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ONTOLOGY REPORT - ANNOTATIONS


Term:leukotriene
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Accession:CHEBI:25029 term browser browse the term
Definition:Any icosanoid from that family of C20 polyunsaturated fatty acids and their derivatives generated by leukocytes from arachidonic acid, each member having four double bonds of which three are conjugated.
Synonyms:related_synonym: Leukotrien;   leucotriene;   leucotrienes;   leukotrienes
 xref: LIPID_MAPS_class:LMFA0302 "LIPID MAPS";   PMID:10922142 "Europe PMC";   PMID:15794321 "Europe PMC";   PMID:3001504 "Europe PMC";   PMID:6129158 "Europe PMC";   PMID:6293196 "Europe PMC";   PMID:6311078 "Europe PMC";   PMID:8842590 "Europe PMC";   PMID:9526099 "Europe PMC";   PMID:9561094 "Europe PMC"
 cyclic_relationship: is_conjugate_acid_of CHEBI:62942


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leukotriene A4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:6480464
G Lta4h leukotriene A4 hydrolase JBrowse link 7 34,288,333 34,320,243 RGD:6480464
G Mgst1 microsomal glutathione S-transferase 1 JBrowse link 4 172,119,382 172,134,609 RGD:6480464
leukotriene B4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:6480464
G Alox5ap arachidonate 5-lipoxygenase activating protein JBrowse link 12 6,854,930 6,879,112 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:6480464
G Ccl12 chemokine (C-C motif) ligand 12 JBrowse link 10 69,476,866 69,478,416 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Cxcl3 chemokine (C-X-C motif) ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cysltr1 cysteinyl leukotriene receptor 1 JBrowse link X 77,671,028 77,700,491 RGD:6480464
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 JBrowse link 19 37,476,083 37,481,326 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:6480464
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:6480464
G Lta4h leukotriene A4 hydrolase JBrowse link 7 34,288,333 34,320,243 RGD:6480464
G Ltb4r leukotriene B4 receptor JBrowse link 15 34,449,299 34,453,352 RGD:6480464
G Ltb4r2 leukotriene B4 receptor 2 JBrowse link 15 34,446,478 34,448,220 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Mgst1 microsomal glutathione S-transferase 1 JBrowse link 4 172,119,382 172,134,609 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Sell selectin L JBrowse link 13 82,369,820 82,387,774 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
leukotriene B5 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ltb4r2 leukotriene B4 receptor 2 JBrowse link 15 34,446,478 34,448,220 RGD:6480464
leukotriene C4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca8 ATP binding cassette subfamily A member 8 JBrowse link 10 98,236,919 98,308,288 RGD:6480464
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Abcc6 ATP binding cassette subfamily C member 6 JBrowse link 1 101,954,786 102,013,252 RGD:6480464
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:6480464
G Alox5ap arachidonate 5-lipoxygenase activating protein JBrowse link 12 6,854,930 6,879,112 RGD:6480464
G Ambp alpha-1-microglobulin/bikunin precursor JBrowse link 5 78,975,690 78,986,021 RGD:6480464
G Ccl12 chemokine (C-C motif) ligand 12 JBrowse link 10 69,476,866 69,478,416 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Clec7a C-type lectin domain containing 7A JBrowse link 4 163,216,152 163,227,367 RGD:6480464
G Cxcl3 chemokine (C-X-C motif) ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cysltr1 cysteinyl leukotriene receptor 1 JBrowse link X 77,671,028 77,700,491 RGD:6480464
G Cysltr2 cysteinyl leukotriene receptor 2 JBrowse link 15 54,903,290 54,941,742 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Ggt5 gamma-glutamyltransferase 5 JBrowse link 20 13,988,444 14,001,296 RGD:6480464
G Gpr17 G protein-coupled receptor 17 JBrowse link 18 24,733,306 24,739,194 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Ltc4s leukotriene C4 synthase JBrowse link 10 35,736,486 35,743,088 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mgst1 microsomal glutathione S-transferase 1 JBrowse link 4 172,119,382 172,134,609 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Pla2g5 phospholipase A2, group V JBrowse link 5 157,247,601 157,268,968 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ralbp1 ralA binding protein 1 JBrowse link 9 113,579,107 113,598,477 RGD:6480464
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6480464
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:6480464
leukotriene D4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Cysltr1 cysteinyl leukotriene receptor 1 JBrowse link X 77,671,028 77,700,491 RGD:6480464
G Cysltr2 cysteinyl leukotriene receptor 2 JBrowse link 15 54,903,290 54,941,742 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Gpr17 G protein-coupled receptor 17 JBrowse link 18 24,733,306 24,739,194 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mgst1 microsomal glutathione S-transferase 1 JBrowse link 4 172,119,382 172,134,609 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:6480464
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6480464
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
leukotriene E4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:6480464
G Cysltr1 cysteinyl leukotriene receptor 1 JBrowse link X 77,671,028 77,700,491 RGD:6480464
G Cysltr2 cysteinyl leukotriene receptor 2 JBrowse link 15 54,903,290 54,941,742 RGD:6480464
G Gpr17 G protein-coupled receptor 17 JBrowse link 18 24,733,306 24,739,194 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Mgst1 microsomal glutathione S-transferase 1 JBrowse link 4 172,119,382 172,134,609 RGD:6480464
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    chemical entity 19677
      atom 19675
        nonmetal atom 19540
          carbon atom 19430
            organic molecular entity 19430
              fatty acid derivative 1008
                icosanoid 450
                  leukotriene 65
                    (12R)-hydroxy-10,11-dihydroleukotriene E4 0
                    (5S,6S)-dihydroxy-(7E,9E,11Z,14Z)-icosatetraenoic acid 0
                    10,11-dihydro-20,20,20-trihydroxyleukotriene B4 0
                    10,11-dihydro-20,20-dihydroxyleukotriene B4 0
                    10,11-dihydroleukotriene B4 0
                    11,12-dihydro-(12R)-hydroxyleukotriene C4 0
                    11,12-dihydro-12-oxoleukotriene C4 0
                    11-trans-LTD4 0
                    11-trans-LTE4 0
                    12-dehydro-leukotriene B4 0
                    12-epi-leukotriene B4 0
                    12-oxo-20-hydroxyleukotriene B4 0
                    12-oxo-6-trans-leukotriene B4 0
                    18-hydroxyleukotriene B4 0
                    19-hydroxyleukotriene B4 0
                    20,20,20-trihydroxyleukotriene B4 0
                    20,20-dihydroxyleukotriene B4 0
                    20-carboxyleukotriene E4 0
                    20-hydroxy-20-oxoleukotriene B4 + 0
                    20-hydroxy-20-oxoleukotriene B4-20-(beta-D-glucuronide) 0
                    20-hydroxy-6-trans-leukotriene B4 0
                    20-oxoleukotriene B4 0
                    20-oxoleukotriene E4 0
                    4,5-leukotriene A4 0
                    5,6-Epoxy-18R-HEPE 0
                    6-trans-leukotriene B4 + 0
                    Delta(6)-trans,Delta(8)-cis-leukotriene B4 0
                    Delta(6)-trans-12-epi-leukotriene B4 0
                    N-acetylleukotriene E4 0
                    eoxin A4 0
                    eoxin C4 0
                    eoxin D4 0
                    eoxin E4 0
                    leukotriene A4 + 3
                    leukotriene B4 + 39
                    leukotriene B5 1
                    leukotriene C3 0
                    leukotriene C4 + 33
                    leukotriene C4 methyl ester 0
                    leukotriene D3 0
                    leukotriene D4 23
                    leukotriene E3 + 0
                    leukotriene E4 + 8
                    leukotriene E4 methyl ester 0
                    leukotriene F4 0
                    omega-Carboxy-N-acetyl-LTE4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      carbon group element atom 19438
                        carbon atom 19430
                          organic molecular entity 19430
                            organic group 18351
                              organic divalent group 18340
                                organodiyl group 18340
                                  carbonyl group 18225
                                    carbonyl compound 18225
                                      carboxylic acid 17930
                                        monocarboxylic acid 17259
                                          fatty acid 15815
                                            fatty acid derivative 1008
                                              icosanoid 450
                                                leukotriene 65
                                                  (12R)-hydroxy-10,11-dihydroleukotriene E4 0
                                                  (5S,6S)-dihydroxy-(7E,9E,11Z,14Z)-icosatetraenoic acid 0
                                                  10,11-dihydro-20,20,20-trihydroxyleukotriene B4 0
                                                  10,11-dihydro-20,20-dihydroxyleukotriene B4 0
                                                  10,11-dihydroleukotriene B4 0
                                                  11,12-dihydro-(12R)-hydroxyleukotriene C4 0
                                                  11,12-dihydro-12-oxoleukotriene C4 0
                                                  11-trans-LTD4 0
                                                  11-trans-LTE4 0
                                                  12-dehydro-leukotriene B4 0
                                                  12-epi-leukotriene B4 0
                                                  12-oxo-20-hydroxyleukotriene B4 0
                                                  12-oxo-6-trans-leukotriene B4 0
                                                  18-hydroxyleukotriene B4 0
                                                  19-hydroxyleukotriene B4 0
                                                  20,20,20-trihydroxyleukotriene B4 0
                                                  20,20-dihydroxyleukotriene B4 0
                                                  20-carboxyleukotriene E4 0
                                                  20-hydroxy-20-oxoleukotriene B4 + 0
                                                  20-hydroxy-20-oxoleukotriene B4-20-(beta-D-glucuronide) 0
                                                  20-hydroxy-6-trans-leukotriene B4 0
                                                  20-oxoleukotriene B4 0
                                                  20-oxoleukotriene E4 0
                                                  4,5-leukotriene A4 0
                                                  5,6-Epoxy-18R-HEPE 0
                                                  6-trans-leukotriene B4 + 0
                                                  Delta(6)-trans,Delta(8)-cis-leukotriene B4 0
                                                  Delta(6)-trans-12-epi-leukotriene B4 0
                                                  N-acetylleukotriene E4 0
                                                  eoxin A4 0
                                                  eoxin C4 0
                                                  eoxin D4 0
                                                  eoxin E4 0
                                                  leukotriene A4 + 3
                                                  leukotriene B4 + 39
                                                  leukotriene B5 1
                                                  leukotriene C3 0
                                                  leukotriene C4 + 33
                                                  leukotriene C4 methyl ester 0
                                                  leukotriene D3 0
                                                  leukotriene D4 23
                                                  leukotriene E3 + 0
                                                  leukotriene E4 + 8
                                                  leukotriene E4 methyl ester 0
                                                  leukotriene F4 0
                                                  omega-Carboxy-N-acetyl-LTE4 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.