 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression EXP Triiodothyronine results in increased expression of FABP5 mRNA CTD PMID:15953391 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Fads2 fatty acid desaturase 2 increases expression EXP Triiodothyronine results in increased expression of FADS2 mRNA CTD PMID:15953391 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
JBrowse link
G Fam171b family with sequence similarity 171, member B decreases expression ISO Triiodothyronine results in decreased expression of FAM171B mRNA CTD PMID:23397585 NCBI chr 3:71,210,048...71,265,419
Ensembl chr 3:71,210,301...71,262,615
JBrowse link
G Fam83h family with sequence similarity 83, member H increases expression ISO Triiodothyronine results in increased expression of FAM83H mRNA CTD PMID:23397585 NCBI chr 7:117,062,748...117,070,936
Ensembl chr 7:117,062,692...117,070,936
JBrowse link
G Fasn fatty acid synthase increases expression EXP Triiodothyronine results in increased expression of FASN mRNA CTD PMID:15953391 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP Triiodothyronine results in increased expression of FDFT1 mRNA CTD PMID:15953391 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP Triiodothyronine results in increased expression of FDPS mRNA CTD PMID:15953391 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA] CTD PMID:11742803 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf18 fibroblast growth factor 18 multiple interactions ISO Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:16150908 NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO
EXP
Triiodothyronine inhibits the reaction [FGF2 protein results in increased phosphorylation of STAT1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; Triiodothyronine promotes the reaction [FGF2 protein promotes the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]]; Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:11742803, PMID:12805413, PMID:16150908 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf7 fibroblast growth factor 7 decreases expression ISO Triiodothyronine results in decreased expression of FGF7 mRNA CTD PMID:15507505 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:16150908 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression
multiple interactions
ISO
EXP
Triiodothyronine results in increased expression of FGFR1 mRNA
Triiodothyronine results in increased expression of FGFR1 mRNA; Triiodothyronine results in increased expression of FGFR1 protein
Cycloheximide inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]; Dactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]; Triiodothyronine promotes the reaction [FGF2 protein promotes the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]]
CTD PMID:12805413, PMID:16150908 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO Triiodothyronine results in increased expression of FGFR2 mRNA CTD PMID:16150908 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression ISO Triiodothyronine results in increased expression of FGFR3 mRNA CTD PMID:16150908 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fkbp10 FKBP prolyl isomerase 10 decreases expression ISO Triiodothyronine results in decreased expression of FKBP10 mRNA CTD PMID:23397585 NCBI chr10:88,326,337...88,338,199
Ensembl chr10:88,326,080...88,338,207
JBrowse link
G Flrt1 fibronectin leucine rich transmembrane protein 1 increases expression ISO Triiodothyronine results in increased expression of FLRT1 mRNA CTD PMID:25172293 NCBI chr 1:222,340,481...222,417,915
Ensembl chr 1:222,344,713...222,350,173
JBrowse link
G Foxo6 forkhead box O6 increases expression ISO Triiodothyronine results in increased expression of FOXO6 mRNA CTD PMID:25172293 NCBI chr 5:139,208,153...139,227,288
Ensembl chr 5:139,208,046...139,227,196
JBrowse link
G Fpgs folylpolyglutamate synthase increases expression EXP Triiodothyronine results in increased expression of FPGS mRNA CTD PMID:15953391 NCBI chr 3:11,717,667...11,729,694
Ensembl chr 3:11,717,667...11,723,327
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP FSHB protein promotes the reaction [Triiodothyronine results in increased expression of INHBB mRNA]; Triiodothyronine promotes the reaction [FSHB protein results in increased expression of INHBB mRNA] CTD PMID:7531505 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 increases expression EXP Triiodothyronine results in increased expression of FXYD2 mRNA CTD PMID:15953391 NCBI chr 8:49,710,334...49,717,492
Ensembl chr 8:49,710,477...49,716,955
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit multiple interactions
increases expression
ISO (4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of G6PC mRNA]; SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of G6PC mRNA] CTD PMID:21815645 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gap43 growth associated protein 43 increases expression EXP Triiodothyronine results in increased expression of GAP43 mRNA; Triiodothyronine results in increased expression of GAP43 protein CTD PMID:15708448 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gba glucosylceramidase beta increases activity EXP Triiodothyronine results in increased activity of GBA protein CTD PMID:9101438 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression EXP Triiodothyronine results in increased expression of GCH1 mRNA CTD PMID:15953391 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gh1 growth hormone 1 multiple interactions
increases expression
EXP
ISO
Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Amiodarone inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; bisphenol A promotes the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein]; Butyric Acid inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Dexamethasone promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]; Pentetic Acid promotes the reaction [Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Polybrominated Biphenyls analog inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Polybrominated Biphenyls analog inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]; Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]; Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]; Triiodothyronine results in increased expression of and results in increased secretion of GH protein; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]
Triiodothyronine results in increased expression of GH mRNA; Triiodothyronine results in increased expression of GH1 mRNA; Triiodothyronine results in increased expression of GH1 protein
CTD PMID:2211641, PMID:2910914, PMID:10720163, PMID:15240998, PMID:17090972, PMID:17928132, PMID:22201216, PMID:24001430, PMID:27420076 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Ghrh growth hormone releasing hormone multiple interactions EXP Triiodothyronine promotes the reaction [Dexamethasone results in increased expression of GHRH mRNA] CTD PMID:17090972 NCBI chr 3:153,449,124...153,468,794
Ensembl chr 3:153,449,125...153,468,794
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Triiodothyronine results in increased expression of GJA1 protein CTD PMID:15685554 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 increases expression EXP Triiodothyronine results in increased expression of GPCPD1 mRNA CTD PMID:15953391 NCBI chr 3:125,169,131...125,213,598
Ensembl chr 3:125,169,135...125,213,607
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression EXP Triiodothyronine results in increased expression of GPD2 mRNA CTD PMID:29357290 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074
JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 increases expression ISO Triiodothyronine results in increased expression of GRIK4 mRNA CTD PMID:23397585 NCBI chr 8:46,804,134...47,237,546
Ensembl chr 8:46,806,147...47,094,352
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions EXP Triiodothyronine inhibits the reaction [goitrin results in increased expression of GSTA2 protein] CTD PMID:7532609 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP Triiodothyronine inhibits the reaction [goitrin results in increased expression of GSTP1 protein] CTD PMID:7532609 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 decreases expression ISO Triiodothyronine results in decreased expression of GULP1 mRNA CTD PMID:23397585 NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072
JBrowse link
G H1f5 H1.5 linker histone, cluster member increases expression ISO Triiodothyronine results in increased expression of H1-5 mRNA CTD PMID:23397585 NCBI chr17:44,766,313...44,766,981
Ensembl chr17:44,766,313...44,766,981
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
ISO Triiodothyronine analog results in increased phosphorylation of H2AX protein
Triiodothyronine analog promotes the reaction [Cisplatin results in increased expression of H2AX protein]
CTD PMID:22383522 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 increases expression EXP Triiodothyronine results in increased expression of HBA-A1 mRNA CTD PMID:15953391 NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649
JBrowse link
G Hbb hemoglobin subunit beta increases expression EXP Triiodothyronine results in increased expression of HBB mRNA CTD PMID:15953391 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hbg1 hemoglobin subunit gamma 1 increases expression EXP Triiodothyronine results in increased expression of HBG1 mRNA CTD PMID:15953391 NCBI chr 1:168,992,841...168,994,219
Ensembl chr 1:168,992,722...168,994,253
JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 increases expression ISO Triiodothyronine results in increased expression of HCN2 mRNA CTD PMID:25172293 NCBI chr 7:12,851,730...12,870,087
Ensembl chr 7:12,851,739...12,874,215
JBrowse link
G Hdc histidine decarboxylase decreases expression EXP Triiodothyronine results in decreased expression of HDC mRNA CTD PMID:29357290 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
G Heg1 heart development protein with EGF-like domains 1 increases expression ISO Triiodothyronine results in increased expression of HEG1 mRNA CTD PMID:25172293 NCBI chr11:70,234,248...70,322,966
Ensembl chr11:70,236,888...70,322,690
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Triiodothyronine results in increased expression of HIF1A mRNA CTD PMID:15507505 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression EXP Triiodothyronine results in increased expression of HIGD1A mRNA CTD PMID:15953391 NCBI chr 8:130,482,492...130,491,888
Ensembl chr 8:130,482,493...130,491,998
JBrowse link
G Hira histone cell cycle regulator increases expression ISO Triiodothyronine results in increased expression of HIRA mRNA CTD PMID:23397585 NCBI chr11:86,168,196...86,276,430
Ensembl chr11:86,168,196...86,276,430
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Triiodothyronine results in increased expression of HMGCS1 mRNA CTD PMID:15953391 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO Triiodothyronine results in increased expression of HMGCS2 mRNA CTD PMID:23397585 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hnrnph3 heterogeneous nuclear ribonucleoprotein H3 increases expression ISO Triiodothyronine results in increased expression of HNRNPH3 mRNA CTD PMID:23397585 NCBI chr20:27,167,926...27,178,172
Ensembl chr20:27,169,267...27,216,941
JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor increases expression ISO Triiodothyronine results in increased expression of HR mRNA CTD PMID:25172293, PMID:26096596 NCBI chr15:52,241,801...52,261,276
Ensembl chr15:52,241,801...52,261,276
JBrowse link
G Hscb HscB mitochondrial iron-sulfur cluster co-chaperone decreases expression ISO Triiodothyronine results in decreased expression of HSCB mRNA CTD PMID:23397585 NCBI chr12:51,878,267...51,888,645
Ensembl chr12:51,878,153...51,888,669
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; Triiodothyronine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B1 mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]; Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA] CTD PMID:21726595
G Hunk hormonally upregulated Neu-associated kinase increases expression ISO Triiodothyronine results in increased expression of HUNK mRNA CTD PMID:25172293 NCBI chr11:30,550,141...30,663,465
Ensembl chr11:30,550,141...30,663,465
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 increases expression EXP Triiodothyronine results in increased expression of IDH1 mRNA CTD PMID:15953391 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
increases secretion
EXP Estradiol inhibits the reaction [Triiodothyronine results in increased expression of IGF1 mRNA]; Estradiol inhibits the reaction [Triiodothyronine results in increased secretion of IGF1 protein] CTD PMID:7684602 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP Triiodothyronine results in increased expression of IGFBP2 mRNA CTD PMID:15953391 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Iglon5 IgLON family member 5 increases expression ISO Triiodothyronine results in increased expression of IGLON5 mRNA CTD PMID:25172293 NCBI chr 1:98,440,186...98,457,942
Ensembl chr 1:98,440,186...98,455,920
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL1B mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL1B protein]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL1B mRNA]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL1B protein] CTD PMID:32223187 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL6 protein]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL6 protein] CTD PMID:32223187 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inhbb inhibin subunit beta B multiple interactions
increases expression
EXP FSHB protein promotes the reaction [Triiodothyronine results in increased expression of INHBB mRNA]; Triiodothyronine promotes the reaction [FSHB protein results in increased expression of INHBB mRNA] CTD PMID:7531505 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 protein; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 protein CTD PMID:27605626 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 increases expression EXP Triiodothyronine results in increased expression of INSIG1 mRNA CTD PMID:15953391 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of IRF1 mRNA CTD PMID:14761676 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Triiodothyronine promotes the reaction [tamibarotene results in increased expression of ITGAM protein] CTD PMID:11201846 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] CTD PMID:22227104 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Itgb5 integrin subunit beta 5 increases expression
decreases expression
ISO Triiodothyronine results in increased expression of ITGB5 mRNA
Triiodothyronine results in decreased expression of ITGB5 mRNA
CTD PMID:23397585 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372
JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase increases expression ISO Triiodothyronine results in increased expression of ITPK1 mRNA CTD PMID:25172293 NCBI chr 6:126,448,920...126,582,188
Ensembl chr 6:126,450,139...126,582,134
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP Triiodothyronine results in increased expression of ITPR1 mRNA CTD PMID:15953391 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Kantr KDM5C adjacent transcript increases expression ISO Triiodothyronine results in increased expression of KANTR mRNA CTD PMID:25172293 NCBI chr  X:22,369,521...22,399,881
Ensembl chr  X:22,369,521...22,399,901
JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 increases expression ISO Triiodothyronine results in increased expression of KCNA1 mRNA CTD PMID:25172293 NCBI chr 4:159,190,781...159,192,526
Ensembl chr 4:159,190,804...159,192,526
JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 decreases expression ISO Triiodothyronine results in decreased expression of KCNA4 mRNA CTD PMID:25172293 NCBI chr 3:98,293,295...98,300,763
Ensembl chr 3:98,297,554...98,300,680
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions ISO [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 protein CTD PMID:27605626 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO Triiodothyronine results in decreased expression of KCTD12 mRNA CTD PMID:25172293 NCBI chr15:87,384,632...87,390,627 JBrowse link
G Kif1b kinesin family member 1B increases expression EXP Triiodothyronine results in increased expression of KIF1B mRNA CTD PMID:15953391 NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491
JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression
increases expression
ISO Triiodothyronine results in decreased expression of KLF9 mRNA
Triiodothyronine results in increased expression of KLF9 mRNA
CTD PMID:15507505, PMID:23397585, PMID:26096596 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Krt13 keratin 13 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KRT13 mRNA CTD PMID:14761676 NCBI chr10:88,032,130...88,036,040
Ensembl chr10:88,032,130...88,036,040
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression
ISO
EXP
Amiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]; desethylamiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]
Triiodothyronine inhibits the reaction [Amiodarone results in decreased expression of LDLR protein]
CTD PMID:9071962, PMID:9712728 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lgi4 leucine-rich repeat LGI family, member 4 increases expression ISO Triiodothyronine results in increased expression of LGI4 mRNA CTD PMID:25172293 NCBI chr 1:89,491,588...89,502,939
Ensembl chr 1:89,491,654...89,502,974
JBrowse link
G Lhx3 LIM homeobox 3 decreases expression ISO Triiodothyronine results in decreased expression of LHX3 mRNA CTD PMID:23397585 NCBI chr 3:3,653,861...3,662,509
Ensembl chr 3:3,654,755...3,661,810
JBrowse link
G Linc00176 long intergenic non-protein coding RNA 176 decreases expression ISO Triiodothyronine results in decreased expression of C20ORF204 mRNA CTD PMID:23397585 NCBI chr 3:177,163,038...177,166,874
Ensembl chr 3:177,164,359...177,166,737
JBrowse link
G Lipe lipase E, hormone sensitive type increases expression ISO Triiodothyronine results in increased expression of LIPE mRNA CTD PMID:30209975 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 decreases expression ISO Triiodothyronine results in decreased expression of LMCD1 mRNA CTD PMID:25172293 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G Lpin3 lipin 3 increases expression ISO Triiodothyronine results in increased expression of LPIN3 mRNA CTD PMID:25172293 NCBI chr 3:156,874,805...156,899,601
Ensembl chr 3:156,886,454...156,899,436
JBrowse link
G Lpl lipoprotein lipase increases expression EXP Triiodothyronine results in increased expression of LPL mRNA CTD PMID:15953391 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lss lanosterol synthase increases expression EXP Triiodothyronine results in increased expression of LSS mRNA CTD PMID:15953391 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Ltb4r leukotriene B4 receptor multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LTB4R mRNA CTD PMID:14761676 NCBI chr15:34,449,299...34,453,352
Ensembl chr15:34,452,116...34,453,171
JBrowse link
G Lyrm9 LYR motif containing 9 decreases expression ISO Triiodothyronine results in decreased expression of LYRM9 mRNA CTD PMID:23397585 NCBI chr10:66,099,478...66,113,559
Ensembl chr10:66,099,531...66,113,559
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases lipidation
increases expression
multiple interactions
ISO Triiodothyronine results in increased lipidation of MAP1LC3B protein
Triiodothyronine results in increased expression of MAP1LC3B mRNA
bafilomycin A1 promotes the reaction [Triiodothyronine results in increased lipidation of MAP1LC3B protein]; Triiodothyronine promotes the reaction [bafilomycin A1 results in increased lipidation of MAP1LC3B protein]
CTD PMID:30209975 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression
ISO
EXP
tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Triiodothyronine results in increased expression of MAPK1 mRNA
Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Triiodothyronine results in increased expression of MAPK1 mRNA]
CTD PMID:12805413, PMID:16150908, PMID:17174366, PMID:28315333 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression
ISO
EXP
tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK3 protein
Triiodothyronine results in increased expression of MAPK3 mRNA
Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK3 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Triiodothyronine results in increased expression of MAPK3 mRNA]
CTD PMID:12805413, PMID:16150908, PMID:17174366, PMID:28315333 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mbp myelin basic protein increases expression ISO Triiodothyronine results in increased expression of MBP protein alternative form CTD PMID:15345905 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Triiodothyronine results in increased expression of ME1 mRNA CTD PMID:15953391, PMID:29357290 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Meioc meiosis specific with coiled-coil domain decreases expression ISO Triiodothyronine results in decreased expression of MEIOC mRNA CTD PMID:23397585 NCBI chr10:90,622,954...90,641,883
Ensembl chr10:90,622,992...90,642,151
JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A increases expression ISO Triiodothyronine results in increased expression of MFSD2A mRNA CTD PMID:25172293 NCBI chr 5:140,642,865...140,657,759
Ensembl chr 5:140,642,885...140,657,745
JBrowse link
G Mier3 MIER family member 3 decreases expression ISO Triiodothyronine results in decreased expression of MIER3 mRNA CTD PMID:23397585 NCBI chr 2:43,266,301...43,295,175
Ensembl chr 2:43,266,739...43,294,889
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of MKI67 mRNA
U 0126 inhibits the reaction [Triiodothyronine results in increased expression of MKI67 mRNA]
CTD PMID:28315333 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmd2 monocyte to macrophage differentiation-associated 2 increases expression EXP Triiodothyronine results in increased expression of MMD2 mRNA CTD PMID:29357290 NCBI chr12:14,021,724...14,078,121
Ensembl chr12:14,021,727...14,078,134
JBrowse link
G Mmp11 matrix metallopeptidase 11 multiple interactions
increases expression
ISO (4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of MMP11 mRNA]; SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of MMP11 mRNA] CTD PMID:21815645 NCBI chr20:13,670,051...13,678,834
Ensembl chr20:13,670,066...13,678,089
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Triiodothyronine inhibits the reaction [TGFB1 protein results in increased secretion of MMP2 protein] CTD PMID:18031379 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased activity of MPO protein CTD PMID:7503757 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Triiodothyronine results in decreased phosphorylation of MTOR protein CTD PMID:30209975 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
increases expression
EXP S100A6 protein inhibits the reaction [Triiodothyronine results in increased expression of MYH6 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA] CTD PMID:11577024, PMID:15578571, PMID:15652358 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions
decreases expression
EXP Triiodothyronine inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
Triiodothyronine results in decreased expression of MYH7 mRNA
CTD PMID:11577024, PMID:15578571 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Naglt1 Na+ dependent glucose transporter 1 increases expression EXP Triiodothyronine results in increased expression of NAGLT1 mRNA CTD PMID:15953391 NCBI chr20:45,095,232...45,107,532
Ensembl chr20:45,094,791...45,107,555
JBrowse link
G Ncapg2 non-SMC condensin II complex, subunit G2 decreases expression ISO Triiodothyronine results in decreased expression of NCAPG2 mRNA CTD PMID:23397585 NCBI chr 6:144,291,313...144,362,454
Ensembl chr 6:144,291,974...144,363,947
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO [Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein; bisphenol A inhibits the reaction [[Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein] CTD PMID:22227104 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Triiodothyronine promotes the reaction [NCOA2 protein binds to THRA protein]; Triiodothyronine promotes the reaction [NCOA2 protein binds to THRB protein]; Triiodothyronine promotes the reaction [THRA protein binds to NCOA2 protein]; Triiodothyronine promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:29146198, PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein] CTD PMID:22227104 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein] CTD PMID:22227104 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression EXP Triiodothyronine results in increased expression of NDUFA5 mRNA CTD PMID:15953391 NCBI chr 4:51,590,413...51,598,771
Ensembl chr 4:51,590,413...51,598,771
JBrowse link
G Nefl neurofilament light decreases expression ISO Triiodothyronine results in decreased expression of NEFL mRNA CTD PMID:25172293 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nefm neurofilament medium decreases expression ISO Triiodothyronine results in decreased expression of NEFM mRNA CTD PMID:25172293 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity
multiple interactions
EXP Triiodothyronine results in increased activity of NFKB1 protein
Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of NFKB1 protein]
CTD PMID:15019085 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nnat neuronatin decreases expression EXP Triiodothyronine results in decreased expression of NNAT mRNA CTD PMID:29357290 NCBI chr 3:154,043,873...154,046,334
Ensembl chr 3:154,043,873...154,046,330
JBrowse link
G Npnt nephronectin increases expression ISO Triiodothyronine results in increased expression of NPNT mRNA CTD PMID:25172293 NCBI chr 2:238,001,767...238,068,886
Ensembl chr 2:238,002,990...238,068,694
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression EXP Triiodothyronine results in increased expression of NR0B2 mRNA CTD PMID:29357290 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]; Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA] CTD PMID:21726595 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nrgn neurogranin increases expression EXP Triiodothyronine results in increased expression of NRGN mRNA; Triiodothyronine results in increased expression of NRGN protein CTD PMID:15708448 NCBI chr 8:40,015,049...40,023,193
Ensembl chr 8:40,015,049...40,023,193
JBrowse link
G Nrp1 neuropilin 1 increases expression EXP Triiodothyronine results in increased expression of NRP1 mRNA CTD PMID:15953391 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP Triiodothyronine results in increased expression of NSDHL mRNA CTD PMID:15953391 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390
JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor increases expression EXP Triiodothyronine results in increased expression of NSMF mRNA CTD PMID:15953391 NCBI chr 3:2,262,173...2,270,996
Ensembl chr 3:2,262,253...2,270,995
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression
increases activity
EXP Triiodothyronine results in increased expression of NT5E mRNA
Triiodothyronine results in increased activity of NT5E protein
CTD PMID:15543949 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Nudt7 nudix hydrolase 7 increases expression EXP Triiodothyronine results in increased expression of NUDT7 mRNA CTD PMID:15953391 NCBI chr19:46,455,745...46,470,070
Ensembl chr19:46,455,761...46,482,050
JBrowse link
G Nup214 nucleoporin 214 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NUP214 mRNA CTD PMID:14761676 NCBI chr 3:9,227,869...9,236,878
NCBI chr 3:10,993,584...11,070,638
Ensembl chr 3:9,227,823...9,236,736
Ensembl chr 3:9,227,823...9,236,736
JBrowse link
G Ocln occludin increases expression EXP Triiodothyronine results in increased expression of OCLN mRNA CTD PMID:15953391 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Olr59 olfactory receptor 59 increases expression EXP Triiodothyronine results in increased expression of OLR59 mRNA CTD PMID:28299817 NCBI chr 1:167,906,030...167,940,688
Ensembl chr 1:167,906,061...167,911,961
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO Triiodothyronine results in increased expression of OSGIN1 mRNA CTD PMID:25172293 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
affects binding
EXP 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine binds to P4HB protein]; bisphenol A inhibits the reaction [Triiodothyronine binds to P4HB protein]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]; Polychlorinated Biphenyls metabolite inhibits the reaction [Triiodothyronine binds to P4HB protein] CTD PMID:17928132, PMID:18515855, PMID:19374345, PMID:22201216 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Padi4 peptidyl arginine deiminase 4 increases expression EXP Triiodothyronine results in increased expression of PADI4 mRNA CTD PMID:15953391 NCBI chr 5:159,260,675...159,293,906
Ensembl chr 5:159,260,675...159,293,673
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 decreases expression ISO Triiodothyronine results in decreased expression of PARP4 mRNA CTD PMID:23397585 NCBI chr15:36,809,362...36,911,167 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
increases expression
EXP
ISO
SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]; SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]
CTD PMID:21815645, PMID:23209300, PMID:30209975 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
affects binding
ISO Triiodothyronine results in increased expression of PCNA protein
THRB protein promotes the reaction [Triiodothyronine results in increased expression of PCNA protein]
Triiodothyronine analog inhibits the reaction [CDKN1A protein binds to PCNA protein]; Triiodothyronine analog inhibits the reaction [POLD3 protein binds to PCNA protein]; Triiodothyronine inhibits the reaction [CDKN1A protein binds to PCNA protein]
Triiodothyronine analog binds to PCNA protein; Triiodothyronine binds to PCNA protein
CTD PMID:17174366, PMID:20638743, PMID:22383522 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 decreases expression ISO Triiodothyronine results in decreased expression of PCSK1 mRNA CTD PMID:15291740 NCBI chr 2:91,450,162...91,497,091
Ensembl chr 2:91,450,162...91,497,091
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 decreases expression ISO Triiodothyronine results in decreased expression of PCSK2 mRNA CTD PMID:15585599 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions
increases expression
ISO
EXP
resveratrol promotes the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]
resveratrol promotes the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]
CTD PMID:23209300 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pdp2 pyruvate dehyrogenase phosphatase catalytic subunit 2 increases expression EXP Triiodothyronine results in increased expression of PDP2 mRNA CTD PMID:29357290 NCBI chr19:597,427...601,556
Ensembl chr19:597,427...601,469
JBrowse link
G Peg10 paternally expressed 10 increases expression ISO Triiodothyronine results in increased expression of PEG10 mRNA CTD PMID:23397585 NCBI chr 4:29,795,524...29,804,517 JBrowse link
G Pex5 peroxisomal biogenesis factor 5 increases expression ISO Triiodothyronine results in increased expression of PEX5 mRNA CTD PMID:23397585 NCBI chr 4:156,983,914...157,009,675
Ensembl chr 4:156,983,915...157,009,674
JBrowse link
G Pfkp phosphofructokinase, platelet increases expression ISO Triiodothyronine results in increased expression of PFKP mRNA CTD PMID:15507505 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 increases expression ISO Triiodothyronine results in increased expression of PHOSPHO1 mRNA CTD PMID:25172293 NCBI chr10:83,635,557...83,643,862
Ensembl chr10:83,636,518...83,643,859
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta increases expression ISO Triiodothyronine results in increased expression of PIK3CD mRNA CTD PMID:25172293 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pla2g6 phospholipase A2 group VI increases expression EXP Triiodothyronine results in increased expression of PLA2G6 mRNA CTD PMID:15953391 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Pld5 phospholipase D family, member 5 increases expression ISO Triiodothyronine results in increased expression of PLD5 mRNA CTD PMID:23397585 NCBI chr13:94,025,696...94,355,219
Ensembl chr13:94,025,369...94,355,219
JBrowse link
G Plin2 perilipin 2 increases expression EXP Triiodothyronine results in increased expression of PLIN2 mRNA CTD PMID:15953391 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Plin3 perilipin 3 multiple interactions ISO [THRA protein co-treated with Triiodothyronine] promotes the reaction [ANGPTL8 protein binds to PLIN3 protein] CTD PMID:24262987 NCBI chr 9:10,769,739...10,781,659
Ensembl chr 9:10,773,901...10,781,109
JBrowse link
G Plxnc1 plexin C1 increases expression ISO Triiodothyronine results in increased expression of PLXNC1 mRNA CTD PMID:23397585 NCBI chr 7:35,848,083...36,000,969
Ensembl chr 7:35,850,398...36,000,906
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression
decreases phosphorylation
ISO Triiodothyronine results in increased expression of PNPLA2 mRNA
Triiodothyronine results in decreased phosphorylation of PNPLA2 protein
CTD PMID:30209975 NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720
JBrowse link
G Podxl podocalyxin-like increases expression EXP Triiodothyronine results in increased expression of PODXL mRNA CTD PMID:15953391 NCBI chr 4:58,829,049...58,893,353
Ensembl chr 4:58,829,060...58,893,170
JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit multiple interactions ISO Triiodothyronine analog inhibits the reaction [POLD3 protein binds to PCNA protein] CTD PMID:22383522 NCBI chr 1:165,085,142...165,122,385
Ensembl chr 1:165,083,622...165,123,455
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of POLG mRNA CTD PMID:14761676 NCBI chr 1:141,172,117...141,188,893
Ensembl chr 1:141,172,531...141,188,031
JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 increases expression EXP Triiodothyronine results in increased expression of POMT1 mRNA CTD PMID:15953391 NCBI chr 3:11,253,424...11,271,873
Ensembl chr 3:11,254,026...11,271,872
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [GW 7647 results in increased activity of PPARA protein] promotes the reaction [Phenobarbital results in increased degradation of Triiodothyronine]; [pirinixic acid results in increased activity of PPARA protein] promotes the reaction [Phenobarbital results in increased degradation of Triiodothyronine]; [Triiodothyronine co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA CTD PMID:19631232, PMID:25048947 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP Triiodothyronine inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG mRNA] CTD PMID:25048947 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP
ISO
Triiodothyronine results in increased expression of PPARGC1A mRNA CTD PMID:23209300, PMID:30209975 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prdm16 PR/SET domain 16 increases expression ISO Triiodothyronine results in increased expression of PRDM16 mRNA CTD PMID:30209975 NCBI chr 5:171,662,277...171,711,561
Ensembl chr 5:171,662,277...171,710,316
JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein decreases expression ISO Triiodothyronine results in decreased expression of PRELP mRNA CTD PMID:25172293 NCBI chr13:50,749,526...50,773,934
Ensembl chr13:50,749,514...50,761,355
JBrowse link
G Prickle2 prickle planar cell polarity protein 2 decreases expression ISO Triiodothyronine results in decreased expression of PRICKLE2 mRNA CTD PMID:25172293 NCBI chr 4:124,238,167...124,584,176
Ensembl chr 4:124,238,167...124,338,176
JBrowse link
G Prl prolactin decreases expression
increases secretion
multiple interactions
EXP Triiodothyronine results in decreased expression of PRL mRNA; Triiodothyronine results in decreased expression of PRL protein
Triiodothyronine results in increased secretion of PRL protein
bisphenol A inhibits the reaction [Triiodothyronine results in increased secretion of PRL protein]; Chlorodiphenyl (54% Chlorine) promotes the reaction [Triiodothyronine results in increased secretion of PRL protein]
CTD PMID:3734668, PMID:17615682 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prokr1 prokineticin receptor 1 increases expression ISO Triiodothyronine results in increased expression of PROKR1 mRNA CTD PMID:25172293 NCBI chr 4:119,375,790...119,386,551
Ensembl chr 4:119,375,778...119,386,590
JBrowse link
G Psca prostate stem cell antigen multiple interactions
increases expression
ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of PSCA mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of PSCA mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of PSCA mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of PSCA protein]
Triiodothyronine results in increased expression of PSCA mRNA; Triiodothyronine results in increased expression of PSCA protein
CTD PMID:14761676 NCBI chr 7:116,090,189...116,091,955
Ensembl chr 7:116,090,189...116,091,955
JBrowse link
G Rab23 RAB23, member RAS oncogene family decreases expression ISO Triiodothyronine results in decreased expression of RAB23 mRNA CTD PMID:23397585 NCBI chr 9:38,469,784...38,496,185
Ensembl chr 9:38,470,298...38,495,176
JBrowse link
G Rab3b RAB3B, member RAS oncogene family increases expression ISO Triiodothyronine results in increased expression of RAB3B mRNA CTD PMID:15507505 NCBI chr 5:128,501,789...128,568,170
Ensembl chr 5:128,501,847...128,568,188
JBrowse link
G Rarb retinoic acid receptor, beta increases expression EXP Triiodothyronine results in increased expression of RARB mRNA CTD PMID:15708448 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
EXP Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of RELA protein] CTD PMID:15019085 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Retsat retinol saturase increases expression EXP Triiodothyronine results in increased expression of RETSAT mRNA CTD PMID:15953391 NCBI chr 4:100,465,365...100,474,128
Ensembl chr 4:100,465,170...100,474,301
JBrowse link
G RGD1306063 similar to HT021 increases expression EXP Triiodothyronine results in increased expression of RGD1306063 mRNA CTD PMID:15953391 NCBI chr15:12,869,217...12,889,144
Ensembl chr15:12,872,408...12,889,108
JBrowse link
G RGD1307603 similar to hypothetical protein MGC37914 decreases expression EXP Triiodothyronine results in decreased expression of RGD1307603 mRNA CTD PMID:29357290 NCBI chr 1:219,309,593...219,312,240
Ensembl chr 1:219,309,592...219,312,240
JBrowse link
G RGD1564801 similar to hepatic multiple inositol polyphosphate phosphatase increases expression EXP Triiodothyronine results in increased expression of RGD1564801 mRNA CTD PMID:15953391 NCBI chr 1:75,151,956...75,154,325
Ensembl chr 1:75,152,883...75,154,325
JBrowse link
G Rhov ras homolog family member V increases expression ISO Triiodothyronine results in increased expression of RHOV mRNA CTD PMID:23397585 NCBI chr 3:111,078,642...111,087,347
Ensembl chr 3:111,078,619...111,087,347
JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Triiodothyronine analog results in increased phosphorylation of RPA2 protein CTD PMID:22383522 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Triiodothyronine results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:30209975 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rxrb retinoid X receptor beta increases expression EXP Triiodothyronine results in increased expression of RXRB mRNA CTD PMID:15708448 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G Rxrg retinoid X receptor gamma increases expression EXP Triiodothyronine results in increased expression of RXRG mRNA CTD PMID:15708448 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G S100a6 S100 calcium binding protein A6 multiple interactions EXP S100A6 protein inhibits the reaction [Triiodothyronine results in increased expression of MYH6 mRNA] CTD PMID:15652358 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP Triiodothyronine results in increased expression of SC5D mRNA CTD PMID:15953391 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP Triiodothyronine results in increased expression of SCD1 mRNA CTD PMID:15953391 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpina6 serpin family A member 6 increases expression EXP Triiodothyronine results in increased expression of SERPINA6 mRNA CTD PMID:29357290 NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247
JBrowse link
G Serpina7 serpin family A member 7 affects binding ISO Triiodothyronine binds to SERPINA7 protein CTD PMID:20804816, PMID:21517007 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 increases expression EXP Triiodothyronine results in increased expression of SIGMAR1 mRNA CTD PMID:15953391 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
affects response to substance
EXP SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein]; SIRT1 protein affects the reaction [Triiodothyronine results in decreased expression of SREBF1 mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A protein]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]
Triiodothyronine results in increased expression of SIRT1 mRNA
SIRT1 protein affects the susceptibility to Triiodothyronine
CTD PMID:23209300 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression EXP Triiodothyronine results in increased expression of SLC10A2 mRNA CTD PMID:28299817 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions
decreases expression
ISO resveratrol inhibits the reaction [Triiodothyronine results in decreased expression of SLC15A1 mRNA]; resveratrol inhibits the reaction [Triiodothyronine results in decreased expression of SLC15A1 protein]
Triiodothyronine results in decreased expression of SLC15A1 mRNA; Triiodothyronine results in decreased expression of SLC15A1 protein
CTD PMID:26394120 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions
increases uptake
ISO bisphenol A inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; bosutinib inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Dasatinib inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Desipramine inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Genistein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Imatinib Mesylate inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Indocyanine Green inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Meclofenamic Acid inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Phloretin inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Sulfobromophthalein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214
JBrowse link
G Slc16a3 solute carrier family 16 member 3 increases expression ISO Triiodothyronine results in increased expression of SLC16A3 mRNA CTD PMID:15507505 NCBI chr10:110,138,519...110,148,360
Ensembl chr10:110,138,586...110,148,358
JBrowse link
G Slc16a6 solute carrier family 16, member 6 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of SLC16A6 mRNA
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of SLC16A6 mRNA]
CTD PMID:21815645 NCBI chr10:97,733,701...97,758,723
Ensembl chr10:97,735,548...97,756,521
JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression ISO Triiodothyronine results in increased expression of SLC1A2 mRNA CTD PMID:25172293 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc25a25 solute carrier family 25 member 25 increases expression EXP Triiodothyronine results in increased expression of SLC25A25 mRNA CTD PMID:29357290 NCBI chr 3:11,442,396...11,476,186
Ensembl chr 3:11,442,397...11,452,529
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Triiodothyronine results in increased expression of SLC2A1 mRNA CTD PMID:15507505 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 protein CTD PMID:27605626 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc2a5 solute carrier family 2 member 5 multiple interactions EXP [Triiodothyronine co-treated with Fructose] results in increased expression of SLC2A5 mRNA CTD PMID:17485832 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
JBrowse link
G Slc38a2 solute carrier family 38, member 2 increases expression EXP Triiodothyronine results in increased expression of SLC38A2 mRNA CTD PMID:29357290 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Slc43a2 solute carrier family 43 member 2 increases expression ISO Triiodothyronine results in increased expression of SLC43A2 mRNA CTD PMID:25172293 NCBI chr10:63,676,317...63,719,283
Ensembl chr10:63,677,396...63,719,283
JBrowse link
G Slc51b solute carrier family 51 subunit beta increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of SLC51B mRNA
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of SLC51B mRNA]
CTD PMID:21815645 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Sned1 sushi, nidogen and EGF-like domains 1 increases expression ISO Triiodothyronine results in increased expression of SNED1 mRNA CTD PMID:25172293 NCBI chr 9:100,380,487...100,439,125
Ensembl chr 9:100,380,515...100,437,056
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
ISO Triiodothyronine inhibits the reaction [Paraquat results in decreased expression of SOD1 mRNA]; Triiodothyronine inhibits the reaction [THRA protein results in increased expression of SOD1 mRNA]; Triiodothyronine inhibits the reaction [THRB protein results in increased expression of SOD1 mRNA]
Triiodothyronine results in decreased expression of SOD1 mRNA
CTD PMID:16738222 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Spen spen family transcriptional repressor increases expression ISO Triiodothyronine results in increased expression of SPEN mRNA CTD PMID:23397585 NCBI chr 5:160,015,573...160,070,915
Ensembl chr 5:160,015,454...160,070,965
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 increases expression ISO Triiodothyronine results in increased expression of SPTLC2 mRNA CTD PMID:23397585 NCBI chr 6:111,334,408...111,417,960
Ensembl chr 6:111,339,136...111,417,954
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO [THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein; Ammonium Chloride inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; ANGPTL8 protein affects the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]
Triiodothyronine results in increased expression of SQSTM1 mRNA
CTD PMID:24262987, PMID:30209975 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] CTD PMID:22227104 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
decreases activity
EXP SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein]; SIRT1 protein affects the reaction [Triiodothyronine results in decreased expression of SREBF1 mRNA] CTD PMID:23209300 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 decreases expression ISO Triiodothyronine results in decreased expression of SFRS3 mRNA CTD PMID:23397585 NCBI chr20:6,288,285...6,298,218
Ensembl chr20:6,288,267...6,298,213
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]]; Triiodothyronine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA] CTD PMID:21726595 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stard8 StAR-related lipid transfer domain containing 8 increases expression ISO Triiodothyronine results in increased expression of STARD8 mRNA CTD PMID:25172293 NCBI chr  X:68,713,157...68,785,046
Ensembl chr  X:68,713,123...68,785,052
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Triiodothyronine inhibits the reaction [FGF2 protein results in increased phosphorylation of STAT1 protein] CTD PMID:16150908 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases expression ISO Triiodothyronine results in increased expression of STAT5A mRNA CTD PMID:25172293 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases expression EXP Triiodothyronine results in increased expression of STAT5B mRNA CTD PMID:15953391 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Stk19 serine/threonine kinase 19 increases expression ISO Triiodothyronine results in increased expression of STK19 mRNA CTD PMID:23397585 NCBI chr20:4,317,440...4,517,128 JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation
multiple interactions
affects sulfation
ISO SULT1A1 protein results in increased sulfation of Triiodothyronine
Triiodothyronine inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]
SULT1A1 gene polymorphism affects the sulfation of Triiodothyronine
CTD PMID:11739018, PMID:15531517 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP Triiodothyronine results in increased expression of SULT2A1 mRNA CTD PMID:15953391 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Sult4a1 sulfotransferase family 4A, member 1 increases metabolic processing ISO SULT4A1 protein results in increased metabolism of Triiodothyronine CTD PMID:12039030 NCBI chr 7:124,958,546...124,982,602
Ensembl chr 7:124,958,546...124,982,566
JBrowse link
G Taf5l TATA-box binding protein associated factor 5 like increases expression ISO Triiodothyronine results in increased expression of TAF5L mRNA CTD PMID:23397585 NCBI chr19:56,781,854...56,801,005
Ensembl chr19:56,781,859...56,799,445
JBrowse link
G Tcim transcriptional and immune response regulator multiple interactions
increases expression
ISO SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of TCIM mRNA] CTD PMID:21815645 NCBI chr16:72,401,526...72,403,180
Ensembl chr16:72,401,887...72,403,179
JBrowse link
G Tex264 testis expressed 264 increases expression EXP Triiodothyronine results in increased expression of TEX264 mRNA CTD PMID:29357290 NCBI chr 8:115,360,706...115,388,299
Ensembl chr 8:115,360,713...115,388,266
JBrowse link
G Tfeb transcription factor EB increases expression ISO Triiodothyronine results in increased expression of TFEB mRNA CTD PMID:25172293 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Triiodothyronine inhibits the reaction [TGFB1 protein results in increased secretion of MMP2 protein]; Triiodothyronine promotes the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:18031379 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgoln2 trans-golgi network protein 2 decreases expression
increases expression
ISO Triiodothyronine results in decreased expression of TGOLN2 mRNA
Triiodothyronine results in increased expression of TGOLN2 mRNA
CTD PMID:23397585 NCBI chr 4:100,475,415...100,483,229
Ensembl chr 4:100,475,416...100,483,168
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions
affects binding
increases expression
increases activity
decreases expression
ISO
EXP
2,2',4,4'-tetrabromodiphenyl ether analog affects the reaction [Triiodothyronine binds to THRA protein]; [THRA protein co-treated with Triiodothyronine] promotes the reaction [ANGPTL8 protein binds to PLIN3 protein]; [THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 protein; Ammonium Chloride inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; ANGPTL8 protein affects the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [Triiodothyronine binds to THRA protein]; bisphenol A inhibits the reaction [Triiodothyronine binds to THRA protein]; bisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; bisphenol F inhibits the reaction [Triiodothyronine binds to THRA protein]; Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; daidzein promotes the reaction [Triiodothyronine results in increased activity of THRA protein]; Genistein promotes the reaction [Triiodothyronine results in increased activity of THRA protein]; KB 130015 inhibits the reaction [Triiodothyronine binds to and results in increased activity of THRA protein]; pentabromodiphenyl ether analog inhibits the reaction [Triiodothyronine binds to THRA protein]; Polybrominated Biphenyls metabolite inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine binds to THRA protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; tetrachlorodian inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased cleavage of CASP3 protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CYCS mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL1B mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of TNF mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL1B protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL6 protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of TNF protein]]; tribromodiphenyl ether 28 analog affects the reaction [Triiodothyronine binds to THRA protein]; Triiodothyronine binds to and results in increased activity of THRA protein; Triiodothyronine inhibits the reaction [THRA protein results in increased expression of SOD1 mRNA]; Triiodothyronine promotes the reaction [NCOA2 protein binds to THRA protein]; Triiodothyronine promotes the reaction [THRA protein binds to NCOA2 protein]
Triiodothyronine results in increased expression of THRA mRNA
2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine results in increased expression of THRA mRNA]; CSK protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]; Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]
[bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of THRA mRNA; [bisphenol A co-treated with Triiodothyronine] results in increased expression of THRA mRNA; Polybrominated Biphenyls inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; Polybrominated Biphenyls metabolite inhibits the reaction [Triiodothyronine binds to THRA protein]; THRA protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; Triiodothyronine binds to and results in increased activity of THRA protein
Triiodothyronine results in decreased expression of THRA mRNA
Triiodothyronine results in increased expression of THRA mRNA; Triiodothyronine results in increased expression of THRA protein
CTD PMID:7684602, PMID:9664232, PMID:11806713, PMID:12414890, PMID:12588052, PMID:15680168, PMID:15708448, PMID:16021636, PMID:16023420, PMID:16738222, PMID:19672399, PMID:21396401, PMID:21726595, PMID:22015988, PMID:22086976, PMID:23112079, PMID:23402801, PMID:24076165, PMID:24262987, PMID:24819616, PMID:25646720, PMID:27993100, PMID:28167136, PMID:29146198, PMID:29688519, PMID:31566444, PMID:32223187 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
decreases expression
affects binding
increases response to substance
increases activity
increases expression
ISO
EXP
2,2',4,4'-tetrabromodiphenyl ether analog affects the reaction [Triiodothyronine binds to THRB protein]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [Triiodothyronine binds to THRB protein]; 2,3,4,7,8-pentachlorodibenzofuran inhibits the reaction [Triiodothyronine results in increased expression of THRB mRNA]; 2,4,6-tribromophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 2,4,6-trichlorophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 2,4,6-triiodophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 4-nonylphenol inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of THRB mRNA]; 6-OH-BDE-47 inhibits the reaction [Triiodothyronine binds to THRB protein]; [THRB protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; [Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Amiodarone inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bis(4-hydroxyphenyl)sulfone analog inhibits the reaction [Triiodothyronine binds to THRB protein]; bis(4-hydroxyphenyl)sulfone analog inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [Triiodothyronine binds to THRB protein]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bisphenol A analog inhibits the reaction [Triiodothyronine binds to THRB protein]; bisphenol A inhibits the reaction [[Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein]; bisphenol A inhibits the reaction [Triiodothyronine binds to THRB protein]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bisphenol F inhibits the reaction [Triiodothyronine binds to THRB protein]; cyhalothrin inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; daidzein promotes the reaction [Triiodothyronine results in increased activity of THRB protein]; deoxynivalenol inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; desethylamiodarone inhibits the reaction [Triiodothyronine binds to THRB protein alternative form]; Genistein promotes the reaction [Triiodothyronine results in increased activity of THRB protein]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; KB 130015 inhibits the reaction [Triiodothyronine binds to and results in increased activity of THRB protein]; methoxyacetic acid promotes the reaction [Triiodothyronine results in increased activity of THRB protein]; pentabromodiphenyl ether analog inhibits the reaction [Triiodothyronine binds to THRB protein]; pentabromophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; Polybrominated Biphenyls metabolite inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; systhane inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; T-2 Toxin inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine binds to THRB protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tetrachlorodian analog inhibits the reaction [Triiodothyronine binds to THRB protein]; tetrachlorodian inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Thyroxine inhibits the reaction [Triiodothyronine binds to THRB protein]; Tretinoin inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tribromodiphenyl ether 28 analog affects the reaction [Triiodothyronine binds to THRB protein]; Triclosan inhibits the reaction [Triiodothyronine binds to THRB protein]; Triiodothyronine binds to and results in increased activity of THRB protein; Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]; Triiodothyronine inhibits the reaction [THRB protein results in increased expression of SOD1 mRNA]; Triiodothyronine promotes the reaction [NCOA2 protein binds to THRB protein]; Triiodothyronine promotes the reaction [THRB protein binds to NCOA2 protein]; Zearalenone inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]
Triiodothyronine results in decreased expression of THRB mRNA
THRB protein results in increased susceptibility to Triiodothyronine
THRB protein promotes the reaction [Triiodothyronine results in decreased expression of CDKN1B protein]; THRB protein promotes the reaction [Triiodothyronine results in increased expression of CCND1 protein]; THRB protein promotes the reaction [Triiodothyronine results in increased expression of PCNA protein]
Triiodothyronine results in increased expression of THRB mRNA; Triiodothyronine results in increased expression of THRB protein
[bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of THRB mRNA; [bisphenol A co-treated with Triiodothyronine] results in increased expression of THRB mRNA; Butyric Acid inhibits the reaction [Triiodothyronine results in increased expression of THRB mRNA]; desethylamiodarone inhibits the reaction [Triiodothyronine binds to THRB protein]; Polybrominated Biphenyls inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; THRB protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; THRB protein promotes the reaction [Triiodothyronine results in increased expression of ATP2A2 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB protein]
CTD PMID:2211641, PMID:8137729, PMID:11577024, PMID:11806713, PMID:12414890, PMID:12538616, PMID:12588052, PMID:15103026, PMID:15598685, PMID:15680168, PMID:15708448, PMID:16021636, PMID:16738222, PMID:18486176, PMID:18584933, PMID:18795168, PMID:19457453, PMID:19672399, PMID:20638743, PMID:20737425, PMID:21396401, PMID:22015988, PMID:22227104, PMID:23112079, PMID:23402801, PMID:24262987, PMID:25646720, PMID:27410513, PMID:27420076, PMID:27993100, PMID:28167136, PMID:28531659, PMID:28973306, PMID:29146198, PMID:29409039, PMID:29688519, PMID:29763311, PMID:31077750, PMID:31566444 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions
increases expression
EXP
ISO
Triiodothyronine inhibits the reaction [Amiodarone results in increased expression of THRSP mRNA]
Triiodothyronine results in increased expression of THRSP mRNA
CTD PMID:2721112, PMID:10357836, PMID:15953391, PMID:28478156 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Tmem184b transmembrane protein 184B multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of TMEM184B mRNA CTD PMID:14761676 NCBI chr 7:120,593,336...120,636,592
Ensembl chr 7:120,593,336...120,636,592
JBrowse link
G Tmem44 transmembrane protein 44 increases expression ISO Triiodothyronine results in increased expression of TMEM44 mRNA CTD PMID:23397585 NCBI chr11:73,737,323...73,774,149
Ensembl chr11:73,738,433...73,774,190
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF mRNA; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF protein; Hexachlorocyclohexane inhibits the reaction [Triiodothyronine results in increased expression of TNF protein]
THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of TNF mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of TNF protein]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of TNF mRNA]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of TNF protein]
CTD PMID:15019085, PMID:32223187 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 multiple interactions
increases expression
ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of TNFRSF9 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of TNFRSF9 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TNFRSF9 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TNFRSF9 protein]
Triiodothyronine results in increased expression of TNFRSF9 mRNA; Triiodothyronine results in increased expression of TNFRSF9 protein
CTD PMID:14761676 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of TOMM20 protein
Chloroquine promotes the reaction [Triiodothyronine results in increased expression of TOMM20 protein]; Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of TOMM20 protein]
CTD PMID:30209975 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions
increases expression
ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 protein]
Triiodothyronine results in increased expression of TRAF1 mRNA; Triiodothyronine results in increased expression of TRAF1 protein
CTD PMID:14761676 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Trim46 tripartite motif-containing 46 increases expression ISO Triiodothyronine results in increased expression of TRIM46 mRNA CTD PMID:23397585 NCBI chr 2:188,548,608...188,561,617
Ensembl chr 2:188,548,644...188,561,360
JBrowse link
G Tshb thyroid stimulating hormone subunit beta decreases expression
multiple interactions
increases secretion
ISO
EXP
Triiodothyronine results in decreased expression of TSHB mRNA
[Triiodothyronine co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in decreased expression of TSHB mRNA alternative form
TSHB protein results in increased secretion of Triiodothyronine
CTD PMID:7827627, PMID:9092800, PMID:11288978, PMID:27420076, PMID:28167136 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Ttbk1 tau tubulin kinase 1 increases expression ISO Triiodothyronine results in increased expression of TTBK1 mRNA CTD PMID:25172293 NCBI chr 9:16,862,305...16,899,399
Ensembl chr 9:16,862,248...16,902,199
JBrowse link
G Ttn titin multiple interactions
affects expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine affects the expression of TTN mRNA]; AKT1 protein affects the reaction [Triiodothyronine affects the expression of TTN mRNA] CTD PMID:18096819 NCBI chr 3:63,565,160...63,837,815 JBrowse link
G Ttr transthyretin affects binding ISO Triiodothyronine binds to TTR protein CTD PMID:20804816, PMID:21517007 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions
increases expression
ISO
EXP
(+)-JQ1 compound inhibits the reaction [[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA]; [Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA
Triiodothyronine results in increased expression of UCP1 mRNA; Triiodothyronine results in increased expression of UCP1 protein
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [Triiodothyronine co-treated with Norepinephrine] results in increased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]; Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]; Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]
CTD PMID:11742803, PMID:26972250, PMID:30209975 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP THRA protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; THRB protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 mRNA]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 protein]; Triiodothyronine promotes the reaction [Bezafibrate results in increased expression of UCP2 mRNA]; Triiodothyronine promotes the reaction [carboprostacyclin results in increased expression of UCP2 mRNA]; Triiodothyronine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA] CTD PMID:12588052, PMID:25048947 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases activity EXP Triiodothyronine results in increased activity of UGCG protein CTD PMID:9101438 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases expression
multiple interactions
EXP Triiodothyronine results in decreased expression of UGT1A1 mRNA
Vitamin A inhibits the reaction [Triiodothyronine results in decreased expression of UGT1A1 mRNA]
CTD PMID:11299074 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression
multiple interactions
EXP Triiodothyronine results in increased expression of UGT1A6 mRNA
Vitamin A inhibits the reaction [Triiodothyronine results in increased expression of UGT1A6 mRNA]
CTD PMID:11299074 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Utp20 UTP20 small subunit processome component multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of UTP20 mRNA CTD PMID:14761676 NCBI chr 7:29,296,360...29,378,105
Ensembl chr 7:29,296,963...29,378,080
JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression
multiple interactions
ISO Triiodothyronine results in increased expression of VDAC1 protein
Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of VDAC1 protein]
CTD PMID:30209975 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Wls Wnt ligand secretion mediator increases expression ISO Triiodothyronine results in increased expression of WLS mRNA CTD PMID:23397585 NCBI chr 2:266,315,036...266,431,220
Ensembl chr 2:266,315,036...266,432,558
JBrowse link
G Zc3h7b zinc finger CCCH-type containing 7B decreases expression ISO Triiodothyronine results in decreased expression of ZC3H7B mRNA CTD PMID:23397585 NCBI chr 7:122,978,999...123,027,166
Ensembl chr 7:122,979,021...123,027,150
JBrowse link
G Zfp113 zinc finger protein 3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ZNF3 mRNA CTD PMID:14761676 NCBI chr12:19,287,541...19,298,172
Ensembl chr12:19,288,403...19,294,888
JBrowse link
G Zfp664 zinc finger protein 664 increases expression ISO Triiodothyronine results in increased expression of ZNF664 mRNA CTD PMID:23397585 NCBI chr12:36,201,327...36,203,396 JBrowse link
G Zmiz1 zinc finger, MIZ-type containing 1 increases expression ISO Triiodothyronine results in increased expression of ZMIZ1 mRNA CTD PMID:23397585 NCBI chr16:1,749,191...1,954,633
Ensembl chr16:1,749,191...1,954,614
JBrowse link
3,3'-diiodothyronine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO [DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine] CTD PMID:21565810 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO 3,3'-diiodothyronine inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] CTD PMID:15531517 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
3-iodobenzyl-5'-N-methylcarboxamidoadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora3 adenosine A3 receptor multiple interactions EXP
ISO
2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate; [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein
CTD PMID:12672554, PMID:15452191, PMID:19966059 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein] CTD PMID:16116186 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression
decreases response to substance
ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of BIRC3 mRNA
BIRC3 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine
CTD PMID:16088125 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases response to substance ISO BIRC5 protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine CTD PMID:16088125 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA] CTD PMID:15452191 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Il12a interleukin 12A multiple interactions ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] CTD PMID:16116186 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; Pertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] CTD PMID:16116186 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 decreases response to substance
decreases expression
ISO NAIP protein results in decreased susceptibility to N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine
N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of NAIP mRNA
CTD PMID:16088125 NCBI chr 2:30,377,505...30,418,578 JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:15452191, PMID:19966059 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions EXP N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA] CTD PMID:15452191 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions EXP N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein] CTD PMID:15452191 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
5-chloro-7-iodoquinolin-8-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Clioquinol inhibits the reaction [[Copper co-treated with Cholesterol] results in increased activity of ACHE protein] CTD PMID:25856695 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ago2 argonaute RISC catalytic component 2 multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 mRNA; [Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 protein CTD PMID:22415087 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO Clioquinol results in decreased expression of AK1 mRNA CTD PMID:19502547 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein]; [Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein CTD PMID:16648635 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; [Clioquinol binds to Copper] which results in increased degradation of APP protein modified form; [Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form; Clioquinol inhibits the reaction [Copper results in increased secretion of APP protein alternative form]; Clioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form]; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form] CTD PMID:16648635, PMID:18346929 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions ISO [Clioquinol binds to Copper] which results in decreased expression of AR protein CTD PMID:17308104 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Clioquinol results in increased phosphorylation of ATM protein CTD PMID:22627294 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bnip3l BCL2 interacting protein 3 like decreases expression ISO Clioquinol results in decreased expression of BNIP3L mRNA CTD PMID:19502547 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Clioquinol inhibits the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17287498 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Clioquinol results in increased expression of CDKN1A mRNA CTD PMID:22627294 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Commd1 copper metabolism domain containing 1 affects response to substance ISO COMMD1 gene SNP affects the susceptibility to Clioquinol CTD PMID:25622337 NCBI chr14:107,664,321...107,759,974
Ensembl chr14:107,664,255...107,760,191
JBrowse link
G Dcp1b decapping mRNA 1B multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of DCP1B mRNA CTD PMID:22415087 NCBI chr 4:151,249,654...151,287,018
Ensembl chr 4:151,250,041...151,285,702
JBrowse link
G Dicer1 dicer 1 ribonuclease III multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of DICER1 protein CTD PMID:22415087 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Drosha drosha ribonuclease III multiple interactions ISO [Clioquinol co-treated with zinc chloride] affects the expression of DROSHA protein CTD PMID:22415087 NCBI chr 2:62,887,267...63,000,307
Ensembl chr 2:62,887,267...62,999,572
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of EGFR protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK1 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; [Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein; [FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of EGFR protein]; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 decreases expression ISO Clioquinol results in decreased expression of EGLN1 mRNA CTD PMID:19502547 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 decreases expression ISO Clioquinol results in decreased expression of EGLN2 mRNA CTD PMID:19502547 NCBI chr 1:83,969,456...83,977,665
Ensembl chr 1:83,969,457...83,977,236
JBrowse link
G Egr1 early growth response 1 increases expression ISO Clioquinol results in increased expression of EGR1 mRNA CTD PMID:19502547 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E mRNA; [Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E protein CTD PMID:22415087 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Epo erythropoietin increases expression
decreases expression
ISO Clioquinol results in increased expression of EPO mRNA
Clioquinol results in decreased expression of EPO mRNA
CTD PMID:16973622, PMID:19502547 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clioquinol promotes the reaction [FOS protein binds to CXCL8 promoter] CTD PMID:29966605 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Clioquinol results in increased expression of GADD45A mRNA CTD PMID:22627294 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gata2 GATA binding protein 2 decreases expression
multiple interactions
ISO Clioquinol results in decreased expression of GATA2 protein
GATA2 protein inhibits the reaction [Clioquinol results in increased expression of CXCL8 mRNA]; GATA2 protein inhibits the reaction [Clioquinol results in increased secretion of CXCL8 protein]
CTD PMID:29966605 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Gata3 GATA binding protein 3 decreases expression
multiple interactions
ISO Clioquinol results in decreased expression of GATA3 protein
Clioquinol inhibits the reaction [GATA3 protein binds to CXCL8 promoter]; GATA3 protein inhibits the reaction [Clioquinol results in increased expression of CXCL8 mRNA]; GATA3 protein inhibits the reaction [Clioquinol results in increased secretion of CXCL8 protein]
CTD PMID:29966605 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Clioquinol results in increased phosphorylation of H2AX protein CTD PMID:22627294 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
decreases hydroxylation
decreases ubiquitination
increases activity
ISO [Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein]; Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein]
[Clioquinol co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A protein; HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein]
Clioquinol results in decreased hydroxylation of HIF1A protein
Clioquinol results in decreased ubiquitination of HIF1A protein
Clioquinol results in increased activity of HIF1A protein
CTD PMID:16973622, PMID:19502547, PMID:19679656 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor multiple interactions
decreases activity
ISO Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein]
Clioquinol results in decreased activity of HIF1AN protein
CTD PMID:16973622 NCBI chr 1:264,309,214...264,319,269
Ensembl chr 1:264,309,214...264,319,267
JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha decreases expression ISO Clioquinol results in decreased expression of HIF3A mRNA CTD PMID:19502547 NCBI chr 1:78,976,318...78,997,869
Ensembl chr 1:78,976,318...78,997,869
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO ITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itga5 integrin subunit alpha 5 multiple interactions ISO ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clioquinol promotes the reaction [JUN protein binds to CXCL8 promoter] CTD PMID:29966605 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK1 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK1 protein]; [Clioquinol binds to Copper] which results in increased phosphorylation of MAPK1 protein; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK1 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:16648635, PMID:18346929 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:16648635, PMID:18346929 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein] CTD PMID:16648635 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO Clioquinol results in increased expression of MIF mRNA CTD PMID:19502547 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mir130a microRNA 130a multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR130A mRNA CTD PMID:22415087 NCBI chr 3:72,141,037...72,141,124
Ensembl chr 3:72,141,037...72,141,124
JBrowse link
G Mir223 microRNA 223 multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR223 mRNA CTD PMID:22415087 NCBI chr  X:65,367,812...65,367,921
Ensembl chr  X:65,367,812...65,367,921
JBrowse link
G Mir29a microRNA 29a multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR29A mRNA CTD PMID:22415087 NCBI chr 4:58,343,931...58,344,018 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP2 protein CTD PMID:16648635 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO [Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP3 protein CTD PMID:16648635 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Clioquinol inhibits the reaction [MOG protein results in increased activity of MMP9 protein] CTD PMID:23360710 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mog myelin oligodendrocyte glycoprotein multiple interactions ISO Clioquinol inhibits the reaction [MOG protein results in increased activity of MMP9 protein] CTD PMID:23360710 NCBI chr20:2,003,871...2,014,284
Ensembl chr20:2,004,052...2,014,286
JBrowse link
G Ngf nerve growth factor multiple interactions ISO Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]; trichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]] CTD PMID:25758465 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions ISO Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]; trichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]] CTD PMID:25758465 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 decreases expression ISO Clioquinol results in decreased expression of P4HA2 mRNA CTD PMID:19502547 NCBI chr10:39,435,227...39,464,134
Ensembl chr10:39,435,227...39,464,188
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO Clioquinol results in increased expression of PGK1 mRNA CTD PMID:19502547 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; [Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of SRC protein CTD PMID:18346929 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
ISO 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Clioquinol results in increased phosphorylation of TP53 protein] CTD PMID:22627294 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
decreases expression
multiple interactions
ISO Clioquinol results in increased expression of VEGFA mRNA; Clioquinol results in increased expression of VEGFA protein
Clioquinol results in decreased expression of VEGFA mRNA
HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein]
CTD PMID:16973622, PMID:19502547 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vopp1 VOPP1 WW domain binding protein decreases expression ISO Clioquinol results in decreased expression of ECOP mRNA CTD PMID:19502547 NCBI chr 4:88,441,067...88,515,141
Ensembl chr 4:88,441,067...88,515,138
JBrowse link
5-iodo-2'-deoxyuridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase affects response to substance ISO MBD4 protein affects the susceptibility to Idoxuridine CTD PMID:16885370 NCBI chr 4:147,744,673...147,756,462
Ensembl chr 4:147,746,186...147,756,294
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Idoxuridine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions EXP Idoxuridine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine] CTD PMID:8713072 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
G Tyms thymidylate synthetase affects uptake ISO TYMS protein affects the uptake of Idoxuridine CTD PMID:15001691 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
5-iodotubercidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases phosphorylation EXP 5-iodotubercidin results in decreased phosphorylation of CDKN1B protein CTD PMID:26953159 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Clk1 CDC-like kinase 1 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK1 protein CTD PMID:26953159 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
JBrowse link
G Clk2 CDC-like kinase 2 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK2 protein CTD PMID:26953159 NCBI chr 2:188,476,789...188,488,809
Ensembl chr 2:188,476,820...188,496,191
JBrowse link
G Clk3 CDC-like kinase 3 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK3 protein CTD PMID:26953159 NCBI chr 8:62,528,135...62,543,550
Ensembl chr 8:62,528,225...62,542,622
JBrowse link
G Clk4 CDC-like kinase 4 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK4 protein CTD PMID:26953159 NCBI chr10:36,715,565...36,733,473
Ensembl chr10:36,715,565...36,733,133
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK1A protein CTD PMID:26953159 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536
JBrowse link
G Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK1B protein CTD PMID:26953159 NCBI chr 1:85,112,819...85,120,840
Ensembl chr 1:85,112,247...85,120,839
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK2 protein CTD PMID:26953159 NCBI chr 7:61,785,423...61,816,775
Ensembl chr 7:61,786,309...61,798,729
JBrowse link
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK3 protein CTD PMID:26953159 NCBI chr13:47,906,230...47,916,877
Ensembl chr13:47,906,231...47,916,877
JBrowse link
G Dyrk4 dual specificity tyrosine phosphorylation regulated kinase 4 decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK4 protein CTD PMID:26953159 NCBI chr 4:159,426,447...159,467,973
Ensembl chr 4:159,427,340...159,467,955
JBrowse link
G Ins2 insulin 2 increases secretion
affects secretion
ISO 5-iodotubercidin results in increased secretion of INS protein
5-iodotubercidin affects the secretion of INS protein
CTD PMID:26953159 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO 5-iodotubercidin results in increased expression of MMP3 mRNA CTD PMID:26953159 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Nefm neurofilament medium increases expression ISO 5-iodotubercidin results in increased expression of NEFM mRNA CTD PMID:26953159 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Olfm4 olfactomedin 4 decreases expression ISO 5-iodotubercidin results in decreased expression of OLFM4 mRNA CTD PMID:26953159 NCBI chr15:62,384,263...62,429,450
Ensembl chr15:62,406,873...62,429,449
JBrowse link
G Reg3b regenerating family member 3 beta decreases expression ISO 5-iodotubercidin results in decreased expression of REG3A mRNA CTD PMID:26953159 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression ISO 5-iodotubercidin results in increased expression of SLC2A2 mRNA CTD PMID:26953159 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
AM-251 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
ISO 4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased expression of ABCG2 protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased expression of ABCG2 protein] CTD PMID:27423937 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of AKT1 protein] CTD PMID:17583570 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 decreases expression ISO AM 251 results in decreased expression of ARPC4 mRNA CTD PMID:16500647 NCBI chr 4:145,330,457...145,340,985
Ensembl chr 4:145,330,457...145,340,984
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 increases expression ISO AM 251 results in increased expression of ARPP21 mRNA CTD PMID:16500647 NCBI chr 8:120,323,895...120,492,790
Ensembl chr 8:120,323,897...120,446,507
JBrowse link
G Ass1 argininosuccinate synthase 1 increases expression ISO AM 251 results in increased expression of ASS1 mRNA CTD PMID:16500647 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO AM 251 results in increased expression of ATF5 mRNA CTD PMID:16500647 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions ISO AM 251 inhibits the reaction [anandamide results in decreased activity of BDKRB1 protein] CTD PMID:19022239 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Cap2 cyclase associated actin cytoskeleton regulatory protein 2 decreases expression ISO AM 251 results in decreased expression of CAP2 mRNA CTD PMID:16500647 NCBI chr17:18,441,614...18,592,866
Ensembl chr17:18,442,127...18,592,750
JBrowse link
G Cars cysteinyl-tRNA synthetase increases expression ISO AM 251 results in increased expression of CARS1 mRNA CTD PMID:16500647 NCBI chr 1:216,759,367...216,801,652
Ensembl chr 1:216,759,366...216,801,656
JBrowse link
G Cavin2 caveolae associated protein 2 decreases expression ISO AM 251 results in decreased expression of CAVIN2 mRNA CTD PMID:16500647 NCBI chr 9:55,244,136...55,256,153
Ensembl chr 9:55,243,255...55,256,340
JBrowse link
G Ccdc86 coiled-coil domain containing 86 decreases expression ISO AM 251 results in decreased expression of CCDC86 mRNA CTD PMID:16500647 NCBI chr 1:226,996,435...227,002,016
Ensembl chr 1:226,996,237...227,002,139
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO AM 251 results in increased expression of CD55 mRNA CTD PMID:16500647 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO AM 251 results in increased expression of CEBPG mRNA CTD PMID:16500647 NCBI chr 1:91,286,956...91,297,459
Ensembl chr 1:91,287,917...91,296,656
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit increases expression ISO AM 251 results in increased expression of CHRNB3 mRNA CTD PMID:16500647 NCBI chr16:68,876,442...68,913,628
Ensembl chr16:68,875,709...68,913,628
JBrowse link
G Cklf chemokine-like factor increases expression ISO AM 251 results in increased expression of CKLF mRNA CTD PMID:16500647 NCBI chr19:903,609...914,880
Ensembl chr19:906,411...914,880
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases activity
ISO
EXP
[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-(5-fluoropentyl)-3-(1-naphthoyl)indole; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-pentyl-3-(1-naphthoyl)indole; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 47497; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 47497 analog; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to HU 211
AM 251 results in decreased activity of CNR1 protein
[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased activity of nimesulide; AM 251 binds to and results in decreased activity of CNR1 protein
CTD PMID:12509806, PMID:17596442, PMID:20590570, PMID:21907772, PMID:24211273 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 multiple interactions
decreases expression
ISO AM 251 inhibits the reaction [Ethanol results in increased cleavage of and results in increased activity of CREB3L3 protein]; AM 251 inhibits the reaction [Ethanol results in increased expression of CREB3L3 mRNA]
AM 251 results in decreased expression of CREB3L3 mRNA
CTD PMID:23894352 NCBI chr 7:11,490,852...11,499,287
Ensembl chr 7:11,490,852...11,499,282
JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO AM 251 results in increased expression of CTH mRNA CTD PMID:16500647 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; AM 251 promotes the reaction [iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; iodopravadoline promotes the reaction [AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]] CTD PMID:17484889 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions ISO AM 251 inhibits the reaction [Ethanol results in increased expression of CYP27A1 mRNA] CTD PMID:23894352 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO AM 251 inhibits the reaction [Ethanol results in increased expression of CYP7A1 mRNA] CTD PMID:23894352 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression
multiple interactions
ISO AM 251 results in decreased expression of CYP7B1 mRNA
AM 251 inhibits the reaction [Ethanol results in increased expression of CYP7B1 mRNA]
CTD PMID:23894352 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO AM 251 inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA] CTD PMID:23894352 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO AM 251 results in increased expression of DDIT3 mRNA CTD PMID:16500647 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO AM 251 results in increased expression of DDIT4 mRNA CTD PMID:16500647 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO AM 251 results in decreased expression of DHX9 mRNA CTD PMID:16500647 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Eftud2 elongation factor Tu GTP binding domain containing 2 decreases expression ISO AM 251 results in decreased expression of EFTUD2 mRNA CTD PMID:16500647 NCBI chr10:90,932,071...90,983,971
Ensembl chr10:90,932,075...90,983,928
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases expression
ISO 4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased expression of EGFR protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased expression of EGFR protein] CTD PMID:27423937 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Ervfrd-1 endogenous retrovirus group FRD member 1, envelope multiple interactions ISO AM 251 affects the reaction [Dronabinol results in decreased expression of ERVFRD-1 mRNA] CTD PMID:26070387 NCBI chr12:25,161,130...25,168,182
Ensembl chr12:25,161,130...25,168,182
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO [AM 251 co-treated with iodopravadoline] promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]; [AM 251 co-treated with iodopravadoline] promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]] CTD PMID:27556861 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression ISO AM 251 results in decreased expression of FEN1 mRNA CTD PMID:16500647 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Fra10ac1 FRA10A associated CGG repeat 1 increases expression ISO AM 251 results in increased expression of FRA10AC1 mRNA CTD PMID:16500647 NCBI chr 1:256,881,688...256,913,617
Ensembl chr 1:256,881,771...256,914,260
JBrowse link
G Gpr55 G protein-coupled receptor 55 multiple interactions
increases activity
ISO 4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased activity of GPR55 protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased activity of GPR55 protein] CTD PMID:27423937 NCBI chr 9:92,961,431...93,011,157
Ensembl chr 9:92,962,738...92,963,697
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO AM 251 results in increased expression of GPX1 mRNA CTD PMID:16500647 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gtf3c5 general transcription factor IIIC subunit 5 decreases expression ISO AM 251 results in decreased expression of GTF3C5 mRNA CTD PMID:16500647 NCBI chr 3:7,144,354...7,164,678
Ensembl chr 3:7,144,250...7,164,654
JBrowse link
G Hax1 HCLS1 associated protein X-1 increases expression ISO AM 251 results in increased expression of HAX1 mRNA CTD PMID:16500647 NCBI chr 2:189,330,900...189,333,305
Ensembl chr 2:189,330,902...189,333,322
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO AM 251 results in increased expression of HMOX1 mRNA CTD PMID:16500647 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnmt histamine N-methyltransferase increases expression ISO AM 251 results in increased expression of HNMT mRNA CTD PMID:16500647 NCBI chr 3:905,111...937,038
Ensembl chr 3:904,765...937,102
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO AM 251 results in decreased expression of HSPA1B mRNA CTD PMID:16500647 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO AM 251 results in decreased expression of HSPA8 mRNA CTD PMID:16500647 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO AM 251 inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA] CTD PMID:22198381 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [AM 251 co-treated with iodopravadoline] promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]; [AM 251 co-treated with iodopravadoline] promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]] CTD PMID:27556861 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Immp2l inner mitochondrial membrane peptidase subunit 2 increases expression ISO AM 251 results in increased expression of IMMP2L mRNA CTD PMID:16500647 NCBI chr 6:60,958,351...61,859,457 JBrowse link
G Irf2bpl interferon regulatory factor 2 binding protein-like increases expression ISO AM 251 results in increased expression of IRF2BPL mRNA CTD PMID:16500647 NCBI chr 6:110,901,940...110,904,288
Ensembl chr 6:110,901,940...110,904,288
JBrowse link
G Lmnb2 lamin B2 decreases expression ISO AM 251 results in decreased expression of LMNB2 mRNA CTD PMID:16500647 NCBI chr 7:11,657,870...11,676,936
Ensembl chr 7:11,660,934...11,675,472
JBrowse link
G LOC103690190 histone H2A type 1-E increases expression ISO AM 251 results in increased expression of H2AC6 mRNA CTD PMID:16500647 NCBI chr17:44,747,686...44,748,229
Ensembl chr17:44,747,796...44,748,188
Ensembl chr17:44,747,796...44,748,188
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 decreases expression ISO AM 251 results in decreased expression of MAP2K3 mRNA CTD PMID:16500647 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; AM 251 inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [methanandamide results in increased phosphorylation of MAPK1 protein]
AM 251 results in increased phosphorylation of MAPK1 protein
CTD PMID:17583570, PMID:17596442, PMID:18159069, PMID:19477951 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; AM 251 inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [methanandamide results in increased phosphorylation of MAPK3 protein]
AM 251 results in increased phosphorylation of MAPK3 protein
CTD PMID:17583570, PMID:17596442, PMID:18159069, PMID:19477951 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO AM 251 results in decreased expression of MCM3 mRNA CTD PMID:16500647 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO AM 251 results in decreased expression of MCM5 mRNA CTD PMID:16500647 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mfn2 mitofusin 2 decreases expression ISO AM 251 results in decreased expression of MFN2 mRNA CTD PMID:16500647 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Ncapd3 non-SMC condensin II complex, subunit D3 decreases expression ISO AM 251 results in decreased expression of NCAPD3 mRNA CTD PMID:16500647 NCBI chr 8:28,075,629...28,145,024
Ensembl chr 8:28,075,551...28,144,741
JBrowse link
G Ncoa7 nuclear receptor coactivator 7 increases expression ISO AM 251 results in increased expression of NCOA7 mRNA CTD PMID:16500647 NCBI chr 1:29,225,727...29,386,642
Ensembl chr 1:29,225,707...29,385,199
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO AM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 mRNA]; AM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 protein] CTD PMID:21603976 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663
JBrowse link
G Papola poly (A) polymerase alpha decreases expression ISO AM 251 results in decreased expression of PAPOLA mRNA CTD PMID:16500647 NCBI chr 6:129,609,068...129,662,002
Ensembl chr 6:129,609,074...129,661,531
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO AM 251 inhibits the reaction [HU 211 results in increased cleavage of PARP1 protein] CTD PMID:19509271 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 increases expression ISO AM 251 results in increased expression of PEA15 mRNA CTD PMID:16500647 NCBI chr13:90,579,844...90,589,466
Ensembl chr13:90,579,846...90,589,466
JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression ISO AM 251 results in decreased expression of PPIF mRNA CTD PMID:16500647 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Ptbp1 polypyrimidine tract binding protein 1 decreases expression ISO AM 251 results in decreased expression of PTBP1 mRNA CTD PMID:16500647 NCBI chr 7:12,663,965...12,673,723
Ensembl chr 7:12,663,965...12,673,718
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO AM 251 results in decreased expression of RACGAP1 mRNA CTD PMID:16500647 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233
JBrowse link
G Rad54l RAD54 like decreases expression ISO AM 251 results in decreased expression of RAD54L mRNA CTD PMID:16500647 NCBI chr 5:134,948,511...134,978,125
Ensembl chr 5:134,948,512...134,978,125
JBrowse link
G Rcc1 regulator of chromosome condensation 1 decreases expression ISO AM 251 results in decreased expression of RCC1 mRNA CTD PMID:16500647 NCBI chr 5:150,508,840...150,531,062
Ensembl chr 5:150,509,040...150,525,254
JBrowse link
G Rcc1l RCC1 like decreases expression ISO AM 251 results in decreased expression of RCC1L mRNA CTD PMID:16500647 NCBI chr12:25,561,871...25,592,337
Ensembl chr12:25,561,777...25,592,342
JBrowse link
G Rfc5 replication factor C subunit 5 decreases expression ISO AM 251 results in decreased expression of RFC5 mRNA CTD PMID:16500647 NCBI chr12:44,931,494...44,941,051
Ensembl chr12:44,931,494...44,941,324
JBrowse link
G Rnaseh1 ribonuclease H1 increases expression ISO AM 251 results in increased expression of RNASEH1 mRNA CTD PMID:16500647 NCBI chr 6:47,916,188...47,925,582
Ensembl chr 6:47,916,188...47,925,571
JBrowse link
G Rpa1 replication protein A1 decreases expression ISO AM 251 results in decreased expression of RPA1 mRNA CTD PMID:16500647 NCBI chr10:62,140,419...62,191,518
Ensembl chr10:62,140,419...62,191,512
JBrowse link
G Rwdd1 RWD domain containing 1 increases expression ISO AM 251 results in increased expression of RWDD1 mRNA CTD PMID:16500647 NCBI chr20:27,534,361...27,552,225
Ensembl chr20:27,535,324...27,552,349
JBrowse link
G Sars1 seryl-tRNA synthetase 1 increases expression ISO AM 251 results in increased expression of SARS1 mRNA CTD PMID:16500647 NCBI chr 2:211,219,743...211,235,475
Ensembl chr 2:211,219,750...211,235,467
JBrowse link
G Sesn2 sestrin 2 increases expression ISO AM 251 results in increased expression of SESN2 mRNA CTD PMID:16500647 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Slc18b1 solute carrier family 18 member B1 decreases expression ISO AM 251 results in decreased expression of SLC18B1 mRNA CTD PMID:16500647 NCBI chr 1:22,705,980...22,748,571
Ensembl chr 1:22,705,916...22,748,422
JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression ISO AM 251 results in increased expression of SLC1A4 mRNA CTD PMID:16500647 NCBI chr14:104,582,884...104,612,417
Ensembl chr14:104,581,190...104,612,597
JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO AM 251 results in increased expression of SLC30A1 mRNA CTD PMID:16500647 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc46a1 solute carrier family 46 member 1 increases expression ISO AM 251 results in increased expression of SLC46A1 mRNA CTD PMID:19145103 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO AM 251 results in increased expression of SLC7A5 mRNA CTD PMID:16500647 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 decreases expression ISO AM 251 results in decreased expression of SPTBN1 mRNA CTD PMID:16500647 NCBI chr14:114,517,839...114,700,199
Ensembl chr14:114,518,816...114,692,764
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO AM 251 results in decreased expression of SRSF1 mRNA CTD PMID:16500647 NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197
JBrowse link
G Stam signal transducing adaptor molecule decreases expression ISO AM 251 results in decreased expression of STAM mRNA CTD PMID:16500647 NCBI chr17:81,209,795...81,256,111
Ensembl chr17:81,209,867...81,255,808
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression ISO AM 251 results in decreased expression of STAT3 mRNA CTD PMID:16500647 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sugp2 SURP and G patch domain containing 2 decreases expression ISO AM 251 results in decreased expression of SUGP2 mRNA CTD PMID:16500647 NCBI chr16:20,908,162...20,939,574
Ensembl chr16:20,910,177...20,939,545
JBrowse link
G Sun1 Sad1 and UNC84 domain containing 1 decreases expression ISO AM 251 results in decreased expression of SUN1 mRNA CTD PMID:16500647 NCBI chr12:17,488,482...17,533,334
Ensembl chr12:17,488,487...17,522,534
JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 decreases expression ISO AM 251 results in decreased expression of TACC3 mRNA CTD PMID:16500647 NCBI chr14:82,336,283...82,350,069
Ensembl chr14:82,336,324...82,347,679
JBrowse link
G Tbl1x transducin (beta)-like 1 X-linked increases expression ISO AM 251 results in increased expression of TBL1X mRNA CTD PMID:16500647 NCBI chr  X:44,959,883...44,988,551
Ensembl chr  X:44,830,849...44,988,551
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [iodopravadoline co-treated with AM 251] inhibits the reaction [Dronabinol results in increased expression of TIMP1 protein]; [iodopravadoline co-treated with AM 251] inhibits the reaction [methanandamide results in increased expression of TIMP1 protein]; AM 251 inhibits the reaction [Dronabinol results in increased expression of TIMP1 protein]; AM 251 inhibits the reaction [methanandamide results in increased expression of TIMP1 protein] CTD PMID:18159069 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tmem126a transmembrane protein 126A increases expression ISO AM 251 results in increased expression of TMEM126A mRNA CTD PMID:16500647 NCBI chr 1:156,283,105...156,291,057
Ensembl chr 1:156,283,128...156,291,052
JBrowse link
G Tnf tumor necrosis factor decreases response to substance ISO AM 251 results in decreased susceptibility to TNF protein CTD PMID:20626112 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO AM 251 results in increased expression of TRIB3 mRNA CTD PMID:16500647 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Tspan10 tetraspanin 10 increases expression ISO AM 251 results in increased expression of TSPAN10 mRNA CTD PMID:16500647 NCBI chr10:109,614,664...109,619,581
Ensembl chr10:109,614,965...109,618,807
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO AM 251 results in increased expression of TXNIP mRNA CTD PMID:16500647 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase decreases expression ISO AM 251 results in decreased expression of UGCG mRNA CTD PMID:16500647 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO AM 251 results in decreased expression of UHRF1 mRNA CTD PMID:16500647 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO AM 251 results in increased expression of VLDLR mRNA CTD PMID:16500647 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO AM 251 results in increased expression of WARS1 mRNA CTD PMID:16500647 NCBI chr 6:132,771,026...132,802,262
Ensembl chr 6:132,771,021...132,802,210
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO AM 251 results in increased expression of XBP1 mRNA CTD PMID:16500647 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 increases expression ISO AM 251 results in increased expression of YARS1 mRNA CTD PMID:16500647 NCBI chr 5:147,375,350...147,403,578
Ensembl chr 5:147,375,350...147,403,571
JBrowse link
G Zfp142 zinc finger protein 142 decreases expression ISO AM 251 results in decreased expression of ZNF142 mRNA CTD PMID:16500647 NCBI chr 9:81,844,138...81,868,086
Ensembl chr 9:81,844,138...81,868,086
JBrowse link
G Zmym6 zinc finger MYM-type containing 6 increases expression ISO AM 251 results in increased expression of ZMYM6 mRNA CTD PMID:16500647 NCBI chr 5:145,138,667...145,186,285
Ensembl chr 5:145,138,697...145,186,357
JBrowse link
amidotrizoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Diatrizoate results in increased expression of AGT protein] CTD PMID:19452295 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO Plant Extracts inhibits the reaction [Diatrizoate results in decreased phosphorylation of AKT1 protein] CTD PMID:25603236 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BAX protein CTD PMID:17173243 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BCL2 protein CTD PMID:17173243 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 affects expression
multiple interactions
increases activity
ISO
EXP
Diatrizoate affects the expression of CASP3 protein
[Diatrizoate co-treated with Iodine] results in increased activity of CASP3 protein
telmisartan inhibits the reaction [Diatrizoate results in increased activity of CASP3 protein]
CTD PMID:17173243, PMID:19452295, PMID:21036957 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G F2 coagulation factor II multiple interactions ISO Diatrizoate inhibits the reaction [F2 protein binds to SERPINC1 protein] CTD PMID:2020943 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link